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Conserved domains on  [gi|31541926|ref|NP_082416|]
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major facilitator superfamily domain-containing protein 8 [Mus musculus]

Protein Classification

MFSD8-like MFS transporter( domain architecture ID 13023588)

MFSD8-like major facilitator superfamily (MFS) transporter similar to MFS domain-containing protein 8, also called ceroid-lipofuscinosis neuronal protein 7 (CLN7), a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 40-508 1.54e-150

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 435.10  E-value: 1.54e-150
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  40 VRILYLTMFLSSVGFSIVIMSIWPYLQKIDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRP-RKEPLIVSISISVAA 118
Cdd:cd17326   1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 119 NCLYAYVHVPAAHNKYYMLIARGLVGFGAGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVFQTCFALIGEKG 198
Cdd:cd17326  81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 199 VTWdIIKLQVNMYTAPVLLAAFLGILNIILILFILREhrvddlgrqcksvnfqeentdepqipegsidqvavVATNIVFF 278
Cdd:cd17326 161 YVI-GIKLRFNMYTAPAWLMAILGIINIILILFFFKE-----------------------------------VVCIFLFF 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 279 VVLFIFAVYETILTPLTLDMYAWTQEQAVLYDGILLVAFGVEAVLVFMGVKLLSKK-IGERAILLGGFVVVWVGFFILLP 357
Cdd:cd17326 205 VVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLP 284

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 358 WGnqfpkiqwedlhnsstpnttfgeiiiglwnssredhseqptgcpieqtwclytpvihlaqfLTAAVLIGTGYPACSVM 437
Cdd:cd17326 285 WG-------------------------------------------------------------ITGVILFGLGYPIGNVM 303

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31541926 438 SYTLYSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFSLVCGIVVLTILLIGAVYKRLV 508
Cdd:cd17326 304 LYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 40-508 1.54e-150

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 435.10  E-value: 1.54e-150
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  40 VRILYLTMFLSSVGFSIVIMSIWPYLQKIDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRP-RKEPLIVSISISVAA 118
Cdd:cd17326   1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 119 NCLYAYVHVPAAHNKYYMLIARGLVGFGAGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVFQTCFALIGEKG 198
Cdd:cd17326  81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 199 VTWdIIKLQVNMYTAPVLLAAFLGILNIILILFILREhrvddlgrqcksvnfqeentdepqipegsidqvavVATNIVFF 278
Cdd:cd17326 161 YVI-GIKLRFNMYTAPAWLMAILGIINIILILFFFKE-----------------------------------VVCIFLFF 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 279 VVLFIFAVYETILTPLTLDMYAWTQEQAVLYDGILLVAFGVEAVLVFMGVKLLSKK-IGERAILLGGFVVVWVGFFILLP 357
Cdd:cd17326 205 VVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLP 284

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 358 WGnqfpkiqwedlhnsstpnttfgeiiiglwnssredhseqptgcpieqtwclytpvihlaqfLTAAVLIGTGYPACSVM 437
Cdd:cd17326 285 WG-------------------------------------------------------------ITGVILFGLGYPIGNVM 303

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31541926 438 SYTLYSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFSLVCGIVVLTILLIGAVYKRLV 508
Cdd:cd17326 304 LYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
34-360 5.59e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 94.27  E-value: 5.59e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  34 KSRWKSVRILYLTMFLSSVGFSIvIMSIWPYLQKiDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSIS 113
Cdd:COG2814   6 RRRWLALLALALGAFLSGLGIGI-VLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 114 ISVAANCLYAyvhvpAAHNKYYMLIARGLVGFGAG-NVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVF-QTCF 191
Cdd:COG2814  84 LFALGSLLCA-----LAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLgGLLA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 192 ALIGEKGVTWdiiklqvnMYTAPVLLAAFLGILNIILILFILREHRVDDLGRQCKSVNFqeentdepqipegsidqvavV 271
Cdd:COG2814 159 DLFGWRWVFL--------VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRL--------------------L 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 272 ATNIVFFVVLFIFAVYETILTPLTLDMYAWTQEQAvlydGILLVAFGVEAVLVFMGVKLLSKKIGERAILLGGFVVVWVG 351
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286


                ....*....
gi 31541926 352 FFILLPWGN 360
Cdd:COG2814 287 LLLLALAGS 295
MFS_1 pfam07690
Major Facilitator Superfamily;
43-470 8.44e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 72.45  E-value: 8.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926    43 LYLTMFLSSVGFSIVIMSIWPYLQKiDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLY 122
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926   123 AYvhvpaAHNKYYMLIARGLVGFGAGNV-AVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVFQTcfALIGEKGVTW 201
Cdd:pfam07690  80 LF-----ASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG--LLASLFGWRA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926   202 diiklqVNMYTAPVLLAAFLGILNIILILFIlrehrvddlgrqcKSVNFQEENTDEPQIPEGSIDQVAVVATNIVFFVVL 281
Cdd:pfam07690 153 ------AFLILAILSLLAAVLLLLPRPPPES-------------KRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926   282 FIFAVYETILtPLTLDMYAWTQEQAvlydGILLVAFGVEAVLVFMGVKLLSKKIGERAILLGGFVVVWVGFFILLpwgnq 361
Cdd:pfam07690 214 FAFFGLLTYL-PLYQEVLGLSALLA----GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLL----- 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926   362 fpkiqwedlhnsstpnttfgeiiiglwnssredhseqptgcpieqtwcLYTPVIHLAQFLTAAVLIGTGYPACSVMSYTL 441
Cdd:pfam07690 284 ------------------------------------------------LLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315

                         410       420
                  ....*....|....*....|....*....
gi 31541926   442 YSKVLGPKPQGIYMGWLTTSGSAARILGP 470
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
78-187 1.30e-12

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 64.98  E-value: 1.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926    78 GWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLYAyvhvpAAHNKYYMLIARGLVGFGAGNV-AVVRSY 156
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFA-----LSSNITVLIIARFLQGFGAAFAlVAGAAL 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 31541926   157 IAGATSLQERTNAMANTSTCQALGFILGPVF 187
Cdd:TIGR00880  76 IADIYPPEERGVALGLMSAGIALGPLLGPPL 106
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 40-508 1.54e-150

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 435.10  E-value: 1.54e-150
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  40 VRILYLTMFLSSVGFSIVIMSIWPYLQKIDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRP-RKEPLIVSISISVAA 118
Cdd:cd17326   1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 119 NCLYAYVHVPAAHNKYYMLIARGLVGFGAGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVFQTCFALIGEKG 198
Cdd:cd17326  81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 199 VTWdIIKLQVNMYTAPVLLAAFLGILNIILILFILREhrvddlgrqcksvnfqeentdepqipegsidqvavVATNIVFF 278
Cdd:cd17326 161 YVI-GIKLRFNMYTAPAWLMAILGIINIILILFFFKE-----------------------------------VVCIFLFF 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 279 VVLFIFAVYETILTPLTLDMYAWTQEQAVLYDGILLVAFGVEAVLVFMGVKLLSKK-IGERAILLGGFVVVWVGFFILLP 357
Cdd:cd17326 205 VVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLP 284

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 358 WGnqfpkiqwedlhnsstpnttfgeiiiglwnssredhseqptgcpieqtwclytpvihlaqfLTAAVLIGTGYPACSVM 437
Cdd:cd17326 285 WG-------------------------------------------------------------ITGVILFGLGYPIGNVM 303

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31541926 438 SYTLYSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFSLVCGIVVLTILLIGAVYKRLV 508
Cdd:cd17326 304 LYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 43-499 8.42e-57

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 193.18  E-value: 8.42e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  43 LYLTMFLSSVGFSIVIMSIWPYLQKI-DQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCL 121
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREFnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 122 YAYvhvpaAHNKYYMLIARGLVGFGAGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVFQTCFAligekgvtw 201
Cdd:cd17330  81 LGL-----SRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS--------- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 202 diiklQVNMYTAPVLLAAFLGILNIILILFILRehrvdDLGRQCksvnfqeentdepqipegsidqvavvatnIVFFVVL 281
Cdd:cd17330 147 -----TPYGYALPFLVAAALALLNLVLVLFFLP-----PLRRLL-----------------------------LVYFLIA 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 282 FIFAVYETILTPLTLDMYAWTQEQAvlydGILLVAFGVEAVLVFMGV-KLLSKKIGERAILLGGFVVVWVGFFiLLPWGN 360
Cdd:cd17330 188 LAFAGLESVFSLFLKDRFGFSPSQI----GLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLL-LLPFAS 262

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 361 QFPkiqwedlhnsstpnttfgeiiiglwnssredhseqptgcpieqtwclytpvihlaQFLTAAVLIGTGYPACSVMSYT 440
Cdd:cd17330 263 SVP-------------------------------------------------------LLVLAAAILAFGTGIVFPALSA 287

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31541926 441 LYSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFSLVCGIVVLTILL 499
Cdd:cd17330 288 LLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 43-505 1.03e-22

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 99.57  E-value: 1.03e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  43 LYLTMFLSSVGFSIVIMSIWPYLQKIDqtADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLY 122
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLG--ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 123 AYvhvpaAHNKYYMLIARGLVGFGAGNVAVVR-SYIAGATSLQERTNAMANTSTCQALGFILGPVFqtCFALIGEKGvtw 201
Cdd:cd17325  79 AF-----ATSYWQLLLARFLQGLASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLL--GGLLADALG--- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 202 diiklqvnmYTAPVLLAAFLGILNIILILFILREHRVDDLGRQCKSVNFQEentdepqIPEGSIDQVAVVATNIVFFVVL 281
Cdd:cd17325 149 ---------YRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRS-------GLRLLLRDRRLLALFLAIFVLA 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 282 FIFAVYETILTPLTLDMYAWTQEQAvlydGILLVAFGVEAVLVFMGVKLLSKKIGERAILLGGFVVVwVGFFILLPWGNQ 361
Cdd:cd17325 213 FAFGALEPFLPLYAAELGGLSPAQI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS-AVALLLLPLATS 287

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 362 FPkiqwedlhnsstpnttfgeiiiglwnssredhseqptgcpieqtwclytpvihlaQFLTAAVLIGTGYPACSVMSYTL 441
Cdd:cd17325 288 FW-------------------------------------------------------LLLLLLALLGLGLGLVFPATLAL 312

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31541926 442 YSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFsLVCGIVVLTILLIGAVYK 505
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF-LAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
34-360 5.59e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 94.27  E-value: 5.59e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  34 KSRWKSVRILYLTMFLSSVGFSIvIMSIWPYLQKiDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSIS 113
Cdd:COG2814   6 RRRWLALLALALGAFLSGLGIGI-VLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 114 ISVAANCLYAyvhvpAAHNKYYMLIARGLVGFGAG-NVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVF-QTCF 191
Cdd:COG2814  84 LFALGSLLCA-----LAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLgGLLA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 192 ALIGEKGVTWdiiklqvnMYTAPVLLAAFLGILNIILILFILREHRVDDLGRQCKSVNFqeentdepqipegsidqvavV 271
Cdd:COG2814 159 DLFGWRWVFL--------VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRL--------------------L 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 272 ATNIVFFVVLFIFAVYETILTPLTLDMYAWTQEQAvlydGILLVAFGVEAVLVFMGVKLLSKKIGERAILLGGFVVVWVG 351
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286


                ....*....
gi 31541926 352 FFILLPWGN 360
Cdd:COG2814 287 LLLLALAGS 295
MFS_1 pfam07690
Major Facilitator Superfamily;
43-470 8.44e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 72.45  E-value: 8.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926    43 LYLTMFLSSVGFSIVIMSIWPYLQKiDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLY 122
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926   123 AYvhvpaAHNKYYMLIARGLVGFGAGNV-AVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVFQTcfALIGEKGVTW 201
Cdd:pfam07690  80 LF-----ASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG--LLASLFGWRA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926   202 diiklqVNMYTAPVLLAAFLGILNIILILFIlrehrvddlgrqcKSVNFQEENTDEPQIPEGSIDQVAVVATNIVFFVVL 281
Cdd:pfam07690 153 ------AFLILAILSLLAAVLLLLPRPPPES-------------KRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926   282 FIFAVYETILtPLTLDMYAWTQEQAvlydGILLVAFGVEAVLVFMGVKLLSKKIGERAILLGGFVVVWVGFFILLpwgnq 361
Cdd:pfam07690 214 FAFFGLLTYL-PLYQEVLGLSALLA----GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLL----- 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926   362 fpkiqwedlhnsstpnttfgeiiiglwnssredhseqptgcpieqtwcLYTPVIHLAQFLTAAVLIGTGYPACSVMSYTL 441
Cdd:pfam07690 284 ------------------------------------------------LLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315

                         410       420
                  ....*....|....*....|....*....
gi 31541926   442 YSKVLGPKPQGIYMGWLTTSGSAARILGP 470
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 45-499 5.94e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 70.53  E-value: 5.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  45 LTMFLSSVGFSIVIMS-IWPYLQKiDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLYA 123
Cdd:cd06174   1 LLLGFFLTGLARGLISpLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 124 yvhvpAAHNKYYMLIARGLVGFGAGNVAVVR-SYIAGATSLQERTNAMANTSTCQALGFILGPVFQTCFALIGEKGVTWD 202
Cdd:cd06174  80 -----FAPSFWLLLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAV 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 203 IIklqvnMYTAPVLLAAFLGILNiililfilrehrVDDLGRQCKSVNFQEENTDEPQIPEGSIDQVAVVATNIVFFVVLF 282
Cdd:cd06174 155 FL-----IAAALALLAAILLLLV------------VPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNL 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 283 IFAVYETILTPLTLDMYAWTQEQAVLydgILLVAFGVEAVLVFMGVKLLSKKIGERAILLGGFVVVWVGFFILLPWGnqf 362
Cdd:cd06174 218 AYYSFSTLLPLFLLDLGGLSVAVAGL---LLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP--- 291

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 363 pkiqwedlhnsstpnttfgeiiiglwnssredhseqptgcpieqtwclytpviHLAQFLTAAVLIGTGYPACSVMSYTLY 442
Cdd:cd06174 292 -----------------------------------------------------SLLLLLLLLLLLGFGLGGLLPLSFALI 318

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31541926 443 SKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVY-TYLGPRWAFSLVCGIVVLTILL 499
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAIL 376
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 43-186 1.30e-12

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 69.18  E-value: 1.30e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  43 LYLTMFLSSVGFSIVIMSIWPYLQKIDqtADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSIsisvaANCLY 122
Cdd:cd17390   1 LYLVGFLDLFGVSMILPLLSTHIRSLG--ASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICL-----LLTAL 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31541926 123 AYVHVPAAHNKYYMLIARGLVGFGAGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPV 186
Cdd:cd17390  74 GYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPV 137
2_A_01_02 TIGR00880
Multidrug resistance protein;
78-187 1.30e-12

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 64.98  E-value: 1.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926    78 GWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLYAyvhvpAAHNKYYMLIARGLVGFGAGNV-AVVRSY 156
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFA-----LSSNITVLIIARFLQGFGAAFAlVAGAAL 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 31541926   157 IAGATSLQERTNAMANTSTCQALGFILGPVF 187
Cdd:TIGR00880  76 IADIYPPEERGVALGLMSAGIALGPLLGPPL 106
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 42-502 2.26e-11

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 65.35  E-value: 2.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  42 ILYLTMFLSSVGFSIvIMSIWPYL--QKIDQTAD-ASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSIsisvaA 118
Cdd:cd17388   3 FILVTVLLDAMGIGL-IMPVLPTLlrEFVGDSADaATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSL-----A 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 119 NCLYAYVHVPAAHNKYYMLIARGLVGFGAGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVfqtcfalIGekG 198
Cdd:cd17388  77 GAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPA-------LG--G 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 199 VTWDIiklqvnMYTAPVLLAAFLGILNIILILFILRE-HRVDDLGRqcksvnfqeeNTDEPQIPEGSIDQV----AVVAT 273
Cdd:cd17388 148 LLGEI------SPRAPFLVAAGLNGLNFLLGLFVLPEsLPPERRRA----------FRWRRANPFGSLRWLtgfpGLLGL 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 274 NIVFFVVLFIFAVYETILTPLTLDMYAWTQEQAvlydGILLVAFGVEAVLV-FMGVKLLSKKIGERAILLGGFVVVWVGf 352
Cdd:cd17388 212 LAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMV----GLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALG- 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 353 FILLPWgnqfpkiqwedlhnsstpnttfgeiiiglwnssredhseqptgcpIEQTWCLYTPVIHLAqfltaavLIGTGYP 432
Cdd:cd17388 287 FLLLAF---------------------------------------------ATQGWMVFPILILLA-------LGGIAGP 314

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31541926 433 ACSvmsyTLYSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLG---PRWAFSLVCGIVVLTILLIGA 502
Cdd:cd17388 315 ALQ----GLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPatwPGLAWIIGAALYLICLVLAYR 383
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 34-187 3.96e-10

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 60.98  E-value: 3.96e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  34 KSRWKSVRILYLTMFLSSVGFSIVIMSIwPYLQKiDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSIS 113
Cdd:COG0477  10 RRRRRALLALALGTFLEGLDFTIVNVAL-PSIAA-DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31541926 114 ISVAANCLYAYVHVPAAhnkyyMLIARGLVGFGAG-NVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVF 187
Cdd:COG0477  88 LFGLASLLCGLAPSPEL-----LIAARALQGIGAGgLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLL 157
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 36-186 2.58e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.13  E-value: 2.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  36 RWKSVRILYLTMFLSSVGFSIVIMSIWPYLQKIdQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISIS 115
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL-GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31541926 116 VAAnclyaYVHVPAAHNKYYMLIARGLVGFGAGNV-AVVRSYIAGATSLQERTNAMANTSTCQALGFILGPV 186
Cdd:cd17325 276 AVA-----LLLLPLATSFWLLLLLLALLGLGLGLVfPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPL 342
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 77-503 1.20e-08

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 56.90  E-value: 1.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  77 LGWVIAS-YSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLYAyvhvpAAHNKYYMLIARGLVGFGAGNVAVVRS 155
Cdd:cd17389  65 FGGLIGSlFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWA-----VSRSFTIFLLSRIVGGISKGNVSLSTA 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 156 YIAGATSLQERTNAMANTSTCQALGFILGPVFQTCFALIGEkgvtwdiiKLQVNMYTAPVLLAAFLGILNIILILFILRE 235
Cdd:cd17389 140 IVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTR--------SLGEVFFSMPALFALVLALADLLFIFFFLPE 211

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 236 hrvdDLGRQCKSVNFqeentdepqipegsidqvavvatniVFFVVLFIFAVYETILTPLTLDMYAWTQ-EQAVLYdgill 314
Cdd:cd17389 212 ----TLPSNLRRLGL-------------------------VYFLYLFLFSGLEFTLTFLTHQRFQYTSmQQGKMF----- 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 315 vafgveavlVFMGVKLlskkigerAILLGGFV----------VVWVGFFILLPwgnqfpkiqwedlhnsstpnttfGEII 384
Cdd:cd17389 258 ---------FFIGIIM--------ALVQGGYVrrikpgkekkAVLQGLILLIP-----------------------AFLL 297

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 385 IGLWNSSredhseqptgcpieqtWCLYTPVIHLAqfLTAAVLIgtgyPACSvmsyTLYSKVLGPKPQGIYMGWLTTSGSA 464
Cdd:cd17389 298 IGWASSV----------------TVLYAGLFLYS--FAAATVV----PCLT----TLVSGYGSDDQKGTVMGIFRSLGAL 351

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 31541926 465 ARILGPVFISHVYTYLGPRWAFSLVCGIVVLTILLIGAV 503
Cdd:cd17389 352 ARALGPIVACTVYWLAGSEACYTIGALLFLLPLLLLARL 390
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 40-500 2.87e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 52.61  E-value: 2.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  40 VRILYLTMFLSSVGFSIVIMSIWPYLQKiDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAAN 119
Cdd:cd17329   1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQ-QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 120 CLYAYvhvpaAHNKYYMLIARGLVGFGAGNV-AVVRSYIAGATSLQERTNAMANTSTCQALGFILGPvfqtcfaLIGekg 198
Cdd:cd17329  80 ALLGF-----AHSPWLFAIALVLTGFGGGLFePASEAMIADVTTPENRTRAFSLLYWAINLGVAIGP-------LLG--- 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 199 vTWdiikLQVNMYTAPVLLAAFLGILNIILILFILREHRvddlgrqcksvnfqeeNTDEPQIPEGSIDQVAVVATNIVFF 278
Cdd:cd17329 145 -GL----LLLYSFRLLFLAAAVLFLLAALVLLFLLPETR----------------PKRRAAEKTEILRGYKIVLRDRAFL 203

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 279 VVLFIFAVYETILTPLTLDMYAWTQEQAVLYDGILLVAFGVEAVLVFMG---VKLLSKKIGERAILLGGFVVVWVGFFIl 355
Cdd:cd17329 204 LFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLqfpVARLVERFRLRKILMIGILLFAIGFAV- 282

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 356 LPWGNQFPKIQwedlhnSSTPNTTFGEIIIGlwnssredhseqptgcPIEQTWclytpVIHLAqfltaavligtgypacs 435
Cdd:cd17329 283 LAFANTLAVLI------LAMIVLTLGEMLVF----------------PAVQTL-----VAALA----------------- 318

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31541926 436 vmsytlyskvlgPKPQ-GIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFsLVCGIVVLTILLI 500
Cdd:cd17329 319 ------------PPDKrGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW-LILAALGLIAAAL 371
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 43-499 6.55e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.44  E-value: 6.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  43 LYLTMFLSSVGFSIVIMSIWPYLQKIDQTADASflGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLY 122
Cdd:cd17489   1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVA--GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 123 AYVHVPAAhnkyyMLIARGLVGFGAGNVAVVRS-YIAGATSLQERTNAMANTSTCQALGFILGPvfqtcfaLIGekgvtw 201
Cdd:cd17489  79 LLATSVAL-----LLVLRLIHGIGWGAFTTAAAtLVADIIPPSRRGEGIGYYGLATTLAMALGP-------ALG------ 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 202 dIIKLQVNMYTAPVLLAAFLGILNIILILFILREHRVDDLGRQCKSVNFQEentdepqipegSIDQVAVVATNIVFfvvl 281
Cdd:cd17489 141 -LFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRR-----------LVEKKVLPPALILF---- 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 282 FIFAVYETILTPLTLdmyaWTQEQAVLYDGILLVAFGveavLVFMGVKLLSKKIGERailLGGFVVVWVGFFILlpwgnq 361
Cdd:cd17489 205 LASIAYGAISTFLPL----YAAERGISNAGLFFTVYA----IALLLSRPFSGKLSDR---KGPKTVIIPGLLLL------ 267

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 362 fpkiqwedlhnsstpnttfgeiIIGLWnssredhseqptgcpieqtwcLYTPVIHLAQFLTAAVLIGTGYPACSVMSYTL 441
Cdd:cd17489 268 ----------------------ALGLL---------------------LLSFAGSPWMLLLAAVLYGLGFGLLFPALQAL 304

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31541926 442 YSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFSLVCGIVVLTILL 499
Cdd:cd17489 305 AVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
34-507 9.41e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.02  E-value: 9.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  34 KSRWKSVRILYLTMFLSSVGFSIvIMSIWPYLQKiDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSIS 113
Cdd:COG2271   6 RYRWRILALLFLAYFLNYLDRSN-LSVAAPPLQA-DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 114 ISVAANCLYAYVHVPAAhnkyyMLIARGLVGFG-AGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVFQTcfA 192
Cdd:COG2271  84 LWGLATLLFGFATSFWQ-----LLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG--W 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 193 LIGEKGVTWDIIklqvnMYTAPVLLAAFlgilniililfilrehrvddlgrqcksvnfqeentdepqipegsidqVAVVA 272
Cdd:COG2271 157 LLAAFGWRAAFL-----ILGLPGLLLAL-----------------------------------------------LRFWL 184

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 273 TNIVFFVVLFIFAVYETILTPLTLDMYAWTQEQAvlydGILLVAFGVEAVLVFMGVKLLSKKIGERAILlggfvVVWVGF 352
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA----GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL-----VLAIGL 255

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 353 FILLPwgnqfpkiqwedlhnsstpnttfgeiiiglwnssredhseqptgcpieqTWCLYTPVIHLAQFLTAAVLIGTGYP 432
Cdd:COG2271 256 LLAAL-------------------------------------------------ALLLLALLPSPALAIALLFLAGFGLG 286

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31541926 433 ACSVMSYTLYSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFSLVCGIVVLTILLIGAVYKRL 507
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 11-187 1.52e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.50  E-value: 1.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  11 EPLLGPGSPGSREWSEIETQEHYKSRWKSVRILYLTMFLSSVGFS-IVIMSIWPYLQKIDQTADASFLGWVIASYSLGQM 89
Cdd:cd06174 174 PDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAyYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGA 253

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  90 VASPLFGLWSNYRPRKEPLIVsISISVAANCLYAYVHVPaahNKYYMLIARGLVGFGAGNVAVVR-SYIAGATSLQERTN 168
Cdd:cd06174 254 LGSLLLGLLSDRLIGRKPLLL-IGLLLMALGLALLLLAP---SLLLLLLLLLLLGFGLGGLLPLSfALIAELFPPEIRGT 329

                       170
                ....*....|....*....
gi 31541926 169 AMANTSTCQALGFILGPVF 187
Cdd:cd06174 330 AFGLLNTFGFLGGAIGPLL 348
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 37-186 1.77e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 1.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  37 WKSVRILYLTMFLSSVGFSIVIMSIWPYLQKIdQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPrkEPLIVSISISV 116
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQER-GGGSAALIGLALAIASLAGAIGALLFGRLKRRLG--KRRLLAIGFAL 272

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31541926 117 AAnclYAYVHVPAAHNKYYMLIARGLVGFGAG-NVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPV 186
Cdd:cd17473 273 MA---LGFLLLALASGLWVVLLGAILAGLGFGlLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
36-180 2.06e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.97  E-value: 2.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  36 RWKSVRILYLTMFLSSVGFSIVIMSIWPYLQKIDQtADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISIS 115
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG-LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31541926 116 VAANCLYAYVHVPAAhnkyyMLIARGLVGFGAG-NVAVVRSYIAGATSLQERTNAMANTSTCQALG 180
Cdd:COG2814 284 ALGLLLLALAGSLWL-----LLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 43-358 3.01e-06

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 49.47  E-value: 3.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  43 LYLTMFLSSVGFSIV--IMSIWpylqkIDQTADAS--FLGWVIASYSLGQMVASPLFGLWSNYR-PRKEPLIVSISISVA 117
Cdd:cd17471   1 LLLATLLTGLAGAFVlpYLSLF-----LTEELGASplQIGIFMTLSALSGIVVSQWLGRLSDRGgDRKPLILLALLAGAL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 118 ANCLYAYVHvpaahnKYYMLIARGLVGFGAGNVAV------VRSYiAGATSLQERTNAMANTSTCQALGFILGPVFQtcF 191
Cdd:cd17471  76 GYLLFAFLR------NYWVLLLVGVVLLSLGAAAFpqlfalAREY-ADRSSGRDATLFNSVLRAAFSLAWVIGPPLA--F 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 192 ALIGEKGVTWdiiklqvNMYTAPVLLAAFLGILNIILilfilrehrvddlgrqcKSVNFQEENTDEPQIPEGSIDQVAVV 271
Cdd:cd17471 147 LLLDVLGFTG-------LFLLAALLYLVVALLVLFLL-----------------PSVKPPAQKATPASSLVKAPVNRRLL 202

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 272 AtniVFFVVLFIFAV---YeTILTPLTLdmyawTQE--QAVLYDGILlvaFGVEAVL--VFM-GVKLLSKKIGERAILLG 343
Cdd:cd17471 203 L---LFAAFTLLFAAnsmY-IIAMPLYV-----TNElgGSESWVGLL---FGLAAALeiPIMlLAGLLAKRFGKRRLLLA 270

                       330
                ....*....|....*
gi 31541926 344 GFVVVwVGFFILLPW 358
Cdd:cd17471 271 GFLAG-VLFYLGLAL 284
Sugar_tr pfam00083
Sugar (and other) transporter;
72-148 4.32e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 49.19  E-value: 4.32e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31541926    72 ADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLYAYVHvpaAHNKYYMLIA-RGLVGFGAG 148
Cdd:pfam00083  43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAK---GKWSVYQLIVgRVLVGIGVG 117
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 42-355 9.18e-06

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 47.98  E-value: 9.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  42 ILYLTMFLSSVGFSIvIMSIWPYLQKIDQtADASFLGWVIASYSLGQMVASPLFGLWSN-YRPRKeplivSISISVAANC 120
Cdd:cd17331   4 IVHLNIVLYATCYWL-QQPVLPYLTKKLG-VDSVVFGYLQTTFSVLQLVGGPLFGRFGDlFGPRA-----ALVLSFLSSA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 121 LYaYVHVPAAHNkYYMLIARGLVGFGAGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVFQTcfaLIGEKGvt 200
Cdd:cd17331  77 LS-YLLLAFASS-VPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGG---LLTKKF-- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 201 wdiiKLQVNMYTAPV--LLAAFLGILNIILILFILREHRVDDLGRQCKSVNFQEentdepqipEGSIDQVAVVATNIVF- 277
Cdd:cd17331 150 ----GEQAAALVAAVgsLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKE---------ILRLLRLPGVAFLLLVk 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 278 FVVLFIFAVYETILTPLTLDMYAWTQEQAvlydGILLVAFGVeAVLVFMG--VKLLSKKIGERAILLGGFVVVWVGFFIL 355
Cdd:cd17331 217 LLSGLPIGMFQSMFSLVAMDFFGLTPEEN----GYLMSYAGV-LGMVVQGllVGPLTKRFGERSLLKLSVALLAIGYLLL 291
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 78-360 1.16e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.54  E-value: 1.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  78 GWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLYAyvhvpAAHNKYYMLIARGLVGFGAGNV-AVVRSY 156
Cdd:cd17324  37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA-----LAPSFALLLLARALAGLAHGGFwAIAAAY 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 157 IAGATSLQERTNAMANTSTCQALGFILGPVFQTcfaLIGEKgVTWdiiklQVNMYTAPVLLAAFLGILNIILILFILREH 236
Cdd:cd17324 112 AADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGG---LLGQL-LGW-----RAAFLAIAVLALLAALLLWRLLPSLPPKKP 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 237 RVDDLGRQCKSVNFQeentdePQIpegsidQVAVVATNIVFFVVlfiFAVYETILTPLTLDMYAWTQEQavlydGILLVA 316
Cdd:cd17324 183 GSLGLLSSLLLLLRN------PRL------RLAYLITFLLFGGF---FALYTYLAPFLTDVPGFSSSAI-----IGLLLL 242

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31541926 317 FGVEAVLVFMGVKLLSKKIGERAILLGGFVVVWVGFFILLPWGN 360
Cdd:cd17324 243 FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPS 286
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 43-187 1.22e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 47.56  E-value: 1.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  43 LYLTMFLSSVGFSIVImSIWPYLqkIDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLY 122
Cdd:cd17502   1 LMLALFLAALDQTIVA-TALPTI--VAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLC 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31541926 123 AyvhvpAAHNKYYMLIARGLVGFGAGNV-AVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVF 187
Cdd:cd17502  78 G-----LAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLI 138
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 45-388 1.37e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 47.17  E-value: 1.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  45 LTMFLSSVGFSIVIMSIwPYLQKiDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLYAY 124
Cdd:cd17321   3 LAVFLAALDVTIVNVAL-PTIAR-DLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 125 vhvpaAHNKYYMLIARGLVGFGAG-----NVAVVRSYIAGAtslqERTNAMANTSTCQALGFILGPVFQtcfALIGEkGV 199
Cdd:cd17321  81 -----APSLAFLIAARALQGIGAAaimpaSLALIAATFPGE----RRGRALGLWGAVVGIGAALGPLLG---GLLLE-LF 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 200 TWDIIKLqVNmytAPVLLAAFLgilniililfilrehrvddLGRqcksvNFqeentdepqipegSIDQVAVVATNIVFFV 279
Cdd:cd17321 148 GWRWIFL-IN---VPIGLVALL-------------------LAR-----TF-------------SGAVLAAFLLGAALGG 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 280 VLFIFAVYETiltpltlDMYAWTQEQAvlydGILLVAFGVEAVLVFMGVKLLSKKIGERAILLGGFVVVWVGFFILLPWG 359
Cdd:cd17321 187 LLFLLPLYLQ-------GVLGYSPLQA----GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLG 255

                       330       340
                ....*....|....*....|....*....
gi 31541926 360 nqfpkiqwedlHNSSTPNTTFGEIIIGLW 388
Cdd:cd17321 256 -----------ADSSVWLLLPGLVLLGLG 273
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
38-187 3.72e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.05  E-value: 3.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  38 KSVRILYLTMFLSSVGFSIVIMSIWPYLQKIDQtADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVA 117
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLG-LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31541926 118 ANCLYAYVHvpaAHNKYYMLIARGLVGFGAGNVAVV-RSYIAGATSLQERTNAMANTST-------CQALGFILGPVF 187
Cdd:COG2211 307 GLLLLFFLG---PGNLWLLLVLAALAGIGLGAILVLpWAMLADVVDYDEWKTGRRREGLyfgiftfAIKLGQALAGAL 381
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
416-500 5.85e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.35  E-value: 5.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 416 HLAQFLTAAVLIGTGYPACSVMSYTLYSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFSLVCGIVVL 495
Cdd:COG2814  97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALL 176


                ....*
gi 31541926 496 TILLI 500
Cdd:COG2814 177 ALLLL 181
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
34-187 2.67e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.30  E-value: 2.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  34 KSRWKSVRILYLTMFLSSVGFSIViMSIWPYLQKIDQtADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSIS 113
Cdd:COG0738   4 KNYRRALIAIYLLFFLWGFATALW-GPLIPALKDAFG-LSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31541926 114 ISVAANCLYAYvhvpaAHNKYYMLIARGLVGFGAGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVF 187
Cdd:COG0738  82 LMALGLLLFAL-----APSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLL 150
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 38-187 2.75e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.31  E-value: 2.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  38 KSVRILYLTMFLSSVGFSIVIMSIWPYLQKIDQtADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVA 117
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPG-FSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 118 ANCLYAYVHVPAAhnkyyMLIARGLVGFGAGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVF 187
Cdd:cd17324 277 LLLLTLLGPSPLL-----LLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAAL 341
MFS_1 pfam07690
Major Facilitator Superfamily;
33-185 4.21e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.41  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926    33 YKSRWKSVRILYLTMFLSsVGFSIVIMSIWPYLQKIDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSI 112
Cdd:pfam07690 194 WKALLRDPVLWLLLALLL-FGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL 272

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31541926   113 SISVAANCLYAYVHVPAAHNKYYMLIArgLVGFGAG-NVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGP 185
Cdd:pfam07690 273 LLLILAALGLLLLSLTLSSLWLLLALL--LLGFGFGlVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_1 pfam07690
Major Facilitator Superfamily;
409-500 6.37e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.02  E-value: 6.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926   409 CLYTPVIHLAQFLTAAVLIGTGYPACSVMSYTLYSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFSL 488
Cdd:pfam07690  77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156

                          90
                  ....*....|..
gi 31541926   489 VCGIVVLTILLI 500
Cdd:pfam07690 157 LAILSLLAAVLL 168
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 42-187 1.10e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 41.41  E-value: 1.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  42 ILYLTMFLSSVGFSIVIMSIWPYLQKIDQTADASFLGwvIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCL 121
Cdd:cd17323   3 IISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLG--VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31541926 122 YAyvhvpAAHNKYYMLIARGLVGFGAGNV-AVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVF 187
Cdd:cd17323  81 CA-----LAPNIAMLIILRFLQGFFGSSPlAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPII 142
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 43-201 1.39e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.00  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  43 LYLTMFLS--SVGFSIVIMSIWpyLQKIDqtADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANC 120
Cdd:cd17477   1 LLLSVALLglGSGLLLPLLSLR--LEREG--VSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 121 LYAYVHVPAAhnkyyMLIARGLVGFG-AGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVFqtcFALIGEKGV 199
Cdd:cd17477  77 LLALTDSPWV-----WFLLRFVMGIGlAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL---LALVGTAGA 148


                ..
gi 31541926 200 TW 201
Cdd:cd17477 149 LP 150
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 42-355 1.40e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.02  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  42 ILYLTMFLSSVGfSIVIMSIWPYLQKIDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCL 121
Cdd:cd17473   3 TLLLASTLTVMA-GAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 122 YAYvhvpaAHNKYYMLIARGLVGFGAGNV-AVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVFQTCFALIGEKGVT 200
Cdd:cd17473  82 GLF-----LDSLYALLASRALLGIGVAGImTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPF 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 201 WdiiklqvnMYTAPVLLAAFLGILNiililfilREHRVDdlgrqcKSVNFQEENTDEPQIPEGSIdqVAVVATNIVFFVV 280
Cdd:cd17473 157 L--------VYLLALPVLILVLLFL--------PEPARK------SKSAASPGAATAAALPWKRV--LPIYFLAFLAMLL 212

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31541926 281 LFIFAVYetilTPLTL-DMYAWTQEQAvlydGILLVAFGVEAVLVFMGVKLLSKKIGERAILLGGFVVVWVGFFIL 355
Cdd:cd17473 213 FYVIPIQ----LPFLLqERGGGSAALI----GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL 280
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 410-500 1.43e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.04  E-value: 1.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 410 LYTPVIHLAQFLTAAVLIGTGYPACSVMSYTLYSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFSLV 489
Cdd:cd17489  77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156

                        90
                ....*....|.
gi 31541926 490 CGIVVLTILLI 500
Cdd:cd17489 157 AVLALLALLLV 167
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 47-187 1.48e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.02  E-value: 1.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  47 MFLSSVGFSIVIMSIwPYLQKiDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLYAyvh 126
Cdd:cd17503   5 AFMAILDTTIVNVAL-PTIMG-DLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCG--- 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31541926 127 vpAAHNKYYMLIARGLVGFGAGNVA-VVRSYIAGATSLQERTNAMANTSTCQALGFILGPVF 187
Cdd:cd17503  80 --LAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTL 139
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 38-199 1.91e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 40.64  E-value: 1.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  38 KSVRILYLTMFLSSVGFSIVIMsIWPYLqkIDQTADASFLGWVIAS------YSLGQMVASPLFGLWSNYRPRKEPLIVS 111
Cdd:cd17504 177 RNVLLANITALLAGFGMFMVFQ-LLPQL--LQLPTPTGFGLGITEAgllllpGALVMLIAGPLAGRLIARVGPRRVLLIG 253

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 112 ISISVAANCLYAYVHVPAAHnkyyMLIARGLVGFGAGN----------VAVVRSYIAGATSLqertNAMANTsTCQALGF 181
Cdd:cd17504 254 LVISAVGLLLLALLHSSLWA----LVVALLLIGIGLGLafaslpnivvESVPPDRTGIATGM----NTVLRT-IGSAIGP 324

                       170
                ....*....|....*...
gi 31541926 182 ILGPVFQTCFALIGEKGV 199
Cdd:cd17504 325 AIAGAILTTYTVSITSGG 342
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
77-506 2.85e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.25  E-value: 2.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  77 LGWVIASYSLGQMVASPLFGLWSN-YRPRKePLIVSISISVAANCLYAYvhvpaAHNKYYMLIARGLVGFGAG-NVAVVR 154
Cdd:COG2223  42 LGLLFAIPVLVGALLRIPLGFLVDrFGPRR-VLLIGLLLLGIGLLLLAL-----AVSYWLLLLLGLLLGIGGGgSFAVGI 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 155 SYIAGATSLQERTNAMANTSTCQALGFILGPVFQTcfALIGEKGVTWDIIklqvnMYTAPVLLAAFLGILNiililfilr 234
Cdd:COG2223 116 ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP--LLIAAFGWRNAFL-----ILGILLLVVAVLAWLF--------- 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 235 ehrvddlgrqcksvnFQEENTDEPQIPEGSIDQVAVVATN-------IVFFVVLFIFAVYETILTPLTLDMYAWTQEQAV 307
Cdd:COG2223 180 ---------------LRDPPAGAAAAAKASLRDQLEALRDprfwllsLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAG 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 308 LYDGILLVAFGVeaVLVFMGVklLSKKIGERAILLGGFVVVWVGFFILLPWGNQFPkiqwedlhnsstpnttfgeiiigl 387
Cdd:COG2223 245 LLAALFALLGAL--GRPLGGW--LSDRIGGRRVLLIVFALMALGLLLLALALGSLW------------------------ 296

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 388 wnssredhseqptgcpieqtwclytpvihlaQFLTAAVLIGTGYPACSVMSYTLYSKVLGPKPQGIYMGWLTTSGSAARI 467
Cdd:COG2223 297 -------------------------------LFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGF 345

                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 31541926 468 LGPVFISHVYTYLG-PRWAFSLVCGIVVLTILLIGAVYKR 506
Cdd:COG2223 346 LGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRR 385
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 36-196 3.43e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.86  E-value: 3.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  36 RWKSVRILYLTMFLSSVGFsIVIMSIWPYLQKIDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISIS 115
Cdd:cd17474 196 RGRGLLTFLVSAFLYFFLY-FAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLL 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 116 VAAnclyAYVHVPAAHNKYYMLIARGLVGFGAG-NVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVfqtCFALI 194
Cdd:cd17474 275 YAL----SLLLLGFVPSLALLLIAIVLFGLGLGlNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPL---LFGLL 347


                ..
gi 31541926 195 GE 196
Cdd:cd17474 348 LE 349
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 42-361 5.54e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.09  E-value: 5.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  42 ILYLTMFLSSVGFSIVImSIWPYLQKiDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCL 121
Cdd:cd17474   3 AVFFATLLAVLGVSIVD-PILPAIAE-ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 122 YAyvhvpAAHNKYYMLIARGLVGFGAG-----NVAVVRSYIAGAtslqERTNAMANTSTCQALGFILGPVFQtcfALIGE 196
Cdd:cd17474  81 CG-----LSDSFALLLAGRALQGIGAAglgplALTLIGDLFEGG----ERAKAMGLYEAALGLGIAVGPLLG---GLLAA 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 197 KGvtwdiiklqvnmYTAPVLLAAFLGILNIILILFILRehrvddlgrqcksvnfqEENTDEPQIPEGSIDQVAVVATNIV 276
Cdd:cd17474 149 IS------------WRYPFFLLAALIPVAFLAILFLLP-----------------EPKEKAKSSSATKLRDLKKALRGRG 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926 277 FFVVLFIFAV----YETILT--PLTLDMYAWTQEQAVlydGILLVAFGVEAVLVFMGV-KLLSKKIGERAILLGGFVVVW 349
Cdd:cd17474 200 LLTFLVSAFLyfflYFAFLTylPFLLELLYGISPIII---GLLFAGWSVLLALGSLFVgRLLKKRFGARRILVIGLLLYA 276

                       330
                ....*....|..
gi 31541926 350 VGFFILLPWGNQ 361
Cdd:cd17474 277 LSLLLLGFVPSL 288
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 73-158 6.05e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.09  E-value: 6.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  73 DASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLYAyvhvpAAHNKYYMLIARGLVGFGAG-NVA 151
Cdd:cd17315  32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA-----LAPNVWVLIVGRFLLGLGVGlASV 106


                ....*..
gi 31541926 152 VVRSYIA 158
Cdd:cd17315 107 LVPLYIS 113
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 78-186 7.40e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 38.74  E-value: 7.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  78 GWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLYAYvhvpaAHNKYYMLIARGLVGFGAGNvAVVRSYI 157
Cdd:cd17472  35 GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAY-----ATSIYGLILGRALQGSGAIS-SVVMALL 108

                        90       100       110
                ....*....|....*....|....*....|...
gi 31541926 158 AGATSLQERTNAMANTSTCQ----ALGFILGPV 186
Cdd:cd17472 109 ADLTREENRTKAMALIGASIgiafAISMVLGPL 141
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 42-187 7.49e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 38.71  E-value: 7.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31541926  42 ILYLTMFLSSVGFSIVIMSiwPYLQKIDQT--ADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAAN 119
Cdd:cd17320   1 LLLLALLVALGPLAIDMYL--PALPAIARDlgASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILAS 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31541926 120 CLYAyvhvpAAHNKYYMLIARGLVGFGAGNVAVV-RSYIAGATSLQERTNAMANTSTCQALGFILGPVF 187
Cdd:cd17320  79 LLCA-----LASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMILAIAPALAPLL 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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