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Conserved domains on  [gi|14042939|ref|NP_114413|]
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leucine-rich melanocyte differentiation-associated protein isoform 2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 705725)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_9 super family cl25994
Leucine-rich repeat;
16-131 4.83e-13

Leucine-rich repeat;


The actual alignment was detected with superfamily member pfam14580:

Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 64.40  E-value: 4.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939    16 RSLEGLSAFRSLEELILDNNQL---GDDLVlPGLPRLHTLTLNKNRITDLENLlDHLAEVtPALEYLSLLGNVacpnelV 92
Cdd:pfam14580  55 RKLDGFPLLRRLKTLLLNNNRIcriGEGLG-EALPNLTELILTNNNLQELGDL-DPLASL-KKLTFLSLLRNP------V 125

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 14042939    93 SLEKDeedykrYRCFVLYKLPNLKFLDAQKVTRQEREEA 131
Cdd:pfam14580 126 TNKPH------YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
16-131 4.83e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 64.40  E-value: 4.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939    16 RSLEGLSAFRSLEELILDNNQL---GDDLVlPGLPRLHTLTLNKNRITDLENLlDHLAEVtPALEYLSLLGNVacpnelV 92
Cdd:pfam14580  55 RKLDGFPLLRRLKTLLLNNNRIcriGEGLG-EALPNLTELILTNNNLQELGDL-DPLASL-KKLTFLSLLRNP------V 125

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 14042939    93 SLEKDeedykrYRCFVLYKLPNLKFLDAQKVTRQEREEA 131
Cdd:pfam14580 126 TNKPH------YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 16-129 7.52e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 7.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939  16 RSLEGLSafRSLEELILDNNQLGDDLVLPGLPRLHTLTLNKNRITDLENLLDHLAEVtPALEYLSLLGNVACPNelvsle 95
Cdd:cd21340 113 RSLAALS--NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSW-PSLRELDLTGNPVCKK------ 183

                        90       100       110
                ....*....|....*....|....*....|....
gi 14042939  96 kdeedyKRYRCFVLYKLPNLKFLDAQKVTRQERE 129
Cdd:cd21340 184 ------PKYRDKIILASKSLEVLDGKEITDTERQ 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-119 3.33e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 3.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939   3 KYLSLSGNHSSnkrSL-EGLSAFRSLEELILDNNQLGD-DLVLPGLPRLHTLTLNKNRITDLENLLDHLaevtPALEYLS 80
Cdd:COG4886 116 ESLDLSGNQLT---DLpEELANLTNLKELDLSNNQLTDlPEPLGNLTNLKSLDLSNNQLTDLPEELGNL----TNLKELD 188

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 14042939  81 LLGnvacpNELVSLEKdeedykryrcfVLYKLPNLKFLD 119
Cdd:COG4886 189 LSN-----NQITDLPE-----------PLGNLTNLEELD 211
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
16-131 4.83e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 64.40  E-value: 4.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939    16 RSLEGLSAFRSLEELILDNNQL---GDDLVlPGLPRLHTLTLNKNRITDLENLlDHLAEVtPALEYLSLLGNVacpnelV 92
Cdd:pfam14580  55 RKLDGFPLLRRLKTLLLNNNRIcriGEGLG-EALPNLTELILTNNNLQELGDL-DPLASL-KKLTFLSLLRNP------V 125

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 14042939    93 SLEKDeedykrYRCFVLYKLPNLKFLDAQKVTRQEREEA 131
Cdd:pfam14580 126 TNKPH------YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 16-129 7.52e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 7.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939  16 RSLEGLSafRSLEELILDNNQLGDDLVLPGLPRLHTLTLNKNRITDLENLLDHLAEVtPALEYLSLLGNVACPNelvsle 95
Cdd:cd21340 113 RSLAALS--NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSW-PSLRELDLTGNPVCKK------ 183

                        90       100       110
                ....*....|....*....|....*....|....
gi 14042939  96 kdeedyKRYRCFVLYKLPNLKFLDAQKVTRQERE 129
Cdd:cd21340 184 ------PKYRDKIILASKSLEVLDGKEITDTERQ 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-119 3.33e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 3.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939   3 KYLSLSGNHSSnkrSL-EGLSAFRSLEELILDNNQLGD-DLVLPGLPRLHTLTLNKNRITDLENLLDHLaevtPALEYLS 80
Cdd:COG4886 116 ESLDLSGNQLT---DLpEELANLTNLKELDLSNNQLTDlPEPLGNLTNLKSLDLSNNQLTDLPEELGNL----TNLKELD 188

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 14042939  81 LLGnvacpNELVSLEKdeedykryrcfVLYKLPNLKFLD 119
Cdd:COG4886 189 LSN-----NQITDLPE-----------PLGNLTNLEELD 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-119 1.08e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 1.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939   3 KYLSLSGNH-SSNKRSLEGLSafrSLEELILDNNQLGD-DLVLPGLPRLHTLTLNKNRITDLENLLDHLaevtPALEYLS 80
Cdd:COG4886 162 KSLDLSNNQlTDLPEELGNLT---NLKELDLSNNQITDlPEPLGNLTNLEELDLSGNQLTDLPEPLANL----TNLETLD 234

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 14042939  81 LLGnvacpNELVSLEKdeedykryrcfvLYKLPNLKFLD 119
Cdd:COG4886 235 LSN-----NQLTDLPE------------LGNLTNLEELD 256
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
6-119 7.28e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 7.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939   6 SLSGNHSSNKRSLEGLSAFRSLEELILDNNQLGD-DLVLPGLPRLHTLTLNKNRITDLENLLDHLaevtPALEYLSLLGn 84
Cdd:COG4886  94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlPEELANLTNLKELDLSNNQLTDLPEPLGNL----TNLKSLDLSN- 168

                        90       100       110
                ....*....|....*....|....*....|....*
gi 14042939  85 vacpNELVSLEKDeedykryrcfvLYKLPNLKFLD 119
Cdd:COG4886 169 ----NQLTDLPEE-----------LGNLTNLKELD 188
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-119 2.76e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 2.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939   3 KYLSLSGNHSSnkrSL-EGLSAFRSLEELILDNNQLGDDLVLPGLPRLHTLTLNKNRITDLENLLDhlaevTPALEYLSL 81
Cdd:COG4886 208 EELDLSGNQLT---DLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN-----LTNLKTLDL 279

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 14042939  82 LGNVACPNELVSLEKDEEDYKRYRCFVLYKLPNLKFLD 119
Cdd:COG4886 280 SNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 26-65 5.18e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 5.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 14042939    26 SLEELILDNNQLGDDLVLPGLPRLHTLTL-NKNRITDLENL 65
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDL 42
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 10-84 7.97e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 7.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939  10 NHSSNKRSLEGLSAF-------RSLEELILDNNQLGDD------LVLPGLPRLHTLTLNKNRITD--LENLLDHLAEVTp 74
Cdd:COG5238 186 YLGCNQIGDEGIEELaealtqnTTVTTLWLKRNPIGDEgaeilaEALKGNKSLTTLDLSNNQIGDegVIALAEALKNNT- 264

                        90
                ....*....|
gi 14042939  75 ALEYLSLLGN 84
Cdd:COG5238 265 TVETLYLSGN 274
LRR_8 pfam13855
Leucine rich repeat;
25-84 8.14e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 8.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14042939    25 RSLEELILDNNQLG--DDLVLPGLPRLHTLTLNKNRITDLE-NLLDHLaevtPALEYLSLLGN 84
Cdd:pfam13855   1 PNLRSLDLSNNRLTslDDGAFKGLSNLKVLDLSNNLLTTLSpGAFSGL----PSLRYLDLSGN 59
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-84 1.52e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 1.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939   5 LSLSGNHSSNK--RSL-EGLSAFRSLEELILDNNQLGDDLVL---PGLPR---LHTLTLNKNRITD--LENLLDHLAEvT 73
Cdd:COG5238 269 LYLSGNQIGAEgaIALaKALQGNTTLTSLDLSVNRIGDEGAIalaEGLQGnktLHTLNLAYNGIGAqgAIALAKALQE-N 347

                        90
                ....*....|.
gi 14042939  74 PALEYLSLLGN 84
Cdd:COG5238 348 TTLHSLDLSDN 358
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 16-71 1.56e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 1.56e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 14042939  16 RSLEGLSAFRSLEELILDNNQLGDDLVLPGLPRLHTLTLNKNRITDLENL--LDHLAE 71
Cdd:cd21340  37 TKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLenLTNLEE 94
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-84 5.98e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 36.69  E-value: 5.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14042939   5 LSLSGNHSSNkrslEGLSAF-------RSLEELILDNNQLGDDLV------LPGLPRLHTLTLNKNRITD--LENLLDHL 69
Cdd:COG5238 241 LDLSNNQIGD----EGVIALaealknnTTVETLYLSGNQIGAEGAialakaLQGNTTLTSLDLSVNRIGDegAIALAEGL 316

                        90
                ....*....|....*
gi 14042939  70 aEVTPALEYLSLLGN 84
Cdd:COG5238 317 -QGNKTLHTLNLAYN 330
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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