NCBI Conserved Domain Search

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

331-589

1.44e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 109.48 E-value: 1.44e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 331 VSPDNDIYIAGGYRPSSsevsidhkAENDFWMYDHSTNRWLSKPSL-LRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLK 409
Cdd:COG3055   19 ALLDGKVYVAGGLSGGS--------ASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPSSTPLN 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 410 SVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGE-------FFLFYEPQKDYWGFLTPMTVPRiQGLAAV--YK 480
Cdd:COG3055   91 DVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWddggnvaWVEVYDPATGTWTQLAPLPTPR-DHLAAAvlPD 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 481 DSIYYIAGtcgnhqrmftvEAYDIELNKWTRKKDFPCDQSinpYLKLVLFQNKLHLFVRATQVTveehvfrtsrkNSLYQ 560
Cdd:COG3055  170 GKILVIGG-----------RNGSGFSNTWTTLAPLPTARA---GHAAAVLGGKILVFGGESGFS-----------DEVEA 224

                        250       260
                 ....*....|....*....|....*....
gi 227497736 561 YDDIADQWMKVYETPdrlwdLGRHFECAV 589
Cdd:COG3055  225 YDPATNTWTALGELP-----TPRHGHAAV 248

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

50-147

1.14e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 98.15 E-value: 1.14e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736    50 DIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASI 129
Cdd:smart00225   1 DVTLVVG-GKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 227497736   130 FQIPSIQDQCAKYMISHL 147
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

379-428

1.50e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 50.69 E-value: 1.50e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 227497736  379 ARIGCKLVYCCGKMYAIGGRvyegDGRNSLKSVECYDSRENCWTTVCAMP 428
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF----DGNQSLNSVEVYDPETNTWSKLPSMP 46

Kelch

Kelch domain;

391-430

1.17e-07

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 48.32 E-value: 1.17e-07

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 227497736   391 KMYAIGGRvyegDGRNSLKSVECYDSRENCWTTVCAMPVA 430
Cdd:smart00612   1 KIYVVGGF----DGGQRLKSVEVYDPETNKWTPLPSMPTP 36

Name

Accession

Description

Interval

E-value

BTB_POZ_KBTBD8

cd18274

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-155

1.84e-95

Pssm-ID: 349583 [Multi-domain] Cd Length: 129 Bit Score: 288.04 E-value: 1.84e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  27 MDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLN 106
Cdd:cd18274    1 MDPLHACSILQQLKAMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 227497736 107 YAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGV 155
Cdd:cd18274   81 YAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129

BACK_KBTBD8

cd18483

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

147-243

2.75e-64

Pssm-ID: 350558 [Multi-domain] Cd Length: 97 Bit Score: 205.86 E-value: 2.75e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                         90
                 ....*....|....*..
gi 227497736 227 EREVHLPEIFAKCIRFP 243
Cdd:cd18483   81 KREMHLPEIFAKCIRMP 97

PHA03098

kelch-like protein; Provisional

50-516

1.66e-56

kelch-like protein; Provisional

Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 199.22 E-value: 1.66e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  50 DIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTEstqKEVrIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASI 129
Cdd:PHA03098  12 ESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEI-NLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIANY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 130 FQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDR 209
Cdd:PHA03098  88 LIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 210 EEHVYESIIRWFEHEQNEREVHLPEIFaKCIRFPLMEDTFIEKIPPQFAQAIAKSCV--EKGPSNTNGC---TQRLGMTA 284
Cdd:PHA03098 168 EDVVLEIIIKWLTSKKNNKYKDICLIL-KVLRITFLSEEGIKKLKRWKLRIKKKKIVfnKRCIKIIYSKkynLNKILPRS 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 285 SEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKppNDLREVGILVSPDNDIYIAGGYRPSSSEVsidhkaeNDFWMYD 364
Cdd:PHA03098 247 STFGSIIYIHITMSIFTYNYITNYSPLSEINTIID--IHYVYCFGSVVLNNVIYFIGGMNKNNLSV-------NSVVSYD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 365 HSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGR---------------------------------------------- 398
Cdd:PHA03098 318 TKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIynsislntveswkpgeskwreepplifprynpcvvnvnnliyvigg 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 399 VYEGDgrNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQG----------EFFLFYEPQKDYWGFLTPMT 468
Cdd:PHA03098 398 ISKND--ELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidnikvyNIVESYNPVTNKWTELSSLN 475

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 227497736 469 VPRIQGLAAVYKDSIYYIAGTCgNHQRMFTVEAYDIELNKWTRKKDFP 516
Cdd:PHA03098 476 FPRINASLCIFNNKIYVVGGDK-YEYYINEIEVYDDKTNTWTLFCKFP 522

BTB_POZ_KBTBD6_7

cd18273

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-156

1.11e-44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349582 [Multi-domain] Cd Length: 142 Bit Score: 155.37 E-value: 1.11e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  28 DPFHACSILKQLKTMYDEGQLTDIVVEVD-------HGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAES 100
Cdd:cd18273    6 DAAHARALLAQLKSFYDARLLTDVTIEVNgpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSES 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 227497736 101 MDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVF 156
Cdd:cd18273   86 MALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141

BTB_POZ_KLHL8

cd18238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-154

8.20e-40

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349547 [Multi-domain] Cd Length: 120 Bit Score: 141.27 E-value: 8.20e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  36 LKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVIL 115
Cdd:cd18238    3 FKVLHQFYENGELCDVTLKVGE-KSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTL 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 227497736 116 TEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIG 154
Cdd:cd18238   82 TVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120

BTB_POZ_KBTBD12

cd18276

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-155

1.61e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349585 [Multi-domain] Cd Length: 127 Bit Score: 129.92 E-value: 1.61e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18276    4 HSLTLLDQLNRMKELAELTDVVL-VAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYS 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGV 155
Cdd:cd18276   83 SDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

153-250

2.68e-34

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 125.35 E-value: 2.68e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  153 IGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHL 232
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHL 81

                          90
                  ....*....|....*...
gi 227497736  233 PEIFAkCIRFPLMEDTFI 250
Cdd:pfam07707  82 PELLS-AVRLPLLSPQYL 98

BTB_POZ_KLHL10

cd18240

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-151

7.48e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349549 [Multi-domain] Cd Length: 120 Bit Score: 124.75 E-value: 7.48e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTmydEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18240    3 MACNVFNELRL---EGKLCDVVIRVN-GVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18240   79 RTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPEN 119

BTB_POZ_KLHL21

cd18250

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-151

9.85e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349559 [Multi-domain] Cd Length: 124 Bit Score: 121.80 E-value: 9.85e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  28 DPFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNY 107
Cdd:cd18250    1 DPAHALHLLRGLSELRAERKFFDVTLCAG-GREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDF 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18250   80 SYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSN 123

BTB_POZ_KLHL24_KRIP6

cd18253

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-151

5.30e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349562 [Multi-domain] Cd Length: 121 Bit Score: 119.94 E-value: 5.30e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVE-GREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18253   80 GKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120

BTB_POZ_KLHL6

cd18236

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-154

1.02e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349545 [Multi-domain] Cd Length: 129 Bit Score: 119.18 E-value: 1.02e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  39 LKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEA 118
Cdd:cd18236   15 LENLRLENSLTDVILCVD-SQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQ 93

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 227497736 119 NVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIG 154
Cdd:cd18236   94 NVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129

BTB_POZ_KLHL7

cd18237

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-154

2.08e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349546 [Multi-domain] Cd Length: 126 Bit Score: 118.36 E-value: 2.08e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18237    4 LLADFMGVMNNMRKQKTLCDVILIVE-GREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIG 154
Cdd:cd18237   83 ARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126

BTB_POZ_KLHL27_IPP

cd18256

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-154

3.06e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349565 [Multi-domain] Cd Length: 125 Bit Score: 117.89 E-value: 3.06e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVG-MELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIG 154
Cdd:cd18256   82 GVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125

BTB_POZ_KLHL18

cd18247

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-145

3.68e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349556 [Multi-domain] Cd Length: 116 Bit Score: 117.38 E-value: 3.68e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  32 ACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTS 111
Cdd:cd18247    3 PSSGFPVMEEIRRQGKLCDVTLKVGD-QKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSG 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 227497736 112 RVILTEANVQALFTAASIFQIPSIQDQCAKYMIS 145
Cdd:cd18247   82 RIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115

BTB_POZ_KLHL12_C3IP1_DKIR

cd18242

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-151

4.05e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349551 [Multi-domain] Cd Length: 124 Bit Score: 117.54 E-value: 4.05e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18242    4 HAKSILNTMNSLRKSNTLCDVTLRVE-GKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18242   83 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123

BTB_POZ_KLHL38

cd18268

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-155

5.11e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349577 [Multi-domain] Cd Length: 129 Bit Score: 117.19 E-value: 5.11e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  32 ACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTS 111
Cdd:cd18268    7 SSELLRQLNSLRQERILTDVILCTG-DKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 227497736 112 RVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGV 155
Cdd:cd18268   86 EILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129

BTB_POZ_KLHL26

cd18255

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-151

8.21e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349564 [Multi-domain] Cd Length: 121 Bit Score: 116.34 E-value: 8.21e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIAD-GQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18255   80 SELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120

BTB_POZ_KLHL23

cd18252

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-154

1.46e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349561 [Multi-domain] Cd Length: 127 Bit Score: 116.08 E-value: 1.46e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  28 DPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNY 107
Cdd:cd18252    1 DSSHPADFLDAFRTFYLDGLFTDITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIG 154
Cdd:cd18252   81 VYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

153-252

1.77e-30

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 114.75 E-value: 1.77e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736   153 IGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHL 232
Cdd:smart00875   2 LGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90       100
                   ....*....|....*....|
gi 227497736   233 PEIFaKCIRFPLMEDTFIEK 252
Cdd:smart00875  82 PELL-EHVRLPLLSPDYLLE 100

BTB_POZ_KLHL35

cd18265

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-154

6.35e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349574 [Multi-domain] Cd Length: 128 Bit Score: 114.10 E-value: 6.35e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYA 108
Cdd:cd18265    4 PCHAERILQVLNAYRRSGTFTDVVLLVD-GKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYM 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIG 154
Cdd:cd18265   83 YGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128

BTB_POZ_KLHL40-like

cd18269

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-155

7.66e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349578 [Multi-domain] Cd Length: 133 Bit Score: 114.04 E-value: 7.66e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  39 LKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEA 118
Cdd:cd18269   18 LKDLLDENKFVDCVLKIG-DKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQ 96

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 227497736 119 NVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGV 155
Cdd:cd18269   97 NVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133

BTB_POZ_KLHL40_KBTBD5

cd18340

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-156

1.64e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349649 [Multi-domain] Cd Length: 134 Bit Score: 113.39 E-value: 1.64e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  39 LKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEA 118
Cdd:cd18340   18 LKDLLDHNKFVDCVLKI-KEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQ 96

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 227497736 119 NVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVF 156
Cdd:cd18340   97 NVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

39-147

2.18e-29

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 111.97 E-value: 2.18e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736   39 LKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVIlTEA 118
Cdd:pfam00651   1 LNELREQGELCDVTLVVG-DKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLI-SEE 78

                          90       100
                  ....*....|....*....|....*....
gi 227497736  119 NVQALFTAASIFQIPSIQDQCAKYMISHL 147
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB_POZ_KBTBD2_BKLHD1

cd18270

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-153

4.19e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 109.32 E-value: 4.19e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18270    9 YAVSLLEQLKFFYEQQLLTDIVLIVE-GTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYT 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSI 153
Cdd:cd18270   88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130

BTB_POZ_ZBTB_KLHL-like

cd18186

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

48-130

7.86e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349497 [Multi-domain] Cd Length: 82 Bit Score: 106.87 E-value: 7.86e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  48 LTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAA 127
Cdd:cd18186    1 LCDVTLVVG-GREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79


                 ...
gi 227497736 128 SIF 130
Cdd:cd18186   80 DKL 82

BTB_POZ_KLHL20_KLEIP

cd18249

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-154

1.34e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349558 [Multi-domain] Cd Length: 128 Bit Score: 104.84 E-value: 1.34e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFScHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18249    6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYA-HRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIG 154
Cdd:cd18249   85 SQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

331-589

1.44e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 109.48 E-value: 1.44e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 331 VSPDNDIYIAGGYRPSSsevsidhkAENDFWMYDHSTNRWLSKPSL-LRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLK 409
Cdd:COG3055   19 ALLDGKVYVAGGLSGGS--------ASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPSSTPLN 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 410 SVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGE-------FFLFYEPQKDYWGFLTPMTVPRiQGLAAV--YK 480
Cdd:COG3055   91 DVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWddggnvaWVEVYDPATGTWTQLAPLPTPR-DHLAAAvlPD 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 481 DSIYYIAGtcgnhqrmftvEAYDIELNKWTRKKDFPCDQSinpYLKLVLFQNKLHLFVRATQVTveehvfrtsrkNSLYQ 560
Cdd:COG3055  170 GKILVIGG-----------RNGSGFSNTWTTLAPLPTARA---GHAAAVLGGKILVFGGESGFS-----------DEVEA 224

                        250       260
                 ....*....|....*....|....*....
gi 227497736 561 YDDIADQWMKVYETPdrlwdLGRHFECAV 589
Cdd:COG3055  225 YDPATNTWTALGELP-----TPRHGHAAV 248

BTB_POZ_KLHL28_BTBD5

cd18257

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-149

1.91e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349566 [Multi-domain] Cd Length: 118 Bit Score: 104.16 E-value: 1.91e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVK-IHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYT 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDP 149
Cdd:cd18257   80 GTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118

BTB_POZ_KLHL2-like

cd18235

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-149

2.42e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349544 [Multi-domain] Cd Length: 121 Bit Score: 104.05 E-value: 2.42e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYA 108
Cdd:cd18235    2 PQHTQKAFDVMNELRKQNLLCDVILVAD-GVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDP 149
Cdd:cd18235   81 YTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121

BTB_POZ_KLHL37_ENC1

cd18267

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-155

3.71e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349576 [Multi-domain] Cd Length: 147 Bit Score: 104.30 E-value: 3.71e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI-VGVEAESMDLVLNY 107
Cdd:cd18267   21 SSYADSVLTHLNLLRQQRLFTDVLLHAGN-RSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFhDSIHPEVLELLLDY 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGV 155
Cdd:cd18267  100 AYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147

BTB_POZ_KLHL30

cd18259

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-154

4.71e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349568 [Multi-domain] Cd Length: 137 Bit Score: 103.76 E-value: 4.71e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYA 108
Cdd:cd18259   13 PSHPQSILDGLQTLRSNPKLSDVTLLVG-GREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFA 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIG 154
Cdd:cd18259   92 YTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

50-147

1.14e-24

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 98.15 E-value: 1.14e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736    50 DIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASI 129
Cdd:smart00225   1 DVTLVVG-GKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 227497736   130 FQIPSIQDQCAKYMISHL 147
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

BTB_POZ_KLHL19_KEAP1

cd18248

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-148

1.73e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349557 [Multi-domain] Cd Length: 124 Bit Score: 98.61 E-value: 1.73e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHG---KTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNY 107
Cdd:cd18248    4 HTKEAFQIMNELRLSQQLCDVTLKVKYQdpkEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEF 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLD 148
Cdd:cd18248   84 AYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124

BACK_KLHL2_like

cd18445

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...

147-253

2.42e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 98.07 E-value: 2.42e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18445    1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                         90       100
                 ....*....|....*....|....*..
gi 227497736 227 EREVHLPEIFAKcIRFPLMEDTFIEKI 253
Cdd:cd18445   81 NRKEHLAELLEH-VRLPLLSPEYLVQR 106

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

306-516

2.45e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 102.93 E-value: 2.45e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 306 CLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDhkaeNDFWMYDHSTNRWLSKPSLLRARIGCKL 385
Cdd:COG3055   42 VYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGANPSSTPL----NDVYVYDPATNTWTKLAPMPTPRGGATA 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 386 VYCCGKMYAIGGRvyegDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKE-KIYVLQGEFFLFYEPQkdyWGFL 464
Cdd:COG3055  118 LLLDGKIYVVGGW----DDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILVIGGRNGSGFSNT---WTTL 190

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 227497736 465 TPMTVPRIQGLAAVYKDSIYYIAGTCGNHQrmfTVEAYDIELNKWTRKKDFP 516
Cdd:COG3055  191 APLPTARAGHAAAVLGGKILVFGGESGFSD---EVEAYDPATNTWTALGELP 239

BTB_POZ_KLHL1-like

cd18234

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

48-153

4.74e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349543 [Multi-domain] Cd Length: 105 Bit Score: 96.67 E-value: 4.74e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  48 LTDiVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAA 127
Cdd:cd18234    1 LCD-VILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATA 79

                         90       100
                 ....*....|....*....|....*.
gi 227497736 128 SIFQIPSIQDQCAKYMISHLDPQNSI 153
Cdd:cd18234   80 CLLQLSEVVEACCGFLMKQLHPSNCL 105

BACK_KBTBD12

cd18485

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

147-244

5.51e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350560 [Multi-domain] Cd Length: 100 Bit Score: 96.34 E-value: 5.51e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18485    1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                         90
                 ....*....|....*...
gi 227497736 227 EREVHLPEIFaKCIRFPL 244
Cdd:cd18485   81 SRVQHLVELL-KQVRLEL 97

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-155

6.14e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 97.61 E-value: 6.14e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  39 LKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEA 118
Cdd:cd18341   18 LKELLDENKFVDCTLKAGD-KSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDG 96

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 227497736 119 NVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGV 155
Cdd:cd18341   97 NVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133

BTB_POZ_KLHL25

cd18254

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-154

8.13e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349563 [Multi-domain] Cd Length: 128 Bit Score: 97.00 E-value: 8.13e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIV-GVEAESMDLVLNY 107
Cdd:cd18254    3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGN-RSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHdSLHPEVLELLLDF 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIG 154
Cdd:cd18254   82 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128

BTB_POZ_NS1BP

cd18306

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-155

1.46e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349615 [Multi-domain] Cd Length: 124 Bit Score: 96.18 E-value: 1.46e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  34 SILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRV 113
Cdd:cd18306    4 SVLAKLNALRKNRQFCDVILQVG-GHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 227497736 114 ILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGV 155
Cdd:cd18306   83 EVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124

BACK_KLHL8

cd18448

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...

146-243

1.91e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 94.68 E-value: 1.91e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 146 HLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQ 225
Cdd:cd18448    1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*...
gi 227497736 226 NEREVHLPEIFAKcIRFP 243
Cdd:cd18448   81 QHRKRHLDDLLSQ-VRLP 97

BACK_KLHL18

cd18457

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...

147-257

2.74e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.

Pssm-ID: 350532 [Multi-domain] Cd Length: 107 Bit Score: 94.68 E-value: 2.74e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227497736 227 EREVHLPEIFAKcIRFPLMEdtfiekipPQF 257
Cdd:cd18457   81 NREEYLPELLSK-VRLPLLR--------PQF 102

BTB_POZ_KLHL17_actinfilin

cd18246

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-149

6.80e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349555 [Multi-domain] Cd Length: 139 Bit Score: 94.71 E-value: 6.80e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  39 LKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEA 118
Cdd:cd18246   30 MNRMRQRGLLCDIVLHVG-TKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEG 108

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227497736 119 NVQALFTAASIFQIPSIQDQCAKYMISHLDP 149
Cdd:cd18246  109 NVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139

BTB_POZ_KLHL2_Mayven

cd18338

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-149

6.82e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349647 [Multi-domain] Cd Length: 121 Bit Score: 93.98 E-value: 6.82e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  28 DPFHACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNY 107
Cdd:cd18338    1 NPRHMKKAFKVMNELRSQNLLCDVTI-VAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDP 149
Cdd:cd18338   80 VYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121

BTB_POZ_KLHL22

cd18251

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-151

2.55e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349560 [Multi-domain] Cd Length: 125 Bit Score: 92.57 E-value: 2.55e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18251    6 HSQALLDGLVALRDSGILFDVVLVVE-GKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18251   85 SELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125

BACK_KLHL1_like

cd18444

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...

147-257

1.60e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 89.70 E-value: 1.60e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18444    2 LHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLP 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227497736 227 EREVHLPEIFAKcIRFPLMedtfiekiPPQF 257
Cdd:cd18444   82 ERKKHLAKLLAL-IRLPLL--------TPQF 103

BTB_POZ_KLHL4

cd18336

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-155

1.69e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349645 [Multi-domain] Cd Length: 126 Bit Score: 90.49 E-value: 1.69e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18336    2 HAEQTFRKMENYLQHKQLCDVLLIAGNLK-IPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGV 155
Cdd:cd18336   81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125

BTB_POZ_KLHL3

cd18339

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-149

6.13e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349648 [Multi-domain] Cd Length: 121 Bit Score: 88.62 E-value: 6.13e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  28 DPFHACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNY 107
Cdd:cd18339    1 NPAHMKKAFKVMNELRSKQLLCDVTI-VAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDP 149
Cdd:cd18339   80 IYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121

BACK_KLHL16_gigaxonin

cd18455

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...

149-241

1.16e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 86.99 E-value: 1.16e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 149 PQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNER 228
Cdd:cd18455    2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                         90
                 ....*....|...
gi 227497736 229 EVHLPEIFAKCIR 241
Cdd:cd18455   82 KVHLKDLMSSCWR 94

BACK_KLHL19_KEAP1

cd18458

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...

147-228

1.34e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 86.58 E-value: 1.34e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18458    2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEE 81


                 ..
gi 227497736 227 ER 228
Cdd:cd18458   82 NR 83

BTB_POZ_ZBTB7A

cd18326

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-140

1.43e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349635 [Multi-domain] Cd Length: 120 Bit Score: 87.30 E-value: 1.43e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYA 108
Cdd:cd18326    6 PDHSSDILSSLNEQRTQGLLCDVVILVE-GREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFA 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQCA 140
Cdd:cd18326   85 YTATLTVSTSNVGDILSAARLLEIPAVSHVCA 116

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

171-245

4.43e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 85.19 E-value: 4.43e-20

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 227497736 171 SKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFaKCIRFPLM 245
Cdd:cd18516   25 ARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERTKALPVLL-ESIRFRLM 98

BACK_KLHL20

cd18459

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...

147-245

3.05e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.

Pssm-ID: 350534 [Multi-domain] Cd Length: 100 Bit Score: 82.86 E-value: 3.05e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18459    2 LDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQ 81

                         90
                 ....*....|....*....
gi 227497736 227 EREVHLPEIFAKcIRFPLM 245
Cdd:cd18459   82 ERRPHLPQVLQH-VRLPLL 99

BACK_KLHL6

cd18446

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...

147-246

5.87e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 82.52 E-value: 5.87e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                         90       100
                 ....*....|....*....|
gi 227497736 227 EREVHLPEIFaKCIRFPLME 246
Cdd:cd18446   81 ERLPLLPRVL-ENVRLPLLD 99

BACK_KLHL29_KBTBD9

cd18468

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...

148-250

8.31e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 81.69 E-value: 8.31e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 148 DPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNE 227
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90       100
                 ....*....|....*....|...
gi 227497736 228 REVHLPEIFAkCIRFPLMEDTFI 250
Cdd:cd18468   81 RKQHIAELLA-VVRLPFIHPSYL 102

BACK_KLHL10

cd18450

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...

147-224

1.13e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 80.73 E-value: 1.13e-18

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKE-QEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHE 224
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79

BTB_POZ_KLHL5

cd18337

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-155

1.30e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349646 [Multi-domain] Cd Length: 130 Bit Score: 82.42 E-value: 1.30e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18337    6 HAEQTFKKMENYLRHKQLCDVVL-VAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGV 155
Cdd:cd18337   85 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129

BACK_KLHL12

cd18452

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...

147-250

3.84e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 80.91 E-value: 3.84e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100
                 ....*....|....*....|....
gi 227497736 227 EREVHLPEIFaKCIRFPLMEDTFI 250
Cdd:cd18452   81 EREDYLPELL-QYVRLPLLSPRYI 103

BTB_POZ_ZBTB7

cd18198

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-143

5.78e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349507 [Multi-domain] Cd Length: 120 Bit Score: 79.91 E-value: 5.78e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYA 108
Cdd:cd18198    6 PDHSSEILSGLNEQRTQGLLCDVVILVQ-GREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFA 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18198   85 YTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119

BTB_POZ_KLHL36

cd18266

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-151

6.60e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349575 [Multi-domain] Cd Length: 135 Bit Score: 80.32 E-value: 6.60e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18266    8 HSNLVLQGLNEQRQRGLFCDVVLVADE-QRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18266   87 SELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEEN 127

BTB_POZ_BTBD9

cd18287

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-117

1.40e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349596 [Multi-domain] Cd Length: 119 Bit Score: 78.82 E-value: 1.40e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18287    5 HVHFLSEDIGALFLNEEYSDVTFVVE-EKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYT 83


                 ....*..
gi 227497736 111 SRVILTE 117
Cdd:cd18287   84 GRLTLTD 90

BACK_KLHL27_IPP

cd18466

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...

147-245

1.78e-17

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.

Pssm-ID: 350541 [Multi-domain] Cd Length: 103 Bit Score: 77.90 E-value: 1.78e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18466    1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVG 80

                         90
                 ....*....|....*....
gi 227497736 227 EREVHLPEIFAKcIRFPLM 245
Cdd:cd18466   81 KRKKHVVEVLEP-VRFPLL 98

BTB_POZ_KLHL1

cd18335

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-155

3.80e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349644 [Multi-domain] Cd Length: 126 Bit Score: 77.78 E-value: 3.80e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18335    2 HAEQTFRKMESYLKQQQLCDVILIAGNRK-IPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGV 155
Cdd:cd18335   81 GCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

43-139

4.31e-17

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 76.61 E-value: 4.31e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  43 YDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQA 122
Cdd:cd18314    1 YNDSEFSDVVLCVGD-RKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLD 79

                         90
                 ....*....|....*..
gi 227497736 123 LFTAASIFQIPSIQDQC 139
Cdd:cd18314   80 LLMLASKYQVPDLEKLC 96

BACK_KLHL17

cd18456

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...

147-249

5.40e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.

Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 76.58 E-value: 5.40e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90       100
                 ....*....|....*....|...
gi 227497736 227 EREVHLPEIFaKCIRFPLMEDTF 249
Cdd:cd18456   81 GRRQHVPRLM-KCVRLPLLSRDF 102

BACK_KBTBD3

cd18480

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

147-228

5.81e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 75.82 E-value: 5.81e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                 ..
gi 227497736 227 ER 228
Cdd:cd18480   81 AR 82

BTB_POZ_KBTBD3_BKLHD3

cd18271

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-151

6.23e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349580 [Multi-domain] Cd Length: 130 Bit Score: 77.57 E-value: 6.23e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18271    7 HGQQILSVLQNFREQNAFFDFNIIV-KDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYT 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18271   86 GKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTN 126

BACK_KLHL40_like

cd18477

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...

147-245

6.42e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Pssm-ID: 350552 [Multi-domain] Cd Length: 99 Bit Score: 76.42 E-value: 6.42e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....*....
gi 227497736 227 EREVHLPEIFaKCIRFPLM 245
Cdd:cd18477   81 NRQKALPTVF-ESIRFRLL 98

BACK_KLHL41_KBTBD10

cd18517

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...

171-245

7.88e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

Pssm-ID: 350592 [Multi-domain] Cd Length: 99 Bit Score: 75.96 E-value: 7.88e-17

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 227497736 171 SKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFaKCIRFPLM 245
Cdd:cd18517   25 ARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKENRVKSLGEIF-DCIRFRLM 98

BTB_POZ_KLHL9_13

cd18239

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-151

8.79e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349548 [Multi-domain] Cd Length: 128 Bit Score: 76.77 E-value: 8.79e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIV-VEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAY 109
Cdd:cd18239    6 HSSVVLQGFDQLRGEGLLCDVTlVPGDGDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIY 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 227497736 110 TSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18239   86 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLEN 127

BACK_KEL_like

cd18508

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...

148-224

1.38e-16

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.

Pssm-ID: 350583 [Multi-domain] Cd Length: 77 Bit Score: 74.75 E-value: 1.38e-16

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227497736 148 DPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHE 224
Cdd:cd18508    1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77

BTB_POZ_KLHL32

cd18261

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-151

1.80e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 76.16 E-value: 1.80e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18261   11 HKDAVLAALNQQRNDGILCDITLVAEEQK-FHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYT 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18261   90 GQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130

BTB_POZ_KLHL34

cd18264

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-151

2.15e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349573 [Multi-domain] Cd Length: 136 Bit Score: 75.99 E-value: 2.15e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18264   11 HGEAVLSQYQSLRAEGFLCDVVLEAE-GNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYT 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18264   90 SWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPEN 130

BTB_POZ_KLHL16_gigaxonin

cd18245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

35-143

2.16e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 75.07 E-value: 2.16e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  35 ILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIV--GVEAESMDLVLNYAYTSR 112
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVG-GEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIEleGISVEVMEEILDYIYTGQ 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227497736 113 VILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18245   80 IKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

50-142

2.34e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 74.84 E-value: 2.34e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  50 DIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQK---EVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTA 126
Cdd:cd18307    3 DVVISVDN-HSFAAHRNVLAAVSPFVKSLISSNDMKATDElsiTIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKG 81

                         90
                 ....*....|....*.
gi 227497736 127 ASIFQIPSIQDQCAKY 142
Cdd:cd18307   82 AKYFNIPRLKDHCVDF 97

BACK_KLHL24

cd18463

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...

147-223

2.50e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.

Pssm-ID: 350538 [Multi-domain] Cd Length: 78 Bit Score: 73.97 E-value: 2.50e-16

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEH 223
Cdd:cd18463    2 LDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78

BTB2_POZ_KLHL33

cd18263

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

36-153

3.85e-16

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349572 [Multi-domain] Cd Length: 118 Bit Score: 74.85 E-value: 3.85e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  36 LKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVIL 115
Cdd:cd18263    1 LQSIEGLWEKGVGCDVQLEAD-GSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHL 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 227497736 116 TEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSI 153
Cdd:cd18263   80 SWENLFEATCTALQLQISGALALCLDFLQREISPARCL 117

BACK_KLHL30

cd18469

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...

147-236

7.46e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.

Pssm-ID: 350544 [Multi-domain] Cd Length: 104 Bit Score: 73.64 E-value: 7.46e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18469    3 IDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQ 82

                         90
                 ....*....|
gi 227497736 227 EREVHLPEIF 236
Cdd:cd18469   83 ARAAHLPELL 92

BACK_KLHL28_BTBD5

cd18467

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...

147-245

8.50e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 73.06 E-value: 8.50e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*....
gi 227497736 227 EREVHLPEIFaKCIRFPLM 245
Cdd:cd18467   81 ERQKYLAQLL-HCVRLPLL 98

BACK_KLHL5

cd18511

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...

146-250

8.76e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.

Pssm-ID: 350586 [Multi-domain] Cd Length: 106 Bit Score: 73.56 E-value: 8.76e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 146 HLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQ 225
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....*
gi 227497736 226 NEREVHLPEIFAKcIRFPLMEDTFI 250
Cdd:cd18511   81 EQRRKDLSKLLAY-IRLPLLAPQFL 104

BACK_KLHL1

cd18509

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...

147-257

1.45e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350584 [Multi-domain] Cd Length: 106 Bit Score: 72.75 E-value: 1.45e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227497736 227 EREVHLPEIFAKcIRFPLMedtfiekiPPQF 257
Cdd:cd18509   82 RRCSDLSMLLAY-IRLPLL--------PPQL 103

BACK_KLHL3

cd18513

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...

147-253

1.46e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.

Pssm-ID: 350588 [Multi-domain] Cd Length: 130 Bit Score: 73.56 E-value: 1.46e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100
                 ....*....|....*....|....*..
gi 227497736 227 EREVHLPEIFAKcIRFPLMEDTFIEKI 253
Cdd:cd18513   81 ARLEHMAKLMEH-VRLPLLPRDYLVQT 106

BACK_KLHL2_Mayven

cd18512

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...

147-250

2.00e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.

Pssm-ID: 350587 [Multi-domain] Cd Length: 130 Bit Score: 73.14 E-value: 2.00e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100
                 ....*....|....*....|....
gi 227497736 227 EREVHLPEIFAKcIRFPLMEDTFI 250
Cdd:cd18512   81 VRQEHMAHLMEH-VRLPLLSREYL 103

BACK_KLHL4

cd18510

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...

146-257

2.97e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350585 [Multi-domain] Cd Length: 106 Bit Score: 71.87 E-value: 2.97e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 146 HLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQ 225
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 227497736 226 NEREVHLPEIFAKcIRFPLMedtfiekiPPQF 257
Cdd:cd18510   81 QNRQKDLGMLLSY-IRLPLL--------PPQL 103

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

325-449

3.88e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 75.96 E-value: 3.88e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 325 REVGILVSPDNDIYIAGGYRPSSsevsidhkAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCC-GKMYAIGGRVYEG- 402
Cdd:COG3055  112 RGGATALLLDGKIYVVGGWDDGG--------NVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPdGKILVIGGRNGSGf 183

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227497736 403 ----------------------DGR--------NSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGE 449
Cdd:COG3055  184 sntwttlaplptaraghaaavlGGKilvfggesGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGE 260

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

147-238

8.04e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 70.47 E-value: 8.04e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                         90
                 ....*....|..
gi 227497736 227 EREVHLPEIFAK 238
Cdd:cd18479   81 SRSQYLSSVLSQ 92

BTB_POZ_ZBTB7C_ZBTB36

cd18328

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-143

1.69e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349637 [Multi-domain] Cd Length: 120 Bit Score: 70.29 E-value: 1.69e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYA 108
Cdd:cd18328    6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQD-QEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFA 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18328   85 YTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BTB_POZ_KBTBD4

cd18272

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

44-155

2.27e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349581 [Multi-domain] Cd Length: 140 Bit Score: 70.31 E-value: 2.27e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  44 DEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQAL 123
Cdd:cd18272   28 EDGLFADVTISVE-GKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQET 106

                         90       100       110
                 ....*....|....*....|....*....|..
gi 227497736 124 FTAASIFQIPSIQDQCAKYMISHLDPQNSIGV 155
Cdd:cd18272  107 YEVADMYQLTALFEECSRFLARTVQVRNCLQV 138

BTB_POZ_ZBTB44

cd18228

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-147

5.53e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349537 [Multi-domain] Cd Length: 126 Bit Score: 68.73 E-value: 5.53e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFtsglteSTQKEVRIVGV-EAESMDLVLN--- 106
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRV-QDKIFRAHKVVLAACSDFFRSKL------VGQASPRLVLVsPAGKCVLDLHhvt 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 227497736 107 ---------YAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHL 147
Cdd:cd18228   75 vtgfaplleYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

40-147

5.93e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 68.03 E-value: 5.93e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  40 KTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRV-ILTEA 118
Cdd:cd18300    1 KLFLNKGLFSDVTFIVE-DGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQApILEDG 79

                         90       100
                 ....*....|....*....|....*....
gi 227497736 119 NVQALFTAASIFQIPSIQDQCAKYMISHL 147
Cdd:cd18300   80 DCVGLIVLANRLCLPRLVALCEQYIVKEL 108

BACK_KLHL7

cd18447

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...

146-244

6.14e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.

Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 67.77 E-value: 6.14e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 146 HLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQ 225
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                         90
                 ....*....|....*....
gi 227497736 226 NEREVHLPEIFAKcIRFPL 244
Cdd:cd18447   81 PNRQPYMVDILAK-VRFPL 98

BTB_POZ_BTBD19

cd18294

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-143

7.40e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349603 [Multi-domain] Cd Length: 111 Bit Score: 68.04 E-value: 7.40e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  37 KQLKTMYDEGQLTDIVVEV-DHGKTFSCHRNVLAAISPYFRSMFTSGL-TESTQKEVRIVGVEAESMDLVLNYAYTSRVI 114
Cdd:cd18294    3 ADMKSLINNPEFSDVKFLVgPERQEIFAHKCILAARCEVFRAMFLTGPqKESTQSPLVLSDIEPEVFRAVLEFIYTNCVT 82

                         90       100
                 ....*....|....*....|....*....
gi 227497736 115 LTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18294   83 LSNHTVIEVLAAAVEYGLDELRKLCERFI 111

BTB_POZ_KLHL31_KBTBD1

cd18260

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-153

2.27e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 66.76 E-value: 2.27e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSgltESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTI-ATKTKSFDVHKVVMASCSEYFRNILKK---DPSLQRVELNDISPLGLATVITYAYT 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSI 153
Cdd:cd18260   77 GKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119

BTB_POZ_KLHL29_KBTBD9

cd18258

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

35-154

2.47e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349567 [Multi-domain] Cd Length: 125 Bit Score: 66.92 E-value: 2.47e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  35 ILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQK---EVRIVGVEAESMDLVLNYAYTS 111
Cdd:cd18258    4 MLKELNQQRRAKEFTDLKIIVE-GKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGeklELTMSNINADVLELLLEFVYTG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 227497736 112 RVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIG 154
Cdd:cd18258   83 SLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

49-130

2.98e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 65.38 E-value: 2.98e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  49 TDIVVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAAS 128
Cdd:cd01165    1 VVLVVE---GEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAAN 77


                 ..
gi 227497736 129 IF 130
Cdd:cd01165   78 FL 79

BACK_KLHL25_like

cd18464

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...

149-245

2.99e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350539 [Multi-domain] Cd Length: 98 Bit Score: 65.98 E-value: 2.99e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 149 PQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNER 228
Cdd:cd18464    2 PSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRR 81

                         90
                 ....*....|....*..
gi 227497736 229 EVHLPEIFaKCIRFPLM 245
Cdd:cd18464   82 HEVLPELL-RSVRLALL 97

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-143

3.46e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 66.60 E-value: 3.46e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTsgLTESTQKEVRIVGvEAESMDLVLNYA 108
Cdd:cd18222    6 PDFSNSVLSHLNQLRMQGRLCDIVVNV-QGQSFRAHKVVLAASSPYFRDHMS--LNEMSTVSISVIK-NPTVFEQLLSFC 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18222   82 YTGRICLQLADIISYLTAASFLQMQHIIDKCTQIL 116

PHA02713

hypothetical protein; Provisional

25-448

6.01e-13

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 71.58 E-value: 6.01e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  25 DAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGL-TESTQKEVRIVGVEAESMDL 103
Cdd:PHA02713   2 DIDDIKHNRRVVSNISNLLDDDILCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMiIRDLVTRVNLQMFDKDAVKN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 104 VLNYAYTSRVilTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVT 183
Cdd:PHA02713  82 IVQYLYNRHI--SSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 184 KEQEFLQLTKDQLISILDSDD-LNVDREEHVYESIIRWFEHEQNEREVHLpeIFAKCI---------RFPLMEDTFIEKI 253
Cdd:PHA02713 160 TTDAFKKTVFEILFDIISTNDnVYLYREGYKVTILLKWLEYNYITEEQLL--CILSCIdiqnldkksRLLLYSNKTINMY 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 254 PpqfaqaiakSCVE---KGPSNTNGCTQRLgmtaseMIICFDAAHKHSGkkqtvPCL---DIVTGRVFKLCKPPNDLREV 327
Cdd:PHA02713 238 P---------SCIQfllDNKQNRNIIPRQL------CLVCHDTKYNVCN-----PCIlvyNINTMEYSVISTIPNHIINY 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 328 GILVSpDNDIYIAGGYR---PSSSEV---SIDHKAENDFwmydhstnrwlskPSLLRARIGCKLVYCCGKMYAIGGRvye 401
Cdd:PHA02713 298 ASAIV-DNEIIIAGGYNfnnPSLNKVykiNIENKIHVEL-------------PPMIKNRCRFSLAVIDDTIYAIGGQ--- 360

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 227497736 402 gDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQG 448
Cdd:PHA02713 361 -NGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG 406

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

32-109

6.25e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 65.74 E-value: 6.25e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 227497736  32 ACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAY 109
Cdd:cd18286    1 CSRLGKDLLQLFLNGEDSDITIKVD-GKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIY 77

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-143

8.03e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 64.91 E-value: 8.03e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGlteSTQK------EVRIVGveaeSMDLV 104
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVK-GVCFKAHKNVLAAFSQYFRSLFQNS---SSQKndvfhlDIKNVG----GIGQI 72

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 227497736 105 LNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18233   73 LDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111

BACK_KLHL37_ENC1

cd18515

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...

149-245

9.15e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 64.61 E-value: 9.15e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 149 PQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNER 228
Cdd:cd18515    2 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKR 81

                         90
                 ....*....|....*..
gi 227497736 229 EVHLPEIFaKCIRFPLM 245
Cdd:cd18515   82 HCYLSELL-QTVRLALL 97

BTB_POZ_ZBTB4

cd18195

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-136

1.17e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349504 [Multi-domain] Cd Length: 124 Bit Score: 64.91 E-value: 1.17e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTS-------------GLTESTQKEVRIVGVE 97
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTK-FRAHRSVLAASSPYFRELLSSplplgaaavaaapGATQSPERVLELPGVK 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 227497736  98 AESMDLVLNYAYTSRVIL-TEANVQALFTAASIFQIPSIQ 136
Cdd:cd18195   80 AGVFSDVLNFIYSSRVALpGSAAAKELGAAGKRLGIPFLQ 119

BACK

cd14733

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...

148-202

2.38e-12

Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 61.91 E-value: 2.38e-12

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 227497736 148 DPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDS 202
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

48-139

3.57e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 63.45 E-value: 3.57e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  48 LTDI--VVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRV-ILTEAN--VQA 122
Cdd:cd18297   12 MSDVtfLVE---GRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVeSLDVAQddALE 88

                         90
                 ....*....|....*..
gi 227497736 123 LFTAASIFQIPSIQDQC 139
Cdd:cd18297   89 LLRAASFFQLDGLKRHC 105

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

48-146

3.80e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 63.40 E-value: 3.80e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  48 LTDI-VVEVDHGKTFSCHRNVLAAISPYFRSMFTSGlTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTA 126
Cdd:cd18231   14 LCDVdIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNA 92

                         90       100
                 ....*....|....*....|
gi 227497736 127 ASIFQIPSIQDQCAKYMISH 146
Cdd:cd18231   93 AAVLQMNDIAASCQELIDSR 112

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-146

4.26e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 63.07 E-value: 4.26e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  39 LKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAiSPYFRSMFTSGLTESTQKEVRI----VGVEAESMDLVLNYAYTSRVI 114
Cdd:cd18305    6 YQTLFLNGENSDITICA-LGREWKLHKIYLCQ-SGYFASMFSGSWKESKETVINLeipdDNITVEALNVVFGSLYRDEIE 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 227497736 115 LTEANVQALFTAASIFQIPSIQDQCAKYMISH 146
Cdd:cd18305   84 IKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-140

4.67e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 63.33 E-value: 4.67e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSG------LTESTQKEV-RIVGVEAESM 101
Cdd:cd18327    6 PEHSSELLSCLNEQRRAGLLCDLTI-KTRGLEYRTHRAVLAACSLYFRKLFTGGgggsgdLGAGGGQDVcELDFVGPEAL 84

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 227497736 102 DLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCA 140
Cdd:cd18327   85 GALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACA 123

BTB_POZ_KLHL14_printor

cd18243

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

24-151

4.88e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349552 [Multi-domain] Cd Length: 130 Bit Score: 63.52 E-value: 4.88e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  24 SDAMDPFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSgltestqKEVRIVGVEAESMDL 103
Cdd:cd18243    8 TSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTA-QGQQFHCHKAVLASCSQYFRSLFSI-------NNLVLQGCSSIGLRL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 227497736 104 VLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18243   80 VLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127

BACK_KLHL25_ENC2

cd18514

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...

147-245

5.13e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).

Pssm-ID: 350589 [Multi-domain] Cd Length: 99 Bit Score: 62.55 E-value: 5.13e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*....
gi 227497736 227 EREVHLPEIFaKCIRFPLM 245
Cdd:cd18514   81 KRKDYLPELL-RNVRLALL 98

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-143

6.20e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 62.74 E-value: 6.20e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFR---SMFT-SGLTESTQKEvrivgveAESMDLV 104
Cdd:cd18220    6 PEYSNTVLSQLNELRLQGKLCDIIVHI-QGQPFRAHKAVLAASSPYFRdhsALSTmSGLSISVIKN-------PNVFEQL 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 227497736 105 LNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18220   78 LSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

BTB_POZ_ZBTB46

cd18230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-148

1.01e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349539 [Multi-domain] Cd Length: 125 Bit Score: 62.39 E-value: 1.01e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVG-VEAESMDLVLNY 107
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCIIVE-GKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDiVTAQGFKAIIDF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLD 148
Cdd:cd18230   81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALD 121

BTB_POZ_KLHL15

cd18244

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-147

1.26e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 62.28 E-value: 1.26e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEV-DHgkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAY 109
Cdd:cd18244   13 HDTSVSAGFRALYEEGLLLDVTLVIeDH--QFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMY 90

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 227497736 110 TSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHL 147
Cdd:cd18244   91 YGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKI 128

BACK_KBTBD6_7

cd18482

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...

147-242

1.34e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 61.36 E-value: 1.34e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKF-LCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQ 225
Cdd:cd18482    1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFqQLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                         90
                 ....*....|....*..
gi 227497736 226 NEREVHLPEIFaKCIRF 242
Cdd:cd18482   81 KERAASAAEVL-KCVRW 96

BTB_POZ_ZBTB5

cd18196

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-151

1.76e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349505 [Multi-domain] Cd Length: 126 Bit Score: 61.60 E-value: 1.76e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVG--VEAESMDLVLN 106
Cdd:cd18196    2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGN-RHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALID 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 227497736 107 YAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18196   81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPMS 125

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-142

2.53e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 60.54 E-value: 2.53e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGltesTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVG-GRVFKAHWSVLACCSHFFQSLYGDG----TSGSVVLPESFAEVFGLLLDFFYT 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKY 142
Cdd:cd18232   76 GELALTRENRDRVLLAAKELRVPEAVELCQRF 107

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-123

2.64e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 60.66 E-value: 2.64e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTEStQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVGDQK-FRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPDAFENVLNYIYS 78

                         90
                 ....*....|...
gi 227497736 111 SRVILTEANVQAL 123
Cdd:cd18209   79 SSLFVEKSSLAAV 91

BTB_POZ_ZBTB27-like

cd18215

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-142

3.59e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349524 [Multi-domain] Cd Length: 113 Bit Score: 60.27 E-value: 3.59e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVG-REQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYT 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKY 142
Cdd:cd18215   81 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-143

3.68e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 60.38 E-value: 3.68e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  34 SILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVrIVGVEAESMDLV----LNYAY 109
Cdd:cd18292    3 EFLQDIAQLYNNEELSDIVLRVG-GKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSE-IELVEDPECAAVfekfLRYLY 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 227497736 110 TSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18292   81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB_POZ_ZBTB43

cd18227

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-143

4.18e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349536 [Multi-domain] Cd Length: 121 Bit Score: 60.34 E-value: 4.18e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFtsgLTESTQKEVRIVGVEAESMDLVLNYA 108
Cdd:cd18227    6 PDFSSTILQKLNQQRQQGQLCDISVVV-QGHLFRAHKAVLAASSPYFCDQV---LLKNSRRIVLPDVMNPRVFENILLSC 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18227   82 YTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

BACK_KLHL22

cd18461

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...

147-246

5.43e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.

Pssm-ID: 350536 Cd Length: 104 Bit Score: 59.77 E-value: 5.43e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRW-FEHEQ 225
Cdd:cd18461    1 VDEENILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLYhYTPEQ 80

                         90       100
                 ....*....|....*....|....
gi 227497736 226 NERE---VHLPEIFAKCIRFPLME 246
Cdd:cd18461   81 VEKDqvsLQEPPKLLEAVRFPLME 104

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-110

6.64e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 60.04 E-value: 6.64e-11

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 227497736  37 KQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18280    3 QHFGALLESEEGADVTFNVD-GEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK 75

BTB_POZ_ZBTB28_BCL6B

cd18332

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-143

9.64e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349641 [Multi-domain] Cd Length: 114 Bit Score: 59.10 E-value: 9.64e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVG-GTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18332   81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

147-246

1.21e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 58.59 E-value: 1.21e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18462    1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                         90       100
                 ....*....|....*....|
gi 227497736 227 EREVHLPEIFAkCIRFPLME 246
Cdd:cd18462   81 KRIECAYDLLS-SIKLDLDE 99

PHA02790

Kelch-like protein; Provisional

58-397

2.85e-10

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 62.75 E-value: 2.85e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  58 GKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI-VGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQ 136
Cdd:PHA02790  30 GGNIIVNSTILKKLSPYFRTHLRQKYTKNKDPVTRVcLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFII 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 137 DQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKE--QEFLQLTkdqLISILDSDDLNVDREEHVY 214
Cdd:PHA02790 110 YTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELEDDiiDNFDYLS---MKLILESDELNVPDEDYVV 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 215 ESIIRWFEHEQNeREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFD-A 293
Cdd:PHA02790 187 DFVIKWYMKRRN-RLGNLLLLIKNVIRSNYLSPRGINNVKWILDCTKIFHCDKQPRKSYKYPFIEYPMNMDQIIDIFHmC 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 294 AHKHSGK-------------KQTVPCLDIVTGRVFKLcKPPNDLREVGILVSPDNDIYIAGGY-RPSSSEVsidhkaend 359
Cdd:PHA02790 266 TSTHVGEvvyliggwmnneiHNNAIAVNYISNNWIPI-PPMNSPRLYASGVPANNKLYVVGGLpNPTSVER--------- 335

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 227497736 360 fWMydHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGG 397
Cdd:PHA02790 336 -WF--HGDAAWVNMPSLLKPRCNPAVASINNVIYVIGG 370

BTB_POZ_ZBTB17_MIZ1

cd18206

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-139

2.99e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349515 [Multi-domain] Cd Length: 112 Bit Score: 57.63 E-value: 2.99e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSgltestQKEVRIVGVE-AESMDLVLNY 107
Cdd:cd18206    3 PQHSQHVLEQLNQQRQLGLLCDCTFVVD-GVDFKAHKAVLAACSEYFRMLFVD------QKDVVHLDISnAAGLGQVLEF 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQC 139
Cdd:cd18206   76 MYTAKLSLSPENVDDVLAVATFLQMQDIVTAC 107

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-143

3.35e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 57.91 E-value: 3.35e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTD--IVVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGV-EAESMDLVLNY 107
Cdd:cd18329    4 HQSRLLQQLDEQRKQELFCDcsILVE---GQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18329   81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

33-152

3.38e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 57.94 E-value: 3.38e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  33 CSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSR 112
Cdd:cd18345    3 CRLSDDLGLLFERSAFSDVTLCVG-GREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 227497736 113 VILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNS 152
Cdd:cd18345   82 APNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVENV 121

BTB_POZ_ZBTB1

cd18192

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-137

3.46e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349501 [Multi-domain] Cd Length: 114 Bit Score: 57.52 E-value: 3.46e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYA 108
Cdd:cd18192    2 PSHSSYVLQQLNNQREWGFLCDCCIAIDD-IYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFM 80

                         90       100
                 ....*....|....*....|....*....
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQD 137
Cdd:cd18192   81 YLGKIMTAPSDFEQLKVAMNYLQLYYIPE 109

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

147-245

3.63e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 57.12 E-value: 3.63e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*....
gi 227497736 227 EREVHLPEIFAKcIRFPLM 245
Cdd:cd18460   81 HRQHFWPELLQH-VRLPFV 98

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

147-220

4.04e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 56.24 E-value: 4.04e-10

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRW 220
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRW 74

BTB_POZ_BAB-like

cd18315

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

58-132

4.23e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349624 [Multi-domain] Cd Length: 85 Bit Score: 56.40 E-value: 4.23e-10

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227497736  58 GKTFSCHRNVLAAISPYFRSMFTSgltESTQKEVRIV--GVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQI 132
Cdd:cd18315   10 GGSLKAHKLVLAAASPYFAALLKE---TPPDEHPVIIlpDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAELLQI 83

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

33-151

4.83e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 57.71 E-value: 4.83e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  33 CSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSR 112
Cdd:cd18343    6 CRLAEDLGNLWENSRFTDCSLFVG-GQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK 84

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 227497736 113 VILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18343   85 APNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123

BACK_KLHL38

cd18476

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...

147-243

5.46e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.

Pssm-ID: 350551 [Multi-domain] Cd Length: 99 Bit Score: 56.67 E-value: 5.46e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLnVDREEHVYESIIRWFEHEQN 226
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                         90
                 ....*....|....*..
gi 227497736 227 EREVHLPEIFAKcIRFP 243
Cdd:cd18476   80 ARKGYIHDLFKK-VRLQ 95

BTB_POZ_ZBTB19_PATZ1

cd18207

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-139

5.53e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349516 [Multi-domain] Cd Length: 128 Bit Score: 57.67 E-value: 5.53e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMY-DEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQ-KEVRIVGVEAESMDLVLNYA 108
Cdd:cd18207    9 HSADMLHNLNQQRkSGGRFCDVLLRVGE-ESFPAHRAVLAACSEYFESVFSAQEGDGGTpRELEMHTISSKVFGDILDFA 87

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQC 139
Cdd:cd18207   88 YTSRIVVRLESFPELMTAAKFLLMRSVIDIC 118

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-143

5.99e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 57.17 E-value: 5.99e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18331    7 HASDVLLNLNRLRSRDILTDVVIVVS-REQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYT 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18331   86 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

44-148

6.51e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 56.92 E-value: 6.51e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  44 DEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQK-----EVRIVGVEAESMDLVLNYAYTSRVILTEA 118
Cdd:cd18296   13 QELSFPDVCFQVE-GHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPE 91

                         90       100       110
                 ....*....|....*....|....*....|
gi 227497736 119 NVQALFTAASIFQIPSIQDQCAKYMISHLD 148
Cdd:cd18296   92 NAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BTB_POZ_ZBTB20_DPZF

cd18208

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-141

7.10e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349517 [Multi-domain] Cd Length: 117 Bit Score: 57.00 E-value: 7.10e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  34 SILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVrivgVEAESMDLVLNYAYTSRV 113
Cdd:cd18208   11 SVLETLNEQRNRGHFCDVTVRI-HGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYSGVL 85

                         90       100
                 ....*....|....*....|....*...
gi 227497736 114 ILTEANVQALFTAASIFQIPSIQDQCAK 141
Cdd:cd18208   86 RVSQSEALQILTAASILQIKTVIDECTR 113

BTB_POZ_BACH1

cd18277

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-143

1.39e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349586 [Multi-domain] Cd Length: 120 Bit Score: 56.23 E-value: 1.39e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFT----SGLTESTQKEVRIVGVEAesmdlVLN 106
Cdd:cd18277   10 HSTNVLLSLNDQRKKDVLCDVTILVE-GQRFRAHRSVLAACSSYFHSRIVgqadAELNITLPEEVTVKGFEP-----LIQ 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 227497736 107 YAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18277   84 FAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-141

1.66e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 55.74 E-value: 1.66e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHGkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVrivgVEAESMDLVLNYA 108
Cdd:cd18334    2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENA-LFRAHKNILAASSMYFKSLVLHDNLINLDTDM----VNPTVFRQILDFI 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 227497736 109 YTSRVILT----EANVQALFTAASIFQIPSIQDQCAK 141
Cdd:cd18334   77 YTGKLLTSdqpgEQNFNALLTAASYLQLHDLAALCRK 113

BTB_POZ_ZBTB22_BING1

cd18210

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-143

1.66e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349519 [Multi-domain] Cd Length: 112 Bit Score: 55.62 E-value: 1.66e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFR-SMFTSGLTESTQKEVrivgVEAESMDLVLNY 107
Cdd:cd18210    2 PEITSSLLESLNQQRMEGKLCDISIHV-QGRVFRAHRAVLAASSPYFHdQVLLKNMSSISLPGV----MDPGAFESVLAS 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18210   77 AYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB_POZ_BACH2

cd18278

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-143

2.40e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349587 [Multi-domain] Cd Length: 124 Bit Score: 55.72 E-value: 2.40e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTS----GLTESTQKEVrivgvEAESMDLVLN 106
Cdd:cd18278   14 HCTNILLCLNDQRKQDILCDVTLIVE-GKEFRAHRAVLAACSEYFLQALVGqtenDLVVSLPEEV-----TARGFGPLLQ 87

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 227497736 107 YAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18278   88 FAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

33-151

2.55e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 55.23 E-value: 2.55e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  33 CSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSR 112
Cdd:cd18279    3 CRLAEDLGNLWENSRFTDCCLCVG-GQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 227497736 113 VILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18279   82 APNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB_POZ_ZBTB29-like

cd18216

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-141

2.75e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349525 [Multi-domain] Cd Length: 118 Bit Score: 55.23 E-value: 2.75e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHGkTFSCHRNVLAAISPYFRSM-FTSGLTESTQkevriVGVEAESMDLVLNY 107
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVENS-LFRAHKNVLAASSGYFKSLvLHDNLIHLDQ-----DMVSPTVFQQILDF 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 227497736 108 AYTSRVI---LTEANVQALFTAASIFQIPSIQDQCAK 141
Cdd:cd18216   75 IYTGKLLdslFEEPNLSEVLAAANYLQLPDLAALCRS 111

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-141

3.57e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 54.91 E-value: 3.57e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHGkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVeaesMDLVLNYA 108
Cdd:cd18333    2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNA-LFRAHKNILAASSVYLKSLVVHDNLINLDHEMVSPGI----FRLILDYI 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 227497736 109 YTSRVI----LTEANVQALFTAASIFQIPSIQDQCAK 141
Cdd:cd18333   77 YTGRLSegdpGSEQNLGAVLAAASYLQIPDLVALCKK 113

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-144

4.06e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 55.04 E-value: 4.06e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSglteSTQKEVRIVG-VEAESMDLVLNY 107
Cdd:cd18290    8 PNFGNSILECLNEQRLQGLYCDVSVVV-KGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPAaVQPQSFQQILSF 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMI 144
Cdd:cd18290   83 CYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTEFFL 119

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

151-224

5.67e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 52.89 E-value: 5.67e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 227497736 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHE 224
Cdd:cd18474    5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

51-143

6.82e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 53.97 E-value: 6.82e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  51 IVVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGV-EAESMDLVLNYAYTSRVILTEANVQALFTAASI 129
Cdd:cd18199   23 IIVE---GRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVfSSDAFSIILDFVYSGKLSLTSQNVIEVMSAASY 99

                         90
                 ....*....|....
gi 227497736 130 FQIPSIQDQCAKYM 143
Cdd:cd18199  100 LQMTDVINVCKTFI 113

BTB_POZ_ZBTB45

cd18229

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-141

9.89e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349538 [Multi-domain] Cd Length: 112 Bit Score: 53.33 E-value: 9.89e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  34 SILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVrivgVEAESMDLVLNYAYTSRV 113
Cdd:cd18229    4 SLLETLNAQRLGGHFCDVTVRI-HDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPV----VPAQTVRQLVEFMYSGSL 78

                         90       100
                 ....*....|....*....|....*...
gi 227497736 114 ILTEANVQALFTAASIFQIPSIQDQCAK 141
Cdd:cd18229   79 VVAQSEALQILTAASILQIKTVIDECTQ 106

BTB_POZ_ETO1-like

cd18190

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

50-130

1.33e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349499 [Multi-domain] Cd Length: 83 Bit Score: 52.13 E-value: 1.33e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  50 DIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI--VGVEAESMDLVLNYAYTSRVILTEA-NVQALFTA 126
Cdd:cd18190    1 DLVFCVG-GEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFeeNGISIEAMRAVIDFSVTGRLDLFSVeNVHEVLEL 79


                 ....
gi 227497736 127 ASIF 130
Cdd:cd18190   80 ASKF 83

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

379-428

1.50e-08

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 50.69 E-value: 1.50e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 227497736  379 ARIGCKLVYCCGKMYAIGGRvyegDGRNSLKSVECYDSRENCWTTVCAMP 428
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF----DGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

50-151

1.53e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 52.49 E-value: 1.53e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  50 DIVVEVDhGKTFSCHRNVLAAISPYFRSmftsgltESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASI 129
Cdd:cd18275    6 DLVIEVS-GQRIRAHKSVLAAKSDYFRA-------RLSRDILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARF 77

                         90       100
                 ....*....|....*....|..
gi 227497736 130 FQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18275   78 LQMPCAAQCAVDAVRAQLCLGN 99

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

51-143

1.62e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 53.01 E-value: 1.62e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  51 IVVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVG-VEAESMDLVLNYAYTSRVILTEANVQALFTAASI 129
Cdd:cd18330   23 IIVE---GRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDiVTSEAFSIILDFLYSGKLDLCSENVIEVMSAASY 99

                         90
                 ....*....|....
gi 227497736 130 FQIPSIQDQCAKYM 143
Cdd:cd18330  100 LQMTDVVNFCKGYI 113

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

421-571

2.05e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 55.93 E-value: 2.05e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 421 WTTVCAMPVAMEFHNAVEYKEKIYVLQGEF-------FLFYEPQKDYWGFLTPM-TVPRIQGLAAVYKDSIYYIAGTCGN 492
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSggsasnsFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 493 HQRMF---TVEAYDIELNKWTRKKDFPcdqSINPYLKLVLFQNKLHLFvraTQVTVEEHVfrtsrkNSLYQYDDIADQWM 569
Cdd:COG3055   83 NPSSTplnDVYVYDPATNTWTKLAPMP---TPRGGATALLLDGKIYVV---GGWDDGGNV------AWVEVYDPATGTWT 150


                 ..
gi 227497736 570 KV 571
Cdd:COG3055  151 QL 152

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

147-223

2.57e-08

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 51.19 E-value: 2.57e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEH 223
Cdd:cd18503    1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

33-152

2.79e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 52.41 E-value: 2.79e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  33 CSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSR 112
Cdd:cd18342    7 CRLADELGGLWENSRFTDCCLCV-AGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGK 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 227497736 113 VILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNS 152
Cdd:cd18342   86 APNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 125

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-141

2.80e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 52.35 E-value: 2.80e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKeVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVK-FRAHRCVLAACSTYFKKLFKKLEVDSSSV-IEIDFLRSDIFEEVLNYMYT 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAK 141
Cdd:cd18204   79 AKISVKKEDVNLMMSSGQILGIRFLDKLCSQ 109

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-151

3.23e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 52.44 E-value: 3.23e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  34 SILKQLKTMYDEGQLTD---IVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTeSTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18281    8 TVKERFAFLFNNETLSDvhfIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18281   87 DEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

35-143

5.10e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 51.88 E-value: 5.10e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  35 ILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTES----TQKEVRIVGVEAESmdLVLNYAYT 110
Cdd:cd18201    8 LLQELNEQRKKGILCDVNIVVS-GKVFRAHKNILVAGSRFFKTLYCFTNKEScdqtTVTHLDVVAVQGFS--VILDFMYS 84

                         90       100       110
                 ....*....|....*....|....*....|...
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18201   85 GNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFI 117

BTB2_POZ_IBtk

cd18302

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

48-139

6.76e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349611 [Multi-domain] Cd Length: 113 Bit Score: 51.21 E-value: 6.76e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  48 LTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT--SRVILTEANVQAL-- 123
Cdd:cd18302    5 LYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTdeASAVKESQNVEFLcn 84

                         90
                 ....*....|....*..
gi 227497736 124 -FTAASIFQIPSIQDQC 139
Cdd:cd18302   85 vLVIADQLLITRLKEIC 101

BTB_POZ_ZBTB38_CIBZ

cd18223

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-137

7.98e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349532 [Multi-domain] Cd Length: 114 Bit Score: 50.94 E-value: 7.98e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTK-FKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYS 79

                         90       100
                 ....*....|....*....|....*...
gi 227497736 111 SRVILTEAN-VQALFTAASIFQIPSIQD 137
Cdd:cd18223   80 SKVVVKRQEtVTDLVAAGKKLGITFLEN 107

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

48-145

1.12e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 50.55 E-value: 1.12e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  48 LTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAA 127
Cdd:cd18352   13 LSDVTFLVE-GRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAA 91

                         90
                 ....*....|....*...
gi 227497736 128 SIFQIPSIQDQCaKYMIS 145
Cdd:cd18352   92 DQYLLEGLKRLC-EYTIA 108

Kelch

Kelch domain;

391-430

1.17e-07

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 48.32 E-value: 1.17e-07

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 227497736   391 KMYAIGGRvyegDGRNSLKSVECYDSRENCWTTVCAMPVA 430
Cdd:smart00612   1 KIYVVGGF----DGGQRLKSVEVYDPETNKWTPLPSMPTP 36

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-139

1.70e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 50.17 E-value: 1.70e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  36 LKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIV-GVEAESMDLVLNYAYTSRVI 114
Cdd:cd18293    3 FLQLHRQQNSGVFCDVLLQAE-GESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVLELqGLKAHTLLKLVDFLYTSELE 81

                         90       100
                 ....*....|....*....|....*
gi 227497736 115 LTEANVQALFTAASIFQIPSIQDQC 139
Cdd:cd18293   82 VSSEEAQDVLAAARRLQISELESLC 106

BTB_POZ_KLHL42

cd18319

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-131

1.79e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349628 [Multi-domain] Cd Length: 93 Bit Score: 49.10 E-value: 1.79e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  59 KTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEAN----------VQALFTAAS 128
Cdd:cd18319   11 RCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQGDstdtleenelLEDLVEAAS 90


                 ...
gi 227497736 129 IFQ 131
Cdd:cd18319   91 FLQ 93

BTB_POZ_ZBTB9

cd18200

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-143

1.84e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349509 [Multi-domain] Cd Length: 111 Bit Score: 49.85 E-value: 1.84e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFtsgLTESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHV-QGRVFRAHKAVLAASSPYFHDKL---LLNDTNCLVLPSVIEAAAFENLLQLIYS 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18200   77 GRLTLCMDALPSHLLVASGLQMWQVVDRCSELL 109

BTB1_POZ_KLHL33

cd18262

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

31-135

2.54e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349571 [Multi-domain] Cd Length: 101 Bit Score: 49.13 E-value: 2.54e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRS--MFTSGLTESTQKEVRIVGVEAesmdlVLNYA 108
Cdd:cd18262    1 HPSQFFGEAQRLREQRLLLDETVSV-GGRSYGVHSVILAAVSSLFRErlLGSNGPLPPLSLEVTPVGWEA-----VLTFA 74

                         90       100
                 ....*....|....*....|....*..
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSI 135
Cdd:cd18262   75 YTGVLGRNPATVGDILVAAEALGAPRV 101

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

64-147

3.55e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 48.93 E-value: 3.55e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  64 HRNVLAAISPYFRSMFTSGLTESTQkEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18282   26 HKYVLATGSSVFYAMFYGGLAENKN-EIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQFL 104


                 ....
gi 227497736 144 ISHL 147
Cdd:cd18282  105 ETSL 108

BTB_POZ_BTBD1

cd18346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

64-151

4.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349655 [Multi-domain] Cd Length: 133 Bit Score: 49.29 E-value: 4.29e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  64 HRNVLAAISPYFRSMFTSGLTeSTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18346   47 HRFVLAAGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 125


                 ....*...
gi 227497736 144 ISHLDPQN 151
Cdd:cd18346  126 TKHLRADN 133

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

37-143

4.35e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 48.36 E-value: 4.35e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  37 KQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFtsglteSTQKEVRIVG-VEAESMDLVLNYAYTSRVIL 115
Cdd:cd18299    1 EDLRNLLHSPSCADVVFILQGGVRIFAHRIVLAAASSVFADLF------LMMTVVTLDSdITPEAFRRVLEFLYTGVLDE 74

                         90       100
                 ....*....|....*....|....*...
gi 227497736 116 TEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18299   75 NEDDLKELKDAAELLELFDLVMMCTNVL 102

BACK_KLHL11

cd18451

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...

147-234

4.84e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 48.03 E-value: 4.84e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQN 226
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 227497736 227 EREVHLPE 234
Cdd:cd18451   81 ERERYFEE 88

BTB_POZ_ZBTB31_myoneurin

cd18217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-139

5.63e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349526 [Multi-domain] Cd Length: 111 Bit Score: 48.21 E-value: 5.63e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTEST---QKEVRIVGVEAesmdlVLNY 107
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQ-FKAHRNVLAAFSEYFGAQYKDTEDNIVfldQSQVSADGFQK-----LLEF 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQC 139
Cdd:cd18217   75 IYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-111

5.71e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 48.69 E-value: 5.71e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTS-GLTESTQKEVRIVGVEAESMDLVLNYAY 109
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVTLLIE-GEEYKAHKSVLAANSEYFRELFIEkGAVSSHEAVVDLSGFCKSSFLPLLEFAY 80


                 ..
gi 227497736 110 TS 111
Cdd:cd18202   81 TS 82

BTB_POZ_NPR_plant

cd18310

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

39-133

7.01e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349619 [Multi-domain] Cd Length: 145 Bit Score: 48.84 E-value: 7.01e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  39 LKTMYDEGQL--TDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVR----------IVGVEAesMDLVLN 106
Cdd:cd18310    7 LENLLDSPDLfySDAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKlelrelipggIVGYDA--FMLVLS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 227497736 107 YAYTSRVILTEA---------------------NVQALFtAASIFQIP 133
Cdd:cd18310   85 YLYSGRLRLVPKegsacvdsdcwhvacrpavdfALEVLY-AASVFQIP 131

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

315-415

8.03e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 50.92 E-value: 8.03e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 315 FKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVsidhkaendfWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYA 394
Cdd:COG3055  187 WTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEV----------EAYDPATNTWTALGELPTPRHGHAAVLTDGKVYV 256

                         90       100
                 ....*....|....*....|.
gi 227497736 395 IGGRVYEGDGRNSLKSVECYD 415
Cdd:COG3055  257 IGGETKPGVRTPLVTSAEVYD 277

BTB_POZ_ZBTB33_KAISO

cd18219

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-137

8.35e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349528 [Multi-domain] Cd Length: 106 Bit Score: 47.90 E-value: 8.35e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  28 DPFHACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGltestQKEVRIVGVEAESMDLVLNY 107
Cdd:cd18219    1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRK-FRAHKNILSASSTYFHQLFSVA-----GQVVELNFIRADIFAEILNY 74

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227497736 108 AYTSRVILTEAN-VQALFTAASIFQIPSIQD 137
Cdd:cd18219   75 IYSSKIVRVRSDlLEELIKSGQLLGVKFIAE 105

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

51-143

8.73e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 47.46 E-value: 8.73e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  51 IVVEvdhGKTFSCHRNVLAAISPYFRSMFT----SGLTESTQKEVRIVGVEAesmdlVLNYAYTSRVILTEANVQALFTA 126
Cdd:cd18955    6 IVVE---DQRFRAHRAVLAACSDYFLSRVVgqtdGDLVITLPEEVTVKGFEP-----LLQFAYTAKLLLSKENVLEVCRC 77

                         90
                 ....*....|....*..
gi 227497736 127 ASIFQIPSIQDQCAKYM 143
Cdd:cd18955   78 AEFLGVHNIEKACFDFL 94

BTB1_POZ_ABTB1_BPOZ1

cd18295

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

39-113

9.66e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349604 [Multi-domain] Cd Length: 119 Bit Score: 48.01 E-value: 9.66e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  39 LKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFtsgltESTQKEVRIVGVEAESMDL-----VLNYAYTSRV 113
Cdd:cd18295   10 LRRLLEQGSYSDVTFNV-HGESFPAHRCILSARSPYFAEMF-----ETKWKDKREINLKHPLVNPdafraLLQYLYTGRL 83

BTB_POZ_KLHL11

cd18241

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

46-151

1.01e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349550 [Multi-domain] Cd Length: 135 Bit Score: 48.31 E-value: 1.01e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  46 GQLTDIVVEV--DHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI------VGVEAESMDLVLNYAYTSRVILTE 117
Cdd:cd18241   21 GLFCDITLAFggAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMrkwssePGPDPDTVEAVIQYMYTGRIRVST 100

                         90       100       110
                 ....*....|....*....|....*....|....
gi 227497736 118 ANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18241  101 GNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134

BACK_BTBD17

cd18493

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...

158-221

1.80e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

Pssm-ID: 350568 Cd Length: 74 Bit Score: 45.65 E-value: 1.80e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 227497736 158 FADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWF 221
Cdd:cd18493   11 YAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

BACK_NS1BP_IVNS1ABP

cd18502

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...

147-221

2.18e-06

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Pssm-ID: 350577 Cd Length: 99 Bit Score: 46.46 E-value: 2.18e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 227497736 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISIL-DSDDLNVDREEHVYESIIRWF 221
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILeSNQELESINERKLCQLVLEWV 76

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-139

2.19e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 47.16 E-value: 2.19e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  34 SILKQLKTMYDEGQLTDIVVEVDH---GKTFSCHRNVLAAISPYFRSMF-TSGLTESTQKEVRIVGVEAESMDLVLNYAY 109
Cdd:cd18211   11 NLLNEMHKLRLLGHLCDVTVQVEHqgsKEEFSAHKAVLAASSKYFKEVFlNEKISDGKNTNVMLNEIYTADFASFLEFVY 90

                         90       100       110
                 ....*....|....*....|....*....|
gi 227497736 110 TSRVILTEANVQALFTAASIFQIPSIQDQC 139
Cdd:cd18211   91 TAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120

BTB_POZ_Rank-5

cd18303

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-153

2.59e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349612 [Multi-domain] Cd Length: 120 Bit Score: 46.55 E-value: 2.59e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  34 SILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAispyfRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRV 113
Cdd:cd18303    4 RLLKTVASLFDKELYSDITIKLA-DKSIPAHKFVLAA-----RSEKWSNENLASTNELDLSDISYEVVLALLRWLYTDEL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 227497736 114 ILTEANVQA--LFTAASIFQIPSIQDQCAKYMISHLDPQNSI 153
Cdd:cd18303   78 DLTLDDEFLleLMKAAKRFQLTDLVERCERALMSSVNVDNCI 119

BTB_POZ_ZBTB3

cd18323

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-141

4.74e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349632 [Multi-domain] Cd Length: 128 Bit Score: 46.36 E-value: 4.74e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVdhGKT-FSCHRNVLAAISPYFRsMFTSglTESTQKEVRIVG---VEAESMDLV 104
Cdd:cd18323    4 PDHSRHLLQSLREQRHQGFLCDCTVLV--GSTqFLAHRAVLASCSPFFH-MFYK--EQLDKRDLVCINneiVTAPAFSLL 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 227497736 105 LNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAK 141
Cdd:cd18323   79 LEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKK 115

BTB_POZ_ZBTB24_ZNF450

cd18212

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-135

7.65e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349521 [Multi-domain] Cd Length: 118 Bit Score: 45.17 E-value: 7.65e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDI--VVEVDHgktFSCHRNVLAAISPYFRSMFTSGlTESTQKEVRIVGVEAESMDLVLNYA 108
Cdd:cd18212    6 HKDTVLTNFEEQRKKDFLCDItlIVENVQ---FRAHKALLAASSEYFSMMFADE-GEVGQSIYMLEGMVAETFGALLEFI 81

                         90       100
                 ....*....|....*....|....*..
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSI 135
Cdd:cd18212   82 YTGCLQVGEKSLEQILATAQFLKVNDL 108

BTB_POZ_ZBTB16_PLZF

cd18205

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-143

9.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349514 [Multi-domain] Cd Length: 107 Bit Score: 45.02 E-value: 9.21e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFtsgltESTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVD-SQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYT 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18205   75 ATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107

BACK_KLHL31_KBTBD1

cd18470

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...

150-242

1.06e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Pssm-ID: 350545 Cd Length: 98 Bit Score: 44.48 E-value: 1.06e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 150 QNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQnERE 229
Cdd:cd18470    4 ENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQ-KRV 82

                         90
                 ....*....|...
gi 227497736 230 VHLPEIFAKcIRF 242
Cdd:cd18470   83 KYAADLLSN-IRF 94

BTB1_POZ_IBtk

cd18301

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

36-117

1.24e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349610 [Multi-domain] Cd Length: 99 Bit Score: 44.20 E-value: 1.24e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  36 LKQLKTMYDEGQLT-DIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQK----EVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18301    5 FKKLLDEADEGDNIhDVVFQVG-GKTFPAHKFILASRSDYFRKLFLSSLLTSEDAvgcdVVHIEKVPPEIFEQLLQFIYT 83


                 ....*..
gi 227497736 111 SRVILTE 117
Cdd:cd18301   84 DTCDLLT 90

BTB2_POZ_RHOBTB3

cd18360

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

39-147

1.28e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349669 [Multi-domain] Cd Length: 110 Bit Score: 44.45 E-value: 1.28e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  39 LKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSrVILTEA 118
Cdd:cd18360    1 LGLFFNSPLLADVVFKI-QGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTD-SCCPAS 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227497736 119 NVQA--LFTAASIFQIPSIQDQCAKYMISHL 147
Cdd:cd18360   79 ILQAmaLLICAEMYQVSRLQHICELYIITQL 109

BTB_POZ_BTBD14A_NAC2

cd18289

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

46-150

1.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349598 [Multi-domain] Cd Length: 131 Bit Score: 44.64 E-value: 1.64e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  46 GQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSglteSTQKEVRIVG-VEAESMDLVLNYAYTSRVILTEANVQALF 124
Cdd:cd18289   27 GLYCDVSIVVK-GQAFKAHRAVLAASSLYFRDLFSG----NSKSAFELPAtVPPACFQQILSFCYTGKLTMAASEQLVVM 101

                         90       100       110
                 ....*....|....*....|....*....|
gi 227497736 125 TAASIFQIPSIQDQCAKYMIS----HLDPQ 150
Cdd:cd18289  102 YTAGFLQIQHIVERGTDLMFKvsspHCDSQ 131

BACK_KLHL26

cd18465

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...

174-245

1.72e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.

Pssm-ID: 350540 Cd Length: 97 Bit Score: 43.74 E-value: 1.72e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227497736 174 YIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIfakC-IRFPLM 245
Cdd:cd18465   28 FTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPSRRASASHVL---ChIRFPLM 97

BTB_POZ_BTBD6

cd18349

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

42-147

2.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349658 [Multi-domain] Cd Length: 109 Bit Score: 43.82 E-value: 2.17e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  42 MYDEGQLTD---IVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTEsTQKEVRIVGVEAESMDLVLNYAYTSRVILTEA 118
Cdd:cd18349    2 MFNNELMADvhfIVGPPGASQRVPAHKYVLAVGSSVFYAMFYGDLAE-VKSEIHIPDVEPAAFLILLKYMYSDEIDLEAD 80

                         90       100
                 ....*....|....*....|....*....
gi 227497736 119 NVQALFTAASIFQIPSIQDQCAKYMISHL 147
Cdd:cd18349   81 TVLATLYAAKKYIVPALAKACVNFLETSL 109

Kelch

Kelch domain;

337-388

3.06e-05

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 41.39 E-value: 3.06e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 227497736   337 IYIAGGYRPSSSEvsidhkaeNDFWMYDHSTNRWLSKPSLLRARIGCKLVYC 388
Cdd:smart00612   2 IYVVGGFDGGQRL--------KSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45

BTB_POZ_BTBD3

cd18348

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

64-152

3.49e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349657 [Multi-domain] Cd Length: 131 Bit Score: 43.85 E-value: 3.49e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  64 HRNVLAAISPYFRSMFTSGLTEStQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYM 143
Cdd:cd18348   40 HKYVLAVGSSVFHAMFYGELAED-KDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFL 118


                 ....*....
gi 227497736 144 ISHLDPQNS 152
Cdd:cd18348  119 ETSLSAKNA 127

BTB_POZ_ZBTB42

cd18956

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-139

3.66e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349737 [Multi-domain] Cd Length: 129 Bit Score: 43.65 E-value: 3.66e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRsMFTSGLTESTQKEVRIVG--VEAESMDLVLN 106
Cdd:cd18956    4 PEHGGRLLGRLRQQRELGFLCDCTVLVGDAR-FPAHRAVLAACSVYFH-LFYRDRPAGGRDTVRLNGdiVTAPAFGRLLD 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 227497736 107 YAYTSRVILTEANVQALFTAASIFQIPSIQDQC 139
Cdd:cd18956   82 FMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114

BTB_POZ_KBTBD13

cd18320

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

51-127

4.50e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349629 [Multi-domain] Cd Length: 83 Bit Score: 42.03 E-value: 4.50e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 227497736  51 IVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILT-EANVQALFTAA 127
Cdd:cd18320    4 VKVWVE-EQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGFRIMLRVLAGERPILNgEEILQAIECAA 80

BACK_BTBD9

cd14822

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...

115-245

4.57e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

Pssm-ID: 350518 [Multi-domain] Cd Length: 101 Bit Score: 42.60 E-value: 4.57e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 115 LTEANVQALFTAASIFQIPSIQDQCAKYMishldpqnsigvfifadhyghqelgDRSKEYirkkflcVTKEQEFLQLTKD 194
Cdd:cd14822    1 LNIRNVCLIYDVASLYSLDDLCQTCCQFM-------------------------DRNAQE-------VLSSEGFLTLSKS 48

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 227497736 195 QLISILDSDDLNVDrEEHVYESIIRWFEHEQNEREVHlPEIFaKCIRFPLM 245
Cdd:cd14822   49 ALKELLSRDSFCAP-EVDIFNAVRRWCEHNPDSKEDA-KEIL-EAVRLPLM 96

BTB2_POZ_RHOBTB1

cd18358

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

38-147

4.75e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349667 [Multi-domain] Cd Length: 126 Bit Score: 43.41 E-value: 4.75e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  38 QLKTMYDEGQLTDIVVEVDHGkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILT- 116
Cdd:cd18358   10 RIKECLSKGTFSDVTFKLDDG-TINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTa 88

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227497736 117 EANVQALFTAASIFQIPSIQDQCAKYMISHL 147
Cdd:cd18358   89 DLDPLELIALANRFCLPHLVALTEQHAVQEL 119

BACK_KLHL9_13

cd18449

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...

150-243

4.75e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Pssm-ID: 350524 [Multi-domain] Cd Length: 95 Bit Score: 42.41 E-value: 4.75e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 150 QNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNERE 229
Cdd:cd18449    4 ENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDDRMQ 83

                         90
                 ....*....|....*...
gi 227497736 230 vhlpeiFA----KCIRFP 243
Cdd:cd18449   84 ------FAaklmENIRFP 95

BTB_POZ_BT

cd18313

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

49-147

5.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349622 [Multi-domain] Cd Length: 102 Bit Score: 42.46 E-value: 5.64e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  49 TDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEAN--VQALFTA 126
Cdd:cd18313    2 ADVEIETDNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEMEkfGIHLLVL 81

                         90       100
                 ....*....|....*....|.
gi 227497736 127 ASIFQIPSIQDQCAKYMISHL 147
Cdd:cd18313   82 SHVYVVPQLKRVCEKGLEQGL 102

BTB_POZ_ZBTB12

cd18203

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-149

5.93e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349512 [Multi-domain] Cd Length: 122 Bit Score: 42.94 E-value: 5.93e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTsgLTESTQKEVRIVGVEAESMDLVLNyA 108
Cdd:cd18203    6 PGHEAATLRNMNQLRSEERFCDVTI-VADSLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSLMHSSRVVADLLLS-C 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDP 149
Cdd:cd18203   82 YTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

BACK_BTBD7

cd18489

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...

174-229

6.51e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.

Pssm-ID: 350564 Cd Length: 98 Bit Score: 42.29 E-value: 6.51e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736 174 YIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVdREEHVYESIIRWFEHE----QNERE 229
Cdd:cd18489   29 FLREEFSQIAQSPVLFELTKEYLIEALQSDFLQA-SELDILKAVLKWGEHQlikrMEERE 87

BTB_POZ_ARMC5

cd18191

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

50-112

9.31e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349500 [Multi-domain] Cd Length: 100 Bit Score: 41.72 E-value: 9.31e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227497736  50 DIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSR 112
Cdd:cd18191    3 DLRFLLDGGTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHYLHGCR 65

BTB_POZ_BTBD2

cd18347

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-151

1.22e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349656 [Multi-domain] Cd Length: 127 Bit Score: 41.98 E-value: 1.22e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  34 SILKQLKTMYDEGQLTDIVVEVDHG---KTFSCHRNVLAAISPYFRSMFTSGLTeSTQKEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18347    8 TVQERFAFLFNNEVLSDVHFLVGKGlgsQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 227497736 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Cdd:cd18347   87 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127

BTB_POZ_BTBD11

cd18351

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

47-139

1.42e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349660 [Multi-domain] Cd Length: 131 Bit Score: 41.89 E-value: 1.42e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  47 QLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTeSTQKEVRIVGVEAESMDLVLNYAY---TSRVILTEANVQAL 123
Cdd:cd18351   23 EMSDVTFLVE-GRPFYAHKVLLFTASPRFKALLSNKPS-AENTCIEISYVKYHIFQLVMQYLYcggTESLLIKNNEIMEL 100

                         90
                 ....*....|....*.
gi 227497736 124 FTAASIFQIPSIQDQC 139
Cdd:cd18351  101 LSAAKFFQLEALQRHC 116

BTB_POZ_TDPOZ

cd18344

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-152

1.45e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349653 [Multi-domain] Cd Length: 128 Bit Score: 41.87 E-value: 1.45e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  28 DPFHacSILKQLKTMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNY 107
Cdd:cd18344    5 DPRH--MLTDDLGELWENSLFTDCCLLV-AGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGF 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 227497736 108 AYTSRVILTEANVQA--LFTAASIFQIPSIQDQCAKYMISHLDPQNS 152
Cdd:cd18344   82 IYTGKAPHLHSHSMAcdVLAAADKYGLEGLKVLCEDALCRNLSVENA 128

BTB_POZ_ZBTB3-like

cd18194

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-141

2.83e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349503 [Multi-domain] Cd Length: 128 Bit Score: 40.96 E-value: 2.83e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRsMFTSGlTESTQKEVRIVG--VEAESMDLVLN 106
Cdd:cd18194    4 PEHSRQLLQCLREQRSQGFLCDCTVLVGSAQ-FPAHRAVLASCSMYFH-LFYRD-RLDKRDLVRLNSdiVTAPAFGLLLD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 227497736 107 YAYTSRVILTEANVQALFTAASIFQIPSIQDQCAK 141
Cdd:cd18194   81 FMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKG 115

BTB_POZ_ZBTB26_Bioref

cd18214

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-149

3.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349523 [Multi-domain] Cd Length: 122 Bit Score: 40.96 E-value: 3.11e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFScHRNVLAAISPYFRSMFTsgLTEStqKEVRIVGVE-AESMDLVLNYAY 109
Cdd:cd18214    8 YGDSMLQKMNKLREQNKFCDVTVHIDDLEVPG-HKVVFAAGSPFLRDQFL--LNDS--REVQISILQnSEVGRQLLLSCY 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 227497736 110 TSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDP 149
Cdd:cd18214   83 TGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

331-376

3.37e-04

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 38.36 E-value: 3.37e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 227497736  331 VSPDNDIYIAGGYRPSSSEvsidhkaeNDFWMYDHSTNRWLSKPSL 376
Cdd:pfam01344   8 VVVGGKIYVIGGFDGNQSL--------NSVEVYDPETNTWSKLPSM 45

BTB2_POZ_RHOBTB2

cd18359

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

38-112

3.40e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349668 [Multi-domain] Cd Length: 124 Bit Score: 40.76 E-value: 3.40e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 227497736  38 QLKTMYDEGQLTDIVVEVDHGkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSR 112
Cdd:cd18359   10 RVKECLAKGTFSDVTFMLDDG-TISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQ 83

BTB_POZ_CP190-like

cd18311

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

35-132

3.79e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349620 [Multi-domain] Cd Length: 110 Bit Score: 40.26 E-value: 3.79e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  35 ILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMftSGLTESTQKEVRIVG-VEAESMDLVLNYAYTSRV 113
Cdd:cd18311    1 FLQRLQNLFNKTEYCDLTLQFRDNEQLKVHRLVLSACTDYFNVL--EQTCEIVDDTLIMPNeLQADAVVPVINFMYTGQL 78

                         90
                 ....*....|....*....
gi 227497736 114 ILTEANVQALFTAASIFQI 132
Cdd:cd18311   79 EFEEKSYGKLLRTAKELNM 97

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-127

3.87e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 40.59 E-value: 3.87e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  31 HACSILKQLKTMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVrIVGVEAESMDLVLNYAYT 110
Cdd:cd18224    9 HPNNLLKELNKCRLSETMCDVTIVVG-NRSFAAHKAVLACAAGYFQKLFLSTELDVARTYV-VDFITPANFEKVLSFIYT 86

                         90
                 ....*....|....*..
gi 227497736 111 SRVILTEANVQALFTAA 127
Cdd:cd18224   87 SELFTDLINVGVIYEVA 103

Kelch_3

pfam13415

Galactose oxidase, central domain;

334-387

4.39e-04

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 38.43 E-value: 4.39e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 227497736  334 DNDIYIAGGYRPSSSevsidhKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVY 387
Cdd:pfam13415   1 GDKLYIFGGLGFDGQ------TRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48

BTB_POZ_ZBTB18_2-like

cd18325

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-139

4.47e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349634 [Multi-domain] Cd Length: 128 Bit Score: 40.40 E-value: 4.47e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYA 108
Cdd:cd18325    4 PDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQ-FRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFM 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQC 139
Cdd:cd18325   83 YEGKLEFSSLPVEDVLAAASYLHMYDIVKVC 113

Kelch_6

pfam13964

Kelch motif;

330-380

4.58e-04

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 38.47 E-value: 4.58e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 227497736  330 LVSPDNDIYIAGGYrpsssevSIDHKAENDFWMYDHSTNRWLSKPSLLRAR 380
Cdd:pfam13964   7 VVSVGGYIYVFGGY-------TNASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_BTBD12_SLX4

cd18288

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

34-139

5.71e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349597 [Multi-domain] Cd Length: 116 Bit Score: 39.75 E-value: 5.71e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  34 SILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTS---GLTESTQKEVRIV---GVEAESMDLVLNY 107
Cdd:cd18288    4 KLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSegfSVEEEGGVTTRRVllgDVSGEAARCFLQY 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQC 139
Cdd:cd18288   84 LYTADTGLPPGLSPHVSELADRFGVSELVHLC 115

BTB_POZ_NPY3-like

cd18312

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

44-127

8.03e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349621 [Multi-domain] Cd Length: 105 Bit Score: 39.24 E-value: 8.03e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  44 DEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSgLTESTQKEVRIVGVE--AESMDLVLNYAYTSRVILTEANVQ 121
Cdd:cd18312    5 DTGEPSDITVRVG-NTTFHLHKFPLCSKSGYFKRLASS-SSESDPSEIELNDFPggAEAFELVAKFCYGMPINLTATNVV 82


                 ....*.
gi 227497736 122 ALFTAA 127
Cdd:cd18312   83 GLRCAA 88

BACK_BTBD19

cd18494

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...

162-211

9.42e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.

Pssm-ID: 350569 Cd Length: 73 Bit Score: 38.06 E-value: 9.42e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 227497736 162 YGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREE 211
Cdd:cd18494   15 YGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELD 64

BTB_POZ_ABTB2_BPOZ2

cd18350

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

47-139

2.04e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349659 [Multi-domain] Cd Length: 134 Bit Score: 38.68 E-value: 2.04e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  47 QLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQ--KEVRIVGVEAESMDLVLNYAY---TSRVILTEANVQ 121
Cdd:cd18350   23 EMSDVTFLVE-GKLFYAHKVLLVTASNRFKSLLTNKSEQESQgsKTIEISDIKYHIFQMLMQYLYyggTESMEIPIADVL 101

                         90
                 ....*....|....*...
gi 227497736 122 ALFTAASIFQIPSIQDQC 139
Cdd:cd18350  102 ELLSAASLFQLDALQRHC 119

BTB_POZ_ZBTB18_RP58

cd18324

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-141

2.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349633 [Multi-domain] Cd Length: 147 Bit Score: 38.87 E-value: 2.18e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYA 108
Cdd:cd18324    4 PDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQ-FRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFM 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 227497736 109 YTSRVILTEANVQALFTAASIFQIPSIQDQCAK 141
Cdd:cd18324   83 YEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKK 115

BTB_POZ_ZBTB40

cd18225

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-145

2.39e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349534 [Multi-domain] Cd Length: 116 Bit Score: 38.27 E-value: 2.39e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  29 PFHACSILKQLKTMYDEGQLTDIVVEVdhGKT-FSCHRNVLAAISPYFRSMFTSGLTESTQKEVrivgVEAESMDLVLNY 107
Cdd:cd18225    4 PNYSRQLLQQLHTLRKEQQFCDCTIFI--GTFhFRAHKLVLAASSLLFKSLLDSTDTISIDASV----VSPEEFALLLEM 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 227497736 108 AYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMIS 145
Cdd:cd18225   78 VYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTS 115

BTB2_POZ_BTBD7

cd18284

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

60-125

2.81e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349593 Cd Length: 146 Bit Score: 38.48 E-value: 2.81e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  60 TFSCHRNVLAAISPYFRSMF----TSGLTESTQKEVRIVGVEAesmdlVLNYAYtSRVILteanvQALFT 125
Cdd:cd18284   29 ELRCHKAILSARSPFFRNLLqrriRTGEDRTLSTPTRIVLDES-----IIPRRY-ARVLL-----HAMYT 87

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

470-516

3.15e-03

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 35.67 E-value: 3.15e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 227497736  470 PRIQGLAAVYKDSIYYIAGTCGNhQRMFTVEAYDIELNKWTRKKDFP 516
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGN-QSLNSVEVYDPETNTWSKLPSMP 46

BACK_ABTB1_BPOZ

cd18497

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...

115-148

3.51e-03

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

Pssm-ID: 350572 Cd Length: 72 Bit Score: 36.37 E-value: 3.51e-03

                         10        20        30
                 ....*....|....*....|....*....|....
gi 227497736 115 LTEANVQALFTAASIFQIPSIQDQCAKYMISHLD 148
Cdd:cd18497    1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLE 34

BTB1_POZ_BTBD7

cd18283

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

49-110

3.97e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349592 [Multi-domain] Cd Length: 92 Bit Score: 36.93 E-value: 3.97e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 227497736  49 TDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQ--KEVRIVGVEAESMDLVLNYAYT 110
Cdd:cd18283    3 TDVDL-VFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEipVDLPTAGIDVPMFSALLRYLYT 65

BTB_POZ_ZBTB41

cd18226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-132

4.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349535 [Multi-domain] Cd Length: 114 Bit Score: 37.09 E-value: 4.74e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497736  39 LKTMYDEGQ----LTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTqkeVRIVGVEAESMDLVLNYAYTSRVI 114
Cdd:cd18226    9 LKYLNDDRQkqssFCDLVITVE-GKEFSAHKVVVAVGSSYFHACLSKNPNTDA---VTLDHVSYSVFQHLLEFLYTSEFF 84

                         90
                 ....*....|....*...
gi 227497736 115 LTEANVQALFTAASIFQI 132
Cdd:cd18226   85 VYENEIPLVLEAAKFLDI 102

Kelch