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Conserved domains on  [gi|15150801|ref|NP_149973|]
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zinc finger protein 682 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204577)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 8.91e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.46  E-value: 8.91e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15150801      4 LTFRDVTIEFSLEEWEFLNPAQQSLYRKVMLENYRNLVSLGLTVSKPELISRLEQRQEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-445 5.66e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 5.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 239 NWCSSLTKHKRIHTgekPYKCEECGKAFHWCSPFVRHK--KIHTGE--KPYTC--EDCGRAFNRHSHLTKHKTIHTGKKP 312
Cdd:COG5048 275 PNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 313 YKCKecgkafnhcslLTIHERTHTGEKPYKCEECgkafnsssilTEHKVIHSGEKPYKCE--KCDKVFKRFSYLTKHKRI 390
Cdd:COG5048 352 AKEK-----------LLNSSSKFSPLLNNEPPQS----------LQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIIT 410

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15150801 391 HTGEKP--YKCEECGKAFNWSSILTEHKRIHTGEKPYNCEECGKaFNRCSHLTRHKK 445
Cdd:COG5048 411 HLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-239 4.19e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*
gi 15150801   215 YLTKHKRIHTGEKPYKCEECGKAFN 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 113-248 1.02e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 113 LRKDGENVGECKDQKEIYNGLNQC----LSTLPSKIFPYNkcvkvfSKSSNLNRENIRHTT-------EKLFKC--MQCG 179
Cdd:COG5189 285 LGFDYEFIHKSVGNKEIRGGISTGemidVRKLPCTNSSSN------GKLAHGGERNIDTPSrmlkvkdGKPYKCpvEGCN 358

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15150801 180 KVFKSHSGLSYHKIiHTEEKLCICEECGKTfkwfsyltKHKRIHTGEKPYKCEECGKAFNWCSSLTKHK 248
Cdd:COG5189 359 KKYKNQNGLKYHML-HGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-464 2.70e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 15150801   439 HLTRHKKIHTAVKRYKCEECGKAFKR 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 8.91e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.46  E-value: 8.91e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15150801      4 LTFRDVTIEFSLEEWEFLNPAQQSLYRKVMLENYRNLVSLGLTVSKPELISRLEQRQEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 3.50e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 3.50e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15150801     3 LLTFRDVTIEFSLEEWEFLNPAQQSLYRKVMLENYRNLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 8.02e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 8.02e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15150801   4 LTFRDVTIEFSLEEWEFLNPAQQSLYRKVMLENYRNLVSL 43
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-445 5.66e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 5.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 239 NWCSSLTKHKRIHTgekPYKCEECGKAFHWCSPFVRHK--KIHTGE--KPYTC--EDCGRAFNRHSHLTKHKTIHTGKKP 312
Cdd:COG5048 275 PNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 313 YKCKecgkafnhcslLTIHERTHTGEKPYKCEECgkafnsssilTEHKVIHSGEKPYKCE--KCDKVFKRFSYLTKHKRI 390
Cdd:COG5048 352 AKEK-----------LLNSSSKFSPLLNNEPPQS----------LQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIIT 410

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15150801 391 HTGEKP--YKCEECGKAFNWSSILTEHKRIHTGEKPYNCEECGKaFNRCSHLTRHKK 445
Cdd:COG5048 411 HLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-407 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*
gi 15150801   383 YLTKHKRIHTGEKPYKCEECGKAFN 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-239 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*
gi 15150801   215 YLTKHKRIHTGEKPYKCEECGKAFN 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 113-248 1.02e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 113 LRKDGENVGECKDQKEIYNGLNQC----LSTLPSKIFPYNkcvkvfSKSSNLNRENIRHTT-------EKLFKC--MQCG 179
Cdd:COG5189 285 LGFDYEFIHKSVGNKEIRGGISTGemidVRKLPCTNSSSN------GKLAHGGERNIDTPSrmlkvkdGKPYKCpvEGCN 358

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15150801 180 KVFKSHSGLSYHKIiHTEEKLCICEECGKTfkwfsyltKHKRIHTGEKPYKCEECGKAFNWCSSLTKHK 248
Cdd:COG5189 359 KKYKNQNGLKYHML-HGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-464 2.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 15150801   439 HLTRHKKIHTAVKRYKCEECGKAFKR 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 8.91e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.46  E-value: 8.91e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15150801      4 LTFRDVTIEFSLEEWEFLNPAQQSLYRKVMLENYRNLVSLGLTVSKPELISRLEQRQEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 3.50e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 3.50e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15150801     3 LLTFRDVTIEFSLEEWEFLNPAQQSLYRKVMLENYRNLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 8.02e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 8.02e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15150801   4 LTFRDVTIEFSLEEWEFLNPAQQSLYRKVMLENYRNLVSL 43
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-445 5.66e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 5.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 239 NWCSSLTKHKRIHTgekPYKCEECGKAFHWCSPFVRHK--KIHTGE--KPYTC--EDCGRAFNRHSHLTKHKTIHTGKKP 312
Cdd:COG5048 275 PNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 313 YKCKecgkafnhcslLTIHERTHTGEKPYKCEECgkafnsssilTEHKVIHSGEKPYKCE--KCDKVFKRFSYLTKHKRI 390
Cdd:COG5048 352 AKEK-----------LLNSSSKFSPLLNNEPPQS----------LQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIIT 410

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15150801 391 HTGEKP--YKCEECGKAFNWSSILTEHKRIHTGEKPYNCEECGKaFNRCSHLTRHKK 445
Cdd:COG5048 411 HLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
292-474 1.39e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 292 RAFNRHSHLTKHKTIHTGK-KPYKCKECGKAFNHCSLLTIHERT--HTGE--KPYKCEE--CGKAFNSSSILTEHKVIHS 364
Cdd:COG5048 268 ASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 365 GEKPYKC--EKCDKVF------KRFSYLTKHKRIHTGEKPYKCEECGKAFNWS-SILTEHKRIHTGEKPYNCE--ECGKA 433
Cdd:COG5048 348 SISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRPYNCKnpPCSKS 427

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 15150801 434 FNRCSHLTRHKKIHTAVKRYKCEECGKaFKRCSHLNEHKRV 474
Cdd:COG5048 428 FNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-496 7.23e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 7.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 203 CEECGKTFKWFSYLTKHKRIHTGEKPYKC--EECGKAFNWCSSLTKHKRIHTG--------------EKPYKCEECGKAF 266
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNnpsdlnskslplsnSKASSSSLSSSSS 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 267 HWCSPF----------VRHKKIHTGEKPY-----TCEDCGRAFN-----------------------RHSHLTKHKTIHT 308
Cdd:COG5048 116 NSNDNNllsshslppsSRDPQLPDLLSISnlrnnPLPGNNSSSVntpqsnslhpplpanslskdpssNLSLLISSNVSTS 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 309 GKKPYKCKEC---GKAFNHCSLLT---------IHERTHTGEKPYKCE---------------ECGKAFNSSSILTEHKV 361
Cdd:COG5048 196 IPSSSENSPLsssYSIPSSSSDQNlensssslpLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASSQSSSP 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 362 IHSGE-------KPYKCEKCDKVFKRFSYLTKHKR--IHTGE--KPYKCEE--CGKAFNWSSILTEHKRIHTGEKPYNCE 428
Cdd:COG5048 276 NESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 429 EC------GKAFNRCSHLTRHKKIHTAVKRYKC---EECGKAFKR----CSHLNEHKRVQRGEksCKYKKCGEAFNHCSN 495
Cdd:COG5048 356 LLnssskfSPLLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRdsnlSLHIITHLSFRPYN--CKNPPCSKSFNRHYN 433


                .
gi 15150801 496 L 496
Cdd:COG5048 434 L 434
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-355 4.55e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 4.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 118 ENVGECKDQKEIYNGLNQCLSTLPSKI---FPYNKCVKVFSKSSNLNRENIRHTTEKLFKCM-QCGKVFKSHSGLSYHK- 192
Cdd:COG5048 231 TNSQLSPKSLLSQSPSSLSSSDSSSSAsesPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSkQCNISFSRSSPLTRHLr 310

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 193 -IIHTEEKL----CICEECGKTFKWFSYLTKHKRIHTGEKPYKCeecgkafNWCSSLTKHKRIHTGEKPykceecgkafh 267
Cdd:COG5048 311 sVNHSGESLkpfsCPYSLCGKLFSRNDALKRHILLHTSISPAKE-------KLLNSSSKFSPLLNNEPP----------- 372

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 268 wcSPFVRHKKIHTGEKPYTCE-DCGRAFNRHSHLTKHKTIHTGKKP--YKCKECGKAFNHCSLLTIHERTHTGEKPYKCE 344
Cdd:COG5048 373 --QSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450

                       250
                ....*....|.
gi 15150801 345 ECGKAFNSSSI 355
Cdd:COG5048 451 ILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
395-448 1.05e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.05e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15150801 395 KPYKCEECGKAFNWSSILTEHKRIHTGEKPYNC--EECGKAFNRCSHLTRHKKIHT 448
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH 87
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 310-388 2.73e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 2.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 310 KKPYKCKECGKAFNHCSLLTIHERTH----TGEKPYKCE--ECGKAFNSSSILTEHK-------------------VIHS 364
Cdd:COG5189 315 KLPCTNSSSNGKLAHGGERNIDTPSRmlkvKDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSA 394

                        90       100
                ....*....|....*....|....
gi 15150801 365 GEKPYKCEKCDKVFKRFSYLTKHK 388
Cdd:COG5189 395 KDKPYRCEVCDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
367-428 3.94e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.94e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15150801 367 KPYKCEKCDKVFKRFSYLTKHKRIHTGEKPYKC--EECGKAFNWSSILTEHKRIHTGEKPYNCE 428
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-407 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*
gi 15150801   383 YLTKHKRIHTGEKPYKCEECGKAFN 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-239 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*
gi 15150801   215 YLTKHKRIHTGEKPYKCEECGKAFN 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-266 6.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.51e-04
                          10        20
                  ....*....|....*....|....
gi 15150801   243 SLTKHKRIHTGEKPYKCEECGKAF 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
339-396 7.04e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.04e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 339 KPYKCEECGKAFNSSSILTEHKVIHSGEKPYKC--EKCDKVFKRFSYLTKHKRIHTGEKP 396
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 113-248 1.02e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 113 LRKDGENVGECKDQKEIYNGLNQC----LSTLPSKIFPYNkcvkvfSKSSNLNRENIRHTT-------EKLFKC--MQCG 179
Cdd:COG5189 285 LGFDYEFIHKSVGNKEIRGGISTGemidVRKLPCTNSSSN------GKLAHGGERNIDTPSrmlkvkdGKPYKCpvEGCN 358

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15150801 180 KVFKSHSGLSYHKIiHTEEKLCICEECGKTfkwfsyltKHKRIHTGEKPYKCEECGKAFNWCSSLTKHK 248
Cdd:COG5189 359 KKYKNQNGLKYHML-HGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
299-324 1.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 15150801   299 HLTKHKTIHTGKKPYKCKECGKAFNH 324
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-436 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*
gi 15150801   412 LTEHKRIHTGEKPYNCEECGKAFNR 436
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-352 1.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.11e-03
                          10        20
                  ....*....|....*....|....*
gi 15150801   328 LTIHERTHTGEKPYKCEECGKAFNS 352
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-354 2.22e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.22e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15150801 283 KPYTCEDCGRAFNRHSHLTKHKTIHTGKKPYKC--KECGKAFNHCSLLTIHERTHTGEKPYKCEECGKAFNSSS 354
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-475 2.26e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 227 KPYKCEECGKAFNWCSSLTKHKRIHTGEKPYKC--EECGKAFHWCSPFVRHKKIHTGEKPYTCEDCGR------------ 292
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 293 ----AFNRHSHLTKHKTIHTGKKP-------------YKCKECGKAFNHCSL----------------------LTIHER 333
Cdd:COG5048 112 ssssNSNDNNLLSSHSLPPSSRDPqlpdllsisnlrnNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 334 THTGEKPYKCEECGKAFNSSSILTEHKVIHSGEKPYKCEKCDKVF------------------------------KRFSY 383
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqspsslsssdssssasesprsslpTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 384 LTKHKRIHTGE-----KPYKCEECGKAFNWSSILTEHKR--IHTGE--KPYNCEE--CGKAFNRCSHLTRHKKIHTAVKR 452
Cdd:COG5048 272 SSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                       330       340
                ....*....|....*....|....*
gi 15150801 453 YKC--EECGKAFKRCSHLNEHKRVQ 475
Cdd:COG5048 352 AKEklLNSSSKFSPLLNNEPPQSLQ 376
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 365-445 2.33e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15150801 365 GEKPYKCE--KCDKVFKRFSYLtKHKRIHTGEKPYKCEecgkafNWSSIltEHKRIHTGEKPYNCEECGKAFNRCSHLTR 442
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 15150801 443 HKK 445
Cdd:COG5189 417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-464 2.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 15150801   439 HLTRHKKIHTAVKRYKCEECGKAFKR 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-374 2.85e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 2.85e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15150801 310 KKPYKCKECGKAFNHCSLLTIHERTHTGEKPYKC--EECGKAFNSSSILTEHKVIHSGEKPYKCEKC 374
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-296 5.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.38e-03
                          10        20
                  ....*....|....*....|...
gi 15150801   274 RHKKIHTGEKPYTCEDCGRAFNR 296
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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