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Conserved domains on  [gi|268370090|ref|NP_083729|]
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WD repeat-containing protein 64 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-538 4.94e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 4.94e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  284 KLHNDWVMKIRYIPALNCFGSCSLDSvhslvleSLK--RLEDNLPVREFAMPRGA-NSFCYCGKANVIVTGGDDKVLRLW 360
Cdd:cd00200    48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTLTGHTSYvSSVAFSPDGRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  361 HpNISTKPVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQTLSVLQVFHDSQGgpgdmQIYSMVYDANHGMLIT 440
Cdd:cd00200   121 D-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEKLLS 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  441 GS--GVIDMYPLTrmIQDTKQVPHTHEREVN--VTLYNKYFhqvLTVCSE-SVIKVWELETGLQIYQIldpHGLSIELTC 515
Cdd:cd00200   195 SSsdGTIKLWDLS--TGKCLGTLRGHENGVNsvAFSPDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVTS 266

                         250       260
                  ....*....|....*....|...
gi 268370090  516 AAIDESGYLFATGAYNGTVKIWD 538
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
393-903 1.08e-07

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  393 SLSSAKVFRVWDIQTLSVLQVFHDSQGgpgdmQIYSMVYDANHGMLITGSGVIDMYPLTRMIQDTKQVPHTHEREVNVTL 472
Cdd:COG2319    11 AASADLALALLAAALGALLLLLLGLAA-----AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  473 YNKYFHQVLTVCSESVIKVWELETGLQIyQILDPHGLSIelTCAAIDESGYLFATGAYNGTVKIWDFGSGQEMKMMPEGK 552
Cdd:COG2319    86 FSPDGRLLASASADGTVRLWDLATGLLL-RTLTGHTGAV--RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  553 DWVEeehglmRLFFLkpqvKQQHLILALERNGTIKiiqgkeddifltvIWELPDAMPYLQYGSHivhlkmstkertmaip 632
Cdd:COG2319   163 GAVT------SVAFS----PDGKLLASGSDDGTVR-------------LWDLATGKLLRTLTGH---------------- 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  633 fpdvelivqktsqqtnyspivDVDVNCIdVFQTEGyNLIACGTTNGMIILWNfiAASVKEIYRpedcfstdpeLDPKRFR 712
Cdd:COG2319   204 ---------------------TGAVRSV-AFSPDG-KLLASGSADGTVRLWD--LATGKLLRT----------LTGHSGS 248

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  713 INDIMFlfrspecvrrSSQDSICSSTqcdsskgpqsskGSKQSIHDADVKGehtdmvGEQQSASRKQPVPISFVE--PQP 790
Cdd:COG2319   249 VRSVAF----------SPDGRLLASG------------SADGTVRLWDLAT------GELLRTLTGHSGGVNSVAfsPDG 300

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  791 PLLVSAHEDGHLRLWTLE-GKLIKdmlPFTKHSAiSLTSLYTDSCCRVLLAGNVEGHVILCSISSfmdpphdekkFKQLL 869
Cdd:COG2319   301 KLLASGSDDGTVRLWDLAtGKLLR---TLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLAT----------GELLR 366

                         490       500       510
                  ....*....|....*....|....*....|....
gi 268370090  870 SWRAHSLEIIQVIYVEEKQLVLTASIDGSVRIWN 903
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-538 4.94e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 4.94e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  284 KLHNDWVMKIRYIPALNCFGSCSLDSvhslvleSLK--RLEDNLPVREFAMPRGA-NSFCYCGKANVIVTGGDDKVLRLW 360
Cdd:cd00200    48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTLTGHTSYvSSVAFSPDGRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  361 HpNISTKPVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQTLSVLQVFHDSQGgpgdmQIYSMVYDANHGMLIT 440
Cdd:cd00200   121 D-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEKLLS 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  441 GS--GVIDMYPLTrmIQDTKQVPHTHEREVN--VTLYNKYFhqvLTVCSE-SVIKVWELETGLQIYQIldpHGLSIELTC 515
Cdd:cd00200   195 SSsdGTIKLWDLS--TGKCLGTLRGHENGVNsvAFSPDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVTS 266

                         250       260
                  ....*....|....*....|...
gi 268370090  516 AAIDESGYLFATGAYNGTVKIWD 538
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
348-555 7.93e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.27  E-value: 7.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  348 IVTGGDDKVLRLWHPNiSTKPVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQTLSVLQVFHDSQGGpgdmqIY 427
Cdd:COG2319   177 LASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-----VR 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  428 SMVYDANHGMLITGS--GVIDMYPLtrmiqDTKQVPHT---HEREVN-VTlynkyFH----QVLTVCSESVIKVWELETG 497
Cdd:COG2319   251 SVAFSPDGRLLASGSadGTVRLWDL-----ATGELLRTltgHSGGVNsVA-----FSpdgkLLASGSDDGTVRLWDLATG 320

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 268370090  498 LQIyQILDPHGLSIelTCAAIDESGYLFATGAYNGTVKIWDFGSGQEMKMMPEGKDWV 555
Cdd:COG2319   321 KLL-RTLTGHTGAV--RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
393-903 1.08e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  393 SLSSAKVFRVWDIQTLSVLQVFHDSQGgpgdmQIYSMVYDANHGMLITGSGVIDMYPLTRMIQDTKQVPHTHEREVNVTL 472
Cdd:COG2319    11 AASADLALALLAAALGALLLLLLGLAA-----AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  473 YNKYFHQVLTVCSESVIKVWELETGLQIyQILDPHGLSIelTCAAIDESGYLFATGAYNGTVKIWDFGSGQEMKMMPEGK 552
Cdd:COG2319    86 FSPDGRLLASASADGTVRLWDLATGLLL-RTLTGHTGAV--RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  553 DWVEeehglmRLFFLkpqvKQQHLILALERNGTIKiiqgkeddifltvIWELPDAMPYLQYGSHivhlkmstkertmaip 632
Cdd:COG2319   163 GAVT------SVAFS----PDGKLLASGSDDGTVR-------------LWDLATGKLLRTLTGH---------------- 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  633 fpdvelivqktsqqtnyspivDVDVNCIdVFQTEGyNLIACGTTNGMIILWNfiAASVKEIYRpedcfstdpeLDPKRFR 712
Cdd:COG2319   204 ---------------------TGAVRSV-AFSPDG-KLLASGSADGTVRLWD--LATGKLLRT----------LTGHSGS 248

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  713 INDIMFlfrspecvrrSSQDSICSSTqcdsskgpqsskGSKQSIHDADVKGehtdmvGEQQSASRKQPVPISFVE--PQP 790
Cdd:COG2319   249 VRSVAF----------SPDGRLLASG------------SADGTVRLWDLAT------GELLRTLTGHSGGVNSVAfsPDG 300

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  791 PLLVSAHEDGHLRLWTLE-GKLIKdmlPFTKHSAiSLTSLYTDSCCRVLLAGNVEGHVILCSISSfmdpphdekkFKQLL 869
Cdd:COG2319   301 KLLASGSDDGTVRLWDLAtGKLLR---TLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLAT----------GELLR 366

                         490       500       510
                  ....*....|....*....|....*....|....
gi 268370090  870 SWRAHSLEIIQVIYVEEKQLVLTASIDGSVRIWN 903
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 480-903 6.20e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 6.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  480 VLTVCSESVIKVWELETGLQIYQiLDPHGLSIeLTCAAIDESGYLfATGAYNGTVKIWDFGSGQEmkmmpeGKDWVEEEH 559
Cdd:cd00200    24 LATGSGDGTIKVWDLETGELLRT-LKGHTGPV-RDVAASADGTYL-ASGSSDKTIRLWDLETGEC------VRTLTGHTS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  560 GLMRLFFLKpqvkQQHLILALERNGTIKIiqgkeddifltviWELPDAMPYLQYGSHivhlkmstkertmaipfpdveli 639
Cdd:cd00200    95 YVSSVAFSP----DGRILSSSSRDKTIKV-------------WDVETGKCLTTLRGH----------------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  640 vqktsqqtnyspivDVDVNCIDVFQTEGYnlIACGTTNGMIILWNFiaasvkeiyrpedcfstdpeldpkrfrindimfl 719
Cdd:cd00200   135 --------------TDWVNSVAFSPDGTF--VASSSQDGTIKLWDL---------------------------------- 164

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  720 fRSPECVRRSSQdsicsstqcdsskgpqsskgskqsiHDADVKGehtdmvgeqqsasrkqpvpISFVEPQPPLLVSAHeD 799
Cdd:cd00200   165 -RTGKCVATLTG-------------------------HTGEVNS-------------------VAFSPDGEKLLSSSS-D 198

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  800 GHLRLWTL-EGKLIKDmlpFTKHSAiSLTSLYTDSCCRVLLAGNVEGHVILcsissfmdppHDEKKFKQLLSWRAHSLEI 878
Cdd:cd00200   199 GTIKLWDLsTGKCLGT---LRGHEN-GVNSVAFSPDGYLLASGSEDGTIRV----------WDLRTGECVQTLSGHTNSV 264

                         410       420
                  ....*....|....*....|....*
gi 268370090  879 IQVIYVEEKQLVLTASIDGSVRIWN 903
Cdd:cd00200   265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 502-538 1.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.50e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 268370090    502 QILDPHGLSIelTCAAIDESGYLFATGAYNGTVKIWD 538
Cdd:smart00320    6 KTLKGHTGPV--TSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 864-903 3.05e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 3.05e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 268370090    864 KFKQLLSWRAHSLEIIQVIYVEEKQLVLTASIDGSVRIWN 903
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-538 4.94e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 4.94e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  284 KLHNDWVMKIRYIPALNCFGSCSLDSvhslvleSLK--RLEDNLPVREFAMPRGA-NSFCYCGKANVIVTGGDDKVLRLW 360
Cdd:cd00200    48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTLTGHTSYvSSVAFSPDGRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  361 HpNISTKPVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQTLSVLQVFHDSQGgpgdmQIYSMVYDANHGMLIT 440
Cdd:cd00200   121 D-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEKLLS 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  441 GS--GVIDMYPLTrmIQDTKQVPHTHEREVN--VTLYNKYFhqvLTVCSE-SVIKVWELETGLQIYQIldpHGLSIELTC 515
Cdd:cd00200   195 SSsdGTIKLWDLS--TGKCLGTLRGHENGVNsvAFSPDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVTS 266

                         250       260
                  ....*....|....*....|...
gi 268370090  516 AAIDESGYLFATGAYNGTVKIWD 538
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-555 7.68e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 7.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  284 KLHNDWVMKIRYIPALNCFGSCSLDSvhslvleSLK--RLEDNLPVREFAMPRGANSFC-YCGKANVIVTGGDDKVLRLW 360
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDG-------TIKvwDLETGELLRTLKGHTGPVRDVaASADGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  361 hpNIST-KPVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQTLSVLQVFHDSQGGpgdmqIYSMVYDANHGMLI 439
Cdd:cd00200    79 --DLETgECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW-----VNSVAFSPDGTFVA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  440 TGSG-----VIDMYPLTRMiqdtkQVPHTHEREVN-VTLYNKYFHqVLTVCSESVIKVWELETGLQIYQiLDPHGLSIel 513
Cdd:cd00200   152 SSSQdgtikLWDLRTGKCV-----ATLTGHTGEVNsVAFSPDGEK-LLSSSSDGTIKLWDLSTGKCLGT-LRGHENGV-- 222

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 268370090  514 TCAAIDESGYLFATGAYNGTVKIWDFGSGQEMKMMPEGKDWV 555
Cdd:cd00200   223 NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSV 264
WD40 COG2319
WD40 repeat [General function prediction only];
348-555 7.93e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.27  E-value: 7.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  348 IVTGGDDKVLRLWHPNiSTKPVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQTLSVLQVFHDSQGGpgdmqIY 427
Cdd:COG2319   177 LASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-----VR 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  428 SMVYDANHGMLITGS--GVIDMYPLtrmiqDTKQVPHT---HEREVN-VTlynkyFH----QVLTVCSESVIKVWELETG 497
Cdd:COG2319   251 SVAFSPDGRLLASGSadGTVRLWDL-----ATGELLRTltgHSGGVNsVA-----FSpdgkLLASGSDDGTVRLWDLATG 320

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 268370090  498 LQIyQILDPHGLSIelTCAAIDESGYLFATGAYNGTVKIWDFGSGQEMKMMPEGKDWV 555
Cdd:COG2319   321 KLL-RTLTGHTGAV--RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
348-555 1.29e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 1.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  348 IVTGGDDKVLRLWHPNiSTKPVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQTLSVLQVFHDSQGGpgdmqIY 427
Cdd:COG2319   135 LASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----VR 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  428 SMVYDANHGMLITGS--GVIDMYPLtrmiqDTKQVPHT---HEREVNVTLYNKYFHQVLTVCSESVIKVWELETGLQIyQ 502
Cdd:COG2319   209 SVAFSPDGKLLASGSadGTVRLWDL-----ATGKLLRTltgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL-R 282

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 268370090  503 ILDPHGLSIelTCAAIDESGYLFATGAYNGTVKIWDFGSGQEMKMMPEGKDWV 555
Cdd:COG2319   283 TLTGHSGGV--NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333
WD40 COG2319
WD40 repeat [General function prediction only];
346-538 7.45e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 7.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  346 NVIVTGGDDKVLRLWHPNiSTKPVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQTLSVLQVFHDSQGGpgdmq 425
Cdd:COG2319   217 KLLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----- 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  426 IYSMVYDANHGMLITGS--GVIDMYPLtrmiqDTKQVPHTHEREVN----VTlynkyFH----QVLTVCSESVIKVWELE 495
Cdd:COG2319   291 VNSVAFSPDGKLLASGSddGTVRLWDL-----ATGKLLRTLTGHTGavrsVA-----FSpdgkTLASGSDDGTVRLWDLA 360

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 268370090  496 TGLQIyQILDPHGLSIelTCAAIDESGYLFATGAYNGTVKIWD 538
Cdd:COG2319   361 TGELL-RTLTGHTGAV--TSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
347-555 8.37e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 8.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  347 VIVTGGDDKVLRLWHPNiSTKPVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQTLSVLQVFHDSQGGpgdmqI 426
Cdd:COG2319    92 LLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA-----V 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  427 YSMVYDANHGMLITGS--GVIDMYPLtrmiqDTKQVPHT---HEREVN-VTlynkyF----HQVLTVCSESVIKVWELET 496
Cdd:COG2319   166 TSVAFSPDGKLLASGSddGTVRLWDL-----ATGKLLRTltgHTGAVRsVA-----FspdgKLLASGSADGTVRLWDLAT 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 268370090  497 GLQIyQILDPHGLSIelTCAAIDESGYLFATGAYNGTVKIWDFGSGQEMKMMPEGKDWV 555
Cdd:COG2319   236 GKLL-RTLTGHSGSV--RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291
WD40 COG2319
WD40 repeat [General function prediction only];
345-555 1.67e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 1.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  345 ANVIVTGGDDKVLRLWhPNISTKPVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQTLSVLQVFHDSQGGpgdm 424
Cdd:COG2319    48 GARLAAGAGDLTLLLL-DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA---- 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  425 qIYSMVYDANHGMLITGS--GVIDMYPLtrmiqDTKQVPHT---HEREVN-VTlynkyF----HQVLTVCSESVIKVWEL 494
Cdd:COG2319   123 -VRSVAFSPDGKTLASGSadGTVRLWDL-----ATGKLLRTltgHSGAVTsVA-----FspdgKLLASGSDDGTVRLWDL 191

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268370090  495 ETGLQIyQILDPHGLSIelTCAAIDESGYLFATGAYNGTVKIWDFGSGQEMKMMPEGKDWV 555
Cdd:COG2319   192 ATGKLL-RTLTGHTGAV--RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 368-555 9.81e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 9.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  368 PVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQTLSVLQVFHDSQGGpgdmqIYSMVYDANHGMLITGS--GVI 445
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP-----VRDVAASADGTYLASGSsdKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  446 DMYPLtrmiqDTKQVPHT---HEREVN-VTLYNKyfHQVLTVCSE-SVIKVWELETGLQIYQILDpHGLSIelTCAAIDE 520
Cdd:cd00200    76 RLWDL-----ETGECVRTltgHTSYVSsVAFSPD--GRILSSSSRdKTIKVWDVETGKCLTTLRG-HTDWV--NSVAFSP 145

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 268370090  521 SGYLFATGAYNGTVKIWDFGSGQEMKMMPEGKDWV 555
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEV 180
WD40 COG2319
WD40 repeat [General function prediction only];
393-903 1.08e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  393 SLSSAKVFRVWDIQTLSVLQVFHDSQGgpgdmQIYSMVYDANHGMLITGSGVIDMYPLTRMIQDTKQVPHTHEREVNVTL 472
Cdd:COG2319    11 AASADLALALLAAALGALLLLLLGLAA-----AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  473 YNKYFHQVLTVCSESVIKVWELETGLQIyQILDPHGLSIelTCAAIDESGYLFATGAYNGTVKIWDFGSGQEMKMMPEGK 552
Cdd:COG2319    86 FSPDGRLLASASADGTVRLWDLATGLLL-RTLTGHTGAV--RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  553 DWVEeehglmRLFFLkpqvKQQHLILALERNGTIKiiqgkeddifltvIWELPDAMPYLQYGSHivhlkmstkertmaip 632
Cdd:COG2319   163 GAVT------SVAFS----PDGKLLASGSDDGTVR-------------LWDLATGKLLRTLTGH---------------- 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  633 fpdvelivqktsqqtnyspivDVDVNCIdVFQTEGyNLIACGTTNGMIILWNfiAASVKEIYRpedcfstdpeLDPKRFR 712
Cdd:COG2319   204 ---------------------TGAVRSV-AFSPDG-KLLASGSADGTVRLWD--LATGKLLRT----------LTGHSGS 248

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  713 INDIMFlfrspecvrrSSQDSICSSTqcdsskgpqsskGSKQSIHDADVKGehtdmvGEQQSASRKQPVPISFVE--PQP 790
Cdd:COG2319   249 VRSVAF----------SPDGRLLASG------------SADGTVRLWDLAT------GELLRTLTGHSGGVNSVAfsPDG 300

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  791 PLLVSAHEDGHLRLWTLE-GKLIKdmlPFTKHSAiSLTSLYTDSCCRVLLAGNVEGHVILCSISSfmdpphdekkFKQLL 869
Cdd:COG2319   301 KLLASGSDDGTVRLWDLAtGKLLR---TLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLAT----------GELLR 366

                         490       500       510
                  ....*....|....*....|....*....|....
gi 268370090  870 SWRAHSLEIIQVIYVEEKQLVLTASIDGSVRIWN 903
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 480-903 6.20e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 6.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  480 VLTVCSESVIKVWELETGLQIYQiLDPHGLSIeLTCAAIDESGYLfATGAYNGTVKIWDFGSGQEmkmmpeGKDWVEEEH 559
Cdd:cd00200    24 LATGSGDGTIKVWDLETGELLRT-LKGHTGPV-RDVAASADGTYL-ASGSSDKTIRLWDLETGEC------VRTLTGHTS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  560 GLMRLFFLKpqvkQQHLILALERNGTIKIiqgkeddifltviWELPDAMPYLQYGSHivhlkmstkertmaipfpdveli 639
Cdd:cd00200    95 YVSSVAFSP----DGRILSSSSRDKTIKV-------------WDVETGKCLTTLRGH----------------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  640 vqktsqqtnyspivDVDVNCIDVFQTEGYnlIACGTTNGMIILWNFiaasvkeiyrpedcfstdpeldpkrfrindimfl 719
Cdd:cd00200   135 --------------TDWVNSVAFSPDGTF--VASSSQDGTIKLWDL---------------------------------- 164

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  720 fRSPECVRRSSQdsicsstqcdsskgpqsskgskqsiHDADVKGehtdmvgeqqsasrkqpvpISFVEPQPPLLVSAHeD 799
Cdd:cd00200   165 -RTGKCVATLTG-------------------------HTGEVNS-------------------VAFSPDGEKLLSSSS-D 198

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  800 GHLRLWTL-EGKLIKDmlpFTKHSAiSLTSLYTDSCCRVLLAGNVEGHVILcsissfmdppHDEKKFKQLLSWRAHSLEI 878
Cdd:cd00200   199 GTIKLWDLsTGKCLGT---LRGHEN-GVNSVAFSPDGYLLASGSEDGTIRV----------WDLRTGECVQTLSGHTNSV 264

                         410       420
                  ....*....|....*....|....*
gi 268370090  879 IQVIYVEEKQLVLTASIDGSVRIWN 903
Cdd:cd00200   265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
792-907 2.63e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  792 LLVSAHEDGHLRLWTLE-GKLIKdmlPFTKHSAiSLTSLYTDSCCRVLLAGNVEGHVILCSISSFmdpphdekkfKQLLS 870
Cdd:COG2319   176 LLASGSDDGTVRLWDLAtGKLLR---TLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATG----------KLLRT 241

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 268370090  871 WRAHSLEIIQVIYVEEKQLVLTASIDGSVRIWNSTSG 907
Cdd:COG2319   242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278
WD40 COG2319
WD40 repeat [General function prediction only];
348-407 2.97e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 2.97e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  348 IVTGGDDKVLRLWHPNiSTKPVGKLVGHMFSITEIVSNEKEQHVISLSSAKVFRVWDIQT 407
Cdd:COG2319   345 LASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 792-907 4.07e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  792 LLVSAHEDGHLRLWTLE-GKLIKDMLPFTKH-SAISLTSLytdscCRVLLAGNVEGHVILcsissfmdppHDEKKFKQLL 869
Cdd:cd00200    65 YLASGSSDKTIRLWDLEtGECVRTLTGHTSYvSSVAFSPD-----GRILSSSSRDKTIKV----------WDVETGKCLT 129

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 268370090  870 SWRAHSLEIIQVIYVEEKQLVLTASIDGSVRIWNSTSG 907
Cdd:cd00200   130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 502-538 1.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.50e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 268370090    502 QILDPHGLSIelTCAAIDESGYLFATGAYNGTVKIWD 538
Cdd:smart00320    6 KTLKGHTGPV--TSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 788-907 1.85e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  788 PQPPLLVSAHEDGHLRLWTLE-GKLIKDmlpFTKHsaisltslyTDSCCRVLLAGNvEGHVILCSISSFM---DPphdeK 863
Cdd:cd00200   145 PDGTFVASSSQDGTIKLWDLRtGKCVAT---LTGH---------TGEVNSVAFSPD-GEKLLSSSSDGTIklwDL----S 207

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 268370090  864 KFKQLLSWRAHSLEIIQVIYVEEKQLVLTASIDGSVRIWNSTSG 907
Cdd:cd00200   208 TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 864-903 3.05e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 3.05e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 268370090    864 KFKQLLSWRAHSLEIIQVIYVEEKQLVLTASIDGSVRIWN 903
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
780-907 5.95e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 5.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  780 PVPISFVEPQPPLLVSAHEDGHLRLWTLEGKLIKdmLPFTKHSAiSLTSLYTDSCCRVLLAGNVEGHVILCSISSFmdpp 859
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLL--RTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLATG---- 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 268370090  860 hdekkfKQLLSWRAHSLEIIQVIYVEEKQLVLTASIDGSVRIWNSTSG 907
Cdd:COG2319   153 ------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 788-908 9.53e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 9.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370090  788 PQPPLLVSAHEDGHLRLWTLE-GKLIKDmlpFTKHSAiSLTSLYTDSCCRVLLAGNVEGHVILCSISSFmdpphdekKFK 866
Cdd:cd00200   103 PDGRILSSSSRDKTIKVWDVEtGKCLTT---LRGHTD-WVNSVAFSPDGTFVASSSQDGTIKLWDLRTG--------KCV 170

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 268370090  867 QLLSwrAHSLEIIQVIYVEEKQLVLTASIDGSVRIWNSTSGH 908
Cdd:cd00200   171 ATLT--GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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