second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 112 RGDLWELPFPCPDGfNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpaTSGGPPAVTLHGISPDVFTHV 191
Cdd:cd18296   1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 14211841 192 LYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLD 235
Cdd:cd18296  78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14211841 234 LDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHV 305
Cdd:cd18497   1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 112 RGDLWELPFPCPDGfNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpaTSGGPPAVTLHGISPDVFTHV 191
Cdd:cd18296   1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 14211841 192 LYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLD 235
Cdd:cd18296  78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14211841 234 LDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHV 305
Cdd:cd18497   1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841   131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsggpPAVTLHGISPDVFTHVLYYMYSDHTeLSPEAAYDV 210
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSV-------SEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDL 83

                          90       100
                  ....*....|....*....|....
gi 14211841   211 LSVADMYLLPGLKRLCGRSLAQML 234
Cdd:pfam00651  84 LAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 14211841     19 INPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEK 68
Cdd:smart00225  46 VSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLK 95

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 112 RGDLWELPFPCPDGfNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpaTSGGPPAVTLHGISPDVFTHV 191
Cdd:cd18296   1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 14211841 192 LYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLD 235
Cdd:cd18296  78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14211841 234 LDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHV 305
Cdd:cd18497   1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 129 CPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsggpPAVTLHGISPDVFTHVLYYMYSDHTELSPEA-A 207
Cdd:cd18286  17 DSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNS-------SEITLTGVSHAAVSFVLLFIYGGVLDLPDDVnL 89

                        90
                ....*....|....*...
gi 14211841 208 YDVLSVADMYLLPGLKRL 225
Cdd:cd18286  90 GELLSLADMYGLDGLKDV 107

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 128 SCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPAtsggppaVTLHGISPDVFTHVLYYMYSDHTELSPEAA 207
Cdd:cd18314   5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKE-------VTLEDVEPEIFETVLKYMYTGQVTLSEENV 77

                        90
                ....*....|....*....
gi 14211841 208 YDVLSVADMYLLPGLKRLC 226
Cdd:cd18314  78 LDLLMLASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEepatsggPPAVTLHGISPDVFTHVLYYMYSDHTE---LSPEAA 207
Cdd:cd18297  14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQ-------TPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDA 86

                        90       100       110
                ....*....|....*....|....*....|.
gi 14211841 208 YDVLSVADMYLLPGLKRLCGRSLAQMLDEDT 238
Cdd:cd18297  87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841   131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsggpPAVTLHGISPDVFTHVLYYMYSDHTeLSPEAAYDV 210
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSV-------SEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDL 83

                          90       100
                  ....*....|....*....|....
gi 14211841   211 LSVADMYLLPGLKRLCGRSLAQML 234
Cdd:pfam00651  84 LAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 104 DCALPPELrGDLWElpfpcpdgfNSC-PDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsgGPpaVTLHG 182
Cdd:cd18279   2 ECRLAEDL-GNLWE---------NSRfTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKK-----NR--VEIND 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 14211841 183 ISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDT 238
Cdd:cd18279  65 VDPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 136 VAGCSFLCHKAFFCGRSDYFRALLDDHFREseepaTSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVAD 215
Cdd:cd18245  21 VGGEEIPVQKNVLAAASPYFRAKLNYNPPK-----DDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAAD 95

                        90
                ....*....|.
gi 14211841 216 MYLLPGLKRLC 226
Cdd:cd18245  96 LLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsggpPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 210
Cdd:cd18240  19 DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEK-------KVYKIPGVSPEMMELIIEYAYTRTVPITAENVEEL 91

                        90
                ....*....|....*.
gi 14211841 211 LSVADMYLLPGLKRLC 226
Cdd:cd18240  92 LPAADQFNIMGIVKAC 107

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 138 GCSFLCHKAFFCGRSDYFRALLDDHFRESEEPAtsggppAVTLHgISPDVFTHVLYYMYSDHTELSP-----EAAYDVLS 212
Cdd:cd18302  15 GKEFPCHKCVLVARLEYFHSMLSSSWIEASSCS------ALTMP-IPSDILEIILDYLYTDEASAVKesqnvEFLCNVLV 87

                        90       100
                ....*....|....*....|..
gi 14211841 213 VADMYLLPGLKRLCGRSLAQML 234
Cdd:cd18302  88 IADQLLITRLKEICEVALVELL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPAtsggppaVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 210
Cdd:cd18250  23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADR-------VVLHGVSAEILGLLLDFSYTGRVTVTQDNVEAL 95

                        90       100
                ....*....|....*....|....*....
gi 14211841 211 LSVADMYLLPGLKRLCGRSLAQMLDEDTV 239
Cdd:cd18250  96 LRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841  99 MALLADCALPPELrGDLWElpfpcPDGFNSCpdiCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPAtsggppaV 178
Cdd:cd18342   1 MVKVPECRLADEL-GGLWE-----NSRFTDC---CLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR-------V 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 14211841 179 TLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQML 234
Cdd:cd18342  65 EINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsggppavtLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 210
Cdd:cd18354  22 DLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIE-----------MSQFSYPVYRAFLEYLYTDSISLSPEDAIGL 90

                        90       100
                ....*....|....*....|....*..
gi 14211841 211 LSVADMYLLPGLKRLCGRSLAQMLDED 237
Cdd:cd18354  91 LDLATFYRENRLKKLCQQTIKQGICEE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPAtsggppaVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 210
Cdd:cd18242  23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSE-------VELQGLTASTMEILLDFVYTETVHVTVENVQEL 95

                        90       100
                ....*....|....*....|....*
gi 14211841 211 LSVADMYLLPGLKRLCGRSLAQMLD 235
Cdd:cd18242  96 LPAACLLQLKGVKQACCEFLESQLD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsggpPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 210
Cdd:cd18268  25 DVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQ-------AKVDLKGIDSDVLDQIVDYVYTGEILITRDNVLPL 97

                        90       100       110
                ....*....|....*....|....*....|..
gi 14211841 211 LSVADMYLLPGLKRLCGRSLAQMLDEDTVVGV 242
Cdd:cd18268  98 MEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESeepatsgGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 210
Cdd:cd18264  30 DVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQES-------KARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDT 102

                        90       100
                ....*....|....*....|....*..
gi 14211841 211 LSVADMYLLPGLKRLCGRSLAQMLDED 237
Cdd:cd18264 103 LEAASYLQVTEAIGLCSQYLINNLAPE 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPAtsggppaVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 210
Cdd:cd18353  22 DLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEV-------IEIDQFSYPVYRAFLEYLYTDSVDLPPEDAIGL 94

                        90
                ....*....|....*.
gi 14211841 211 LSVADMYLLPGLKRLC 226
Cdd:cd18353  95 LDLATSYCENRLKKLC 110

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHfreSEEPATSGGPPAVTLHGISPDVFTHVLYYMYSD 198
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSS---LLTSEDAVGCDVVHIEKVPPEIFEQLLQFIYTD 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsggpPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 210
Cdd:cd18255  20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQ-------DEIELKGVSAKGLKHILDFAYTSELTLDLDCIQDV 92

                        90       100
                ....*....|....*....|....*....
gi 14211841 211 LSVAD-MYLLPGLKrLCGRSLAQMLDEDT 238
Cdd:cd18255  93 LGAAVhLQMLPVVE-LCEEFLKSAMSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALL-DDHFRES--------EEPATSggppavtlhgispDVFTHVLYYMYSDHTE 201
Cdd:cd18292  19 DIVLRVGGKVFHAHRLILAKSSDVFRVMLsNDWWSESkqseielvEDPECA-------------AVFEKFLRYLYTGQIS 85

                        90       100
                ....*....|....*....|....*
gi 14211841 202 LSPEAAYDVLSVADMYLLPGLKRLC 226
Cdd:cd18292  86 VNLETALPLLMLADKYNVTDLKQLC 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 127 NSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsggpPAVTLHGISPDVFTHVLYYMYSDHTELSPEA 206
Cdd:cd18236  22 NSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYE-------EKIIIKGVDAETMQILLDYTYTSKVLITKQN 94

                        90       100       110
                ....*....|....*....|....*....|....*
gi 14211841 207 AYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVG 241
Cdd:cd18236  95 VQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsggpPAVTLH-GISPDVFTHVLYYMYSDHTELSPEAAYD 209
Cdd:cd18267  42 DVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQD-------SEVNFHdSIHPEVLELLLDYAYSSRVIINEENAES 114

                        90       100       110
                ....*....|....*....|....*....|...
gi 14211841 210 VLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGV 242
Cdd:cd18267 115 LLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPAtsggppaVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 210
Cdd:cd18272  34 DVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRV-------IELKDVSESVFQLLVDYIYHGTVKLRVEELQET 106

                        90       100
                ....*....|....*....|....*
gi 14211841 211 LSVADMYLLPGLKRLCGRSLAQMLD 235
Cdd:cd18272 107 YEVADMYQLTALFEECSRFLARTVQ 131

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 140 SFLCHKAFFCGRSDYFRALLDDHFRESeepatsgGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLL 219
Cdd:cd18248  36 EFMAHKVVLASSSPYFKAMFTSGLREC-------GMEVVPIEGVHPCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQM 108

                        90
                ....*....|....*.
gi 14211841 220 PGLKRLCGRSLAQMLD 235
Cdd:cd18248 109 DSVVKACCDFLEQQLD 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14211841 124 DGFNScpDICFRVAGCSFLCHKAFFCgRSDYFRALLDDHFRESEEPAtsggppaVTL----HGISPDVFTHVLYYMYSDH 199
Cdd:cd18305  12 NGENS--DITICALGREWKLHKIYLC-QSGYFASMFSGSWKESKETV-------INLeipdDNITVEALNVVFGSLYRDE 81