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Conserved domains on  [gi|327532773|ref|NP_112238|]
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keratin-associated protein 4-6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-134 4.42e-13

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 64.43  E-value: 4.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327532773    3 SSCCGSVCSDQGCGLETCCRPSCCQTTCCRTTCCRPSCC--------VSSCCRPQCCQSVCCQPTCCRPSCCPSCCQTTC 74
Cdd:pfam01500  17 GGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCrptcqpccQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAV 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 327532773   75 CRTTCCR-PSCCVSSCCRPQCCQSVCCQPTCCRPSCSISSCCRPSCCVSRCCRSQCCQSVC 134
Cdd:pfam01500  97 SSRTRWCrPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 84-205 2.88e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 37.08  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327532773   84 CCVSSCCRPQCCQSVCCQPTCCRPSCSISSCCRPSCCVSRCCRSQCCQSVCCQPTCCRPSCCISSccrpsccessccrpc 163
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC--------------- 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 327532773  164 ccRPCCCLRPVC---------------GRVSCHTTCYRPTCVISTCPRPLCCASSCC 205
Cdd:pfam01500  69 --QPTCCQTSSCqtgcggigygqegssGAVSSRTRWCRPDCRVEGTCLPPCCVVSCT 123
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-134 4.42e-13

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 64.43  E-value: 4.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327532773    3 SSCCGSVCSDQGCGLETCCRPSCCQTTCCRTTCCRPSCC--------VSSCCRPQCCQSVCCQPTCCRPSCCPSCCQTTC 74
Cdd:pfam01500  17 GGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCrptcqpccQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAV 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 327532773   75 CRTTCCR-PSCCVSSCCRPQCCQSVCCQPTCCRPSCSISSCCRPSCCVSRCCRSQCCQSVC 134
Cdd:pfam01500  97 SSRTRWCrPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 84-205 2.88e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 37.08  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327532773   84 CCVSSCCRPQCCQSVCCQPTCCRPSCSISSCCRPSCCVSRCCRSQCCQSVCCQPTCCRPSCCISSccrpsccessccrpc 163
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC--------------- 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 327532773  164 ccRPCCCLRPVC---------------GRVSCHTTCYRPTCVISTCPRPLCCASSCC 205
Cdd:pfam01500  69 --QPTCCQTSSCqtgcggigygqegssGAVSSRTRWCRPDCRVEGTCLPPCCVVSCT 123
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-134 4.42e-13

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 64.43  E-value: 4.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327532773    3 SSCCGSVCSDQGCGLETCCRPSCCQTTCCRTTCCRPSCC--------VSSCCRPQCCQSVCCQPTCCRPSCCPSCCQTTC 74
Cdd:pfam01500  17 GGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCrptcqpccQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAV 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 327532773   75 CRTTCCR-PSCCVSSCCRPQCCQSVCCQPTCCRPSCSISSCCRPSCCVSRCCRSQCCQSVC 134
Cdd:pfam01500  97 SSRTRWCrPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
89-133 5.18e-11

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 55.47  E-value: 5.18e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 327532773   89 CCRPQCCQSVCCQPTCCRPSCSISSCCRPSCCVSRCCRSQCCQSV 133
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 15-204 4.88e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 53.26  E-value: 4.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327532773   15 CGLETCCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCPSCCQTtccrttccrpsCCVSSCCRPQC 94
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQP-----------CCQTSCCQPTC 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327532773   95 CQSVCCQPTCCRPSCSISSCCRPSCCVSRCCRSQCCQSVCCQPTCCRPSCCISSCcrpsccessccrpcccrpccclrpv 174
Cdd:pfam01500  73 CQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTC------------------------- 127

                         170       180       190
                  ....*....|....*....|....*....|
gi 327532773  175 CGRVSCHTTCYRPTCVISTCPRPLCCASSC 204
Cdd:pfam01500 128 CQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
82-118 6.57e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 50.07  E-value: 6.57e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 327532773   82 PSCCVSSCCRPQCCQSVCCQPTCCRPSCSISSCCRPS 118
Cdd:pfam13885   9 PSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
82-120 7.36e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 49.69  E-value: 7.36e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 327532773   82 PSCCVSSCCRPQCCQSVCCQPTCCRPSCSISSCCRPSCC 120
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
40-108 3.38e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 45.45  E-value: 3.38e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 327532773   40 CCVSSCCRPQCCQSVCCQPtccrpsccpsccqttccrttccrpSCCVSSCCRPQCCQSVCCQPTCCRPS 108
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQP------------------------SCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
15-59 9.49e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.52  E-value: 9.49e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 327532773   15 CGLETCCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPT 59
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
38-98 5.37e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 36.59  E-value: 5.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 327532773   38 PSCCVSSCCRPQCCQSVCCQPTCCRpsccpsccqttccrttccrPSCCVSSCCRPQCCQSV 98
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQ-------------------PSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 84-205 2.88e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 37.08  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327532773   84 CCVSSCCRPQCCQSVCCQPTCCRPSCSISSCCRPSCCVSRCCRSQCCQSVCCQPTCCRPSCCISSccrpsccessccrpc 163
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC--------------- 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 327532773  164 ccRPCCCLRPVC---------------GRVSCHTTCYRPTCVISTCPRPLCCASSCC 205
Cdd:pfam01500  69 --QPTCCQTSSCqtgcggigygqegssGAVSSRTRWCRPDCRVEGTCLPPCCVVSCT 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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