NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|14670352|ref|NP_127493|]
View 

general transcription factor II-I isoform 2 [Homo sapiens]

Protein Classification

GTF2I repeat domain-containing protein( domain architecture ID 10502978)

GTF2I repeat domain-containing protein similar to Homo sapiens general transcription factor II-I which interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
112-186 9.72e-41

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 143.91  E-value: 9.72e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   112 LRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGISFIIKR 186
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
446-520 1.21e-36

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 132.35  E-value: 1.21e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   446 LRKMVDQLFCKKFAEALGSTEAKAVPYQKFEAHPNDLYVEGLPENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKR 520
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
341-415 1.99e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 128.89  E-value: 1.99e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   341 LRKQVEELFERKYAQAIKAKGPVTIPYPLFQSHVEDLYVEGLPEGIPFRRPSTYGIPRLERILLAKERIRFVIKK 415
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
551-625 5.90e-34

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 124.65  E-value: 5.90e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   551 LRKQVEEIFNLKFAQALGLTEAVKVPYPVFESNPEFLYVEGLPEGIPFRSPTWFGIPRLERIVRGSNKIKFVVKK 625
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
713-777 4.32e-31

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 116.56  E-value: 4.32e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   713 LKQKVENLFNEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRN 777
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEA 65
GTF2I super family cl08383
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
848-922 1.30e-20

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


The actual alignment was detected with superfamily member pfam02946:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 86.51  E-value: 1.30e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   848 LREQVNDLFSRKFGEAIGMGFPVKVPYRKITINPGCVVVDGMPPGVSFKAPSYLEISSMRRILDSAEFIKFTVIR 922
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
112-186 9.72e-41

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 143.91  E-value: 9.72e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   112 LRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGISFIIKR 186
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
446-520 1.21e-36

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 132.35  E-value: 1.21e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   446 LRKMVDQLFCKKFAEALGSTEAKAVPYQKFEAHPNDLYVEGLPENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKR 520
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
341-415 1.99e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 128.89  E-value: 1.99e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   341 LRKQVEELFERKYAQAIKAKGPVTIPYPLFQSHVEDLYVEGLPEGIPFRRPSTYGIPRLERILLAKERIRFVIKK 415
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
551-625 5.90e-34

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 124.65  E-value: 5.90e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   551 LRKQVEEIFNLKFAQALGLTEAVKVPYPVFESNPEFLYVEGLPEGIPFRSPTWFGIPRLERIVRGSNKIKFVVKK 625
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
713-777 4.32e-31

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 116.56  E-value: 4.32e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   713 LKQKVENLFNEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRN 777
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEA 65
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
848-922 1.30e-20

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 86.51  E-value: 1.30e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   848 LREQVNDLFSRKFGEAIGMGFPVKVPYRKITINPGCVVVDGMPPGVSFKAPSYLEISSMRRILDSAEFIKFTVIR 922
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
112-186 9.72e-41

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 143.91  E-value: 9.72e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   112 LRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGISFIIKR 186
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
446-520 1.21e-36

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 132.35  E-value: 1.21e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   446 LRKMVDQLFCKKFAEALGSTEAKAVPYQKFEAHPNDLYVEGLPENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKR 520
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
341-415 1.99e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 128.89  E-value: 1.99e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   341 LRKQVEELFERKYAQAIKAKGPVTIPYPLFQSHVEDLYVEGLPEGIPFRRPSTYGIPRLERILLAKERIRFVIKK 415
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
551-625 5.90e-34

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 124.65  E-value: 5.90e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   551 LRKQVEEIFNLKFAQALGLTEAVKVPYPVFESNPEFLYVEGLPEGIPFRSPTWFGIPRLERIVRGSNKIKFVVKK 625
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
713-777 4.32e-31

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 116.56  E-value: 4.32e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   713 LKQKVENLFNEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRN 777
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEA 65
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
848-922 1.30e-20

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 86.51  E-value: 1.30e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670352   848 LREQVNDLFSRKFGEAIGMGFPVKVPYRKITINPGCVVVDGMPPGVSFKAPSYLEISSMRRILDSAEFIKFTVIR 922
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH