BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  14 CYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggataa 93
Cdd:cd18207   1 SYTYQVSQHSADMLHNLNQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGT-------------- 66

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14670364  94 pgggaggSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQ 162
Cdd:cd18207  67 -------PRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQSNVQ 128

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14670364 379 GEKPYSCPV--CGLRFKRKDRMSYHVR---------------SHDGSV--GKPYICQSCGKGFSRPDHLNGHIKQVH 436
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspeKMNIFSakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  14 CYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggataa 93
Cdd:cd18207   1 SYTYQVSQHSADMLHNLNQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGT-------------- 66

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14670364  94 pgggaggSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQ 162
Cdd:cd18207  67 -------PRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQSNVQ 128

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364     42 DVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGaadggpadvggataapgggaggSRELEMHTISSKVFGDILDFA 121
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD----------------------KSEIYLDDVSPEDFRALLNFL 58

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 14670364    122 YTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQS 159
Cdd:smart00225  59 YTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKL 96

FOG: Zn-finger [General function prediction only];

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 14670364 357 CEICGKIFRDVYHLNRHKLSHSGEKPYSCPVCGLRFKRKDRMS--YHVRSHDGS 408
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNN 89

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364 329 PRLGENGlPISEDPDGPRKRSRTRKQVACEI--CGKIFRDVYHLNRHKL---------------SHSG----EKPYSCPV 387
Cdd:COG5189 325 GKLAHGG-ERNIDTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspeKMNIfsakDKPYRCEV 403

                        90       100
                ....*....|....*....|
gi 14670364 388 CGLRFKRKDRMSYHVR-SHD 406
Cdd:COG5189 404 CDKRYKNLNGLKYHRKhSHD 423

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 14670364    383 YSCPVCGLRFKRKDRMSYHVRSH 405
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  14 CYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggataa 93
Cdd:cd18207   1 SYTYQVSQHSADMLHNLNQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGT-------------- 66

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14670364  94 pgggaggSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQ 162
Cdd:cd18207  67 -------PRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQSNVQ 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  40 FCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggGAGGSRELEMHTISSKVFGDILD 119
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGM----------------------KESSSSEIELDDVSPEAFEALLD 58

                        90       100
                ....*....|....*....|....
gi 14670364 120 FAYTSRIVVRLESFPELMTAAKFL 143
Cdd:cd18186  59 YIYTGELELSEENVEELLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  21 RHSTEMLHNLNQQRKnGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggataapgggagg 100
Cdd:cd18256   2 KHASLILAQLNKLRG-QHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSK--------------------- 59

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 14670364 101 sRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIK 157
Cdd:cd18256  60 -DVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLK 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggGAGGS 101
Cdd:cd18242   4 HAKSILNTMNSLRKSN-TLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEM----------------------SEKGK 60

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 14670364 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQE 154
Cdd:cd18242  61 SEVELQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCE 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364   3 RVNDASCGPSGCYTYQVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadg 82
Cdd:cd18267   4 RKSRASSGSMNIYLFHKSSYADSVLTHLNLLRQQR-LFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGL-------- 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14670364  83 gpadvggataapggGAGGSRELEMH-TISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQS 159
Cdd:cd18267  75 --------------KESQDSEVNFHdSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKN 138

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAqlgdggaadggpadvggataapGGGAGGS 101
Cdd:cd18198   8 HSSEILSGLNEQRTQG-LLCDVVILVQGREYRTHRSVLAACSQYFKKLFTS----------------------GAVVDQQ 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 14670364 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIK 157
Cdd:cd18198  65 NVYEIDFVSPEALTALLEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364     42 DVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGaadggpadvggataapgggaggSRELEMHTISSKVFGDILDFA 121
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD----------------------KSEIYLDDVSPEDFRALLNFL 58

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 14670364    122 YTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQS 159
Cdd:smart00225  59 YTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADggpadvggataapgggaggs 101
Cdd:cd18328   8 HSSEVLCSLNEQRHDG-LLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYV-------------------- 66

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 14670364 102 reLEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVI 156
Cdd:cd18328  67 --YEIDFVTPEALSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  21 RHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQlgdggaadggpadvggataapgggagG 100
Cdd:cd18332   1 RHSSDVLLNLNELRKRD-ILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGR--------------------------V 53

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14670364 101 SRELEMHTISSKV----FGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIK 157
Cdd:cd18332  54 GEGVSVLTLPSGLeargFQLLLDFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  15 YTYQVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGpadvggataap 94
Cdd:cd18278   7 YVYESTVHCTNILLCLNDQRKQD-ILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLP----------- 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 14670364  95 gggaggsrelemHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEIC 152
Cdd:cd18278  75 ------------EEVTARGFGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSC 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  18 QVSRHSTEMLHNLNQQRkNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggG 97
Cdd:cd18261   7 QSKSHKDAVLAALNQQR-NDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCM----------------------V 63

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14670364  98 AGGSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18261  64 ESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQ 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQlgdggaadggpadvggataapgGGAGGS 101
Cdd:cd18223   1 HSDTVLSCLNEQRIQG-ILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQ----------------------EIWISS 57

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 14670364 102 RELEMHTISSKVFGDILDFAYTSRIVV-RLESFPELMTAAKFL 143
Cdd:cd18223  58 HVLELPDLKAEVFAEILNFIYSSKVVVkRQETVTDLVAAGKKL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggGAGGS 101
Cdd:cd18254   5 HPDCVLTHLNTLRKQC-MFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGL----------------------RESLD 61

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 14670364 102 RELEMH-TISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQS 159
Cdd:cd18254  62 STVNFHdSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAqlgdggaadggpadvGGATAAPGGGAGGS 101
Cdd:cd18327   8 HSSELLSCLNEQRRAG-LLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTG---------------GGGGSGDLGAGGGQ 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 14670364 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIK 157
Cdd:cd18327  72 DVCELDFVGPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  15 YTYQVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDggaadggpadvggataap 94
Cdd:cd18277   3 FAYESSVHSTNVLLSLNDQRKKD-VLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADA------------------ 63

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14670364  95 gggaggsrELEM---HTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEIC 152
Cdd:cd18277  64 --------ELNItlpEEVTVKGFEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggGAGGS 101
Cdd:cd18235   4 HTQKAFDVMNELRKQN-LLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDL----------------------SESRA 60

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 14670364 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQE 154
Cdd:cd18235  61 NRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCD 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  17 YQVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapgg 96
Cdd:cd18249   1 YTSDKHPRQTLEAINLLRKHR-ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGEL---------------------- 57

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14670364  97 gaGGSRELE--MHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18249  58 --AESRQTEvtIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKR 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSaqlgdggaadggpadvggataapGGGAGGS 101
Cdd:cd18204   1 HKTVFLKTLNEQRLEG-EFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFK-----------------------KLEVDSS 56

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 14670364 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQE 154
Cdd:cd18204  57 SVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQ 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  20 SRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggGAG 99
Cdd:cd18237   2 AKLLADFMGVMNNMRKQK-TLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNM----------------------TES 58

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 14670364 100 GSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18237  59 KSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  17 YQVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapgg 96
Cdd:cd18266   3 YRWADHSNLVLQGLNEQRQRG-LFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGM---------------------- 59

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14670364  97 GAGGSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18266  60 REAHQKEVELVGASYIGLKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLEN 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  17 YQVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapgg 96
Cdd:cd18259  10 FCLPSHPQSILDGLQTLRSNP-KLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDF---------------------- 66

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14670364  97 GAGGSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18259  67 VESISARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQ 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  20 SRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAqlgdggaadggpadvggataapgggag 99
Cdd:cd18219   2 TQYSGSLLKSLNEQRGHG-LFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSV--------------------------- 53

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 14670364 100 GSRELEMHTISSKVFGDILDFAYTSRIV-VRLESFPELMTAAKFL 143
Cdd:cd18219  54 AGQVVELNFIRADIFAEILNYIYSSKIVrVRSDLLEELIKSGQLL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670364  41 CDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGpadvggataapgggaggsrelemHTISSKVFGDILDF 120
Cdd:cd18955   2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDLVITLP-----------------------EEVTVKGFEPLLQF 58

                        90       100       110
                ....*....|....*....|....*....|..
gi 14670364 121 AYTSRIVVRLESFPELMTAAKFLLMRSVIEIC 152
Cdd:cd18955  59 AYTAKLLLSKENVLEVCRCAEFLGVHNIEKAC 90