BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  14 CYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggataa 93
Cdd:cd18207   1 SYTYQVSQHSADMLHNLNQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGT-------------- 66

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14670362  94 pgggaggSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQ 162
Cdd:cd18207  67 -------PRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQSNVQ 128

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 14670362   369 HLNRHKLSHSGEKPYSCPVCGLRFKR 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

C2H2-type zinc finger;

                          10        20
                  ....*....|....*....|....*.
gi 14670362   442 HKCQTCNASFATRDRLRSHLACHEDK 467
Cdd:pfam13912   2 HECSECGKSFPSYQALGGHKKSHRKE 27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  14 CYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggataa 93
Cdd:cd18207   1 SYTYQVSQHSADMLHNLNQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGT-------------- 66

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14670362  94 pgggaggSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQ 162
Cdd:cd18207  67 -------PRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQSNVQ 128

Putative zinc-finger between two C2H2 zinc-fingers on Patz; zf-C2H2_assoc3 is a partially unstructured region on Patz or POZ-, AT hook-, and zinc finger-containing proteins of higher eukaryotes. It lies between the two C2H2-type zinc-fingers towards the C-terminus of these proteins and may well be an unusual zinc-finger itself.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670362   492 GPSNFCSICN---REGQ----KCSHQDPIESSDSYGDLSDASDLKTPEKQSANGSFSCDMAVP-KNKMESDGEKK 558
Cdd:pfam16637   1 GGAAFHCVRTcgvKDGQentgKCPHLESEESSDSFGELSNGSDLKSPEKQDGNGAFACDLVSPeGSKAKTEPEKK 75

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 14670362   369 HLNRHKLSHSGEKPYSCPVCGLRFKR 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14670362 379 GEKPYSCPV--CGLRFKRKDRMSYHVR---------------SHDGSV--GKPYICQSCGKGFSRPDHLNGHIKQVH 436
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspeKMNIFSakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|.
gi 14670362   357 CEICGKIFRDVYHLNRHKLSH 377
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  14 CYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggataa 93
Cdd:cd18207   1 SYTYQVSQHSADMLHNLNQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGT-------------- 66

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14670362  94 pgggaggSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQ 162
Cdd:cd18207  67 -------PRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQSNVQ 128

Putative zinc-finger between two C2H2 zinc-fingers on Patz; zf-C2H2_assoc3 is a partially unstructured region on Patz or POZ-, AT hook-, and zinc finger-containing proteins of higher eukaryotes. It lies between the two C2H2-type zinc-fingers towards the C-terminus of these proteins and may well be an unusual zinc-finger itself.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14670362   492 GPSNFCSICN---REGQ----KCSHQDPIESSDSYGDLSDASDLKTPEKQSANGSFSCDMAVP-KNKMESDGEKK 558
Cdd:pfam16637   1 GGAAFHCVRTcgvKDGQentgKCPHLESEESSDSFGELSNGSDLKSPEKQDGNGAFACDLVSPeGSKAKTEPEKK 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGPADVGgataapgggaggs 101
Cdd:cd18228   2 HSQELLGKLNSLRNEG-HFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSPAGKCV------------- 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 14670362 102 reLEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQS 159
Cdd:cd18228  68 --LDLHHVTVTGFAPLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSS 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggataapgggaggs 101
Cdd:cd18255   1 HSVTLLQGLNALRAKG-QLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQ---------------------- 57

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 14670362 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18255  58 DEIELKGVSAKGLKHILDFAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKS 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggataapgggaggs 101
Cdd:cd18306   1 HPESVLAKLNALRKNR-QFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESI---------------------- 57

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14670362 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEIC-QEVIKQSNVQ 162
Cdd:cd18306  58 LTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACgDFLLEKLTPQ 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggGAGGS 101
Cdd:cd18257   1 HSEQLLQGLNLLRQHH-ELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNL----------------------SEKEN 57

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 14670362 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEIC 152
Cdd:cd18257  58 SEVEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVLKEC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAqlgdggaadggpadvggataapGGGAGGS 101
Cdd:cd18198   8 HSSEILSGLNEQRTQG-LLCDVVILVQGREYRTHRSVLAACSQYFKKLFTS----------------------GAVVDQQ 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 14670362 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIK 157
Cdd:cd18198  65 NVYEIDFVSPEALTALLEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  21 RHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQlgdggaadggpadvggataapggGAGG 100
Cdd:cd18202   1 KHGQTVLDQLNQQRLNN-QFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEK-----------------------GAVS 56

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362 101 SRE--LEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18202  57 SHEavVDLSGFCKSSFLPLLEFAYTSELTFDFCSMAEVAMLARHLFMNEVLEICESVHKQ 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  21 RHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQlgdggaadggpadvggataapgggagG 100
Cdd:cd18332   1 RHSSDVLLNLNELRKRD-ILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGR--------------------------V 53

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14670362 101 SRELEMHTISSKV----FGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIK 157
Cdd:cd18332  54 GEGVSVLTLPSGLeargFQLLLDFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  18 QVSRHSTEMLHNLNQQRkNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggG 97
Cdd:cd18261   7 QSKSHKDAVLAALNQQR-NDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCM----------------------V 63

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14670362  98 AGGSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18261  64 ESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQ 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  30 LNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggataapgggaggsRELEMHTI 109
Cdd:cd18240   8 FNELRLEG-KLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEK----------------------KVYKIPGV 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 14670362 110 SSKVFGDILDFAYTSRIVVRLESFPELMTAA-KFLLMRSVIEICQEVIKQ 158
Cdd:cd18240  65 SPEMMELIIEYAYTRTVPITAENVEELLPAAdQFNIMGIVKACCDFLEDQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggPADVGGATAAPGGGAGGS 101
Cdd:cd18195   1 HAGALLLQLNEQRLRG-LFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPL---------PLGAAAVAAAPGATQSPE 70

                        90       100
                ....*....|....*....|....*..
gi 14670362 102 RELEMHTISSKVFGDILDFAYTSRIVV 128
Cdd:cd18195  71 RVLELPGVKAGVFSDVLNFIYSSRVAL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQlgdggaadggpadvggataapgGGAGGS 101
Cdd:cd18223   1 HSDTVLSCLNEQRIQG-ILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQ----------------------EIWISS 57

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 14670362 102 RELEMHTISSKVFGDILDFAYTSRIVV-RLESFPELMTAAKFL 143
Cdd:cd18223  58 HVLELPDLKAEVFAEILNFIYSSKVVVkRQETVTDLVAAGKKL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggGAGGS 101
Cdd:cd18250   4 HALHLLRGLSELRAER-KFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGEL----------------------RESRA 60

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 14670362 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18250  61 DRVVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQ 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  15 YTYQVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDggaadggpadvggataap 94
Cdd:cd18277   3 FAYESSVHSTNVLLSLNDQRKKD-VLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADA------------------ 63

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14670362  95 gggaggsrELEM---HTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEIC 152
Cdd:cd18277  64 --------ELNItlpEEVTVKGFEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggGAGGS 101
Cdd:cd18235   4 HTQKAFDVMNELRKQN-LLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDL----------------------SESRA 60

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 14670362 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQE 154
Cdd:cd18235  61 NRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCD 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  26 MLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGpadvggataapgggaggsreLE 105
Cdd:cd18245   1 LLRALNSFREEP-HLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYK--------------------IE 59

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 14670362 106 MHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIK 157
Cdd:cd18245  60 LEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  18 QVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQlgdggaadggpadvggataapggg 97
Cdd:cd18222   4 EIPDFSNSVLSHLNQLRMQG-RLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLN------------------------ 58

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14670362  98 aggsrelEMHTIS------SKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQI 163
Cdd:cd18222  59 -------EMSTVSisviknPTVFEQLLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILEGIHFKI 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  20 SRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggGAG 99
Cdd:cd18237   2 AKLLADFMGVMNNMRKQK-TLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNM----------------------TES 58

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 14670362 100 GSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18237  59 KSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  21 RHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGPADvggataapgggagg 100
Cdd:cd18215   1 RHASDVLLNLNRLRSRD-ILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPE-------------- 65

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 14670362 101 srelemhtISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVI 156
Cdd:cd18215  66 --------IEPEGFRILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapgggagGS 101
Cdd:cd18194   6 HSRQLLQCLREQRSQG-FLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRL-------------------------DK 59

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 14670362 102 RE---LEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQ 153
Cdd:cd18194  60 RDlvrLNSDIVTAPAFGLLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  20 SRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAqlgdggaadggpadvggataapgggag 99
Cdd:cd18219   2 TQYSGSLLKSLNEQRGHG-LFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSV--------------------------- 53

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 14670362 100 GSRELEMHTISSKVFGDILDFAYTSRIV-VRLESFPELMTAAKFL 143
Cdd:cd18219  54 AGQVVELNFIRADIFAEILNYIYSSKIVrVRSDLLEELIKSGQLL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14670362  18 QVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggataapggg 97
Cdd:cd18331   3 QFTRHASDVLLNLNRLRSRD-ILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQL----------------------- 58

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14670362  98 aggSRELEMHTISSKV----FGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVI 156
Cdd:cd18331  59 ---KCNLSVINLDPEInpegFNILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118