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Conserved domains on  [gi|13470094|ref|NP_085145|]
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apolipoprotein L5 [Homo sapiens]

Protein Classification

ApoL domain-containing protein( domain architecture ID 10527210)

ApoL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ApoL pfam05461
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ...
 51-345 2.46e-135

Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.


:

Pssm-ID: 461657  Cd Length: 298  Bit Score: 390.47  E-value: 2.46e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13470094    51 VNLCQSWKINNLMSTVHSDEAGMLSYFL--FEELMRCDKDSMPDgNLSEEEKLFLSYFPLHKFELEQNIKELNTLADQVD 128
Cdd:pfam05461   1 LTEDEAWERFVAEAELSRDEADALREALneLTTLMAIEDKDMLQ-KDQQERERFLKEFPQVKRELEENIRKLHALADEVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13470094   129 TTHELLTKTSLVASSSGAVSGVMNILGLALAPVTAGGSLMLSATGTGLGAAAAITNIVTNVLENRSNSAARDKASRLGP- 207
Cdd:pfam05461  80 KVHRGCTISNVVASSTGAVSGILTILGLALAPVTAGGSLVLSATGLGLGAAAAVTGVSTSIVEHSSNSSAEAEASRLVSt 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13470094   208 ----LTTSHEAFGGINWSEIEAAgfcvNKCVKAIQGI-KDLHAYQMAKSNSGFMAMVKNFVAKRHIPFWTARGVQRAFEG 282
Cdd:pfam05461 160 stdkLKVVAEVLGGITPKVLSLA----LDCIQVLKGIgKNIRAIRLAKANPRLVASAKRFMTTGRISAQSGKQVQRAFGG 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13470094   283 TTLAMTNGAWVMGAAGAGFLLMKDMSSFLQSWKHLEDGARTETAEELRALAKKLEQELDRLTQ 345
Cdd:pfam05461 236 TALAMSKGARIMGAATAGVFLLLDVVSLVKESKHLHEGAKSESAEELRQQAQELEEKLEELTQ 298
 
Name Accession Description Interval E-value
ApoL pfam05461
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ...
 51-345 2.46e-135

Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.


Pssm-ID: 461657  Cd Length: 298  Bit Score: 390.47  E-value: 2.46e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13470094    51 VNLCQSWKINNLMSTVHSDEAGMLSYFL--FEELMRCDKDSMPDgNLSEEEKLFLSYFPLHKFELEQNIKELNTLADQVD 128
Cdd:pfam05461   1 LTEDEAWERFVAEAELSRDEADALREALneLTTLMAIEDKDMLQ-KDQQERERFLKEFPQVKRELEENIRKLHALADEVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13470094   129 TTHELLTKTSLVASSSGAVSGVMNILGLALAPVTAGGSLMLSATGTGLGAAAAITNIVTNVLENRSNSAARDKASRLGP- 207
Cdd:pfam05461  80 KVHRGCTISNVVASSTGAVSGILTILGLALAPVTAGGSLVLSATGLGLGAAAAVTGVSTSIVEHSSNSSAEAEASRLVSt 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13470094   208 ----LTTSHEAFGGINWSEIEAAgfcvNKCVKAIQGI-KDLHAYQMAKSNSGFMAMVKNFVAKRHIPFWTARGVQRAFEG 282
Cdd:pfam05461 160 stdkLKVVAEVLGGITPKVLSLA----LDCIQVLKGIgKNIRAIRLAKANPRLVASAKRFMTTGRISAQSGKQVQRAFGG 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13470094   283 TTLAMTNGAWVMGAAGAGFLLMKDMSSFLQSWKHLEDGARTETAEELRALAKKLEQELDRLTQ 345
Cdd:pfam05461 236 TALAMSKGARIMGAATAGVFLLLDVVSLVKESKHLHEGAKSESAEELRQQAQELEEKLEELTQ 298
ClyA_MakA-like cd22655
Vibrio cholerae cytotoxin MakA (motility associated killing factor A), and similar proteins; ...
 112-197 2.14e-04

Vibrio cholerae cytotoxin MakA (motility associated killing factor A), and similar proteins; This model includes Vibrio cholerae motility associated killing factor A (MakA) cytotoxin, a member of the cytolysin A (ClyA) family of alpha pore-forming toxins (alpha-PFTs). The MakA protein is encoded by the mak operon. Transport of the MakA protein from the bacteria is shown to occur by flagellum-dependent secretion, highlighting a non-conventional and direct role of flagella in pathogenesis of V. cholerae; a conserved N-terminal FTPP motif is essential for MakA secretion via the flagellum channel in a proton motive force-dependent manner. Structure of MakA shows an elongated, almost entirely alpha-helical protein, with the head domain consisting of two helices and three beta-strands that together with the short beta-strand of the tail domain forms a four-stranded sheet. MakA has been demonstrated to cause toxicity in both Caenorhabditis elegans and zebrafish.


Pssm-ID: 439153 [Multi-domain]  Cd Length: 342  Bit Score: 43.04  E-value: 2.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13470094 112 ELEQNIKELNT----LADQVDTThelltKTSLVASSSGA-VSGVMNILGLALAPVTAGGSLMLSATGTGlGAAAAITNIV 186
Cdd:cd22655 151 DLQADIDKINNaianLNAEIAKD-----NKAIAAAQIAIgVGIFELVFGVALAPATATGGASLILAGIG-AASIAGGAVT 224

                        90
                ....*....|.
gi 13470094 187 TNVLENRSNSA 197
Cdd:cd22655 225 WGIMQSKINDY 235
 
Name Accession Description Interval E-value
ApoL pfam05461
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ...
 51-345 2.46e-135

Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.


Pssm-ID: 461657  Cd Length: 298  Bit Score: 390.47  E-value: 2.46e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13470094    51 VNLCQSWKINNLMSTVHSDEAGMLSYFL--FEELMRCDKDSMPDgNLSEEEKLFLSYFPLHKFELEQNIKELNTLADQVD 128
Cdd:pfam05461   1 LTEDEAWERFVAEAELSRDEADALREALneLTTLMAIEDKDMLQ-KDQQERERFLKEFPQVKRELEENIRKLHALADEVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13470094   129 TTHELLTKTSLVASSSGAVSGVMNILGLALAPVTAGGSLMLSATGTGLGAAAAITNIVTNVLENRSNSAARDKASRLGP- 207
Cdd:pfam05461  80 KVHRGCTISNVVASSTGAVSGILTILGLALAPVTAGGSLVLSATGLGLGAAAAVTGVSTSIVEHSSNSSAEAEASRLVSt 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13470094   208 ----LTTSHEAFGGINWSEIEAAgfcvNKCVKAIQGI-KDLHAYQMAKSNSGFMAMVKNFVAKRHIPFWTARGVQRAFEG 282
Cdd:pfam05461 160 stdkLKVVAEVLGGITPKVLSLA----LDCIQVLKGIgKNIRAIRLAKANPRLVASAKRFMTTGRISAQSGKQVQRAFGG 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13470094   283 TTLAMTNGAWVMGAAGAGFLLMKDMSSFLQSWKHLEDGARTETAEELRALAKKLEQELDRLTQ 345
Cdd:pfam05461 236 TALAMSKGARIMGAATAGVFLLLDVVSLVKESKHLHEGAKSESAEELRQQAQELEEKLEELTQ 298
ClyA_MakA-like cd22655
Vibrio cholerae cytotoxin MakA (motility associated killing factor A), and similar proteins; ...
 112-197 2.14e-04

Vibrio cholerae cytotoxin MakA (motility associated killing factor A), and similar proteins; This model includes Vibrio cholerae motility associated killing factor A (MakA) cytotoxin, a member of the cytolysin A (ClyA) family of alpha pore-forming toxins (alpha-PFTs). The MakA protein is encoded by the mak operon. Transport of the MakA protein from the bacteria is shown to occur by flagellum-dependent secretion, highlighting a non-conventional and direct role of flagella in pathogenesis of V. cholerae; a conserved N-terminal FTPP motif is essential for MakA secretion via the flagellum channel in a proton motive force-dependent manner. Structure of MakA shows an elongated, almost entirely alpha-helical protein, with the head domain consisting of two helices and three beta-strands that together with the short beta-strand of the tail domain forms a four-stranded sheet. MakA has been demonstrated to cause toxicity in both Caenorhabditis elegans and zebrafish.


Pssm-ID: 439153 [Multi-domain]  Cd Length: 342  Bit Score: 43.04  E-value: 2.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13470094 112 ELEQNIKELNT----LADQVDTThelltKTSLVASSSGA-VSGVMNILGLALAPVTAGGSLMLSATGTGlGAAAAITNIV 186
Cdd:cd22655 151 DLQADIDKINNaianLNAEIAKD-----NKAIAAAQIAIgVGIFELVFGVALAPATATGGASLILAGIG-AASIAGGAVT 224

                        90
                ....*....|.
gi 13470094 187 TNVLENRSNSA 197
Cdd:cd22655 225 WGIMQSKINDY 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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