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Conserved domains on  [gi|13786164|ref|NP_112624|]
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cadherin-1 precursor [Rattus norvegicus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10555552)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 32-120 9.54e-40

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 462590  Cd Length: 90  Bit Score: 141.69  E-value: 9.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164    32 CRPGFSSEVYTFLVPERhLERGHILGRVKFEGCTGRPRTAFFSEDSRFKVSTDGVITVKRHLKLHKLETSFLVHAWDSSY 111
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRR-LEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHG 80

                          90
                  ....*....|
gi 13786164   112 RK-LSTKVTL 120
Cdd:pfam08758  81 EKmASVKVTV 90
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 2.26e-36

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


:

Pssm-ID: 206635  Cd Length: 98  Bit Score: 132.47  E-value: 2.26e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 162 IPPINCPENQKGefPQRLVQIKSNRDKETTVFYSITGPGADKPPvGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSS 241
Cdd:cd00031   1 IPDGSAVEGRSR--GSFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 13786164 242 NGEAVEDPMEIVVTVTDQNDN 262
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 270-375 2.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 2.07e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 270 VFEGSVAEGALPGTSVMQVSATDADDDINtynAAIAYTILSQDPElphkNMFTVNRDTGVISVvTSGLDRESYPTYTLVV 349
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                        90       100
                ....*....|....*....|....*.
gi 13786164 350 QAADLQGEGLSTTAKAVITVKDINDN 375
Cdd:cd11304  73 TATDGGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 822-881 1.22e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.30  E-value: 1.22e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   822 ADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 881
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 496-595 4.41e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 4.41e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 496 RVEVPEDFGVGLEIASYTAREPDTFMEQKITYRIWRDTA-NWLEINPETGVISTRAEMDREdsehvKNSTYTALIIATDD 574
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 13786164 575 GSPIATGTGTLLLVLSDVNDN 595
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 383-462 1.04e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 1.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 383 TYQGQVLEN-EVGARIATLKVTDDDAPntPAWNAVYTVV-NDPDHQFTVitDPKTneGILKTAKGLDFEAKQQYILHVTV 460
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVsGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74


                ..
gi 13786164 461 EN 462
Cdd:cd11304  75 TD 76
Cadherin pfam00028
Cadherin domain;
608-690 9.25e-10

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.15  E-value: 9.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   608 QRNPKPHVITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAEqesliLQPRKDL---EIGEYKINLKLSDN--QNKDQV 682
Cdd:pfam00028  10 PVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGD-----ISTTKPLdreSIGEYELTVEATDSggPPLSST 84


                  ....*...
gi 13786164   683 TTLEVHVC 690
Cdd:pfam00028  85 ATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 32-120 9.54e-40

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 141.69  E-value: 9.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164    32 CRPGFSSEVYTFLVPERhLERGHILGRVKFEGCTGRPRTAFFSEDSRFKVSTDGVITVKRHLKLHKLETSFLVHAWDSSY 111
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRR-LEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHG 80

                          90
                  ....*....|
gi 13786164   112 RK-LSTKVTL 120
Cdd:pfam08758  81 EKmASVKVTV 90
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 2.26e-36

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 132.47  E-value: 2.26e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 162 IPPINCPENQKGefPQRLVQIKSNRDKETTVFYSITGPGADKPPvGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSS 241
Cdd:cd00031   1 IPDGSAVEGRSR--GSFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 13786164 242 NGEAVEDPMEIVVTVTDQNDN 262
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 32-118 7.04e-36

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 130.48  E-value: 7.04e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164     32 CRPGFSSEVYTFLVPeRHLERGHILGRVKFEGCTGRPRTAFFSEDSRFKVSTDGVITVKRHLKLHKLETSFLVHAWDSSY 111
Cdd:smart01055   1 CKPGFSEEKYTFHVP-SHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQG 79


                   ....*...
gi 13786164    112 -RKLSTKV 118
Cdd:smart01055  80 qEKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 270-375 2.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 2.07e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 270 VFEGSVAEGALPGTSVMQVSATDADDDINtynAAIAYTILSQDPElphkNMFTVNRDTGVISVvTSGLDRESYPTYTLVV 349
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                        90       100
                ....*....|....*....|....*.
gi 13786164 350 QAADLQGEGLSTTAKAVITVKDINDN 375
Cdd:cd11304  73 TATDGGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 822-881 1.22e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.30  E-value: 1.22e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   822 ADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 881
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
271-369 1.74e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 1.74e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   271 FEGSVAEGALPGTSVMQVSATDADDdinTYNAAIAYTILSQDPElphkNMFTVNRDTGVISVVTSgLDRESYPTYTLVVQ 350
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90
                  ....*....|....*....
gi 13786164   351 AADLQGEGLSTTAKAVITV 369
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 289-377 9.11e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 9.11e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164    289 SATDADDDINtynAAIAYTILSQDPelphKNMFTVNRDTGVIsVVTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVIT 368
Cdd:smart00112   1 SATDADSGEN---GKVTYSILSGND----DGLFSIDPETGEI-TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 13786164    369 VKDINDNAP 377
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 496-595 4.41e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 4.41e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 496 RVEVPEDFGVGLEIASYTAREPDTFMEQKITYRIWRDTA-NWLEINPETGVISTRAEMDREdsehvKNSTYTALIIATDD 574
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 13786164 575 GSPIATGTGTLLLVLSDVNDN 595
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 513-597 1.30e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 1.30e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164    513 TAREPDTFMEQKITYRIWRDTA-NWLEINPETGVISTRAEMDREdsehvKNSTYTALIIATDDGSPIATGTGTLLLVLSD 591
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 13786164    592 VNDNAP 597
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
163-257 4.41e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 4.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   163 PPINCPENQK-GEFPQRLVQIKSNRDKETTVFYSITGPGADkppvGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSS 241
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 13786164   242 NGEAVEDPMEIVVTVT 257
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 191-264 4.13e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 4.13e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13786164    191 TVFYSITGPGADkppvGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSSNGEAVEDPMEIVVTVTDQNDNRP 264
Cdd:smart00112  12 KVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
497-585 1.83e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 1.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   497 VEVPEDFGVGLEIASYTAREPDTFMEQKITYRIWRD-TANWLEINPETGVISTRAEMDREdsehvKNSTYTALIIATDDG 575
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSG 77

                          90
                  ....*....|
gi 13786164   576 SPIATGTGTL 585
Cdd:pfam00028  78 GPPLSSTATV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 383-462 1.04e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 1.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 383 TYQGQVLEN-EVGARIATLKVTDDDAPntPAWNAVYTVV-NDPDHQFTVitDPKTneGILKTAKGLDFEAKQQYILHVTV 460
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVsGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74


                ..
gi 13786164 461 EN 462
Cdd:cd11304  75 TD 76
Cadherin pfam00028
Cadherin domain;
384-463 1.60e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   384 YQGQVLENE-VGARIATLKVTDDDAPntPAWNAVYTVVND-PDHQFTVitDPKTneGILKTAKGLDFEAKQQYILHVTVE 461
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGgPGGNFRI--DPDT--GDISTTKPLDRESIGEYELTVEAT 74


                  ..
gi 13786164   462 NE 463
Cdd:pfam00028  75 DS 76
Cadherin pfam00028
Cadherin domain;
608-690 9.25e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.15  E-value: 9.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   608 QRNPKPHVITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAEqesliLQPRKDL---EIGEYKINLKLSDN--QNKDQV 682
Cdd:pfam00028  10 PVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGD-----ISTTKPLdreSIGEYELTVEATDSggPPLSST 84


                  ....*...
gi 13786164   683 TTLEVHVC 690
Cdd:pfam00028  85 ATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 32-120 9.54e-40

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 141.69  E-value: 9.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164    32 CRPGFSSEVYTFLVPERhLERGHILGRVKFEGCTGRPRTAFFSEDSRFKVSTDGVITVKRHLKLHKLETSFLVHAWDSSY 111
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRR-LEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHG 80

                          90
                  ....*....|
gi 13786164   112 RK-LSTKVTL 120
Cdd:pfam08758  81 EKmASVKVTV 90
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 2.26e-36

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 132.47  E-value: 2.26e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 162 IPPINCPENQKGefPQRLVQIKSNRDKETTVFYSITGPGADKPPvGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSS 241
Cdd:cd00031   1 IPDGSAVEGRSR--GSFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 13786164 242 NGEAVEDPMEIVVTVTDQNDN 262
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 32-118 7.04e-36

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 130.48  E-value: 7.04e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164     32 CRPGFSSEVYTFLVPeRHLERGHILGRVKFEGCTGRPRTAFFSEDSRFKVSTDGVITVKRHLKLHKLETSFLVHAWDSSY 111
Cdd:smart01055   1 CKPGFSEEKYTFHVP-SHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQG 79


                   ....*...
gi 13786164    112 -RKLSTKV 118
Cdd:smart01055  80 qEKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 270-375 2.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 2.07e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 270 VFEGSVAEGALPGTSVMQVSATDADDDINtynAAIAYTILSQDPElphkNMFTVNRDTGVISVvTSGLDRESYPTYTLVV 349
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                        90       100
                ....*....|....*....|....*.
gi 13786164 350 QAADLQGEGLSTTAKAVITVKDINDN 375
Cdd:cd11304  73 TATDGGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 822-881 1.22e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.30  E-value: 1.22e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   822 ADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 881
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
271-369 1.74e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 1.74e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   271 FEGSVAEGALPGTSVMQVSATDADDdinTYNAAIAYTILSQDPElphkNMFTVNRDTGVISVVTSgLDRESYPTYTLVVQ 350
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90
                  ....*....|....*....
gi 13786164   351 AADLQGEGLSTTAKAVITV 369
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 289-377 9.11e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 9.11e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164    289 SATDADDDINtynAAIAYTILSQDPelphKNMFTVNRDTGVIsVVTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVIT 368
Cdd:smart00112   1 SATDADSGEN---GKVTYSILSGND----DGLFSIDPETGEI-TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 13786164    369 VKDINDNAP 377
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 496-595 4.41e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 4.41e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 496 RVEVPEDFGVGLEIASYTAREPDTFMEQKITYRIWRDTA-NWLEINPETGVISTRAEMDREdsehvKNSTYTALIIATDD 574
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 13786164 575 GSPIATGTGTLLLVLSDVNDN 595
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 513-597 1.30e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 1.30e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164    513 TAREPDTFMEQKITYRIWRDTA-NWLEINPETGVISTRAEMDREdsehvKNSTYTALIIATDDGSPIATGTGTLLLVLSD 591
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 13786164    592 VNDNAP 597
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
163-257 4.41e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 4.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   163 PPINCPENQK-GEFPQRLVQIKSNRDKETTVFYSITGPGADkppvGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSS 241
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 13786164   242 NGEAVEDPMEIVVTVT 257
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 168-262 1.87e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 1.87e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 168 PENQKGefPQRLVQIK-SNRDKET--TVFYSITGPGADkppvGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSSNGE 244
Cdd:cd11304   7 PENAPP--GTVVLTVSaTDPDSGEngEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 13786164 245 AVEDPMEIVVTVTDQNDN 262
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 191-264 4.13e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 4.13e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13786164    191 TVFYSITGPGADkppvGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSSNGEAVEDPMEIVVTVTDQNDNRP 264
Cdd:smart00112  12 KVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
497-585 1.83e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 1.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   497 VEVPEDFGVGLEIASYTAREPDTFMEQKITYRIWRD-TANWLEINPETGVISTRAEMDREdsehvKNSTYTALIIATDDG 575
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSG 77

                          90
                  ....*....|
gi 13786164   576 SPIATGTGTL 585
Cdd:pfam00028  78 GPPLSSTATV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 383-462 1.04e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 1.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164 383 TYQGQVLEN-EVGARIATLKVTDDDAPntPAWNAVYTVV-NDPDHQFTVitDPKTneGILKTAKGLDFEAKQQYILHVTV 460
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVsGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74


                ..
gi 13786164 461 EN 462
Cdd:cd11304  75 TD 76
Cadherin pfam00028
Cadherin domain;
384-463 1.60e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   384 YQGQVLENE-VGARIATLKVTDDDAPntPAWNAVYTVVND-PDHQFTVitDPKTneGILKTAKGLDFEAKQQYILHVTVE 461
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGgPGGNFRI--DPDT--GDISTTKPLDRESIGEYELTVEAT 74


                  ..
gi 13786164   462 NE 463
Cdd:pfam00028  75 DS 76
Cadherin pfam00028
Cadherin domain;
608-690 9.25e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.15  E-value: 9.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13786164   608 QRNPKPHVITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAEqesliLQPRKDL---EIGEYKINLKLSDN--QNKDQV 682
Cdd:pfam00028  10 PVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGD-----ISTTKPLdreSIGEYELTVEATDSggPPLSST 84


                  ....*...
gi 13786164   683 TTLEVHVC 690
Cdd:pfam00028  85 ATVTITVL 92
Cadherin_3 pfam16184
Cadherin-like;
367-425 8.98e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 36.81  E-value: 8.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13786164   367 ITVKDINDNAP-IFNPSTYqgQVLENEVgARIAT--LKVTDDDapnTPAWNAVYTVVNDPDH 425
Cdd:pfam16184   9 ITIIPVNDEAPvLTTNTGL--RLWEGSS-RPITPdlLQAEDPD---TPPEDLTYTVVQGPSH 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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