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Conserved domains on  [gi|229577391|ref|NP_116098|]
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pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 [Homo sapiens]

Protein Classification

phytoene desaturase family protein( domain architecture ID 11440907)

phytoene desaturase family protein is an NAD(P)/FAD-dependent oxidoreductase that catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to phytoene desaturase, which converts phytoene into 3,4-didehydrolycopene via several intermediates by introducing up to five double bonds into phytoene

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0009055|GO:0016117|GO:0016116
SCOP:  4000128|3000055

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 35-580 3.04e-126

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 379.58  E-value: 3.04e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIiPGFKFSRASYLLSLLRP--QIYTDLELKKHgLRLH 112
Cdd:COG1233    4 YDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGRARTFER-PGFRFDVGPSVLTMPGVleRLFRELGLEDY-LELV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 113 LRNPySFTPMLEEGagskvpRCLLLGTDMAENQKQIAQFSQKDAQVFPKYEEFMHRLA-LAIDPLLDaapvdmaafqhgs 191
Cdd:COG1233   82 PLDP-AYRVPFPDG------RALDLPRDLERTAAELERLFPGDAEAYRRFLAELRRLYdALLEDLLY------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 192 llqrmRSLSTLKPLLKAgrilgAQLPRYYEVLTAPITKVLDQWFESEPLKATLATdavIGAMTSPHTPGSGYVLLHHVMG 271
Cdd:COG1233  142 -----RPLLSLRDLLRP-----LALARLLRLLLRSLRDLLRRYFKDPRLRALLAG---QALYLGLSPDRTPALYALIAYL 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 272 GlegMQGAWGYVQGGMGALSDAIASSATTHGASIFTEKTVAKVQVnSEGCVQGVVLEDGTEVRSKMVLSNTSPQITFLKL 351
Cdd:COG1233  209 E---YAGGVWYPKGGMGALADALARLAEELGGEIRTGAEVERILV-EGGRATGVRLADGEEIRADAVVSNADPAHTYLRL 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 352 TPQEWLPEEFLERISQLDTRSPVTKINVAVDR-LPSflaapnaprgqpLPHHQcsIHLNcEDtllLHQAFEDAMDGLPSH 430
Cdd:COG1233  285 LGEEALPARYRRRLERFRYSPSAFKLYLGLDGpLPG------------LAHHT--IHLS-ED---YEAAFDDIFRGRLPE 346

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 431 RPVIELCIPSSLDPTLAPPGCHVVSLFTQyMPYTLagGKAWDEqERDAYADRVFDCIEVYAPGFKDSVVGRDILTPPDLE 510
Cdd:COG1233  347 DPSLYVSIPSLTDPSLAPEGKHTLWVLVP-VPYGL--EDAWDE-LKEEYAERILARLERYAPGLRDRIVAREVLTPLDFE 422

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 229577391 511 RIFGLPGGNIFHCAMSLDQLYFARPvplhSGYRCPLQGLYLCGSGAHPGGGVMGAA--GRNAAHVAFRDLKS 580
Cdd:COG1233  423 RYLNLVGGAIYGGAHTLDQSAFFRP----SNYRTPIPGLYLVGASTHPGGGVPGVLisGRLAARRILKDLKR 490
 
Name Accession Description Interval E-value
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 35-580 3.04e-126

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 379.58  E-value: 3.04e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIiPGFKFSRASYLLSLLRP--QIYTDLELKKHgLRLH 112
Cdd:COG1233    4 YDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGRARTFER-PGFRFDVGPSVLTMPGVleRLFRELGLEDY-LELV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 113 LRNPySFTPMLEEGagskvpRCLLLGTDMAENQKQIAQFSQKDAQVFPKYEEFMHRLA-LAIDPLLDaapvdmaafqhgs 191
Cdd:COG1233   82 PLDP-AYRVPFPDG------RALDLPRDLERTAAELERLFPGDAEAYRRFLAELRRLYdALLEDLLY------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 192 llqrmRSLSTLKPLLKAgrilgAQLPRYYEVLTAPITKVLDQWFESEPLKATLATdavIGAMTSPHTPGSGYVLLHHVMG 271
Cdd:COG1233  142 -----RPLLSLRDLLRP-----LALARLLRLLLRSLRDLLRRYFKDPRLRALLAG---QALYLGLSPDRTPALYALIAYL 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 272 GlegMQGAWGYVQGGMGALSDAIASSATTHGASIFTEKTVAKVQVnSEGCVQGVVLEDGTEVRSKMVLSNTSPQITFLKL 351
Cdd:COG1233  209 E---YAGGVWYPKGGMGALADALARLAEELGGEIRTGAEVERILV-EGGRATGVRLADGEEIRADAVVSNADPAHTYLRL 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 352 TPQEWLPEEFLERISQLDTRSPVTKINVAVDR-LPSflaapnaprgqpLPHHQcsIHLNcEDtllLHQAFEDAMDGLPSH 430
Cdd:COG1233  285 LGEEALPARYRRRLERFRYSPSAFKLYLGLDGpLPG------------LAHHT--IHLS-ED---YEAAFDDIFRGRLPE 346

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 431 RPVIELCIPSSLDPTLAPPGCHVVSLFTQyMPYTLagGKAWDEqERDAYADRVFDCIEVYAPGFKDSVVGRDILTPPDLE 510
Cdd:COG1233  347 DPSLYVSIPSLTDPSLAPEGKHTLWVLVP-VPYGL--EDAWDE-LKEEYAERILARLERYAPGLRDRIVAREVLTPLDFE 422

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 229577391 511 RIFGLPGGNIFHCAMSLDQLYFARPvplhSGYRCPLQGLYLCGSGAHPGGGVMGAA--GRNAAHVAFRDLKS 580
Cdd:COG1233  423 RYLNLVGGAIYGGAHTLDQSAFFRP----SNYRTPIPGLYLVGASTHPGGGVPGVLisGRLAARRILKDLKR 490
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 37-580 3.65e-33

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 132.79  E-value: 3.65e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391   37 AVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEiIPGFKFSrasyllslLRPQIYTDLELKKHGLRL---HL 113
Cdd:TIGR02734   1 AVVIGAGFGGLALAIRLAAAGIPVTVVEQRDKPGGRAGVLE-DDGFRFD--------TGPTVITMPEALEELFALagrDL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  114 RNPYSFTPM-------LEEGAGSKVPrclllgTDMAENQKQIAQFSQKDAQVFPKYEEFMHRL-ALAIDPLLDAAPVDMA 185
Cdd:TIGR02734  72 ADYVELVPLdpfyrlcWEDGSQLDVD------NDQEELEAQIARFNPGDVAGYRRFLDYAERVyREGYRKLGYVPFLSPR 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  186 AFQHGSLLQRMRSLSTlkpllkagRILGAQLPRYyevltapitkvldqwFESEPLKATLATDAV-IGamTSPHTPGSGYV 264
Cdd:TIGR02734 146 DLLRADAPQLLALLAW--------RSLYSKVARF---------------FSDERLRQAFSFHALfLG--GNPFRTPSIYA 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  265 LLHHvmggLEGMQGAWgYVQGGMGALSDAIASSATTHGASIFTEKTVAKVQVnSEGCVQGVVLEDGTEVRSKMVLSNTSP 344
Cdd:TIGR02734 201 LISA----LEREWGVW-FPRGGTGALVAAMAKLAEDLGGELRLNAEVIRIET-EGGRATAVHLADGERLDADAVVSNADL 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  345 QITFLKLTPQewlPEEFLERISQLDTRSPVtkiNVAVdrLPSFLAAPNAPRGQPLPHHqcSIHLNCEDTLLLHQAFEdam 424
Cdd:TIGR02734 275 HHTYRRLLPN---HPRRRYPAARLSRKRPS---PSLF--VLYFGLLGVDGHWPQLAHH--TLCFGPRYKELFDEIFR--- 341

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  425 DGLPSHRPVIELCIPSSLDPTLAPPGCHvvslfTQYM----PYTLAGGKAWDeQERDAYADRVFDCIEVYA-PGFKDSVV 499
Cdd:TIGR02734 342 KGRLAEDPSLYLHRPTVTDPSLAPPGCE-----SLYVlapvPHLGTADVDWS-VEGPRYRDRILAYLEERAiPGLRDRIV 415

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  500 GRDILTPPDLERIFGLPGGNIFHCAMSLDQLYFARPVPLHSGyrcpLQGLYLCGSGAHPGGGVMG--AAGRNAAHVAFRD 577
Cdd:TIGR02734 416 VERTFTPADFRDRYNAWLGSAFSLEHTLTQSAWFRPHNRDRK----IDNLYLVGAGTHPGAGVPGvlGSAKATAKLMLGD 491


                  ...
gi 229577391  578 LKS 580
Cdd:TIGR02734 492 LAP 494
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 46-571 1.61e-15

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 79.07  E-value: 1.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391   46 GLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEiIPGFKFSRASYLLSLLRPQIYTdlELKKHGLRLHLRNPYSFTPMLEE 125
Cdd:pfam01593   3 GLAAARELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGAQPPLLA--LLKELGLEDRLVLPDPAPFYTVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  126 GAGSKVPRCLLlgtdmaenqkqiaQFSQKDAQVFPKYEEFMH---RLALAIDPLLdAAPVDMAAFQHGSLLQRMRSLStl 202
Cdd:pfam01593  80 FAGGRRYPGDF-------------RRVPAGWEGLLEFGRLLSipeKLRLGLAALA-SDALDEFDLDDFSLAESLLFLG-- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  203 kpllkagrilgaqlpRYYEVLTAPITKVLDQWFESEPLKATLATDAVIGAMTSphtpGSGYVLLHHVMGGLEGMQGAwgy 282
Cdd:pfam01593 144 ---------------RRGPGDVEVWDRLIDPELFAALPFASGAFAGDPSELSA----GLALPLLWALLGEGGSLLLP--- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  283 vQGGMGALSDAIASSAttHGASIFTEKTVAKVQVNSEGCvqGVVLEDGTEVRSKMVLSnTSPQITFLKLTPQEWLPEEFL 362
Cdd:pfam01593 202 -RGGLGALPDALAAQL--LGGDVRLNTRVRSIDREGDGV--TVTLTDGEVIEADAVIV-TVPLGVLKRILFTPPLPPEKA 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  363 ERISQLDTRsPVTKINVAVDRlpsflaapnaprgQPLPHHQCSiHLNCEDTLLLHQAFEdamdglpshrpvielcipSSL 442
Cdd:pfam01593 276 RAIRNLGYG-PVNKVHLEFDR-------------KFWPDLGLL-GLLSELLTGLGTAFS------------------WLT 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  443 DPTLAPPGCHVVslftqYMPYTLAGGKAWDEQE--RDAYADRVFDCIEvyapgfkdSVVGRDILTPPDLERiFGLPGGNI 520
Cdd:pfam01593 323 FPNRAPPGKGLL-----LLVYVGPGDRARELEGlsDEELLQAVLRDLR--------KLFGEEAPEPLRVLV-SDWHTDPW 388

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 229577391  521 FHCAMSLDQlYFARPVPLHSGYRCPLQGLYLCGSGAHPG--GGVMGA--AGRNAA 571
Cdd:pfam01593 389 PRGSYSLPQ-YGPGHDDYRPLARTPDPGLFFAGEHTSTGypGTVEGAieSGRRAA 442
PRK07233 PRK07233
hypothetical protein; Provisional
 38-389 5.61e-07

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 52.20  E-value: 5.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  38 VVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTeeiipgFKFSrasyllsllrpqiytDLELKK---HglrlHLR 114
Cdd:PRK07233   3 AIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGLAAS------FEFG---------------GLPIERfyhH----IFK 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 115 NPYSFTPMLEE-GAGSKVprcLLLGTDMAenqkqiaQFSQKDaqvfpkyeefMHRLAlaidplldaAPVDMAAFQHGSLL 193
Cdd:PRK07233  58 SDEALLELLDElGLEDKL---RWRETKTG-------YYVDGK----------LYPLG---------TPLELLRFPHLSLI 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 194 QRMR-SLSTL--------KPLLKAG------RILGaqlPRYYEVLTAPItkvldqwFESeplKATLATDAV--------I 250
Cdd:PRK07233 109 DKFRlGLLTLlarrikdwRALDKVPaeewlrRWSG---EGVYEVFWEPL-------LES---KFGDYADDVsaawlwsrI 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 251 GAMTSPHTPGSGYVLlhhvmgglegmqgawGYVQGGMGALSDAIASSATTHGASIFTEKTVAKVQVNsEGCVQGVVLeDG 330
Cdd:PRK07233 176 KRRGNRRYSLFGEKL---------------GYLEGGFATLIDALAEAIEARGGEIRLGTPVTSVVID-GGGVTGVEV-DG 238

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 229577391 331 TEVRSKMVLSNTSPQItFLKLTPQewLPEEFLERISQLD----------TRSPVTKI---NVAVDRLPsFLA 389
Cdd:PRK07233 239 EEEDFDAVISTAPPPI-LARLVPD--LPADVLARLRRIDyqgvvcmvlkLRRPLTDYywlNINDPGAP-FGG 306
 
Name Accession Description Interval E-value
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 35-580 3.04e-126

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 379.58  E-value: 3.04e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIiPGFKFSRASYLLSLLRP--QIYTDLELKKHgLRLH 112
Cdd:COG1233    4 YDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGRARTFER-PGFRFDVGPSVLTMPGVleRLFRELGLEDY-LELV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 113 LRNPySFTPMLEEGagskvpRCLLLGTDMAENQKQIAQFSQKDAQVFPKYEEFMHRLA-LAIDPLLDaapvdmaafqhgs 191
Cdd:COG1233   82 PLDP-AYRVPFPDG------RALDLPRDLERTAAELERLFPGDAEAYRRFLAELRRLYdALLEDLLY------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 192 llqrmRSLSTLKPLLKAgrilgAQLPRYYEVLTAPITKVLDQWFESEPLKATLATdavIGAMTSPHTPGSGYVLLHHVMG 271
Cdd:COG1233  142 -----RPLLSLRDLLRP-----LALARLLRLLLRSLRDLLRRYFKDPRLRALLAG---QALYLGLSPDRTPALYALIAYL 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 272 GlegMQGAWGYVQGGMGALSDAIASSATTHGASIFTEKTVAKVQVnSEGCVQGVVLEDGTEVRSKMVLSNTSPQITFLKL 351
Cdd:COG1233  209 E---YAGGVWYPKGGMGALADALARLAEELGGEIRTGAEVERILV-EGGRATGVRLADGEEIRADAVVSNADPAHTYLRL 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 352 TPQEWLPEEFLERISQLDTRSPVTKINVAVDR-LPSflaapnaprgqpLPHHQcsIHLNcEDtllLHQAFEDAMDGLPSH 430
Cdd:COG1233  285 LGEEALPARYRRRLERFRYSPSAFKLYLGLDGpLPG------------LAHHT--IHLS-ED---YEAAFDDIFRGRLPE 346

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 431 RPVIELCIPSSLDPTLAPPGCHVVSLFTQyMPYTLagGKAWDEqERDAYADRVFDCIEVYAPGFKDSVVGRDILTPPDLE 510
Cdd:COG1233  347 DPSLYVSIPSLTDPSLAPEGKHTLWVLVP-VPYGL--EDAWDE-LKEEYAERILARLERYAPGLRDRIVAREVLTPLDFE 422

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 229577391 511 RIFGLPGGNIFHCAMSLDQLYFARPvplhSGYRCPLQGLYLCGSGAHPGGGVMGAA--GRNAAHVAFRDLKS 580
Cdd:COG1233  423 RYLNLVGGAIYGGAHTLDQSAFFRP----SNYRTPIPGLYLVGASTHPGGGVPGVLisGRLAARRILKDLKR 490
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 37-580 3.65e-33

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 132.79  E-value: 3.65e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391   37 AVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEiIPGFKFSrasyllslLRPQIYTDLELKKHGLRL---HL 113
Cdd:TIGR02734   1 AVVIGAGFGGLALAIRLAAAGIPVTVVEQRDKPGGRAGVLE-DDGFRFD--------TGPTVITMPEALEELFALagrDL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  114 RNPYSFTPM-------LEEGAGSKVPrclllgTDMAENQKQIAQFSQKDAQVFPKYEEFMHRL-ALAIDPLLDAAPVDMA 185
Cdd:TIGR02734  72 ADYVELVPLdpfyrlcWEDGSQLDVD------NDQEELEAQIARFNPGDVAGYRRFLDYAERVyREGYRKLGYVPFLSPR 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  186 AFQHGSLLQRMRSLSTlkpllkagRILGAQLPRYyevltapitkvldqwFESEPLKATLATDAV-IGamTSPHTPGSGYV 264
Cdd:TIGR02734 146 DLLRADAPQLLALLAW--------RSLYSKVARF---------------FSDERLRQAFSFHALfLG--GNPFRTPSIYA 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  265 LLHHvmggLEGMQGAWgYVQGGMGALSDAIASSATTHGASIFTEKTVAKVQVnSEGCVQGVVLEDGTEVRSKMVLSNTSP 344
Cdd:TIGR02734 201 LISA----LEREWGVW-FPRGGTGALVAAMAKLAEDLGGELRLNAEVIRIET-EGGRATAVHLADGERLDADAVVSNADL 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  345 QITFLKLTPQewlPEEFLERISQLDTRSPVtkiNVAVdrLPSFLAAPNAPRGQPLPHHqcSIHLNCEDTLLLHQAFEdam 424
Cdd:TIGR02734 275 HHTYRRLLPN---HPRRRYPAARLSRKRPS---PSLF--VLYFGLLGVDGHWPQLAHH--TLCFGPRYKELFDEIFR--- 341

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  425 DGLPSHRPVIELCIPSSLDPTLAPPGCHvvslfTQYM----PYTLAGGKAWDeQERDAYADRVFDCIEVYA-PGFKDSVV 499
Cdd:TIGR02734 342 KGRLAEDPSLYLHRPTVTDPSLAPPGCE-----SLYVlapvPHLGTADVDWS-VEGPRYRDRILAYLEERAiPGLRDRIV 415

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  500 GRDILTPPDLERIFGLPGGNIFHCAMSLDQLYFARPVPLHSGyrcpLQGLYLCGSGAHPGGGVMG--AAGRNAAHVAFRD 577
Cdd:TIGR02734 416 VERTFTPADFRDRYNAWLGSAFSLEHTLTQSAWFRPHNRDRK----IDNLYLVGAGTHPGAGVPGvlGSAKATAKLMLGD 491


                  ...
gi 229577391  578 LKS 580
Cdd:TIGR02734 492 LAP 494
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 46-571 1.61e-15

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 79.07  E-value: 1.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391   46 GLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEiIPGFKFSRASYLLSLLRPQIYTdlELKKHGLRLHLRNPYSFTPMLEE 125
Cdd:pfam01593   3 GLAAARELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGAQPPLLA--LLKELGLEDRLVLPDPAPFYTVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  126 GAGSKVPRCLLlgtdmaenqkqiaQFSQKDAQVFPKYEEFMH---RLALAIDPLLdAAPVDMAAFQHGSLLQRMRSLStl 202
Cdd:pfam01593  80 FAGGRRYPGDF-------------RRVPAGWEGLLEFGRLLSipeKLRLGLAALA-SDALDEFDLDDFSLAESLLFLG-- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  203 kpllkagrilgaqlpRYYEVLTAPITKVLDQWFESEPLKATLATDAVIGAMTSphtpGSGYVLLHHVMGGLEGMQGAwgy 282
Cdd:pfam01593 144 ---------------RRGPGDVEVWDRLIDPELFAALPFASGAFAGDPSELSA----GLALPLLWALLGEGGSLLLP--- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  283 vQGGMGALSDAIASSAttHGASIFTEKTVAKVQVNSEGCvqGVVLEDGTEVRSKMVLSnTSPQITFLKLTPQEWLPEEFL 362
Cdd:pfam01593 202 -RGGLGALPDALAAQL--LGGDVRLNTRVRSIDREGDGV--TVTLTDGEVIEADAVIV-TVPLGVLKRILFTPPLPPEKA 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  363 ERISQLDTRsPVTKINVAVDRlpsflaapnaprgQPLPHHQCSiHLNCEDTLLLHQAFEdamdglpshrpvielcipSSL 442
Cdd:pfam01593 276 RAIRNLGYG-PVNKVHLEFDR-------------KFWPDLGLL-GLLSELLTGLGTAFS------------------WLT 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  443 DPTLAPPGCHVVslftqYMPYTLAGGKAWDEQE--RDAYADRVFDCIEvyapgfkdSVVGRDILTPPDLERiFGLPGGNI 520
Cdd:pfam01593 323 FPNRAPPGKGLL-----LLVYVGPGDRARELEGlsDEELLQAVLRDLR--------KLFGEEAPEPLRVLV-SDWHTDPW 388

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 229577391  521 FHCAMSLDQlYFARPVPLHSGYRCPLQGLYLCGSGAHPG--GGVMGA--AGRNAA 571
Cdd:pfam01593 389 PRGSYSLPQ-YGPGHDDYRPLARTPDPGLFFAGEHTSTGypGTVEGAieSGRRAA 442
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
39-99 6.03e-10

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 55.23  E-value: 6.03e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 229577391   39 VIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEiIPGFKFSR-ASYLLSLLRPQIY 99
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYR-VPGYVFDYgAHIFHGSDEPNVR 61
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 33-72 2.72e-08

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 56.41  E-value: 2.72e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 229577391  33 PEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGA 72
Cdd:COG2072    5 EHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGT 44
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 35-574 4.18e-07

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 52.53  E-value: 4.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEiIPGFK--------FSRASYLLSLLRpqiytDLELKK 106
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGLIRTVE-VDGFRidrgphsfLTRDPEVLELLR-----ELGLGD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 107 hglRLHLRNPysftpmleegagsKVPRCLLLGT--DMAENQKQIAQFSqkdaqVFPKYEEFMHRLALAIDPLLDAAPVDM 184
Cdd:COG1232   76 ---ELVWPNT-------------RKSYIYYGGKlhPLPQGPLALLRSP-----LLSLAGKLRALLELLAPRRPPGEDESL 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 185 AAFqhgsLLQRM-RSLST--LKPLLK---AGRI--LGAQ--LPRYYEVLtapitkvldqwfeseplkatLATDAVIGAMT 254
Cdd:COG1232  135 AEF----VRRRFgREVYErlVEPLLEgvyAGDPdeLSADwaFPRLKRLE--------------------LEHGSLIKGAL 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 255 SPHTPGSGyvllhhvmgglegmQGAWGYVQGGMGALSDAIASSATthGASIFTEKTVAKVQVNSEGcvQGVVLEDGTEVR 334
Cdd:COG1232  191 ALRKGAKA--------------GEVFGYLRGGLGTLVEALAEALE--AGEIRLGTRVTAIEREGGG--WRVTTSDGETIE 252

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 335 SKMVLSNTSPQITfLKLTPQewLPEEFLERISQLDTRSPVTkINVAVDRlpsflaapnaprgQPLPHHQCsihlncedTL 414
Cdd:COG1232  253 ADAVVSATPAPAL-ARLLAP--LPPEVAAALAGIPYASVAV-VALGFDR-------------PDLPPPDG--------FG 307

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 415 LLHQAFEDamdglpshRPVIELCIPSSLDPTLAPPGCHVVSLFtqympYTLAGGKAWDEQERDAYADRVFDcievyapgf 494
Cdd:COG1232  308 WLVPRDEG--------VPILAVTFSSNKWPHRAPDGKVLLRLE-----VGGAGDPELWQLSDEELVALALA--------- 365

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 495 kdsvvgrdiltppDLERIFGLPGGNIFHCAMSLDQlyfARPVPlHSGYR----------CPLQGLYLCGSgAHPGGGV-- 562
Cdd:COG1232  366 -------------DLRKLLGIDAEPVDTRVVRWPK---AYPQY-TVGHLervaairealAALPGLYLAGR-AYDGVGLpd 427

                        570
                 ....*....|...
gi 229577391 563 -MGAAGRNAAHVA 574
Cdd:COG1232  428 cIRSGREAAERIL 440
PRK07233 PRK07233
hypothetical protein; Provisional
 38-389 5.61e-07

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 52.20  E-value: 5.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  38 VVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTeeiipgFKFSrasyllsllrpqiytDLELKK---HglrlHLR 114
Cdd:PRK07233   3 AIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGLAAS------FEFG---------------GLPIERfyhH----IFK 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 115 NPYSFTPMLEE-GAGSKVprcLLLGTDMAenqkqiaQFSQKDaqvfpkyeefMHRLAlaidplldaAPVDMAAFQHGSLL 193
Cdd:PRK07233  58 SDEALLELLDElGLEDKL---RWRETKTG-------YYVDGK----------LYPLG---------TPLELLRFPHLSLI 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 194 QRMR-SLSTL--------KPLLKAG------RILGaqlPRYYEVLTAPItkvldqwFESeplKATLATDAV--------I 250
Cdd:PRK07233 109 DKFRlGLLTLlarrikdwRALDKVPaeewlrRWSG---EGVYEVFWEPL-------LES---KFGDYADDVsaawlwsrI 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 251 GAMTSPHTPGSGYVLlhhvmgglegmqgawGYVQGGMGALSDAIASSATTHGASIFTEKTVAKVQVNsEGCVQGVVLeDG 330
Cdd:PRK07233 176 KRRGNRRYSLFGEKL---------------GYLEGGFATLIDALAEAIEARGGEIRLGTPVTSVVID-GGGVTGVEV-DG 238

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 229577391 331 TEVRSKMVLSNTSPQItFLKLTPQewLPEEFLERISQLD----------TRSPVTKI---NVAVDRLPsFLA 389
Cdd:PRK07233 239 EEEDFDAVISTAPPPI-LARLVPD--LPADVLARLRRIDyqgvvcmvlkLRRPLTDYywlNINDPGAP-FGG 306
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 39-86 1.84e-06

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 50.52  E-value: 1.84e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 229577391  39 VIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGaaVTEEIIPGFKFSR 86
Cdd:COG0493  126 VVGSGPAGLAAAYQLARAGHEVTVFEALDKPGG--LLRYGIPEFRLPK 171
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 39-83 2.28e-06

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 50.18  E-value: 2.28e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 229577391  39 VIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGaaVTEEIIPGFK 83
Cdd:PRK11749 145 VIGAGPAGLTAAHRLARKGYDVTIFEARDKAGG--LLRYGIPEFR 187
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
35-82 2.79e-06

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 49.35  E-value: 2.79e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 229577391  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHViGG-AAVTEEI--IPGF 82
Cdd:COG0492    1 YDVVIIGAGPAGLTAAIYAARAGLKTLVIEGGEP-GGqLATTKEIenYPGF 50
PRK06370 PRK06370
FAD-containing oxidoreductase;
33-74 4.55e-06

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 49.43  E-value: 4.55e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 229577391  33 PEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHViGGAAV 74
Cdd:PRK06370   4 QRYDAIVIGAGQAGPPLAARAAGLGMKVALIERGLL-GGTCV 44
PRK12775 PRK12775
putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin ...
 23-86 8.90e-06

putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional


Pssm-ID: 183738 [Multi-domain]  Cd Length: 1006  Bit Score: 48.78  E-value: 8.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 229577391   23 DNTEARGGLKPEYD-----AVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGaaVTEEIIPGFKFSR 86
Cdd:PRK12775  414 DNARAKPVKPPRFSkklgkVAICGSGPAGLAAAADLVKYGVDVTVYEALHVVGG--VLQYGIPSFRLPR 480
PLN02576 PLN02576
protoporphyrinogen oxidase
 23-71 1.07e-05

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 48.09  E-value: 1.07e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 229577391  23 DNTEARGGLKPEYDAVVIGAGHNGLVAAAYLQ-RLGVNTAVFERRHVIGG 71
Cdd:PLN02576   1 SAIAEGSAAASSKDVAVVGAGVSGLAAAYALAsKHGVNVLVTEARDRVGG 50
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 27-83 2.32e-05

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 47.08  E-value: 2.32e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 229577391  27 ARGGLKPEYDAV-------VIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGaaVTEEIIPGFK 83
Cdd:PRK12810 129 EEGWVKPDPPVKrtgkkvaVVGSGPAGLAAADQLARAGHKVTVFERADRIGG--LLRYGIPDFK 190
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
33-383 4.21e-05

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 46.07  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391  33 PEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGaavteeiipgfkfsRasyllsllrpqIYTDlelkkhglRLH 112
Cdd:COG1231    6 RGKDVVIVGAGLAGLAAARELRKAGLDVTVLEARDRVGG--------------R-----------VWTL--------RFG 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 113 LRNPYsftpmLEEGAGskvprclLLGTDMAENQKQIAQFsqkDAQVFPKYEEFMHRLAlaidpLLDAAPVDMAAFQHgsl 192
Cdd:COG1231   53 DDGLY-----AELGAM-------RIPPSHTNLLALAREL---GLPLEPFPNENGNALL-----YLGGKRVRAGEIAA--- 109

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 193 lqRMRSLSTLkpLLKAGRILGAQLPRYYEVLTA----PITKVLDQWFESEPLKATLATdAVIGAMTSPHTPGSGYVLLHH 268
Cdd:COG1231  110 --DLRGVAEL--LAKLLRALAAALDPWAHPAAEldreSLAEWLRRNGASPSARRLLGL-LGAGEYGADPDELSLLDLLRY 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577391 269 VMGGLEGMQGAwgYVQGGMGALSDAIASSAtthGASIFTEKTVAKVQVNSEGCVqgVVLEDGTEVRSKMVLSNTSPQI-T 347
Cdd:COG1231  185 AASAGGGAQQF--RIVGGMDQLPRALAAEL---GDRIRLGAPVTRIRQDGDGVT--VTTDDGGTVRADAVIVTVPPSVlR 257

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 229577391 348 FLKLTPQewLPEEFLERISQLdTRSPVTKINVAVDR 383
Cdd:COG1231  258 RIEFDPP--LPAAKRAAIQRL-PYGAAIKVFLQFDR 290
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 34-80 8.74e-05

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 45.08  E-value: 8.74e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 229577391  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHViGGAAVTEEIIP 80
Cdd:COG1249    3 DYDLVVIGAGPGGYVAAIRAAQLGLKVALVEKGRL-GGTCLNVGCIP 48
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 34-74 1.02e-04

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 44.82  E-value: 1.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 229577391  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAV 74
Cdd:COG1053    3 EYDVVVVGSGGAGLRAALEAAEAGLKVLVLEKVPPRGGHTA 43
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 36-73 1.51e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 44.31  E-value: 1.51e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 229577391   36 DAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAA 73
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSGA 38
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
34-74 1.66e-04

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 44.38  E-value: 1.66e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 229577391  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAV 74
Cdd:PRK05249   5 DYDLVVIGSGPAGEGAAMQAAKLGKRVAVIERYRNVGGGCT 45
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 33-66 2.25e-04

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 43.39  E-value: 2.25e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 229577391  33 PEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERR 66
Cdd:COG0654    2 MRTDVLIVGGGPAGLALALALARAGIRVTVVERA 35
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
34-72 2.81e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 43.36  E-value: 2.81e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 229577391  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGA 72
Cdd:COG0665    2 TADVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPGSGA 40
PLN02976 PLN02976
amine oxidase
 38-76 4.32e-04

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 43.32  E-value: 4.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 229577391   38 VVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTE 76
Cdd:PLN02976  697 IVVGAGPAGLTAARHLQRQGFSVTVLEARSRIGGRVYTD 735
Thi4 pfam01946
Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.
 34-73 5.89e-04

Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.


Pssm-ID: 460393  Cd Length: 232  Bit Score: 41.69  E-value: 5.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 229577391   34 EYDAVVIGAGHNGLVAAAYL-QRLGVNTAVFERRHVIGGAA 73
Cdd:pfam01946  17 ESDVVIVGAGSSGLTAAYYLaKNRGLKVAIIERSVSPGGGA 57
PRK10157 PRK10157
putative oxidoreductase FixC; Provisional
 35-82 8.83e-04

putative oxidoreductase FixC; Provisional


Pssm-ID: 182273 [Multi-domain]  Cd Length: 428  Bit Score: 41.82  E-value: 8.83e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 229577391  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVT---------EEIIPGF 82
Cdd:PRK10157   6 FDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTggrlyahslEHIIPGF 62
PRK10015 PRK10015
oxidoreductase; Provisional
 34-82 1.26e-03

oxidoreductase; Provisional


Pssm-ID: 182194 [Multi-domain]  Cd Length: 429  Bit Score: 41.50  E-value: 1.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 229577391  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFER------RHVIGG---AAVTEEIIPGF 82
Cdd:PRK10015   5 KFDAIVVGAGVAGSVAALVMARAGLDVLVIERgdsagcKNMTGGrlyAHTLEAIIPGF 62
GIDA pfam01134
Glucose inhibited division protein A;
36-63 2.29e-03

Glucose inhibited division protein A;


Pssm-ID: 250388 [Multi-domain]  Cd Length: 391  Bit Score: 40.61  E-value: 2.29e-03
                          10        20
                  ....*....|....*....|....*...
gi 229577391   36 DAVVIGAGHNGLVAAAYLQRLGVNTAVF 63
Cdd:pfam01134   1 DVIVIGGGHAGCEAALAAARMGAKVLLI 28
PRK07208 PRK07208
hypothetical protein; Provisional
 36-77 2.37e-03

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 40.64  E-value: 2.37e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 229577391  36 DAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEE 77
Cdd:PRK07208   6 SVVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVGGISRTVT 47
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 34-71 2.59e-03

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 40.51  E-value: 2.59e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 229577391  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHvIGG 71
Cdd:PRK06416   4 EYDVIVIGAGPGGYVAAIRAAQLGLKVAIVEKEK-LGG 40
PRK06753 PRK06753
hypothetical protein; Provisional
 39-69 3.32e-03

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 40.06  E-value: 3.32e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 229577391  39 VIGAGHNGLVAAAYLQRLGVNTAVFERRHVI 69
Cdd:PRK06753   5 IIGAGIGGLTAAALLQEQGHEVKVFEKNESV 35
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 35-66 4.31e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 39.61  E-value: 4.31e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 229577391   35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERR 66
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIEDE 32
PRK12844 PRK12844
3-ketosteroid-delta-1-dehydrogenase; Reviewed
 34-72 4.56e-03

3-ketosteroid-delta-1-dehydrogenase; Reviewed


Pssm-ID: 183787 [Multi-domain]  Cd Length: 557  Bit Score: 39.74  E-value: 4.56e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 229577391  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGA 72
Cdd:PRK12844   6 TYDVVVVGSGGGGMCAALAAADSGLEPLIVEKQDKVGGS 44
PRK06481 PRK06481
flavocytochrome c;
31-71 4.82e-03

flavocytochrome c;


Pssm-ID: 180584 [Multi-domain]  Cd Length: 506  Bit Score: 39.82  E-value: 4.82e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 229577391  31 LKPEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGG 71
Cdd:PRK06481  58 LKDKYDIVIVGAGGAGMSAAIEAKDAGMNPVILEKMPVAGG 98
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 34-65 6.74e-03

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 39.01  E-value: 6.74e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 229577391  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFER 65
Cdd:PRK06292   3 KYDVIVIGAGPAGYVAARRAAKLGKKVALIEK 34
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 37-113 6.78e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 35.64  E-value: 6.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 229577391   37 AVVIGAGHNGLVAAAYLQRLGVNTAVFERRhviggaavtEEIIPGFKFSRASYLLSllrpqiytdlELKKHGLRLHL 113
Cdd:pfam00070   2 VVVVGGGYIGLELAGALARLGSKVTVVERR---------DRLLPGFDPEIAKILQE----------KLEKNGIEFLL 59
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 36-74 7.93e-03

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 38.81  E-value: 7.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 229577391   36 DAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAV 74
Cdd:pfam00890   1 DVLVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFGGATA 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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