|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
45-450 |
0e+00 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 713.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 45 VYHAAIVIFLEFFAWGLLTTPMLTVLHETFSQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPI 124
Cdd:cd17387 1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 125 PLMRISPWWYFAMISVSGVFSVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATV 204
Cdd:cd17387 81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 205 VALLDICFILVAVPESLPEKMRPVSWGAQISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIG 284
Cdd:cd17387 161 VALLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 285 FGSVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISA 364
Cdd:cd17387 241 FEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 365 LVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHVELTELGP----KLNSNNVPLQGAVIPGPPFLFGACIVL 440
Cdd:cd17387 321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPvqssKQRMQNPSLEGAIIPGPPFLFGAISVL 400
|
410
....*....|
gi 94721311 441 MSFLVALFIP 450
Cdd:cd17387 401 LAILVASFIP 410
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
48-448 |
4.36e-69 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 224.76 E-value: 4.36e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 48 AAIVIFLEFFAWGLLTTPMLTVLHET-FSQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPL 126
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 127 MRISP--WWYFAMISVSGVFSVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATV 204
Cdd:cd17330 81 LGLSRnlWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 205 VALLDICFILVAVPeslpekmrpvswgaqiswkqadpfaslkkvgkdsTVLLICITVFLSYLPEAGQYSSFFLYLRQVIG 284
Cdd:cd17330 161 LALLNLVLVLFFLP----------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFG 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 285 FGSVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGS-QAWMMWAAGTVAAMSSITFPAIS 363
Cdd:cd17330 207 FSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALS 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 364 ALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFymfhveltelgpklnsnnvplqGAVIPGPPFLFGACIVLMSF 443
Cdd:cd17330 287 ALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY----------------------SFLGPGVPFLLAAGLLLIAL 344
|
....*
gi 94721311 444 LVALF 448
Cdd:cd17330 345 FLLSL 349
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
50-448 |
3.50e-40 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 149.32 E-value: 3.50e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 50 IVIFLEFFAWGLLTtPMLTVLHETFSQHT---FLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPL 126
Cdd:cd17388 6 VTVLLDAMGIGLIM-PVLPTLLREFVGDSadaATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 127 MRISP--WWYFAMISVSGVFSVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLsASYGDSLVVLVATV 204
Cdd:cd17388 85 MAFAPtlWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLL-GEISPRAPFLVAAG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 205 VALLDICFILVAVPESLPEKMRPvswgaQISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIG 284
Cdd:cd17388 164 LNGLNFLLGLFVLPESLPPERRR-----AFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 285 FGSVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISA 364
Cdd:cd17388 239 WSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 365 LVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFhveltelgpklnsnnvplqGAVIPGPPFLFGACIVLMSFL 444
Cdd:cd17388 319 LLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS-------------------PATWPGLAWIIGAALYLICLV 379
|
....
gi 94721311 445 VALF 448
Cdd:cd17388 380 LAYR 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
49-449 |
3.52e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 115.37 E-value: 3.52e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 49 AIVIFLEFFAWGLLTtPMLTVLHETFSQHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLL-GTVFFTCFPIPLM 127
Cdd:cd17325 2 SLALFLDMLGYGIII-PILPLYAESLGASVAQI-GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLlGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 128 RISPWWYFAMISV-SGVFS-VTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVV 205
Cdd:cd17325 80 FATSYWQLLLARFlQGLASaAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 206 ALLDICFILVAVPESLPEKmrpvswgAQISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGF 285
Cdd:cd17325 160 ALLALVLALLLLPEPRPPP-------NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 286 GSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVA-AMSSITFPAISA 364
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQ-PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 365 LVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHveltelgpklnsnnvplqgaviPGPPFLFGACIVLMSFL 444
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG----------------------FATPFLAAAALLLLAAV 369
|
....*
gi 94721311 445 VALFI 449
Cdd:cd17325 370 LFLLL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
49-392 |
3.26e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 106.60 E-value: 3.26e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 49 AIVIFLEFFAWGLLTtPMLTVLHETFsQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMR 128
Cdd:COG2814 16 ALGAFLSGLGIGIVL-PALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 129 ISP--WWYFAMISVSGVFS-VTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVV 205
Cdd:COG2814 94 LAPslWLLLAARFLQGLGAgALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 206 ALLDICFILVAVPESLPEKMRPVSwgaqiswkqadpfASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGF 285
Cdd:COG2814 174 ALLALLLLLRLLPESRPAARARLR-------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 286 GSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAISA 364
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQA 319
|
330 340
....*....|....*....|....*...
gi 94721311 365 LVSRNAESDQQGVAQGIITGIRGLCNGL 392
Cdd:COG2814 320 LVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
48-405 |
1.88e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.04 E-value: 1.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 48 AAIVIFLEFFAWGLLTTPMLTVLHETfsQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLM 127
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF--GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 128 RISPWWYFAMIS---VSGVFSVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATV 204
Cdd:cd06174 79 AFAPSFWLLLLGrflLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 205 VALLDICFIL-VAVPESLPEKMRPVSwgaqISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVI 283
Cdd:cd06174 159 AALALLAAILlLLVVPDPPESARAKN----EEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 284 GFGSVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGT-VAAMSSITFPAI 362
Cdd:cd06174 235 GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlLGFGLGGLLPLS 314
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 94721311 363 SALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFH 405
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
49-394 |
1.07e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 93.25 E-value: 1.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 49 AIVIFLEFFAWGLLTTPMLTVLHETFsQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFP--IPL 126
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 127 MRISPWWYFAMISVSGVF-SVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVV 205
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 206 ALldICFILVAVPESLPEKMRPVSWGAqiswKQADPFASLKKVGKDstVLLICITVFLSYLPEAGQYSSFFLYLRQVIGF 285
Cdd:pfam07690 161 SL--LAAVLLLLPRPPPESKRPKPAEE----ARLSLIVAWKALLRD--PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 286 GSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGF----GSQAWMMWAAGTVAAMSSITFPA 361
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRRRRLLLALLLLILAALGLLLlsltLSSLWLLLALLLLGFGFGLVFPA 311
|
330 340 350
....*....|....*....|....*....|...
gi 94721311 362 ISALVSRNAESDQQGVAQGIITGIRGLCNGLGP 394
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
83-404 |
3.17e-20 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 92.29 E-value: 3.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 83 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI--SPWWYFAMISVSGVF-SVTFSVIFAYVADVT 159
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 160 QEHERSTAYGWVSATFAASLVSSPAIGAYLsasYGDSLVVLVATVVALLDICFILVA--VPESLPEKMRPvswgaqiswK 237
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLL---LLYSFRLLFLAAAVLFLLAALVLLflLPETRPKRRAA---------E 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 238 QADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQTaFLSILMRSLG 317
Cdd:cd17329 186 KTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQF-PVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 318 NKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPAL 396
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLgEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLV 344
|
....*...
gi 94721311 397 YGFIFYMF 404
Cdd:cd17329 345 GGLLLDLL 352
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
80-404 |
2.98e-18 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 86.56 E-value: 2.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 80 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMIS--VSGVFSVTFSVIFAYVAD 157
Cdd:cd17389 64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSriVGGISKGNVSLSTAIVAD 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 158 VTQEHERSTAYGWVSATFAASLVSSPAIGAYLS------ASYGDSLVVLVATVVALLDICFILVAVPESLPEKMRPVSWG 231
Cdd:cd17389 144 VTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFAsftrslGEVFFSMPALFALVLALADLLFIFFFLPETLPSNLRRLGLV 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 232 aqiswkqadpfaslkkvgkdstvllicitVFLSYLPEAG-QYSSFFLyLRQVIGFGSVKIAAFIAMVGILSIVAQTAFLS 310
Cdd:cd17389 224 -----------------------------YFLYLFLFSGlEFTLTFL-THQRFQYTSMQQGKMFFFIGIIMALVQGGYVR 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 311 ILmRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLC 389
Cdd:cd17389 274 RI-KPGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFaAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALA 352
|
330
....*....|....*
gi 94721311 390 NGLGPALYGFIFYMF 404
Cdd:cd17389 353 RALGPIVACTVYWLA 367
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
83-450 |
3.49e-17 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 83.80 E-value: 3.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 83 GLIQGVKGLLSFLSAPLIGALSD----VWG-RKPFLLGTVFFTCFPIPLMRISP--------WWYFAMISVSGVFSVTFS 149
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILIGAIPLALSFVLLFTAPdlsptgklIYALVTYLLLGLAYTLVN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 150 VIF-AYVADVTQE-HERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVA------VPESL 221
Cdd:COG2211 129 IPYsALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFlltffgTKERP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 222 PEKMRPVSWgaqiswkqadpFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILS 301
Cdd:COG2211 209 VPEEEKVSL-----------KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 302 IVAqTAFLSILMRSLGNKNTVLLGLGFQ---MLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQ--- 375
Cdd:COG2211 278 LLG-APLWPRLAKRFGKKKAFIIGLLLAalgLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktg 356
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 94721311 376 ----GVAQGIITGIRGLCNGLGPALYGFIfymfhveLTELGPKLNSNNVPLQGAVIPGPPFLFGACIVLMSFLVALFIP 450
Cdd:COG2211 357 rrreGLYFGIFTFAIKLGQALAGALAGLL-------LALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYP 428
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
50-445 |
2.31e-16 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 80.40 E-value: 2.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 50 IVIFLEFFAWGLLTTPMLtvlHETFSQHTFLMNGLIQGVKGLLSflsAPLIGALSDVWGRKP--------FLLGTVFFTC 121
Cdd:cd17386 6 PIVFLYMFASVLSGPVTQ---NFVYAANFYLYMNLMGSIPPLFS---SLFLGSWSDRYGRKPpllmslvgLLLSSLILVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 122 FPIPLMRISPWWYF---AMISVSGVFSVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLV 198
Cdd:cd17386 80 IVYFTTVPSVWWFYlsaIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 199 VLVATVVALLDICFILVAVpeslpekmrpvswgaqiswkqadpfaslkkvgkdSTVLLICITVFLSYLPEAGQYSSFFLY 278
Cdd:cd17386 160 FSISAALLLIALLYILFFL----------------------------------TLLILLLLAAFLTIFVLSGESDVLYLF 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 279 LRQVIGFGSVKIAAFIAmVGILSIVAQTAFLSILMRSLGNKNTV---LLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMS 355
Cdd:cd17386 206 VLEKFAWNVKDFSYFST-LGSLIYLTGMLGGVLLLRCLLKMSDStlaMLGLASHILSSLLFAFATNTWMMYLAAVVGMFN 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 356 SITFPAISALVSRNAESDQQGVaqgiITGIRGLCNGLGPALYGFIFymfhveltelgpklnSNNVPLQGAVIPGPPFLFG 435
Cdd:cd17386 285 GIVGPMIRSILSKLVPKSEQGK----IFSLLSVLESLSPLVASPIY---------------NNIYKATLTTFPGFFFLLS 345
|
410
....*....|
gi 94721311 436 ACIVLMSFLV 445
Cdd:cd17386 346 AGLLLIPVIL 355
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
42-400 |
6.06e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.51 E-value: 6.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 42 RPSVYHAAIVIFLEFFAWGLLTT---PMLTVLHETFSQHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVF 118
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATAlwgPLIPALKDAFGLSDAQA-GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 119 FTCFPIPLMRISPWWYFAMIS--VSGV-FSVTFSVIFAYVADVTQEHeRSTAYGWVSATFAASLVSSPAIGAYLSASYGD 195
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLAlfLLGLgLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 196 SLVVLVATVVALLDICFILVAVPESLPEKMRPVSwgaqiswKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSF 275
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 276 FLYLRQVIGFgSVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWM-MWAAGTVAAM 354
Cdd:COG0738 234 PLYLKDVLGL-SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLaLIGLALVGLG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 94721311 355 SSITFPAISALVSRNAESDQQGVAqGIITGIRGLCNGLGPALYGFI 400
Cdd:COG0738 313 LSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFL 357
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
83-409 |
2.85e-15 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 77.27 E-value: 2.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 83 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGT-------VFFTCFPIPLMRISPWWYFAMISVSGVFSVTFSVIF-AY 154
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 155 VADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATvvalldICFILVAVPESLPEKMRPVSWGAQI 234
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA------LSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 235 SWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAqTAFLSILMR 314
Cdd:cd06173 191 SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 315 SLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITF-PAISALVSRNAESDQQGVAQGIITGIRGLCNGLG 393
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349
|
330
....*....|....*.
gi 94721311 394 PALYGFIFYMFHVELT 409
Cdd:cd06173 350 ALLAGLLADALGLSAV 365
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
48-401 |
7.66e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 76.05 E-value: 7.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 48 AAIVIFLEFFawglLTTPMLTVLHETFSQHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLM 127
Cdd:cd17324 7 AAFAIGTTEY----VIQGLLPDIARDFGVSVAQA-GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 128 RISPWWYFAMIS--VSGVF-SVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATV 204
Cdd:cd17324 82 ALAPSFALLLLAraLAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 205 VALLDICFILVAVPESLPEKMRPVSwgaqiswkqadPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIG 284
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLG-----------LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 285 FGSVKIAAFIAMVGILSIVAQTAFLSILMRslGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTV--AAMSSITFPAI 362
Cdd:cd17324 231 FSSSAIIGLLLLFGVAGVVGSPLAGRLADR--GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVlwGLGFFAAHSAL 308
|
330 340 350
....*....|....*....|....*....|....*....
gi 94721311 363 SALVSRNAEsDQQGVAQGIITGIRGLCNGLGPALYGFIF 401
Cdd:cd17324 309 QTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVL 346
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
81-401 |
1.51e-13 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 72.25 E-value: 1.51e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 81 MNGLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTCFPIPLMRI-SPWWYFamIS-VSGVFSVTFSVIFAYVAD 157
Cdd:cd17331 36 VFGYLQTTFSVLQLVGGPLFGRFGDLFGpRAALVLSFLSSALSYLLLAFAsSVPMLF--LSrLPSVFMHAMQAAQMVVTD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 158 VTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPES-----LPEKMRPVSWGA 232
Cdd:cd17331 114 LTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNtkskrEKEAKESASPPS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 233 QISWKQADPFASLKKVGKdstvllICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQTAFLSIL 312
Cdd:cd17331 194 VFNLKEILRLLRLPGVAF------LLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 313 MRSLGNKNTVLLGLGFQMLQLAWYGF-GSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNG 391
Cdd:cd17331 268 TKRFGERSLLKLSVALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRT 347
|
330
....*....|
gi 94721311 392 LGPALYGFIF 401
Cdd:cd17331 348 VSPTIGGALL 357
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
50-427 |
4.78e-13 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 70.33 E-value: 4.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 50 IVIFLEFFAWGLLTTPMLTVLHETFSQHTflMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI 129
Cdd:cd17390 3 LVGFLDLFGVSMILPLLSTHIRSLGASPT--VIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 130 SPWWYFAMIS--VSGVFSVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGdslvvLVATVVAL 207
Cdd:cd17390 81 STSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDG-----GFYYVALL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 208 LDICFILVAVpeslpekmrpvswgaqISWkqadpfASLKKVGKDSTV-LLICITVFLSylpeagqYSSFFLYLRQVIGFG 286
Cdd:cd17390 156 CSAIFILNAG----------------LVW------FLLSKLWDLLLVrFLMGFSVLLF-------RSNFSLYLEERFDLS 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 287 SVKIAAFIAMVGILSIVAQtaFLSILMRSLGNKNTVLLGLGFQMLQ---LAWYGFGSQAWMMWAAGT-VAAMSSITFPAI 362
Cdd:cd17390 207 PKTIGYLISYSGVLGALSG--FLVGRILKLYKNNEYLLLLHSFILLalsLLGLALAPSIWLLVLCLTpLSISSAVLRTCS 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 94721311 363 SALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIfymfhVELTELGPKLNSNNVPLQGAVI 427
Cdd:cd17390 285 TSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLL-----QEFSVSGPGLLGAVLALAAILL 344
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
95-450 |
6.88e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 66.83 E-value: 6.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 95 LSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMIS--VSGVFSVTFSVIFAYVADVTQEHERSTAYGWVS 172
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGraLQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 173 ATFAASLVSSPAIGAYLSASYGDSLVVLVATVvalldICFILVAVPESLPEKM--RPVSWGAQIswkqadpfaslkkvgk 250
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAP-----VAVLLAALVPLIDLRLlrRRNVLLANI---------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 251 dsTVLLICITVFLSYlpeagQYSSFFLYLRQVIGFG-SVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGFQ 329
Cdd:cd17504 185 --TALLAGFGMFMVF-----QLLPQLLQLPTPTGFGlGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVIS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 330 MLQLAWYGF-GSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHVE 407
Cdd:cd17504 258 AVGLLLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVS 337
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 94721311 408 LTelgpklnSNNVPLQGAVIPGppFLFGACIVLMSFLVALFIP 450
Cdd:cd17504 338 IT-------SGGVPTEGAYVLA--FLIGAALALAALLLSLLIP 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
48-450 |
5.02e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.12 E-value: 5.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 48 AAIVIFLEFFAWGLLTTPMLTVLHETFSQHtflmnGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFT---CFPI 124
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQL-----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWglaTLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 125 PLMRiSPWWYFAMISVSGVF-SVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGdslvvlvat 203
Cdd:COG2271 93 GFAT-SFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG--------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 204 vvalLDICFILVAVPeslpekmrPVSWGAqiswkqadpfaslkkvgkdSTVLLICITVFLSYLPEAGQYSSFFLYLRQVI 283
Cdd:COG2271 163 ----WRAAFLILGLP--------GLLLAL-------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 284 GFGSVKIAAFIAMVGILSIVAqTAFLSILMRSLG--NKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSI-TFP 360
Cdd:COG2271 212 GLSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFG 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 361 AISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHveltelgpklnsnnvplqgaviPGPPFLFGACIVL 440
Cdd:COG2271 291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG----------------------YQAAFLLLAALAL 348
|
410
....*....|
gi 94721311 441 MSFLVALFIP 450
Cdd:COG2271 349 LAALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
48-401 |
1.01e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 63.36 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 48 AAIVIFLEF---FAWGLLTTPMLTVLHETFSQhtflmNGLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTcfp 123
Cdd:COG2223 10 ATLAFFLAFgvwYLWSVLAPPLAEEFGLSAAQ-----LGLLFAIPVLVGALLRIPLGFLVDRFGpRRVLLIGLLLLG--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 124 IPLM----RISPWWYFAMISVSGVFS-VTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLV 198
Cdd:COG2223 82 IGLLllalAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 199 VLVATvvalldICFILVAVPESLPEKMRPVSWGAqiswKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLY 278
Cdd:COG2223 162 FLILG------ILLLVVAVLAWLFLRDPPAGAAA----AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 279 LRQVIGFGSVKIAAFIAMVGILSIVAqTAFLSILMRSLGNKNTVLLGLGFQMLQLAW--YGFGSQAWMMWAAGTVAAMSS 356
Cdd:COG2223 232 LVDQFGLSAATAGLLAALFALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLlaLALGSLWLFLVLFLLLGLALG 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 94721311 357 ITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIF 401
Cdd:COG2223 311 GGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
98-450 |
2.09e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 62.19 E-value: 2.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 98 PLIGALSDVWGRKP-FLLGTVFFT-----CFpiplMRISPWWYFAMISVSGVF-SVTFSVIFAYVADVTQEHERSTAYGW 170
Cdd:cd17321 49 LLAGRLGDRFGRKRvFLIGLALFGlasllCA----LAPSLAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRALGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 171 VSATFAASLVSSPAIGAylsasygdslvvlvatvvalldicfILVAVpeslpekmrpVSWGAqISWKQAdPFASLKKVGK 250
Cdd:cd17321 125 WGAVVGIGAALGPLLGG-------------------------LLLEL----------FGWRW-IFLINV-PIGLVALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 251 dSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAqTAFLSILMRSLGNKNTVLLGLGFQM 330
Cdd:cd17321 168 -RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 331 LQLAWYGFGSQAWMMW--AAGTVAAM--SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYM-FH 405
Cdd:cd17321 246 VGLLLLALLGADSSVWllLPGLVLLGlgLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAgLS 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 94721311 406 VELTELGPKLNSNNVPLQGAVIPGPPFLFGACIVLMSFLVALFIP 450
Cdd:cd17321 326 ANLGDSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-194 |
3.10e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.82 E-value: 3.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 16 EPEAGAMPEKRAGAQAAGSTWLQGFGRPSVYHAAIVIFLEFFAWGLLTTPMLTVLHETFSqHTFLMNGLIQGVKGLLSFL 95
Cdd:cd17325 172 PEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGG-LSPAQIGLLFGAQGLASAL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 96 SAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISP--WWYFAMISVSGV-FSVTFSVIFAYVADVTQEHERSTAYGWVS 172
Cdd:cd17325 251 SQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATsfWLLLLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFN 330
|
170 180
....*....|....*....|..
gi 94721311 173 ATFAASLVSSPAIGAYLSASYG 194
Cdd:cd17325 331 TAFSLGMVLGPLLGGFLYDAFG 352
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
60-383 |
7.56e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 60.66 E-value: 7.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 60 GLLTTPMLTVLHETFSQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLL-GTVFFTCF-PIPLMRISPWWYFAM 137
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIaGLLLYGIGgVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 138 -----ISVSGVFSVTFSVIfayvADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSAS--------YGDSLvvlvatv 204
Cdd:cd17473 95 rallgIGVAGIMTLATALI----GDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIgwrapflvYLLAL------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 205 valldICFILVAVpeSLPEKMRPVSwgaqiswKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIG 284
Cdd:cd17473 164 -----PVLILVLL--FLPEPARKSK-------SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 285 FGSVKIAAFIAMVGILSIVAQTAFlSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAM-SSITFPAIS 363
Cdd:cd17473 230 GSAALIGLALAIASLAGAIGALLF-GRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLN 308
|
330 340
....*....|....*....|
gi 94721311 364 ALVSRNAESDQQGVAQGIIT 383
Cdd:cd17473 309 SWAMSLVPPELRGRAMGIVT 328
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
83-400 |
1.12e-09 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 60.29 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 83 GLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTC---FPIPLMRISPWWYFAMISVSGVFSVTFSVIFAYVAdV 158
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVlffLSLFFVAQIFWLLLLLVILGAFFSAPVVPLVDSIT-L 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 159 TQEHERSTAYG----WVSATFAAslvSSPAIGAYLSASYGDslvvlvatvvALLDICFI------LVAVPESLPEKMRPV 228
Cdd:cd17335 114 QYLGEERERYGkqrlWGSIGFGI---AALLVGILIDRSSTY----------KNYTIAFYvfavlmLLALLLALKFPFRPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 229 SWGAQISWKQadpfasLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVigfGSVKIAAFIAM-VGILSIVAQTA 307
Cdd:cd17335 181 HPEPNENTGG------LLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDL---GGSKTLIGLLWtVGVVSEIPFFF 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 308 FLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMwaaGTVAAMSSITF----PAISALVSRNAESDQQGVAQGIIT 383
Cdd:cd17335 252 FSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFalvwAAAVSYASAAAPPGLRATAQGLLQ 328
|
330
....*....|....*..
gi 94721311 384 girGLCNGLGPALYGFI 400
Cdd:cd17335 329 ---GLYFGLGGGLGSLI 342
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
88-405 |
2.60e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 59.21 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 88 VKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFT--CFPIPLMRISPWWYFAMISVSGVFSVTFS-VIFAYVADVTQEHE 163
Cdd:cd17355 46 VGLLAFGLAQPFVGRLLDRFGpRRVMLLGLLLLAagLVLLALATSLWQLYLLWGLLGGGGAGTLAaVAFATVAAWWFERR 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 164 RSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVvalldicFILVAVPESLPEKMRPVSWGAQISWKQAD--- 240
Cdd:cd17355 126 RGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLAL-------LALLVLVPVLLLLRRRPADLALRAYDDASpas 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 241 PFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQvIGFGSVKIAAFIAMVGILSIVAQTaFLSILMRSLGNKN 320
Cdd:cd17355 199 PGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRL-LSGWLGDRYSPRR 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 321 TVLLGLGFQMLQLAWYGFG-SQAWMMWAAGTVAAMSSI-TFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYG 398
Cdd:cd17355 277 LLAASYALRALGLALLLLLpFPPLALLLFAALFGLGWGaTVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGG 356
|
....*..
gi 94721311 399 FIFYMFH 405
Cdd:cd17355 357 LLYDRTG 363
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
50-448 |
3.29e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.76 E-value: 3.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 50 IVIFLEFFAWGLLTTPM-LTVLHETFSQHtflMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLG--TVFFTCFPIPL 126
Cdd:cd17489 3 LANFFFFLSFYLLLPVLpLYAHDLGGSEA---VAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIglLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 127 MRISPWWYFAMISVSGV-FSVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVv 205
Cdd:cd17489 80 LATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 206 alldicFILVAVPESLPEKMRPVSWGAQISWKQADPFASLKKVgkdstVLLICITVFLSYLPEAGQYSSFFLYLRQVigf 285
Cdd:cd17489 159 ------LALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKK-----VLPPALILFLASIAYGAISTFLPLYAAER--- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 286 GSVKIAAFIAMVGILSIVAQTAFLSILMRsLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAISA 364
Cdd:cd17489 225 GISNAGLFFTVYAIALLLSRPFSGKLSDR-KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 365 LVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHveltelgpklnsnnvplqgaviPGPPFLFGACIVLMSFL 444
Cdd:cd17489 304 LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG----------------------YRAMFLLAAVVVLLALV 361
|
....
gi 94721311 445 VALF 448
Cdd:cd17489 362 LYIF 365
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
23-194 |
1.47e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.81 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 23 PEKRAGAQAAGSTWLQGFGRPSVYHAAIVIFLEFFAWGLLTTPMLTVLHETFSQhTFLMNGLIQGVKGLLSFLSAPLIGA 102
Cdd:COG2223 185 AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGL-SAATAGLLAALFALLGALGRPLGGW 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 103 LSDVWGRKPFLLGT---VFFTCFPIPLMRISPWWYFAMISVSGVF-SVTFSVIFAYVADVTQEHERSTAYGWVSATFAAS 178
Cdd:COG2223 264 LSDRIGGRRVLLIVfalMALGLLLLALALGSLWLFLVLFLLLGLAlGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLG 343
|
170
....*....|....*.
gi 94721311 179 LVSSPAIGAYLSASYG 194
Cdd:COG2223 344 GFLGPLLFGALLDATG 359
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
49-401 |
2.76e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 55.68 E-value: 2.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 49 AIVIFLEFFawGL-LTTPMLTVLHETFSQHTFLMNGLIQGVKGLL-SFLSAPLiGALSDVWGRKP-FLLGTVFFTC-FPI 124
Cdd:cd17472 2 SLIFSLRML--GMfLVLPVLSVYAKSLPGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPvILFGLLLFIAgSLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 125 PLMRISPWWYFAMISVSGVFSVTfSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATV 204
Cdd:cd17472 79 AAYATSIYGLILGRALQGSGAIS-SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 205 VALLDICFILVAVPESLPEKmrpvswgaQISWKQAdpfASLKKVGKDSTVLLICITVFLSYLpeagQYSSFF----LYLR 280
Cdd:cd17472 158 LSLVSLLILLFFVPDPPKIV--------QISEKEK---KKLKKLLKNKRLLRLDFSIFILHF----VLMAFFyilpLLLT 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 281 QVIG--------FGSVKIAAFIAMVgILSIVAQTAF-LSILMRSlgnkNTVLLGLGFQMLqlawyGFGSQAWMMWAAGTV 351
Cdd:cd17472 223 QLGGgkgqlwkvYLPAILIGFILMV-PFVIYAEKKGkMKQVFVS----SILLIAVGFLLL-----LFAATSLWLLIIGLI 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 94721311 352 AAMSSITF--PAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIF 401
Cdd:cd17472 293 IFFIGFNLleALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLW 344
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
83-404 |
3.04e-08 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 55.71 E-value: 3.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 83 GLIQGVKGLLSFLSAPLIGALSDVWGR--KPFLLGTVFFTCFPIPLMRISP----WWYFAMISVSGVFSVTFSVIFAyVA 156
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGKrkAVVRLASILAAVLFLSVLFIPIsltfWWLALLVVLFSFFWNAILPQFE-VA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 157 DVTQEHERSTAYG----WVSATFAASLVSSPAIGAYLSASYGDSLVVLvatvvalldICFILVAVPESLPEKMRPVSWGA 232
Cdd:pfam12832 116 TLQHLGEKRKDYGrqrlWGSVGFALSVFGLGALFDHYSVGLLPSVLFY---------LFAALMLLSLLLPLAPPEMEYES 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 233 QISwkqadPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQViGFGSVKIAAFIAmVGILSIVAQTAFLSIL 312
Cdd:pfam12832 187 KGG-----SKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENL-GASNTLLGALWA-LGVVAEIPLFFYAHRL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 313 MRSLGNKNTVLLGLGFQMLQLAWYGFG-SQAWMMWAAGTVAAMS-SITFPAISALVSRNAESDQQGVAQGIITGIR-GLC 389
Cdd:pfam12832 260 LRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAISfGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYfGLG 339
|
330
....*....|....*
gi 94721311 390 NGLGPALYGFIFYMF 404
Cdd:pfam12832 340 GALGSLIGGQLWDLF 354
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
22-175 |
7.68e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.21 E-value: 7.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 22 MPE-KRAGAQAAGSTWLQGFGRPSVYHAAIVIFLEFFAWGLLTTPMLTVLHETFsQHTFLMNGLIQGVKGLLSFLSAPLI 100
Cdd:COG2814 185 LPEsRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVLGALLA 263
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 94721311 101 GALSDVWGRKPFLLGTVFFTCFPIPLMRI--SPWWYFAMISVSGV-FSVTFSVIFAYVADVTQEHERSTAYGWVSATF 175
Cdd:COG2814 264 GRLADRFGRRRLLLIGLLLLALGLLLLALagSLWLLLLALFLLGFgFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
83-405 |
1.16e-07 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 54.00 E-value: 1.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 83 GLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTCFPIPLM---RISPWWYFAMISVSGVFSVTFSVIF--AYVA 156
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGrKKPFLAFFTLLGVLATAALffvAPGGLWLGLLLFVLANIGFEGSLVFynAFLP 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 157 DVTQEHERST--AYGW--------VSATFAASLVSSPAIGAYLSASYGDSlvvlvatvvalldICFILVA---------- 216
Cdd:COG2270 135 DIATPEEIGRvsGLGWalgylggvLLLLINLALFLKPEAFGLPDAGEAVR-------------ISFLLTAlwwllfalpl 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 217 ---VPESLPEKMRPVSWGAQISWKQAdpFASLKKVGKDSTVL--LICITVFLSYLpeAGQYSSFFLYLRQVIGFGSVKIA 291
Cdd:COG2270 202 flfLPERPRPGPAPPRGAVRAGFREL--RRTLRELRRYRDLLrfLLAYFFYRDGV--QTVIAFAGIYAAGVLGFSTTELI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 292 AFIAMVGILSIVAQTAFlSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAIS-ALVSRNA 370
Cdd:COG2270 278 VFGLLVQIVAALGALLF-GRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLI 356
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 94721311 371 ESDQQGVAQGI------ITGIrglcngLGPALYGFIFYMFH 405
Cdd:COG2270 357 PPGREAEFFGLyalsgkAASF------LGPLLFGLVTQLTG 391
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
45-401 |
5.82e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.80 E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 45 VYHAAIVIFLEFFAWGLLTtPMLTVLHETFSQHTFlMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLL-GTVFFTCFP 123
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVD-PILPAIAEALGASPA-QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLpGLLLFGIGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 124 -IPLMRISPWWYFAMISVSGVFSVTFSVI-FAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASygdSLVVLV 201
Cdd:cd17474 79 lLCGLSDSFALLLAGRALQGIGAAGLGPLaLTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI---SWRYPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 202 ATVVALLDICFILVAV-PESLPEKMRPVSWGAQISWKQADPFASLKKVGKDSTVLLICITVFLSYLPeagqyssffLYLR 280
Cdd:cd17474 156 FLLAALIPVAFLAILFlLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP---------FLLE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 281 QVIGFGSVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSS-ITF 359
Cdd:cd17474 227 LLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLgLNL 306
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 94721311 360 PAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIF 401
Cdd:cd17474 307 PLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL 348
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
44-194 |
2.50e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.48 E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 44 SVYHAAIVIFLEFFAWGLLTTPMLTVLHETFsQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFP 123
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94721311 124 IPLMRI----SPWWYFAMISVSGVFS-VTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYG 194
Cdd:COG2271 260 LALLLLallpSPALAIALLFLAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
91-194 |
4.10e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.08 E-value: 4.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 91 LLSFLSAPLIGALSDVWGRKP-FLLGTVFFTCFPIPLM-RISPWWYFAMISVSGVF-SVTFSVIFAYVADVTQEHERSTA 167
Cdd:cd17370 245 LVYALAAYPAGRLSDRIGRKKlLILGYLSLALAYLGFAlGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTA 324
|
90 100
....*....|....*....|....*..
gi 94721311 168 YGWVSATFAASLVSSPAIGAYLSASYG 194
Cdd:cd17370 325 YGLFNTVVGIGWLLASLIAGYLWDLIS 351
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
99-401 |
4.51e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 48.73 E-value: 4.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 99 LIGALSDVWGRKPFLL-GTVFF--TCFpIPLMRISPWWYFAMISVSGVFSVTFSVI-FAYVADVTQEHERSTAYGWVSAT 174
Cdd:cd17320 53 LYGPLSDRFGRRPVLLaGLLLFilASL-LCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMI 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 175 FAASLVSSPAIGAYLSASYGDSLVVLVATVVALldICFILVA--VPESLPEKMRPVSWGAQiswkqadpFASLKKVGKDS 252
Cdd:cd17320 132 LAIAPALAPLLGGLLLLFFGWRAIFVFLALLGL--LLLLLVLlfLPETLPEEKRKPLLSSL--------LRAYKRVLKNR 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 253 TVLLICITVFLSYLPEAGQYS-SFFLYLrQVIGFGSVKIAAFIAMVGILSIVAqTAFLSILMRSLGNKNTVLLGLGFQ-- 329
Cdd:cd17320 202 RFLGYALALGLSFAGLFAYLAaAPFIYI-EQLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRRLLRLGLLLLla 279
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94721311 330 ----MLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRnAESDQQGVAQGIITGIRGLCNGLGPALYGFIF 401
Cdd:cd17320 280 aalvLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE-PFPHVAGTASALLGFLQFLIGALAGALVGLLP 354
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
48-194 |
7.95e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.88 E-value: 7.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 48 AAIVIFLEFFAWGLLTtPMLTVLHETFSQHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKP-FLLGTVFFTCFPIPL 126
Cdd:COG0477 19 LALGTFLEGLDFTIVN-VALPSIAADLGASSAQL-GWIVSAYLLGRAIGLLLFGRLGDRYGRKRvLLIGLLLFGLASLLC 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 127 -MRISPWWYFAMISVSGVF-SVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYG 194
Cdd:COG0477 97 gLAPSPELLIAARALQGIGaGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
48-196 |
1.15e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 47.52 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 48 AAIVIFLEFFAWGLLTTPMLTVLHET--FSQHTFLMNGLIQGVkglLSFLSAPLIGALSDVWGRKP-FLLGTVFFTCFPI 124
Cdd:cd17369 233 AIGLRLAENVLFYLFTTFALSYATQTlgVDRSTVLLAVLIASV---VAAITIPLFGWLSDRVGRRPvYLAGALLAALFAF 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 125 PLM-----RISPWWYFAMISVSGVF-SVTFSVIFAYVADVTQEHERSTAYGwVSATFAASLVSS--PAIGAYLSASYGDS 196
Cdd:cd17369 310 PFFwlldtGSTWLIVLAAVVVLGVLhGMMYGPQAAFLAELFPTRVRYTGAS-LGYQLGAILGGGfaPLIATALVAATGSW 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
257-469 |
6.88e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.11 E-value: 6.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 257 ICITVFLSYLPEAGqYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNKNTVLLGLGFQMLQLAWY 336
Cdd:cd06174 1 LLLGFFLTGLARGL-ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQ-PLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 337 GFGSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHVELTELgpkl 415
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLgSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAV---- 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 94721311 416 nsnnvplqgavipgppFLFGACIVLMSFLVALFIPEYSKASGVQKHSNSSSGSL 469
Cdd:cd06174 155 ----------------FLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSV 192
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
48-194 |
9.21e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 9.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 48 AAIVIFLEFFAWGLLTTPMLTVLHETF---SQHTFLMNGLIqgvkGLLSFLSAPLIGALSDVWGRKPFLL-GTVFFTCFP 123
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYLQTVLglsPATSSLYLLLI----SLGALVGALIAGLLSDRIGRKKTLViGLILSGILA 257
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94721311 124 IPL---MRISPWWYFAMISVSGVFSVTFSVIF-AYVADVTQEHERSTAYGWVSAT-FAASLVSSPAIGAYLSASYG 194
Cdd:cd17316 258 LPLfylLSGSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVRATGVGLSYNLgRLGGGGAPPLIALLLASTGG 333
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
257-404 |
9.67e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 9.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 257 ICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNKNTVLLGLGFQMLQLAWY 336
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 94721311 337 GFGSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMF 404
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
57-448 |
1.14e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 44.54 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 57 FAWGLLTTPMLTVLHETFSQHTFLmnGLIQGVKGLLSFLSAPLIGALSDV----WG-RKPFLLGTVFFTCFPIPLMRISP 131
Cdd:cd17313 13 FGWALENSYVPPILQTLGLSHALI--GFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 132 WWYFAMISVSGVFSVTFSVIF----------------AYVADVTQEHERSTAYGWVSatFAASLVSspaIGAYLSASYGD 195
Cdd:cd17313 91 DIGLALGDGPRTWALVLFVLGivlldfamnvcqgpvrALLPDLVPPEQRSKANGIIN--FMGGLGG---VLGYLLGAILW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 196 SLVVLVATVVALLDICFILVA-------------VPEslpEKMRPVSWGAQISWKQADPFASLKKV--GKDSTVLLICIT 260
Cdd:cd17313 166 DHNWFGFALGGNLKVPFYIGAiillvcvlvtlffVKE---PPLSPEAGEHSENPSLGEVLKSLLKLlkIMPRSLLRLLLV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 261 VFLSYLpeAGQYSSFF--LYLRQVIGFG----------SVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGF 328
Cdd:cd17313 243 IFFWWI--AFFPFELFftDYMGEEVYHGtsaasshygaGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 329 QMLQLAWYGFGSQAW----MMWAAG-TVAAMSSITFPAISALVSRNAESdqQGVAQGIITGIRGLCNGLGPALYGFIFYM 403
Cdd:cd17313 321 FAVGMALMALVHNVTvalvLFALGGiGWATININPYPLVSDYHSESGRG--QGTDTGLLNLAISLAQILVSLLAGPIIDV 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 94721311 404 FHVeltelgpklnsnnvplqgavipGPPFLFGACIVLMSFLVALF 448
Cdd:cd17313 399 KGY----------------------GTVFPVAAVASFLSLVGALF 421
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
244-401 |
1.17e-04 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 44.22 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 244 SLKKVGKDSTVLLICITVFLSYLPeAGQYSSFFLYLRQVIGFGSVKIAAFIAmVGILSIVAQTAFLSILMRSLGNKNTVL 323
Cdd:cd17479 195 GLRLLGGDGRAILYALTVFLVGFV-GSTVQNFLFWLMQDKGGSELHMGLSIA-LALLSEILMSFFGNWLLRKLGHAGCVV 272
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 94721311 324 LGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITF-PAISALVSRNAesdQQGVAQGIITGIRGLCNGLGPALYGFIF 401
Cdd:cd17479 273 LGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALwWAVNSQVEFLA---SPGMERSLQLVLRALYYGIGFALGSFVS 348
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
83-400 |
2.06e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.79 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 83 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISP--WWYFAMISVSGVFSVTFSVIFAYVADVTQ 160
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTnvWQLLILRLLQGVFSGYVPNATALIASQTP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 161 EhERStayGWVSATFAASLVS----SPAIGAYLSASYGDSLVVLVATVVALldICFILVAVpeSLPEKMRPVSWGAQISW 236
Cdd:cd17391 119 K-EKS---GWALGTLSTGVVAgtliGPLLGGFLADLFGIRNVFFITGGLLF--LAFLLTLF--FVKEDFKPVEKKKMVST 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 237 KQAdpfasLKKVGKDSTVLLICITVFLSylpeagQYSSFF------LYLRQVIGFGSvKIAAFIAMV----GILSIVAqT 306
Cdd:cd17391 191 KEV-----WNSVPNPSLLISLFVTTFII------QLANQSiepiltLYIRQLMGDAS-NLAFISGLVfsatGVSSLLS-A 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 307 AFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAW-MMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGI 385
Cdd:cd17391 258 PRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSF 337
|
330
....*....|....*
gi 94721311 386 RGLCNGLGPALYGFI 400
Cdd:cd17391 338 QYLGNVAGPLLGSAI 352
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
21-194 |
2.15e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.69 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 21 AMPEKRAGAQAAGSTWLQGFGRPSVYHAAIVIFLEFFAWGLLTTPMLTVLHETFSQHTFLMNGLIqGVKGLLSFLSAPLI 100
Cdd:cd17324 176 SLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL-LLFGVAGVVGSPLA 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 101 GALSDVWGRKPFLLGTVFFT--CFPIPLMRISPWWYFAMISVSGV-FSVTFSVIFAYVADVTQEHeRSTAYGWVSATFAA 177
Cdd:cd17324 255 GRLADRGGRRALLIALLLLAaaLLLLTLLGPSPLLLLVGLVLWGLgFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNL 333
|
170
....*....|....*..
gi 94721311 178 SLVSSPAIGAYLSASYG 194
Cdd:cd17324 334 GGALGAALGGLVLDHGG 350
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
95-401 |
2.54e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 43.36 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 95 LSAPLIGALSDV----WGR-KPFLL------GTVFFTCF--PIPLMRISPWWYFAMISVSGVFSVTFSVIF-AYVADVTQ 160
Cdd:cd17332 50 INDPLMGYLIDRtrsrWGRfRPWLLwgaiplALLFVLLFttPDGSGTGKLIYALITYILLDLLYTLVNIPYtALIPELTD 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 161 E-HERSTAYGW--VSATFAASLVSS--PAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESlpekmRPVSWGAQIS 235
Cdd:cd17332 130 DpEERTSLTSWrmFFATIGGLLVTVlpPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGT-----RERVVPPEEE 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 236 WKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGfGSVKIAAFIAMVGILSIVAqTAFLSILMRS 315
Cdd:cd17332 205 KSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLG-GRAELVLLLLLILSGALLA-LLPWPPLKKR 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 316 LGNKNTVLLGLGFQMLQLAWYGFGS--QAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQ--QGV-AQGIITGIRGLC 389
Cdd:cd17332 283 FGKKKAFFIGLLLAILGLLLLFFLPpgNLVLILVLAVLAGIgYGGANLLPWAMLADVIDYGElkTGKrREGIFYSVMTFF 362
|
330
....*....|..
gi 94721311 390 NGLGPALYGFIF 401
Cdd:cd17332 363 RKLGLALAGALV 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
62-447 |
3.57e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 3.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 62 LTTPMLTVLHETfsqhTFLMnGLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTCFPIPLMRISPWWYFAMISV 140
Cdd:cd17370 21 ILPLFLVVLGAS----AAAV-GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 141 S------GVFSvtfSVIFAYVADVTQEHERSTAYGWVSA--TFAASLvsSPAIGAYLSASYGDSLVVLVATVVALLDI-C 211
Cdd:cd17370 96 IlerlgkGIRT---PPRDALLADATPPSGRGKAFGLHRAldTLGAVL--GPLLAALLLYLLGGNYRTIFLLAAIPALLaL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 212 FILVAVPESLPEKMRPvswgaqiswKQADPFASLKKVGKDSTVLLICITVFlsylpEAGQYS-SFFLYLRQVIGFGSVKI 290
Cdd:cd17370 171 LILLFVVKEYPRPPKL---------RKKSKKTSLKKLPKAFWLYLLAVALF-----ALGNFSfAFLILRAQELGLSAALI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 291 AAFIAMVGILSIVAQTAFlSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAISALVSRN 369
Cdd:cd17370 237 PLLYALFNLVYALAAYPA-GRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADL 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 94721311 370 AESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHVELTelgpklnsnnvplqgavipgppFLFGACIVLMSFLVAL 447
Cdd:cd17370 316 VPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAA----------------------FLFSAVLALIALLLLL 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
64-409 |
4.71e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 4.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 64 TPMLTVLHETFSqHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISP--WWYFAMISVS 141
Cdd:cd17478 16 PALLPLLIAKLG-LSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPnyWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 142 GVFSVTFSVIFAYVADVTQEHERSTAYGWVSA--TFAASLvsSPAIGAYLSASYGDSLVVLVATVVAlldICFILVAVPE 219
Cdd:cd17478 95 GIGSAAFHPEGARLASQAAGGRRGLAMSIFSVggNLGFAL--GPLIAAALVALFGGLGLLILLIIPG---LAVALLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 220 SLPEKMRPVSWGAQISWKQAdpfaslkKVGKDSTVLLICITVFLSYLPEAGqYSSFF-LYLRQVigFGSVKIAAFIAMVG 298
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARST-------LKGVWRALLLLLIIVFLRSWVLSS-LTTFLpFYLVQR--GYSLVFAGLLLSLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 299 ILSIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRNAeSDQQGVA 378
Cdd:cd17478 240 LFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVGLA 318
|
330 340 350
....*....|....*....|....*....|.
gi 94721311 379 QGIITGIRGLCNGLGPALYGFIFYMFHVELT 409
Cdd:cd17478 319 SGLMMGLSFGLGGIGAPVLGALADAFGLESV 349
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
253-400 |
5.62e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.27 E-value: 5.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 253 TVLLICITVFLSYLpEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNKNTVLLGLGFQMLQ 332
Cdd:COG2814 11 ALLALALGAFLSGL-GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 94721311 333 LAWYGFGSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFI 400
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
51-194 |
5.74e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.21 E-value: 5.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 51 VIFLEFF---AWGLLTTPMLTVLHETFSQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKP-----FLLGTVFftCF 122
Cdd:cd17353 217 LLWLMFFlnaTAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNtlsiaFLIQGVA--MF 294
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 94721311 123 PIPLMRISPWWYFAMISVSGV-FSVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYG 194
Cdd:cd17353 295 LLPFIGSVAVLFVLGVALIGFcYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGG 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
257-451 |
6.84e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.79 E-value: 6.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 257 ICITVFLSYLPEAGQYSSFFLYLRQvIGFGSVKIAAFIAMVGILSIVAQTaFLSILMRSLGNKNTVLLGLGFQMLQLAWY 336
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSP-PAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 337 GFGSQAWMMWAAGTVA-AMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHVELtelgpkl 415
Cdd:cd17325 79 AFATSYWQLLLARFLQgLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRA------- 151
|
170 180 190
....*....|....*....|....*....|....*.
gi 94721311 416 nsnnvplqgavipgpPFLFGACIVLMSFLVALFIPE 451
Cdd:cd17325 152 ---------------PFLVCAALALLALVLALLLLP 172
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
91-194 |
1.66e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 40.64 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 91 LLSFLSAPLIGA-LSDVWGRKP-FLLGTVFFTCFPIPL-MRISPWWYFAMISVSGVFSVTFSVIFA-YVADVTQEHERST 166
Cdd:cd17323 44 VLGFGLGPLIWApLSELYGRRPvYLVSLFIFVIFQIGCaLAPNIAMLIILRFLQGFFGSSPLAIGAgTIADLFTPEERGK 123
|
90 100
....*....|....*....|....*....
gi 94721311 167 AYG-WVSATFAASLVsSPAIGAYLSASYG 194
Cdd:cd17323 124 AMGvYSLGPLLGPAL-GPIIGGFITQSLG 151
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
48-400 |
1.75e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 48 AAIVIFLEFFAWGLLTTPMLTVLHETFSQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLM 127
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 128 RISP--WWYFAMISVSGVF-SVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLvatv 204
Cdd:cd17316 84 GLLPtpILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWR---- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 205 valldICFILVAVPESLPEKMRPVSWGAQISWkqadpfaslkkvgkdsTVLLICITVFLSYLPEagqyssfflYLRQVIG 284
Cdd:cd17316 160 -----ILFLIGALPALLALLLRRRTLLLILLW----------------FFISFGYYGLTTFLPT---------YLQTVLG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 285 FGSVKIAAFIAMVGILSIVAqTAFLSILMRSLGNKNTVLLG--LGFQMLQLAWYGFGSQAWMMWAAG-TVAAMSSITFPA 361
Cdd:cd17316 210 LSPATSSLYLLLISLGALVG-ALIAGLLSDRIGRKKTLVIGliLSGILALPLFYLLSGSPTLLLLLLfILSFFVGGVWGA 288
|
330 340 350
....*....|....*....|....*....|....*....
gi 94721311 362 ISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFI 400
Cdd:cd17316 289 LYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
250-450 |
2.33e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.25 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 250 KDSTVLLICITVFLSYLpeaGQYSSFF---LYLRQVIGFGSVKIAAFIAMVGILSIVAQTaFLSILMRSLGNKNTVLLGL 326
Cdd:cd17503 176 KDRNFTLGLLLSFLLGL---GLFGAMFllpLYLQNVLGYSAFESGLVLAPGGLASAILSP-LVGRLLDKFGPRLLLLAGL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 327 ---GFQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFY 402
Cdd:cd17503 252 lllALGTLLLAFLTPDTSLWLIILPLFIRGLGmGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 94721311 403 MFHVELTELGPKLNSNNVPLQGAVIP-GPPFLFGACIVLMSFLVALFIP 450
Cdd:cd17503 332 NRTQFHHSRLSELLAQQVQKQALIIAfNDAFLVSAILLLVGLLLALFLR 380
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
90-169 |
2.85e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 39.97 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 90 GLLSFLSAPLIGALSDVWGRKPFLLGT-VFFTCFPIPLMRI-----SPWWYFAMISVSGVFSVTFSVIFAYV-ADVTQEH 162
Cdd:cd17367 269 LLVFMLLQPLGGRLSDRIGRRPLLLFFgIGGTLATVPLLSAldhtdSPYTAFALVLVGLVFLSGYTSINAVVkAELFPTH 348
|
....*..
gi 94721311 163 ERSTAYG 169
Cdd:cd17367 349 VRALGVG 355
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
91-194 |
2.92e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.85 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 91 LLSFLSAPLIGALSDVWGRKP-FLLGTVFFT--CFPIPLMRISPWWYFAM----ISVSGVFSVTFSVIfayvADVTQEHE 163
Cdd:cd17502 41 LTSTAFQPIYGKLSDLFGRKWvLLIAIVIFElgSLLCGLAPNMTMLIVGRaiqgIGGGGLMSLAFIII----ADLVPPRE 116
|
90 100 110
....*....|....*....|....*....|.
gi 94721311 164 RSTAYGWVSATFAASLVSSPAIGAYLSASYG 194
Cdd:cd17502 117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLS 147
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
80-401 |
5.01e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.21 E-value: 5.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 80 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPlmrispwwYFAMISVSGVFSvtfsvifayvadvt 159
Cdd:pfam13347 72 LLSAIILAVSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIP--------YWSLGPELTRDY-------------- 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 160 qeHERSTAYGWVS-----ATFAASLVSSPAIGAYLS-ASYGDSLVVLVATVVALLDICFILVAVPESLPEKMRPVSWGAQ 233
Cdd:pfam13347 130 --DERTSLTSYRSffsvgGGLLAAALAFPLVLILGGtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQ 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 234 ISWKQAdpFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVkiAAFIAMVGILSIVAQTAFLSILM 313
Cdd:pfam13347 208 KEAGSL--LDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFA--ASAFPLVFTIGALLGIPLWPPLA 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 314 RSLGNKNTVLLGLGFQM--LQLAWYGFGSQAWMMWAAGTVA----AMSSITFPAISALVSRNAESDQQGVAQGIITGIRG 387
Cdd:pfam13347 284 KRIGKKNTYILGALITIagFALALLLGPNNTLLFLVLYIIIgfgyGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWS 363
|
330
....*....|....
gi 94721311 388 LCNGLGPALYGFIF 401
Cdd:pfam13347 364 FISKLATGVGLGVS 377
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
49-187 |
6.66e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.93 E-value: 6.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721311 49 AIVIFLEFFAWGLLTTPMLTVLHETFSQHTFLMNGLIqGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFF------TCF 122
Cdd:cd17314 212 FIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLM-SIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTilglglCAF 290
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94721311 123 PIPLMRIsPWWYFAMISVSG-VFSVTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGA 187
Cdd:cd17314 291 LFLLKMT-PVGLVLTGSLLGfSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGA 355
|
|
| |
