NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|190014607|ref|NP_115925|]
View 

netrin-G2 precursor [Homo sapiens]

Protein Classification

Laminin_N and EGF_Lam domain-containing protein( domain architecture ID 11079851)

Laminin_N and EGF_Lam domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
60-285 1.57e-59

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 196.65  E-value: 1.57e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014607   60 TCG-DPPERFCSHENP---YLCSnECDASNPDLAHPPRLMFDKEEEGLATYWQSITWSRypSPLEANITLSWNKTVELTD 135
Cdd:pfam00055  19 TCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVI--QYENVNLTLDLGKEFHFTY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014607  136 dVVMTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSSSsahRVLCTEEYSR-WAGSKKEKHVRfe 214
Cdd:pfam00055  96 -LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVICTSEYSDiSPLTGGEVIFS-- 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190014607  215 vrdrfAIFAGPDLRNMDNlytrlesAKGLKEFFTLTDLRMRLLRPALGGTYVQ--RENLYKYFYAISNIEVIG 285
Cdd:pfam00055 170 -----TLEGRPSANIFDY-------SPELQDWLTATNIRIRLLRLHTLGDELLddPSVLRKYYYAISDISVGG 230
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 409-456 1.52e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.81  E-value: 1.52e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 190014607  409 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHYWRQGCYPNVC 456
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 286-332 1.37e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.64  E-value: 1.37e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 190014607 286 RCKCNLHANLCSM-REGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGS 332
Cdd:cd00055    1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 353-401 2.46e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 2.46e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 190014607 353 CECYGHSNRCSYIDFLNVVtCVsCKHNTRGQHCQHCRLGYYRNGSAELD 401
Cdd:cd00055    2 CDCNGHGSLSGQCDPGTGQ-CE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
60-285 1.57e-59

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 196.65  E-value: 1.57e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014607   60 TCG-DPPERFCSHENP---YLCSnECDASNPDLAHPPRLMFDKEEEGLATYWQSITWSRypSPLEANITLSWNKTVELTD 135
Cdd:pfam00055  19 TCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVI--QYENVNLTLDLGKEFHFTY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014607  136 dVVMTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSSSsahRVLCTEEYSR-WAGSKKEKHVRfe 214
Cdd:pfam00055  96 -LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVICTSEYSDiSPLTGGEVIFS-- 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190014607  215 vrdrfAIFAGPDLRNMDNlytrlesAKGLKEFFTLTDLRMRLLRPALGGTYVQ--RENLYKYFYAISNIEVIG 285
Cdd:pfam00055 170 -----TLEGRPSANIFDY-------SPELQDWLTATNIRIRLLRLHTLGDELLddPSVLRKYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 60-285 5.06e-36

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 134.02  E-value: 5.06e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014607    60 TCGDP-PERFC----SHENPYLCsNECDASNPDLAHPPRLMFDKEEEGLATYWQSITWSRYPspLEANITLSWNKTVELT 134
Cdd:smart00136  25 TCGEPgPERYCklvgHTEQGKKC-DYCDARNPRRSHPAENLTDGNNPNNPTWWQSEPLSNGP--QNVNLTLDLGKEFHVT 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014607   135 DdVVMTFEYGRPTVMVLEKSlDNGRTWQPYQFYAEDCMEAFGMSARRArdMSSSSAHRVLCTEEYSRWAGSKK-EKHVRF 213
Cdd:smart00136 102 Y-VILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGP--ITKGNEDEVICTSEYSDIVPLEGgEIAFSL 177

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190014607   214 -EVRdrfaifagPDLRNmdnlytrLESAKGLKEFFTLTDLRMRLLRPALGGTYV---QRENLYKYFYAISNIEVIG 285
Cdd:smart00136 178 lEGR--------PSATD-------FDNSPVLQEWVTATNIRVRLTRLRTLGDELmddRPEVTRRYYYAISDIAVGG 238
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 409-456 1.52e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.81  E-value: 1.52e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 190014607  409 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHYWRQGCYPNVC 456
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 409-446 3.57e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 3.57e-07
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 190014607 409 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHY 446
Cdd:cd00055    2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYY 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
409-446 9.03e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 45.77  E-value: 9.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 190014607   409 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHY 446
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYY 39
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 286-332 1.37e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.64  E-value: 1.37e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 190014607 286 RCKCNLHANLCSM-REGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGS 332
Cdd:cd00055    1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 353-401 2.46e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 2.46e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 190014607 353 CECYGHSNRCSYIDFLNVVtCVsCKHNTRGQHCQHCRLGYYRNGSAELD 401
Cdd:cd00055    2 CDCNGHGSLSGQCDPGTGQ-CE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 287-323 3.67e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.41  E-value: 3.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 190014607  287 CKCNLHANL---CSMREGslQCECEHNTTGPDCGKCKKNF 323
Cdd:pfam00053   1 CDCNPHGSLsdtCDPETG--QCLCKPGVTGRHCDRCKPGY 38
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
60-285 1.57e-59

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 196.65  E-value: 1.57e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014607   60 TCG-DPPERFCSHENP---YLCSnECDASNPDLAHPPRLMFDKEEEGLATYWQSITWSRypSPLEANITLSWNKTVELTD 135
Cdd:pfam00055  19 TCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVI--QYENVNLTLDLGKEFHFTY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014607  136 dVVMTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSSSsahRVLCTEEYSR-WAGSKKEKHVRfe 214
Cdd:pfam00055  96 -LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVICTSEYSDiSPLTGGEVIFS-- 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190014607  215 vrdrfAIFAGPDLRNMDNlytrlesAKGLKEFFTLTDLRMRLLRPALGGTYVQ--RENLYKYFYAISNIEVIG 285
Cdd:pfam00055 170 -----TLEGRPSANIFDY-------SPELQDWLTATNIRIRLLRLHTLGDELLddPSVLRKYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 60-285 5.06e-36

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 134.02  E-value: 5.06e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014607    60 TCGDP-PERFC----SHENPYLCsNECDASNPDLAHPPRLMFDKEEEGLATYWQSITWSRYPspLEANITLSWNKTVELT 134
Cdd:smart00136  25 TCGEPgPERYCklvgHTEQGKKC-DYCDARNPRRSHPAENLTDGNNPNNPTWWQSEPLSNGP--QNVNLTLDLGKEFHVT 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014607   135 DdVVMTFEYGRPTVMVLEKSlDNGRTWQPYQFYAEDCMEAFGMSARRArdMSSSSAHRVLCTEEYSRWAGSKK-EKHVRF 213
Cdd:smart00136 102 Y-VILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGP--ITKGNEDEVICTSEYSDIVPLEGgEIAFSL 177

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190014607   214 -EVRdrfaifagPDLRNmdnlytrLESAKGLKEFFTLTDLRMRLLRPALGGTYV---QRENLYKYFYAISNIEVIG 285
Cdd:smart00136 178 lEGR--------PSATD-------FDNSPVLQEWVTATNIRVRLTRLRTLGDELmddRPEVTRRYYYAISDIAVGG 238
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 409-456 1.52e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.81  E-value: 1.52e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 190014607  409 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHYWRQGCYPNVC 456
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 409-446 3.57e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 3.57e-07
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 190014607 409 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHY 446
Cdd:cd00055    2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYY 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
409-446 9.03e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 45.77  E-value: 9.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 190014607   409 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHY 446
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYY 39
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 286-332 1.37e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.64  E-value: 1.37e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 190014607 286 RCKCNLHANLCSM-REGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGS 332
Cdd:cd00055    1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 353-401 2.46e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 2.46e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 190014607 353 CECYGHSNRCSYIDFLNVVtCVsCKHNTRGQHCQHCRLGYYRNGSAELD 401
Cdd:cd00055    2 CDCNGHGSLSGQCDPGTGQ-CE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 287-323 3.67e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.41  E-value: 3.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 190014607  287 CKCNLHANL---CSMREGslQCECEHNTTGPDCGKCKKNF 323
Cdd:pfam00053   1 CDCNPHGSLsdtCDPETG--QCLCKPGVTGRHCDRCKPGY 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH