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Conserved domains on  [gi|13562088|ref|NP_112153|]
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leucine-rich repeat-containing protein 3 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183727)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
69-125 1.06e-15

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.48  E-value: 1.06e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 13562088    69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAgGLRLLDLSYNRI 125
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
32-68 3.65e-07

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.39  E-value: 3.65e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 13562088     32 ACPQPCRCPDhagaVAVFCSLRGLQEVPEDIPANTVL 68
Cdd:smart00013   1 ACPAPCNCSG----TAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
69-125 1.06e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.48  E-value: 1.06e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 13562088    69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAgGLRLLDLSYNRI 125
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-147 3.23e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 3.23e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088  49 FCSLRGLQEVPEDIPANTVL--LKLDANKISHLPDgAFQHLHRLRELDLSHNAIEAIgSATFAGLAgGLRLLDLSYNRIQ 126
Cdd:COG4886 142 DLSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLT-NLEELDLSGNQLT 218

                        90       100
                ....*....|....*....|...
gi 13562088 127 RIPkDALGKLSA--KIRLSHNPL 147
Cdd:COG4886 219 DLP-EPLANLTNleTLDLSNNQL 240
LRRNT smart00013
Leucine rich repeat N-terminal domain;
32-68 3.65e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.39  E-value: 3.65e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 13562088     32 ACPQPCRCPDhagaVAVFCSLRGLQEVPEDIPANTVL 68
Cdd:smart00013   1 ACPAPCNCSG----TAVDCSGRGLTEVPLDLPPDTTL 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
40-147 1.09e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088   40 PDH--AGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDG---AFQHLH---------------RLRELDLSHNA 99
Cdd:PRK15370 299 PAHlpSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASlppELQVLDvsknqitvlpetlppTITTLDVSRNA 378

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 13562088  100 IEAIGSatfaGLAGGLRLLDLSYNRIQRIPKD-----ALGKLSAKIRLSHNPL 147
Cdd:PRK15370 379 LTNLPE----NLPAALQIMQASRNNLVRLPESlphfrGEGPQPTRIIVEYNPF 427
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-162 5.16e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 5.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088  69 LKLDANKISHLpDGaFQHLHRLRELDLSHNAIE-----AIGSATFAGLAGGLRLLDLSYNRIQRIpkDALGKLSA--KIR 141
Cdd:cd21340  73 LYLGGNRISVV-EG-LENLTNLEELHIENQRLPpgeklTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNleQLD 148

                        90       100
                ....*....|....*....|....*..
gi 13562088 142 LSHNPLHCECALQEA------LWELKL 162
Cdd:cd21340 149 ASNNQISDLEELLDLlsswpsLRELDL 175
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 32-63 3.21e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 3.21e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 13562088    32 ACPQPCRCPDhagaVAVFCSLRGLQEVPEDIP 63
Cdd:pfam01462   1 ACPVPCHCSA----TVVNCSDRGLTAVPRDLP 28
LRR smart00370
Leucine-rich repeats, outliers;
87-110 5.99e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 5.99e-03
                           10        20
                   ....*....|....*....|....
gi 13562088     87 LHRLRELDLSHNAIEAIGSATFAG 110
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
69-125 1.06e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.48  E-value: 1.06e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 13562088    69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAgGLRLLDLSYNRI 125
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-147 3.23e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 3.23e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088  49 FCSLRGLQEVPEDIPANTVL--LKLDANKISHLPDgAFQHLHRLRELDLSHNAIEAIgSATFAGLAgGLRLLDLSYNRIQ 126
Cdd:COG4886 142 DLSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLT-NLEELDLSGNQLT 218

                        90       100
                ....*....|....*....|...
gi 13562088 127 RIPkDALGKLSA--KIRLSHNPL 147
Cdd:COG4886 219 DLP-EPLANLTNleTLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-147 4.37e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 4.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088  55 LQEVPEDIPANTVL--LKLDANKISHLPDgAFQHLHRLRELDLSHNAIEAIGSatFAGLAGgLRLLDLSYNRIQRIPKDA 132
Cdd:COG4886 194 ITDLPEPLGNLTNLeeLDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTN-LEELDLSNNQLTDLPPLA 269

                        90
                ....*....|....*.
gi 13562088 133 -LGKLSaKIRLSHNPL 147
Cdd:COG4886 270 nLTNLK-TLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-161 7.26e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 7.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088  69 LKLDANKISHLPDgAFQHLHRLRELDLSHNAIEAIGSAtFAGLAgGLRLLDLSYNRIQRIPkDALGKLSA--KIRLSHNP 146
Cdd:COG4886 118 LDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLT-NLKSLDLSNNQLTDLP-EELGNLTNlkELDLSNNQ 193

                        90
                ....*....|....*
gi 13562088 147 LHcecALQEALWELK 161
Cdd:COG4886 194 IT---DLPEPLGNLT 205
LRR_8 pfam13855
Leucine rich repeat;
89-147 3.80e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 3.80e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13562088    89 RLRELDLSHNAIEAIGSATFAGLAgGLRLLDLSYNRIQRIPKDALGKLSA--KIRLSHNPL 147
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSlrYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
32-68 3.65e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.39  E-value: 3.65e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 13562088     32 ACPQPCRCPDhagaVAVFCSLRGLQEVPEDIPANTVL 68
Cdd:smart00013   1 ACPAPCNCSG----TAVDCSGRGLTEVPLDLPPDTTL 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-147 5.40e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 5.40e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088  55 LQEVPEDIPANTVLLKLDANKISHLpdgafQHLHRLRELDLSHNAIEAIGSAtFAGLAgGLRLLDLSYNRIQRIPkDALG 134
Cdd:COG4886  85 LLLGLTDLGDLTNLTELDLSGNEEL-----SNLTNLESLDLSGNQLTDLPEE-LANLT-NLKELDLSNNQLTDLP-EPLG 156

                        90
                ....*....|....*
gi 13562088 135 KLSA--KIRLSHNPL 147
Cdd:COG4886 157 NLTNlkSLDLSNNQL 171
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
40-147 1.09e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088   40 PDH--AGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDG---AFQHLH---------------RLRELDLSHNA 99
Cdd:PRK15370 299 PAHlpSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASlppELQVLDvsknqitvlpetlppTITTLDVSRNA 378

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 13562088  100 IEAIGSatfaGLAGGLRLLDLSYNRIQRIPKD-----ALGKLSAKIRLSHNPL 147
Cdd:PRK15370 379 LTNLPE----NLPAALQIMQASRNNLVRLPESlphfrGEGPQPTRIIVEYNPF 427
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-129 2.40e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 2.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088   42 HAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPdgafQHL-HRLRELDLSHNAIEAIGSAtfagLAGGLRLLDL 120
Cdd:PRK15370 219 QGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELP----ERLpSALQSLDLFHNKISCLPEN----LPEELRYLSV 290


                 ....*....
gi 13562088  121 SYNRIQRIP 129
Cdd:PRK15370 291 YDNSIRTLP 299
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 69-148 3.54e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 3.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088   69 LKLDANKIS-HLPDgAFQHLHRLRELDLSHNAIEAIGSATFAGLAgGLRLLDLSYNRIQ-RIPKDaLGKLSA--KIRLSH 144
Cdd:PLN00113 504 LKLSENKLSgEIPD-ELSSCKKLVSLDLSHNQLSGQIPASFSEMP-VLSQLDLSQNQLSgEIPKN-LGNVESlvQVNISH 580


                 ....
gi 13562088  145 NPLH 148
Cdd:PLN00113 581 NHLH 584
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
54-181 3.83e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 3.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088   54 GLQEVPEDIPANTVLLKLDANKISHLPdgafQHLH-RLRELDLSHNAIEAIGsatfAGLAGGLRLLDLSYNRIQRIPKDA 132
Cdd:PRK15370 189 GLTTIPACIPEQITTLILDNNELKSLP----ENLQgNIKTLYANSNQLTSIP----ATLPDTIQEMELSINRITELPERL 260

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 13562088  133 LGKLSAKIrLSHNPLHC-ECALQEALWELKLDPDSVDEIACH--TSVQEEFV 181
Cdd:PRK15370 261 PSALQSLD-LFHNKISClPENLPEELRYLSVYDNSIRTLPAHlpSGITHLNV 311
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-162 5.16e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 5.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088  69 LKLDANKISHLpDGaFQHLHRLRELDLSHNAIE-----AIGSATFAGLAGGLRLLDLSYNRIQRIpkDALGKLSA--KIR 141
Cdd:cd21340  73 LYLGGNRISVV-EG-LENLTNLEELHIENQRLPpgeklTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNleQLD 148

                        90       100
                ....*....|....*....|....*..
gi 13562088 142 LSHNPLHCECALQEA------LWELKL 162
Cdd:cd21340 149 ASNNQISDLEELLDLlsswpsLRELDL 175
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-161 7.92e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 7.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088  61 DIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNaiEAIGSATfaglagGLRLLDLSYNRIQRIPkDALGKLSA-- 138
Cdd:COG4886  69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--EELSNLT------NLESLDLSGNQLTDLP-EELANLTNlk 139

                        90       100
                ....*....|....*....|...
gi 13562088 139 KIRLSHNPLHcecALQEALWELK 161
Cdd:COG4886 140 ELDLSNNQLT---DLPEPLGNLT 159
PLN03150 PLN03150
hypothetical protein; Provisional
 87-145 1.31e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 1.31e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 13562088   87 LHRLRELDLSHNAIEAIGSATFAGLAGgLRLLDLSYNRIQRIPKDALGKLSAKIRLSHN 145
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITS-LEVLDLSYNSFNGSIPESLGQLTSLRILNLN 498
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 74-171 2.72e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 2.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088  74 NKISHLPDgaFQHLHRLRELDLSHNAIEAIGsatfaGLAG--GLRLLDLSYNRIQRIpkDALGKLSAkirLSHnpLHCEC 151
Cdd:cd21340  34 NKITKIEN--LEFLTNLTHLYLQNNQIEKIE-----NLENlvNLKKLYLGGNRISVV--EGLENLTN---LEE--LHIEN 99

                        90       100
                ....*....|....*....|.
gi 13562088 152 -ALQEALwELKLDPDSVDEIA 171
Cdd:cd21340 100 qRLPPGE-KLTFDPRSLAALS 119
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 32-63 3.21e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 3.21e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 13562088    32 ACPQPCRCPDhagaVAVFCSLRGLQEVPEDIP 63
Cdd:pfam01462   1 ACPVPCHCSA----TVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 74-130 1.52e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 1.52e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13562088  74 NKISHLPDgaFQHLHRLRELDLSHNAIEAIG--SATFAGLaGGLRLLDLSYNRIQRIPK 130
Cdd:cd21340 130 NNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSW-PSLRELDLTGNPVCKKPK 185
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-145 2.01e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 2.01e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13562088  69 LKLDANKISHLPDGAfqHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRLSHN 145
Cdd:COG4886 255 LDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR smart00370
Leucine-rich repeats, outliers;
87-110 5.99e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 5.99e-03
                           10        20
                   ....*....|....*....|....
gi 13562088     87 LHRLRELDLSHNAIEAIGSATFAG 110
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
87-110 5.99e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 5.99e-03
                           10        20
                   ....*....|....*....|....
gi 13562088     87 LHRLRELDLSHNAIEAIGSATFAG 110
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 42-160 7.00e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.33  E-value: 7.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13562088  42 HAGAVAvfcslrgLQEVPEDIPANTVLlKLDANKI-----SHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGG-- 114
Cdd:cd00116 207 DEGASA-------LAETLASLKSLEVL-NLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEke 278

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 13562088 115 -LRLLDLSYNRIqripKDALGKLSAKIrlshnpLHCECALQEALWEL 160
Cdd:cd00116 279 sLLELDLRGNKF----GEEGAQLLAES------LLEPGNELESLWVK 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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