NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|39995107|ref|NP_148936|]
View 

fas-activated serine/threonine kinase isoform 4 [Homo sapiens]

Protein Classification

FAST kinase domain-containing protein( domain architecture ID 10535844)

FAST kinase domain-containing protein similar to human Fas-activated serine/threonine (FAST) kinase that phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 214-303 1.48e-18

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 462448  Cd Length: 89  Bit Score: 79.92  E-value: 1.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995107   214 RRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRArcKYSHKDIVAEGLRQLLGEEKY-RQDLTVPPGYCTDFL 292
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKK--KSPLQKEVLEALKELLGGENYfRSNVLTPYGYTIDFE 78

                          90
                  ....*....|.
gi 39995107   293 LCASSSGAVLP 303
Cdd:pfam08368  79 CKLDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 136-202 1.81e-12

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 62.12  E-value: 1.81e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 39995107   136 VQKLVLPFGRLNYLP-LEQQFMPCLERILARE-AGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFIN 202
Cdd:pfam06743   1 LLSLLLPFARLNYLPpNAEEFFEKLESVLESYlSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQ 69
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 343-395 2.66e-12

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


:

Pssm-ID: 214932  Cd Length: 58  Bit Score: 61.48  E-value: 2.66e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 39995107    343 RWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQK 395
Cdd:smart00952   6 PSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
 
Name Accession Description Interval E-value
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 214-303 1.48e-18

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 79.92  E-value: 1.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995107   214 RRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRArcKYSHKDIVAEGLRQLLGEEKY-RQDLTVPPGYCTDFL 292
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKK--KSPLQKEVLEALKELLGGENYfRSNVLTPYGYTIDFE 78

                          90
                  ....*....|.
gi 39995107   293 LCASSSGAVLP 303
Cdd:pfam08368  79 CKLDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 136-202 1.81e-12

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 62.12  E-value: 1.81e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 39995107   136 VQKLVLPFGRLNYLP-LEQQFMPCLERILARE-AGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFIN 202
Cdd:pfam06743   1 LLSLLLPFARLNYLPpNAEEFFEKLESVLESYlSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQ 69
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 343-395 2.66e-12

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 61.48  E-value: 2.66e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 39995107    343 RWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQK 395
Cdd:smart00952   6 PSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 342-395 1.89e-10

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 56.05  E-value: 1.89e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 39995107   342 ERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQK 395
Cdd:pfam08373   5 GPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQLKTKEEKVEYLKKK 58
 
Name Accession Description Interval E-value
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 214-303 1.48e-18

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 79.92  E-value: 1.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995107   214 RRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRArcKYSHKDIVAEGLRQLLGEEKY-RQDLTVPPGYCTDFL 292
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKK--KSPLQKEVLEALKELLGGENYfRSNVLTPYGYTIDFE 78

                          90
                  ....*....|.
gi 39995107   293 LCASSSGAVLP 303
Cdd:pfam08368  79 CKLDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 136-202 1.81e-12

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 62.12  E-value: 1.81e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 39995107   136 VQKLVLPFGRLNYLP-LEQQFMPCLERILARE-AGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFIN 202
Cdd:pfam06743   1 LLSLLLPFARLNYLPpNAEEFFEKLESVLESYlSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQ 69
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 343-395 2.66e-12

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 61.48  E-value: 2.66e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 39995107    343 RWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQK 395
Cdd:smart00952   6 PSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 342-395 1.89e-10

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 56.05  E-value: 1.89e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 39995107   342 ERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQK 395
Cdd:pfam08373   5 GPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQLKTKEEKVEYLKKK 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH