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Conserved domains on  [gi|226371727|ref|NP_110446|]
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glucose-fructose oxidoreductase domain-containing protein 2 isoform 1 precursor [Homo sapiens]

Protein Classification

-; -; Gfo/Idh/MocA family oxidoreductase; Gfo/Idh/MocA family oxidoreductase( domain architecture ID 11430574)

-; -; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to biliverdin reductase A (BLVRA)

CATH:  3.40.50.720
Gene Ontology:  GO:0016491|GO:0016651
PubMed:  26749496

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
1-263 9.81e-40

Predicted dehydrogenase [General function prediction only];


:

Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 142.76  E-value: 9.81e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727   1 MKMLpGVGVFGTGSSARVLVPLLRA-EGFTVEALWGKTEEEAKQLAEEMNIAFYTSrTDDILLHQDVDLVCISIPPPLTR 79
Cdd:COG0673    1 MDKL-RVGIIGAGGIGRAHAPALAAlPGVELVAVADRDPERAEAFAEEYGVRVYTD-YEELLADPDIDAVVIATPNHLHA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727  80 QISVKALGIGKNVVCEK--AATSVDAFRMVTASRYYpQLMSLVGNVLRFLPAFVRMKQLISEHYVGAVMICDARiYSGSL 157
Cdd:COG0673   79 ELAIAALEAGKHVLCEKplALTLEEARELVAAAEEA-GVVLMVGFNRRFDPAVRAARELIDSGAIGEIRSVRAR-FGHPR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727 158 LSPSYGWICD-ELMGGGGLHTMGTYIVDLLTHLTGRRAEKVHGLLKTFVRQNaairgirhVTSDDFCFFQMLMGGGVCST 236
Cdd:COG0673  157 PAGPADWRFDpELAGGGALLDLGIHDIDLARWLLGSEPESVSATGGRLVPDR--------VEVDDTAAATLRFANGAVAT 228

                        250       260
                 ....*....|....*....|....*...
gi 226371727 237 VTLNFNMPGAFVHEVM-VVGSAGRLVAR 263
Cdd:COG0673  229 LEASWVAPGGERDERLeVYGTKGTLFVD 256
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
1-263 9.81e-40

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 142.76  E-value: 9.81e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727   1 MKMLpGVGVFGTGSSARVLVPLLRA-EGFTVEALWGKTEEEAKQLAEEMNIAFYTSrTDDILLHQDVDLVCISIPPPLTR 79
Cdd:COG0673    1 MDKL-RVGIIGAGGIGRAHAPALAAlPGVELVAVADRDPERAEAFAEEYGVRVYTD-YEELLADPDIDAVVIATPNHLHA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727  80 QISVKALGIGKNVVCEK--AATSVDAFRMVTASRYYpQLMSLVGNVLRFLPAFVRMKQLISEHYVGAVMICDARiYSGSL 157
Cdd:COG0673   79 ELAIAALEAGKHVLCEKplALTLEEARELVAAAEEA-GVVLMVGFNRRFDPAVRAARELIDSGAIGEIRSVRAR-FGHPR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727 158 LSPSYGWICD-ELMGGGGLHTMGTYIVDLLTHLTGRRAEKVHGLLKTFVRQNaairgirhVTSDDFCFFQMLMGGGVCST 236
Cdd:COG0673  157 PAGPADWRFDpELAGGGALLDLGIHDIDLARWLLGSEPESVSATGGRLVPDR--------VEVDDTAAATLRFANGAVAT 228

                        250       260
                 ....*....|....*....|....*...
gi 226371727 237 VTLNFNMPGAFVHEVM-VVGSAGRLVAR 263
Cdd:COG0673  229 LEASWVAPGGERDERLeVYGTKGTLFVD 256
GFO_IDH_MocA pfam01408
Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. ...
 6-111 1.38e-14

Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 426248 [Multi-domain]  Cd Length: 120  Bit Score: 69.54  E-value: 1.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727    6 GVGVFGTGSSARVLVPLLRA--EGFTVEALWGKTEEEAKQLAEEMNIAFYTSrTDDILLHQDVDLVCISIPPPLTRQISV 83
Cdd:pfam01408   2 RVGIIGAGKIGSKHARALNAsqPGAELVAILDPNSERAEAVAESFGVEVYSD-LEELLNDPEIDAVIVATPNGLHYDLAI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 226371727   84 KALGIGKNVVCEK--AATSVDAFRMVTASR 111
Cdd:pfam01408  81 AALEAGKHVLCEKplATTVEEAKELVELAK 110
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
1-263 9.81e-40

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 142.76  E-value: 9.81e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727   1 MKMLpGVGVFGTGSSARVLVPLLRA-EGFTVEALWGKTEEEAKQLAEEMNIAFYTSrTDDILLHQDVDLVCISIPPPLTR 79
Cdd:COG0673    1 MDKL-RVGIIGAGGIGRAHAPALAAlPGVELVAVADRDPERAEAFAEEYGVRVYTD-YEELLADPDIDAVVIATPNHLHA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727  80 QISVKALGIGKNVVCEK--AATSVDAFRMVTASRYYpQLMSLVGNVLRFLPAFVRMKQLISEHYVGAVMICDARiYSGSL 157
Cdd:COG0673   79 ELAIAALEAGKHVLCEKplALTLEEARELVAAAEEA-GVVLMVGFNRRFDPAVRAARELIDSGAIGEIRSVRAR-FGHPR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727 158 LSPSYGWICD-ELMGGGGLHTMGTYIVDLLTHLTGRRAEKVHGLLKTFVRQNaairgirhVTSDDFCFFQMLMGGGVCST 236
Cdd:COG0673  157 PAGPADWRFDpELAGGGALLDLGIHDIDLARWLLGSEPESVSATGGRLVPDR--------VEVDDTAAATLRFANGAVAT 228

                        250       260
                 ....*....|....*....|....*...
gi 226371727 237 VTLNFNMPGAFVHEVM-VVGSAGRLVAR 263
Cdd:COG0673  229 LEASWVAPGGERDERLeVYGTKGTLFVD 256
GFO_IDH_MocA pfam01408
Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. ...
 6-111 1.38e-14

Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 426248 [Multi-domain]  Cd Length: 120  Bit Score: 69.54  E-value: 1.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727    6 GVGVFGTGSSARVLVPLLRA--EGFTVEALWGKTEEEAKQLAEEMNIAFYTSrTDDILLHQDVDLVCISIPPPLTRQISV 83
Cdd:pfam01408   2 RVGIIGAGKIGSKHARALNAsqPGAELVAILDPNSERAEAVAESFGVEVYSD-LEELLNDPEIDAVIVATPNGLHYDLAI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 226371727   84 KALGIGKNVVCEK--AATSVDAFRMVTASR 111
Cdd:pfam01408  81 AALEAGKHVLCEKplATTVEEAKELVELAK 110
GFO_IDH_MocA_C pfam02894
Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or ...
 134-360 7.53e-05

Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 427044  Cd Length: 203  Bit Score: 43.56  E-value: 7.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727  134 KQLISEHYVGAVMICDARIYSGSLL-SPSYGWICDELMGGGGLHTMGTYIVDLLTHLTGRRAEKVhgllktfvrqnaair 212
Cdd:pfam02894   1 KELIENGVLGEVVMVTVHTRDPFRPpQEFKRWRVDPEKSGGALYDLGIHTIDLLIYLFGEPPSVV--------------- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371727  213 giRHVTSDDFCFFQM-LMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADlYGQKNSATQEElllRDSLAVGAGL 291
Cdd:pfam02894  66 --AVYASEDTAFATLeFKNGAVGTLETSGGSIVEANGHRISIHGTKGSIELDGID-DGLLSVTVVGE---PGWATDDPMV 139

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226371727  292 PEQGPQDVPLLYLKGMVYM--VQALRQSFQGQGDrrtwdrtpvsMAASFEDGLYMQSVVDAIKRSSRSGEW 360
Cdd:pfam02894 140 RKGGDEVPEFLGSFAGGYLleYDAFLEAVRGGKV----------VLVDAEDGLYALAVIEAAYESAEEGRP 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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