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Conserved domains on  [gi|58037377|ref|NP_083249|]
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leucine-rich repeat-containing protein 15 precursor [Mus musculus]

Protein Classification

LRR_8 and LRRCT domain-containing protein( domain architecture ID 12156242)

protein containing domains LRR_8, LRR, and LRRCT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-441 3.67e-31

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 3.67e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 103 LRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNNLEYIPEGVFDHLVGLTKLNLGN 182
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 183 NGFTHLS-PRVFQHLGNLQVLRLYENRlsdipmgTFDALGNLQELALQENQIGTLsPGLFHNNRNLQRLYLSNNHISHLP 261
Cdd:COG4886  81 LLSLLLLgLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 262 PGIFmQLPHLNKLTLFGNSLKELsPGVFGPMPNLRELWLYNNHITSLPDnAFSHLNQLQVLILSHNQLSYIsPGAFNGLT 341
Cdd:COG4886 153 EPLG-NLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLT 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 342 NLRELSLHTNALQDLDGnvFRSLANLRNVSLQNNRLRQLPGSifANVNGLMTIQLQNNNLENLPLGIFDHLGNLCELRLY 421
Cdd:COG4886 229 NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304

                       330       340
                ....*....|....*....|
gi 58037377 422 DNPWRCDSNILPLHDWLILN 441
Cdd:COG4886 305 LLLLNLLELLILLLLLTTLL 324
LRR_8 pfam13855
Leucine rich repeat;
54-113 1.61e-05

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.61e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377    54 NAMSLQILNTHITELPEDKFLNISALIALKMEKNELANIMPGAFRNLGSLRHLSLANNKL 113
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
423-462 1.70e-05

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.42  E-value: 1.70e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 58037377    423 NPWRCDSNILPLHDWLILNRARLGTDTLpVCSSPASVRGQ 462
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDL-RCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-441 3.67e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 3.67e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 103 LRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNNLEYIPEGVFDHLVGLTKLNLGN 182
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 183 NGFTHLS-PRVFQHLGNLQVLRLYENRlsdipmgTFDALGNLQELALQENQIGTLsPGLFHNNRNLQRLYLSNNHISHLP 261
Cdd:COG4886  81 LLSLLLLgLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 262 PGIFmQLPHLNKLTLFGNSLKELsPGVFGPMPNLRELWLYNNHITSLPDnAFSHLNQLQVLILSHNQLSYIsPGAFNGLT 341
Cdd:COG4886 153 EPLG-NLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLT 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 342 NLRELSLHTNALQDLDGnvFRSLANLRNVSLQNNRLRQLPGSifANVNGLMTIQLQNNNLENLPLGIFDHLGNLCELRLY 421
Cdd:COG4886 229 NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304

                       330       340
                ....*....|....*....|
gi 58037377 422 DNPWRCDSNILPLHDWLILN 441
Cdd:COG4886 305 LLLLNLLELLILLLLLTTLL 324
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-401 7.86e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 103.39  E-value: 7.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   82 LKMEKNELANIMPGA-FRNLGSLRHLSLANNKLKNLPVRLFqdVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNN 160
Cdd:PLN00113  98 INLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNV 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  161 LEYIPEGVFDHLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRLYENRLS-DIPMgTFDALGNLQELALQENQIGTLSPG 239
Cdd:PLN00113 176 LVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPY-EIGGLTSLNHLDLVYNNLTGPIPS 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  240 LFHNNRNLQRLYLSNNHIS-HLPPGIFmQLPHLNKLTLFGNSLKELSPGVFGPMPNLRELWLYNNHITSLPDNAFSHLNQ 318
Cdd:PLN00113 255 SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPR 333

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  319 LQVLILSHNQLSYISPGAFNGLTNLRELSLHTNALQDLDGNVFRSLANLRNVSLQNNRLR-QLPGSIFAnVNGLMTIQLQ 397
Cdd:PLN00113 334 LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGA-CRSLRRVRLQ 412


                 ....
gi 58037377  398 NNNL 401
Cdd:PLN00113 413 DNSF 416
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 196-375 7.06e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 82.53  E-value: 7.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 196 LGNLQVLRLYENRLSDIpmGTFDALGNLQELALQENQIGTLsPGLfHNNRNLQRLYLSNNHISHLPPgiFMQLPHLNKLT 275
Cdd:cd21340   1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKI-ENL-EFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 276 LFGNSLKELSpGVFGPmPNLRELWLYNNHI------TSLPDNAFSHLNQLQVLILSHNQLSYISPgaFNGLTNLRELSLH 349
Cdd:cd21340  75 LGGNRISVVE-GLENL-TNLEELHIENQRLppgeklTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDAS 150

                       170       180
                ....*....|....*....|....*...
gi 58037377 350 TNALQDLD--GNVFRSLANLRNVSLQNN 375
Cdd:cd21340 151 NNQISDLEelLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
293-353 3.50e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 3.50e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58037377   293 PNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISPGAFNGLTNLRELSLHTNAL 353
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
54-113 1.61e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.61e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377    54 NAMSLQILNTHITELPEDKFLNISALIALKMEKNELANIMPGAFRNLGSLRHLSLANNKL 113
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
423-462 1.70e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.42  E-value: 1.70e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 58037377    423 NPWRCDSNILPLHDWLILNRARLGTDTLpVCSSPASVRGQ 462
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDL-RCASPSSLRGP 39
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 396-467 1.81e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.15  E-value: 1.81e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58037377    396 LQNNNLENLPLGIFDHLGNLCELRLYDNPWRCDSNILPLHDWLILNRARLGTDTLPVCSSPASVRGQSLVII 467
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGI 73
LRR smart00370
Leucine-rich repeats, outliers;
292-315 6.59e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.95  E-value: 6.59e-04
                           10        20
                   ....*....|....*....|....
gi 58037377    292 MPNLRELWLYNNHITSLPDNAFSH 315
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-441 3.67e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 3.67e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 103 LRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNNLEYIPEGVFDHLVGLTKLNLGN 182
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 183 NGFTHLS-PRVFQHLGNLQVLRLYENRlsdipmgTFDALGNLQELALQENQIGTLsPGLFHNNRNLQRLYLSNNHISHLP 261
Cdd:COG4886  81 LLSLLLLgLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 262 PGIFmQLPHLNKLTLFGNSLKELsPGVFGPMPNLRELWLYNNHITSLPDnAFSHLNQLQVLILSHNQLSYIsPGAFNGLT 341
Cdd:COG4886 153 EPLG-NLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLT 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 342 NLRELSLHTNALQDLDGnvFRSLANLRNVSLQNNRLRQLPGSifANVNGLMTIQLQNNNLENLPLGIFDHLGNLCELRLY 421
Cdd:COG4886 229 NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304

                       330       340
                ....*....|....*....|
gi 58037377 422 DNPWRCDSNILPLHDWLILN 441
Cdd:COG4886 305 LLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-423 1.39e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.89  E-value: 1.39e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  48 PSPLPWNAMSLQILNTHITELPEDKFLNISALIALKMEKNELANIMPGAFRNLGSLRHLSLANNKLknlpvrlFQDVNNL 127
Cdd:COG4886  43 LSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 128 ETLLLSNNQLVQIqPAQFSQFSNLKELQLYGNNLEYIPEgVFDHLVGLTKLNLGNNGFTHLsPRVFQHLGNLQVLRLYEN 207
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 208 RLSDIPMgTFDALGNLQELALQENQIGTLSPGLfHNNRNLQRLYLSNNHISHLPpgIFMQLPHLNKLTLFGNSLKELSPg 287
Cdd:COG4886 193 QITDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP- 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 288 vFGPMPNLRELWLYNNHITSLPDNAFSHLNQLQVLIL----SHNQLSYISPGAFNGLTNLRELSLHTNALQDLDGNVFRS 363
Cdd:COG4886 268 -LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLllllLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 364 LANLRNVSLQNNRLRQLPGSIFANVNGLMTIQLQNNNLENLPLGIFDHLGNLCELRLYDN 423
Cdd:COG4886 347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-420 3.06e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.34  E-value: 3.06e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  96 AFRNLGSLRHLSLANNKLKNLPVRLFQdVNNLETLLLSNNQLVQIqPAQFSQFSNLKELQLYGNNLEYIPEgVFDHLVGL 175
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNL 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 176 TKLNLGNNGFTHLsPRVFQHLGNLQVLRLYENRLSDIPmGTFDALGNLQELALQENQIGTLsPGLFhNNRNLQRLYLSNN 255
Cdd:COG4886 185 KELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDL-PELG-NLTNLEELDLSNN 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 256 HISHLPPgiFMQLPHLNKLTLFGNSLKELspgvfgpmpNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISPG 335
Cdd:COG4886 261 QLTDLPP--LANLTNLKTLDLSNNQLTDL---------KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 336 AFNGLTNLRELSLHTNALQDLDGNVFRSLANLRNVSLQNNRLRQLPGSIFANVNGLMTIQLQNNNLENLPLGIFDHLGNL 415
Cdd:COG4886 330 LKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409


                ....*
gi 58037377 416 CELRL 420
Cdd:COG4886 410 AVNTE 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-401 7.86e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 103.39  E-value: 7.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   82 LKMEKNELANIMPGA-FRNLGSLRHLSLANNKLKNLPVRLFqdVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNN 160
Cdd:PLN00113  98 INLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNV 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  161 LEYIPEGVFDHLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRLYENRLS-DIPMgTFDALGNLQELALQENQIGTLSPG 239
Cdd:PLN00113 176 LVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPY-EIGGLTSLNHLDLVYNNLTGPIPS 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  240 LFHNNRNLQRLYLSNNHIS-HLPPGIFmQLPHLNKLTLFGNSLKELSPGVFGPMPNLRELWLYNNHITSLPDNAFSHLNQ 318
Cdd:PLN00113 255 SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPR 333

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  319 LQVLILSHNQLSYISPGAFNGLTNLRELSLHTNALQDLDGNVFRSLANLRNVSLQNNRLR-QLPGSIFAnVNGLMTIQLQ 397
Cdd:PLN00113 334 LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGA-CRSLRRVRLQ 412


                 ....
gi 58037377  398 NNNL 401
Cdd:PLN00113 413 DNSF 416
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-401 3.60e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 101.46  E-value: 3.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   76 ISALIALKMEKNELANIMPGAFRNLGSLRHLSLANNKLKN-LPVRLFqDVNNLETLLLSNNQLVQIQPAQFSQFSNLKEL 154
Cdd:PLN00113 235 LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEIL 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  155 QLYGNNLE-YIPEGVfDHLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRLYENRLS-DIPMGTFDAlGNLQELALQENQ 232
Cdd:PLN00113 314 HLFSNNFTgKIPVAL-TSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSNS 391

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  233 IGTLSPGLFHNNRNLQRLYLSNNHISHLPPGIFMQLPHLNKLTLFGNSLKELSPGVFGPMPNLRELWL-YNNHITSLPDn 311
Cdd:PLN00113 392 LEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLaRNKFFGGLPD- 470

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  312 aFSHLNQLQVLILSHNQLSYISPGAFNGLTNLRELSLHTNALQDLDGNVFRSLANLRNVSLQNNRLR-QLPGSiFANVNG 390
Cdd:PLN00113 471 -SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPAS-FSEMPV 548

                        330
                 ....*....|.
gi 58037377  391 LMTIQLQNNNL 401
Cdd:PLN00113 549 LSQLDLSQNQL 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-401 5.06e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.45  E-value: 5.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   77 SALIALKMEKNELANIMPGAFRNLGSLRHLSLANNKL-KNLPVRLFQdVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQ 155
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQ-MKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLD 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  156 LYGNNL--------------EY-----------IPEGVFDhLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRLYENRLS 210
Cdd:PLN00113 243 LVYNNLtgpipsslgnlknlQYlflyqnklsgpIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  211 -DIPMGtFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISHLPPGIFMQLPHLNKLTLFGNSLKELSPGVF 289
Cdd:PLN00113 322 gKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSL 400

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  290 GPMPNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISPGAFNGLTNLRELSLHTNALQDLDGNVFRSlANLRN 369
Cdd:PLN00113 401 GACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLEN 479

                        330       340       350
                 ....*....|....*....|....*....|..
gi 58037377  370 VSLQNNRLRQLPGSIFANVNGLMTIQLQNNNL 401
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 127-423 5.67e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.06  E-value: 5.67e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  127 LETLLLSNNQLV-QIQPAQFSQFSNLKELQLYGNNLE-YIPEGvfdHLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRL 204
Cdd:PLN00113  95 IQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRG---SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  205 YENRLSDIPMGTFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISHLPPGIFMQLPHLNKLTLFGNSLKEL 284
Cdd:PLN00113 172 GGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGP 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  285 SPGVFGPMPNLRELWLYNNHIT-SLPDNAFShLNQLQVLILSHNQLSYISPGAFNGLTNLRELSLHTNALQDLDGNVFRS 363
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTS 330

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58037377  364 LANLRNVSLQNNRLRqlpGSIFANV---NGLMTIQLQNNNLE-NLPLGIFDHlGNLCELRLYDN 423
Cdd:PLN00113 331 LPRLQVLQLWSNKFS---GEIPKNLgkhNNLTVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSN 390
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 196-375 7.06e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 82.53  E-value: 7.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 196 LGNLQVLRLYENRLSDIpmGTFDALGNLQELALQENQIGTLsPGLfHNNRNLQRLYLSNNHISHLPPgiFMQLPHLNKLT 275
Cdd:cd21340   1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKI-ENL-EFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 276 LFGNSLKELSpGVFGPmPNLRELWLYNNHI------TSLPDNAFSHLNQLQVLILSHNQLSYISPgaFNGLTNLRELSLH 349
Cdd:cd21340  75 LGGNRISVVE-GLENL-TNLEELHIENQRLppgeklTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDAS 150

                       170       180
                ....*....|....*....|....*...
gi 58037377 350 TNALQDLD--GNVFRSLANLRNVSLQNN 375
Cdd:cd21340 151 NNQISDLEelLDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 130-351 8.39e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.67  E-value: 8.39e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 130 LLLSNNQLVQIQPaqFSQFSNLKELQLYGNNLEYIPegvfdHLVGLTKLnlgnngfTHLsprvfqHLGNlqvlrlyeNRL 209
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE-----NLEFLTNL-------THL------YLQN--------NQI 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 210 SDIPMgtFDALGNLQELALQENQIGTLSpGLfHNNRNLQRLYLSNNhisHLPPGifmqlphlNKLTLFGNSLKELSpgvf 289
Cdd:cd21340  59 EKIEN--LENLVNLKKLYLGGNRISVVE-GL-ENLTNLEELHIENQ---RLPPG--------EKLTFDPRSLAALS---- 119

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58037377 290 gpmPNLRELWLYNNHITSLpdNAFSHLNQLQVLILSHNQLSYISP--GAFNGLTNLRELSLHTN 351
Cdd:cd21340 120 ---NSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-353 1.06e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.58  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   50 PLPWNAMSLQIL-------NTHITELPEdKFLNISALIALKMEKNELANIMPGAFRNLGSLRHLSLANNKLKNLPVRLFQ 122
Cdd:PLN00113 275 PIPPSIFSLQKLisldlsdNSLSGEIPE-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLG 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  123 DVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNNLE-YIPEGVFDhLVGLTKLNLGNNGFTHLSPRVFQHLGNLQV 201
Cdd:PLN00113 354 KHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGA-CRSLRRVRLQDNSFSGELPSEFTKLPLVYF 432

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  202 LRLYENRLS-DIPMGTFDaLGNLQELALQENQIGTLSPGLFhNNRNLQRLYLSNNHISHLPPGIFMQLPHLNKLTLFGNS 280
Cdd:PLN00113 433 LDISNNNLQgRINSRKWD-MPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK 510

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 58037377  281 LKELSPGVFGPMPNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISPGAFNGLTNLRELSLHTNAL 353
Cdd:PLN00113 511 LSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 100-309 1.79e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.81  E-value: 1.79e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 100 LGSLRHLSLANNKLKNLPvrLFQDVNNLETLLLSNNQLVQIQpaQFSQFSNLKELQLYGNNLEYIpEGvFDHLVGLTKLN 179
Cdd:cd21340   1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 180 LGNNGFTHLSPrvFQHLGNLQVLRLYENRLSDIPMGTFD-----ALGN-LQELALQENQIGTLSPglFHNNRNLQRLYLS 253
Cdd:cd21340  75 LGGNRISVVEG--LENLTNLEELHIENQRLPPGEKLTFDprslaALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDAS 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 58037377 254 NNHIShlppgifmqlphlnkltlfgnSLKELSPgVFGPMPNLRELWLYNNHITSLP 309
Cdd:cd21340 151 NNQIS---------------------DLEELLD-LLSSWPSLRELDLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-293 4.93e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.04  E-value: 4.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   44 IVAMPSPLPWNAMSLQILNTHITELPEDKFLNISALIALKMEKNELANIMPgafrnlGSLRHLSLANNKLKNLPVRLfqd 123
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLP------DTIQEMELSINRITELPERL--- 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  124 VNNLETLLLSNNQLVQIqPAQFSQfsNLKELQLYGNNLEYIPEgvfdHL-VGLTKLNLGNNGFTHLsPRVFQHlgNLQVL 202
Cdd:PRK15370 261 PSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRTLPA----HLpSGITHLNVQSNSLTAL-PETLPP--GLKTL 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  203 RLYENRLSDIPMGTFDAlgnLQELALQENQIGTLSPGLfhnNRNLQRLYLSNNHISHLPPGIFMQLPHL----NKLTLFG 278
Cdd:PRK15370 331 EAGENALTSLPASLPPE---LQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPENLPAALQIMqasrNNLVRLP 404

                        250
                 ....*....|....*
gi 58037377  279 NSLKELSPGvfGPMP 293
Cdd:PRK15370 405 ESLPHFRGE--GPQP 417
LRR_8 pfam13855
Leucine rich repeat;
293-353 3.50e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 3.50e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58037377   293 PNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISPGAFNGLTNLRELSLHTNAL 353
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
269-329 5.05e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 5.05e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58037377   269 PHLNKLTLFGNSLKELSPGVFGPMPNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQL 329
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
126-406 5.10e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 65.57  E-value: 5.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  126 NLETLLLSNNQLVQIqPAQFSQfsnLKELQLYGNNLEYIPegVFDHlvGLTKLNLGNNGFTHLsPRVFQHLGNLQVlrlY 205
Cdd:PRK15387 223 HITTLVIPDNNLTSL-PALPPE---LRTLEVSGNQLTSLP--VLPP--GLLELSIFSNPLTHL-PALPSGLCKLWI---F 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  206 ENRLSDIPMgtfdALGNLQELALQENQIGTLsPGLfhnNRNLQRLYLSNNHISHLPpgifmQLPH-LNKLTLFGNSLKEL 284
Cdd:PRK15387 291 GNQLTSLPV----LPPGLQELSVSDNQLASL-PAL---PSELCKLWAYNNQLTSLP-----TLPSgLQELSVSDNQLASL 357

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  285 SPgvfgpMPN-LRELWLYNNHITSLPdnafSHLNQLQVLILSHNQLSYIS--PgafnglTNLRELSLHTNALQDLDgnvf 361
Cdd:PRK15387 358 PT-----LPSeLYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLTSLPvlP------SELKELMVSGNRLTSLP---- 418

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 58037377  362 RSLANLRNVSLQNNRLRQLPGSIFaNVNGLMTIQLQNNNLENLPL 406
Cdd:PRK15387 419 MLPSGLLSLSVYRNQLTRLPESLI-HLSSETTVNLEGNPLSERTL 462
LRR_8 pfam13855
Leucine rich repeat;
245-305 6.44e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 6.44e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58037377   245 RNLQRLYLSNNHISHLPPGIFMQLPHLNKLTLFGNSLKELSPGVFGPMPNLRELWLYNNHI 305
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
222-281 6.70e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 6.70e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   222 NLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISHLPPGIFMQLPHLNKLTLFGNSL 281
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
198-257 3.27e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 3.27e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   198 NLQVLRLYENRLSDIPMGTFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHI 257
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
318-377 4.83e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 4.83e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   318 QLQVLILSHNQLSYISPGAFNGLTNLRELSLHTNALQDLDGNVFRSLANLRNVSLQNNRL 377
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
126-185 5.82e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 5.82e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   126 NLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNNLEYIPEGVFDHLVGLTKLNLGNNGF 185
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 274-423 6.01e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 6.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 274 LTLFGNSLKELspGVFGPMPNLRELWLYNNHITSLPDnaFSHLNQLQVLILSHNQLSYISPgaFNGLTNLRELSLHTNAL 353
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58037377 354 QDLDGnvFRSLANLRNVSLQNNRLR---QL---PGSIFANVNGLMTIQLQNNNLENL-PLGifdHLGNLCELRLYDN 423
Cdd:cd21340  81 SVVEG--LENLTNLEELHIENQRLPpgeKLtfdPRSLAALSNSLRVLNISGNNIDSLePLA---PLRNLEQLDASNN 152
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 151-331 2.01e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 59.29  E-value: 2.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 151 LKELQLYGNNLEYIPEGV------FDHLVGLTKLNLGNNGFTHLSPRVFQ-----------HLGN--------------- 198
Cdd:cd00116  53 LKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGPDGCGVLEsllrssslqelKLNNnglgdrglrllakgl 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 199 ------LQVLRLYENRLSDIPM----GTFDALGNLQELALQENQIG-----TLSPGLFHNnRNLQRLYLSNNHISHLP-- 261
Cdd:cd00116 133 kdlppaLEKLVLGRNRLEGASCealaKALRANRDLKELNLANNGIGdagirALAEGLKAN-CNLEVLDLNNNGLTDEGas 211

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 262 --PGIFMQLPHLNKLTLFGNSLK-----ELSPGVFGPMPNLRELWLYNNHIT---------SLPDNAfshlnQLQVLILS 325
Cdd:cd00116 212 alAETLASLKSLEVLNLGDNNLTdagaaALASALLSPNISLLTLSLSCNDITddgakdlaeVLAEKE-----SLLELDLR 286


                ....*.
gi 58037377 326 HNQLSY 331
Cdd:cd00116 287 GNKFGE 292
LRR_8 pfam13855
Leucine rich repeat;
174-233 6.27e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 6.27e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   174 GLTKLNLGNNGFTHLSPRVFQHLGNLQVLRLYENRLSDIPMGTFDALGNLQELALQENQI 233
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
149-209 3.12e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 3.12e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58037377   149 SNLKELQLYGNNLEYIPEGVFDHLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRLYENRL 209
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
102-161 7.77e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 7.77e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   102 SLRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNNL 161
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 79-374 2.41e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 54.11  E-value: 2.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377    79 LIALKMEKNELANIMPGAfRNLGSLRHLSLANNK-LKNLPVrlFQDVNNLETLLLSN-NQLVQIqPAQFSQFSNLKELQL 156
Cdd:PLN03210  613 LVKLQMQGSKLEKLWDGV-HSLTGLRNIDLRGSKnLKEIPD--LSMATNLETLKLSDcSSLVEL-PSSIQYLNKLEDLDM 688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   157 -YGNNLEYIPEGVfdHLVGLTKLNLgnNGFTHLspRVFQHLG-NLQVLRLYENRLSDIPMGTfdALGNLQELALQENQIG 234
Cdd:PLN03210  689 sRCENLEILPTGI--NLKSLYRLNL--SGCSRL--KSFPDIStNISWLDLDETAIEEFPSNL--RLENLDELILCEMKSE 760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   235 TL-------SPGLFHNNRNLQRLYLSNN--------------HISHL-----------PPGIfmQLPHLNKLTLFGNSLK 282
Cdd:PLN03210  761 KLwervqplTPLMTMLSPSLTRLFLSDIpslvelpssiqnlhKLEHLeiencinletlPTGI--NLESLESLDLSGCSRL 838

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   283 ELSPGVfgpMPNLRELWLYNNHITSLPdnafshlnqlqVLILSHNQLSYISpgaFNGLTNLRELSLHTNALQDLDGNVFR 362
Cdd:PLN03210  839 RTFPDI---STNISDLNLSRTGIEEVP-----------WWIEKFSNLSFLD---MNGCNNLQRVSLNISKLKHLETVDFS 901

                         330
                  ....*....|..
gi 58037377   363 SLANLRNVSLQN 374
Cdd:PLN03210  902 DCGALTEASWNG 913
LRR_8 pfam13855
Leucine rich repeat;
87-137 7.33e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 7.33e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 58037377    87 NELANIMPGAFRNLGSLRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQL 137
Cdd:pfam13855  11 NRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
250-415 8.52e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 8.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  250 LYLSNNHISHLPPGIfmqlpHLNKLTLFGNSLKELSpgVFGPMPN-LRELWLYNNHITSLPDnafsHL-NQLQVLILSHN 327
Cdd:PRK15370 204 LILDNNELKSLPENL-----QGNIKTLYANSNQLTS--IPATLPDtIQEMELSINRITELPE----RLpSALQSLDLFHN 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  328 QLSYISPGAFNGltnLRELSLHTNALQDLDGNVFRSLANLrnvSLQNNRLRQLPGSIFANvngLMTIQLQNNNLENLPLG 407
Cdd:PRK15370 273 KISCLPENLPEE---LRYLSVYDNSIRTLPAHLPSGITHL---NVQSNSLTALPETLPPG---LKTLEAGENALTSLPAS 343


                 ....*...
gi 58037377  408 IFDHLGNL 415
Cdd:PRK15370 344 LPPELQVL 351
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 87-199 1.23e-06

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 47.92  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377    87 NELANIMPGAFRNLGSLRHLSLaNNKLKNLPVRLFQDvNNLETLLLSNNqLVQIQPAQFSQFSNLKELQLYgNNLEYIPE 166
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITL-PSSLTSIGSYAFYN-CSLTSITIPSS-LTSIGEYAFSNCSNLKSITLP-SNLTSIGS 95

                          90       100       110
                  ....*....|....*....|....*....|...
gi 58037377   167 GVFDHLvGLTKLNLGNNgFTHLSPRVFQHLGNL 199
Cdd:pfam13306  96 YAFSNC-SLKSITIPSS-VTTIGSYAFSNCSNL 126
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 271-387 1.24e-06

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 47.92  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   271 LNKLTlFGNSLKELSPGVFGPMPNLRELWLYNNhITSLPDNAFSHLNqLQVLILShNQLSYISPGAFNGLTNLRELSLHT 350
Cdd:pfam13306  13 LTSIT-IPSSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCSNLKSITLPS 88

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 58037377   351 NaLQDLDGNVFRSlANLRNVSLQNNrLRQLPGSIFAN 387
Cdd:pfam13306  89 N-LTSIGSYAFSN-CSLKSITIPSS-VTTIGSYAFSN 122
LRR_8 pfam13855
Leucine rich repeat;
366-424 8.03e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.03e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 58037377   366 NLRNVSLQNNRLRQLPGSIFANVNGLMTIQLQNNNLENLPLGIFDHLGNLCELRLYDNP 424
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
54-113 1.61e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.61e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377    54 NAMSLQILNTHITELPEDKFLNISALIALKMEKNELANIMPGAFRNLGSLRHLSLANNKL 113
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
423-462 1.70e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.42  E-value: 1.70e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 58037377    423 NPWRCDSNILPLHDWLILNRARLGTDTLpVCSSPASVRGQ 462
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDL-RCASPSSLRGP 39
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 396-467 1.81e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.15  E-value: 1.81e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58037377    396 LQNNNLENLPLGIFDHLGNLCELRLYDNPWRCDSNILPLHDWLILNRARLGTDTLPVCSSPASVRGQSLVII 467
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGI 73
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 87-231 5.03e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 5.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  87 NELANImpgafRNLGSLR---HLSLANNK------LKNLPvrlfqdvnNLETLLLSNNQLVQIqpAQFSQFSNLKELQLY 157
Cdd:cd21340  34 NKITKI-----ENLEFLTnltHLYLQNNQiekienLENLV--------NLKKLYLGGNRISVV--EGLENLTNLEELHIE 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 158 GNNLeyiPEGV---FD------HLVGLTKLNLGNNGFTHLSPrvFQHLGNLQVLRLYENRLSDIP--MGTFDALGNLQEL 226
Cdd:cd21340  99 NQRL---PPGEkltFDprslaaLSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLREL 173


                ....*
gi 58037377 227 ALQEN 231
Cdd:cd21340 174 DLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-204 6.26e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 6.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377   44 IVAMPSPLPWNAMSLQILNTHITELPEDKFLNISALIALKMEKNELANIMPGAFRNlgslrhLSLANNKLKNLPVRLfqd 123
Cdd:PRK15370 295 IRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQV------LDVSKNQITVLPETL--- 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  124 VNNLETLLLSNNQLVQIqPAQFSqfSNLKELQLYGNNLEYIPEGVfDHLVGL----TKLNLGNNGFT------------- 186
Cdd:PRK15370 366 PPTITTLDVSRNALTNL-PENLP--AALQIMQASRNNLVRLPESL-PHFRGEgpqpTRIIVEYNPFSertiqnmqrlmss 441

                        170       180
                 ....*....|....*....|
gi 58037377  187 --HLSPRVFQHLGNLQVLRL 204
Cdd:PRK15370 442 vgYQGPRVLFAMGDFSIVRV 461
LRR_8 pfam13855
Leucine rich repeat;
341-401 2.50e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.50e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58037377   341 TNLRELSLHTNALQDLDGNVFRSLANLRNVSLQNNRLRQLPGSIFANVNGLMTIQLQNNNL 401
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR smart00370
Leucine-rich repeats, outliers;
292-315 6.59e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.95  E-value: 6.59e-04
                           10        20
                   ....*....|....*....|....
gi 58037377    292 MPNLRELWLYNNHITSLPDNAFSH 315
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
292-315 6.59e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.95  E-value: 6.59e-04
                           10        20
                   ....*....|....*....|....
gi 58037377    292 MPNLRELWLYNNHITSLPDNAFSH 315
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PLN03150 PLN03150
hypothetical protein; Provisional
 250-340 8.80e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 8.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377  250 LYLSNNHISHLPPGIFMQLPHLNKLTLFGNSLKELSPGVFGPMPNLRELWL-YNNHITSLPDnAFSHLNQLQVLILSHNQ 328
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLsYNSFNGSIPE-SLGQLTSLRILNLNGNS 501

                         90
                 ....*....|..
gi 58037377  329 LSYISPGAFNGL 340
Cdd:PLN03150 502 LSGRVPAALGGR 513
LRR smart00370
Leucine-rich repeats, outliers;
245-265 2.76e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 2.76e-03
                           10        20
                   ....*....|....*....|.
gi 58037377    245 RNLQRLYLSNNHISHLPPGIF 265
Cdd:smart00370   2 PNLRELDLSNNQLSSLPPGAF 22
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
245-265 2.76e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 2.76e-03
                           10        20
                   ....*....|....*....|.
gi 58037377    245 RNLQRLYLSNNHISHLPPGIF 265
Cdd:smart00369   2 PNLRELDLSNNQLSSLPPGAF 22
LRR_9 pfam14580
Leucine-rich repeat;
300-375 3.14e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.98  E-value: 3.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58037377   300 LYNNHITSLpDNaFSHLNQLQVLILSHNQLSYISPGAFNGLTNLRELSLHTNALQDL-DGNVFRSLANLRNVSLQNN 375
Cdd:pfam14580  49 FSDNEIRKL-DG-FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELgDLDPLASLKKLTFLSLLRN 123
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 293-329 4.16e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 4.16e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 58037377   293 PNLRELWLYNNHITSLPdnAFSHLNQLQVLILSHNQL 329
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 102-274 5.36e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 5.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 102 SLRHLSLANNKLKNLPVRLFQDV----NNLETLLLSNNQlVQIQPAQ-----FSQFSNLKELQLYGNNLEYipEGVF--- 169
Cdd:COG5238 237 SLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNQ-IGAEGAIalakaLQGNTTLTSLDLSVNRIGD--EGAIala 313

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037377 170 DHLVG---LTKLNLGNNG---------FTHLsprvfQHLGNLQVLRLYENRLSDIPMgtfDAL-------GNLQELALQE 230
Cdd:COG5238 314 EGLQGnktLHTLNLAYNGigaqgaialAKAL-----QENTTLHSLDLSDNQIGDEGA---IALakylegnTTLRELNLGK 385

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 58037377 231 NQIG-----TLSPGLFHNnrNLQRLYLSNNHISHLPPG-IFMQLPHLNKL 274
Cdd:COG5238 386 NNIGkqgaeALIDALQTN--RLHTLILDGNLIGAEAQQrLEQLLERIKSV 433
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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