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Conserved domains on  [gi|254939582|ref|NP_083900|]
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lipase maturation factor 1 [Mus musculus]

Protein Classification

lipase maturation factor family protein( domain architecture ID 10535984)

lipase maturation factor family protein similar to vertebrate lipase maturation factor, which is involved in the maturation of specific proteins in the endoplasmic reticulum, and may be required for maturation and transport of active lipoprotein lipase through the secretory pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 169-547 7.94e-166

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


:

Pssm-ID: 462004  Cd Length: 419  Bit Score: 477.98  E-value: 7.94e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  169 YSFGWESQLLETGFLGIFLSPLWTLSRLPKnTPTSQIVLWGFRWLIFRIMLGAGLIKVRGDK-CWLDLTCMDFHYETQPV 247
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLPK-SPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCpTWWDLTALDYHYETQPL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  248 PNPIAYYLHRSPWWFHRFETLSNHFVELLVPFFLFLG-RRMRILHGVLQILFQVILIISGNLSFLNWLTIVPSLACFDDA 326
Cdd:pfam06762  80 PTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDDA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  327 ALGFLFPSGPQGLKKQVLEIQREDT--------------QRVQPKPRDRGCLVRQVVNISLGI-LVAWLSVPVVINLLSS 391
Cdd:pfam06762 160 FLYFWTPESRKKPPRTRLLSVIETLlsllvyglliygtvSLFGLKISENGTFLRRVTLPSIVLgLVSLLSVPVCALLRSN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  392 RQI-------------------------------MNTSFNPLRIVNTYGAFGSVTKERTEVILQGTvspnaSAPDAVWED 440
Cdd:pfam06762 240 KLIqsiqlaivtlaavllfalslvpfsvrnllsrMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGS-----NDGEGPWKE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  441 YEFKCKPGDPWRQPCLISPYHYRLDWLMWFAAFQTYEQNEWILHLAGKLLAGDSEALALLAVNPFEGRtPPRWIRGEHYR 520
Cdd:pfam06762 315 YEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-PPKYVRAELYR 393

                         410       420
                  ....*....|....*....|....*..
gi 254939582  521 YKFSLPgGQHATQGKWWIRKRIGPYFP 547
Cdd:pfam06762 394 YRFTTP-GERRATGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 169-547 7.94e-166

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 477.98  E-value: 7.94e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  169 YSFGWESQLLETGFLGIFLSPLWTLSRLPKnTPTSQIVLWGFRWLIFRIMLGAGLIKVRGDK-CWLDLTCMDFHYETQPV 247
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLPK-SPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCpTWWDLTALDYHYETQPL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  248 PNPIAYYLHRSPWWFHRFETLSNHFVELLVPFFLFLG-RRMRILHGVLQILFQVILIISGNLSFLNWLTIVPSLACFDDA 326
Cdd:pfam06762  80 PTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDDA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  327 ALGFLFPSGPQGLKKQVLEIQREDT--------------QRVQPKPRDRGCLVRQVVNISLGI-LVAWLSVPVVINLLSS 391
Cdd:pfam06762 160 FLYFWTPESRKKPPRTRLLSVIETLlsllvyglliygtvSLFGLKISENGTFLRRVTLPSIVLgLVSLLSVPVCALLRSN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  392 RQI-------------------------------MNTSFNPLRIVNTYGAFGSVTKERTEVILQGTvspnaSAPDAVWED 440
Cdd:pfam06762 240 KLIqsiqlaivtlaavllfalslvpfsvrnllsrMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGS-----NDGEGPWKE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  441 YEFKCKPGDPWRQPCLISPYHYRLDWLMWFAAFQTYEQNEWILHLAGKLLAGDSEALALLAVNPFEGRtPPRWIRGEHYR 520
Cdd:pfam06762 315 YEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-PPKYVRAELYR 393

                         410       420
                  ....*....|....*....|....*..
gi 254939582  521 YKFSLPgGQHATQGKWWIRKRIGPYFP 547
Cdd:pfam06762 394 YRFTTP-GERRATGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 169-547 7.94e-166

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 477.98  E-value: 7.94e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  169 YSFGWESQLLETGFLGIFLSPLWTLSRLPKnTPTSQIVLWGFRWLIFRIMLGAGLIKVRGDK-CWLDLTCMDFHYETQPV 247
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLPK-SPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCpTWWDLTALDYHYETQPL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  248 PNPIAYYLHRSPWWFHRFETLSNHFVELLVPFFLFLG-RRMRILHGVLQILFQVILIISGNLSFLNWLTIVPSLACFDDA 326
Cdd:pfam06762  80 PTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDDA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  327 ALGFLFPSGPQGLKKQVLEIQREDT--------------QRVQPKPRDRGCLVRQVVNISLGI-LVAWLSVPVVINLLSS 391
Cdd:pfam06762 160 FLYFWTPESRKKPPRTRLLSVIETLlsllvyglliygtvSLFGLKISENGTFLRRVTLPSIVLgLVSLLSVPVCALLRSN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  392 RQI-------------------------------MNTSFNPLRIVNTYGAFGSVTKERTEVILQGTvspnaSAPDAVWED 440
Cdd:pfam06762 240 KLIqsiqlaivtlaavllfalslvpfsvrnllsrMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGS-----NDGEGPWKE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939582  441 YEFKCKPGDPWRQPCLISPYHYRLDWLMWFAAFQTYEQNEWILHLAGKLLAGDSEALALLAVNPFEGRtPPRWIRGEHYR 520
Cdd:pfam06762 315 YEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-PPKYVRAELYR 393

                         410       420
                  ....*....|....*....|....*..
gi 254939582  521 YKFSLPgGQHATQGKWWIRKRIGPYFP 547
Cdd:pfam06762 394 YRFTTP-GERRATGAWWKRERVGEYFP 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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