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Conserved domains on  [gi|58037271|ref|NP_082246|]
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sperm microtubule associated protein 2-like isoform 1 [Mus musculus]

Protein Classification

THEG domain-containing protein( domain architecture ID 10633003)

THEG domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 208-275 7.48e-16

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 71.46  E-value: 7.48e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58037271   208 PVSEAALKAKLSKRIEDLAQPRLVSRHYVPNRiqyyyscgreSVIWEISPPALVTRPSKRIQKLAKPN 275
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDR----------PVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 398-457 1.04e-14

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 68.38  E-value: 1.04e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037271   398 WPVSYAATHSQVSERVQELANPHTRGPANlVYYDPNVFKVKPSALKAHCSDRVKELAEPI 457
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKPKEPHDIY-EPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 363-419 1.25e-11

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 59.52  E-value: 1.25e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 58037271   363 PVAPAALLANPSKRTIFLAKSKRVHEDYLPIRDARWPVSYAATHSQVSERVQELANP 419
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKP 58
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 253-344 7.70e-08

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 48.74  E-value: 7.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037271   253 WEISPPALVTRPSKRIQKLAKPnkfkaqslikretvpgttrysdpsprilrlsiaKGTNPSYLPPKTLETKISFSTLSAV 332
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKP---------------------------------KEPHDIYEPDRPVEWKVSPAALKAK 47

                          90
                  ....*....|..
gi 58037271   333 ATPRIVDLAHPR 344
Cdd:pfam14912  48 PSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 173-229 1.49e-06

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 45.27  E-value: 1.49e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 58037271   173 KCFYSRKRVQDLSKPKkqwgtPDRRLFWGNQDPIRPVSEAALKAKLSKRIEDLAQPR 229
Cdd:pfam14912   8 LKAKASPRLKELAKPK-----EPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
 
Name Accession Description Interval E-value
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 208-275 7.48e-16

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 71.46  E-value: 7.48e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58037271   208 PVSEAALKAKLSKRIEDLAQPRLVSRHYVPNRiqyyyscgreSVIWEISPPALVTRPSKRIQKLAKPN 275
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDR----------PVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 398-457 1.04e-14

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 68.38  E-value: 1.04e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037271   398 WPVSYAATHSQVSERVQELANPHTRGPANlVYYDPNVFKVKPSALKAHCSDRVKELAEPI 457
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKPKEPHDIY-EPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 363-419 1.25e-11

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 59.52  E-value: 1.25e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 58037271   363 PVAPAALLANPSKRTIFLAKSKRVHEDYLPIRDARWPVSYAATHSQVSERVQELANP 419
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKP 58
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 253-344 7.70e-08

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 48.74  E-value: 7.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037271   253 WEISPPALVTRPSKRIQKLAKPnkfkaqslikretvpgttrysdpsprilrlsiaKGTNPSYLPPKTLETKISFSTLSAV 332
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKP---------------------------------KEPHDIYEPDRPVEWKVSPAALKAK 47

                          90
                  ....*....|..
gi 58037271   333 ATPRIVDLAHPR 344
Cdd:pfam14912  48 PSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 173-229 1.49e-06

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 45.27  E-value: 1.49e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 58037271   173 KCFYSRKRVQDLSKPKkqwgtPDRRLFWGNQDPIRPVSEAALKAKLSKRIEDLAQPR 229
Cdd:pfam14912   8 LKAKASPRLKELAKPK-----EPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
 
Name Accession Description Interval E-value
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 208-275 7.48e-16

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 71.46  E-value: 7.48e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58037271   208 PVSEAALKAKLSKRIEDLAQPRLVSRHYVPNRiqyyyscgreSVIWEISPPALVTRPSKRIQKLAKPN 275
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDR----------PVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 398-457 1.04e-14

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 68.38  E-value: 1.04e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037271   398 WPVSYAATHSQVSERVQELANPHTRGPANlVYYDPNVFKVKPSALKAHCSDRVKELAEPI 457
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKPKEPHDIY-EPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 363-419 1.25e-11

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 59.52  E-value: 1.25e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 58037271   363 PVAPAALLANPSKRTIFLAKSKRVHEDYLPIRDARWPVSYAATHSQVSERVQELANP 419
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKP 58
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 253-344 7.70e-08

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 48.74  E-value: 7.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037271   253 WEISPPALVTRPSKRIQKLAKPnkfkaqslikretvpgttrysdpsprilrlsiaKGTNPSYLPPKTLETKISFSTLSAV 332
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKP---------------------------------KEPHDIYEPDRPVEWKVSPAALKAK 47

                          90
                  ....*....|..
gi 58037271   333 ATPRIVDLAHPR 344
Cdd:pfam14912  48 PSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 173-229 1.49e-06

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 45.27  E-value: 1.49e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 58037271   173 KCFYSRKRVQDLSKPKkqwgtPDRRLFWGNQDPIRPVSEAALKAKLSKRIEDLAQPR 229
Cdd:pfam14912   8 LKAKASPRLKELAKPK-----EPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 323-384 2.57e-06

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 44.50  E-value: 2.57e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58037271   323 KISFSTLSAVATPRIVDLAHPRIKIEGLCYERErselPIRPVAPAALLANPSKRTIFLAKSK 384
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDRP----VEWKVSPAALKAKPSPRIEELAKPK 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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