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Conserved domains on  [gi|16118240|ref|NP_114167|]
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keratin-associated protein 9-2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 37-173 8.77e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.89  E-value: 8.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16118240    37 CCQPACCVSSCCQP-CCRPTCCQNTCCRTTCCQPTCvTSCCQPSCCSTPCCQPTCCGSSCCGQTSCGSSCGQSSSCAPVY 115
Cdd:pfam01500  24 CCQPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRW 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16118240   116 CRRTCYYPTTVCLPGCLNQSCGSNCCQ------PCCRPACCETTCCrttcfQPTCVSSCCQPSC 173
Cdd:pfam01500 103 CRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQCSEPTC 161
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 37-173 8.77e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.89  E-value: 8.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16118240    37 CCQPACCVSSCCQP-CCRPTCCQNTCCRTTCCQPTCvTSCCQPSCCSTPCCQPTCCGSSCCGQTSCGSSCGQSSSCAPVY 115
Cdd:pfam01500  24 CCQPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRW 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16118240   116 CRRTCYYPTTVCLPGCLNQSCGSNCCQ------PCCRPACCETTCCrttcfQPTCVSSCCQPSC 173
Cdd:pfam01500 103 CRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQCSEPTC 161
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
47-96 4.16e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 39.92  E-value: 4.16e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 16118240  47 CCQPCCrptCCQNTCCRTTCCQPTCVTSCCQPSCCstpCCQPTCCGSSCC 96
Cdd:COG3901 634 CCCGCC---CCCCKCCCIVIIIDGIIIINECCCCC---CLCCRRCQDDPL 677
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 37-173 8.77e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.89  E-value: 8.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16118240    37 CCQPACCVSSCCQP-CCRPTCCQNTCCRTTCCQPTCvTSCCQPSCCSTPCCQPTCCGSSCCGQTSCGSSCGQSSSCAPVY 115
Cdd:pfam01500  24 CCQPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRW 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16118240   116 CRRTCYYPTTVCLPGCLNQSCGSNCCQ------PCCRPACCETTCCrttcfQPTCVSSCCQPSC 173
Cdd:pfam01500 103 CRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQCSEPTC 161
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
51-96 2.21e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 50.84  E-value: 2.21e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 16118240    51 CCRPTCCQNTCCRTTCCQPtcvtSCCQPSCCSTPCCQPTCCGSSCC 96
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQP----SCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
37-79 4.20e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 50.07  E-value: 4.20e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 16118240    37 CCQPACCVSSCCQP-CCRPTCCQNTCCRTTCCQPTC-VTSCCQPS 79
Cdd:pfam13885   1 CCQPSCCQPSCCQPsCCQPSCCQPSCCQPSCCRPSCcRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
32-75 1.68e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 1.68e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 16118240    32 CSSTPCCQPACCVSSCCQP-CCRPTCCQNTCCRTTCCQPTCVTSC 75
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPsCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
47-89 2.60e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 47.76  E-value: 2.60e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 16118240    47 CCQP-CCRPTCCQNTCCRTTCCQPT-CVTSCCQPSCCSTPCCQPT 89
Cdd:pfam13885   1 CCQPsCCQPSCCQPSCCQPSCCQPScCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 31-145 2.93e-08

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 50.56  E-value: 2.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16118240    31 TCSSTPCCQPACCVSSCCQPCCRPtCCQNTCCRTTCCQPtcvtSCCQPSCCSTPCCQPTCCGSSCCGQTSCGSSCGQSSS 110
Cdd:pfam01500  38 SCCQTSCCQPTTFQSSCCRPTCQP-CCQTSCCQPTCCQT----SSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGT 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 16118240   111 CAPVYCRRTCYYPT-----TVCLPGCLNQSCGSNCCQPCC 145
Cdd:pfam01500 113 CLPPCCVVSCTPPTccqlhHAQASCCRPSYCGQSCCRPAC 152
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
30-70 2.48e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 45.07  E-value: 2.48e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 16118240    30 TTCSSTPCCQPACCVSSCCQP-CCRPTCCQNTCCRTTCCQPT 70
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPsCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-96 1.17e-06

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 45.94  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16118240     2 THCCSPCCQPTCCRTTCCRTTCwKPTTVTTCSSTPCCQPACCVSSCCQP----------------CCRPTCCQNTCCRTT 65
Cdd:pfam01500  38 SCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQTGCGGIgygqegssgavssrtrWCRPDCRVEGTCLPP 116

                          90       100       110
                  ....*....|....*....|....*....|..
gi 16118240    66 CCQPTCV-TSCCQPSCCSTPCCQPTCCGSSCC 96
Cdd:pfam01500 117 CCVVSCTpPTCCQLHHAQASCCRPSYCGQSCC 148
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
47-96 4.16e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 39.92  E-value: 4.16e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 16118240  47 CCQPCCrptCCQNTCCRTTCCQPTCVTSCCQPSCCstpCCQPTCCGSSCC 96
Cdd:COG3901 634 CCCGCC---CCCCKCCCIVIIIDGIIIINECCCCC---CLCCRRCQDDPL 677
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
80-124 6.72e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.82  E-value: 6.72e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 16118240    80 CCSTPCCQPTCCGSSCCGQTSCGSSCGQSSSCAPVYCRRTCYYPT 124
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
37-91 2.47e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 37.61  E-value: 2.47e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 16118240  37 CCQPACCVSSCCQPCCRPTCCQNTCCRTT---CCQPTCvtsCCQPSCCSTPCCQPTCC 91
Cdd:COG3901 628 RRRRRECCCGCCCCCCKCCCIVIIIDGIIiinECCCCC---CLCCRRCQDDPLCPPRI 682
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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