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Conserved domains on  [gi|85861229|ref|NP_082177|]
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general transcription factor 3C polypeptide 2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 555-640 1.71e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 555 SLAWMPTrpHHHLAAGYYNGMVVFWNLPTNSPLQRIRL---------------------SDGSLKLY------PFQCFLA 607
Cdd:cd00200 140 SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLTGhtgevnsvafspdgekllsssSDGTIKLWdlstgkCLGTLRG 217

                        90       100       110
                ....*....|....*....|....*....|...
gi 85861229 608 HDQAVRTIQWCKaNSHFLVSAGSDRKIKFWDLR 640
Cdd:cd00200 218 HENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 53-292 3.02e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 3.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229    53 PPPLPGFEDSS--DRRLPPDQESLTRLEQQDLSSEmskvsnTRASKPSGRRGGRTARGAKRPQQRKPPSTPLVPGLLDQS 130
Cdd:PHA03247 2552 PPPLPPAAPPAapDRSVPPPRPAPRPSEPAVTSRA------RRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229   131 NPLSTPMPKKRSQKSKGDLLLLKLSKGLDQPESPH---------PKRPPEDFETPsgERPRRRAAQVALLYLQELAEELS 201
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRvsrprrarrLGRAAQASSPP--QRPRRRAARPTVGSLTSLADPPP 2703

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229   202 TALPAPPLSGPKSPKVSSPTKPKKTRQASSQGEEDGSARDEDfVLQVEGEDEEESEAPSENSSDPEPVAPRSTPRGPAAG 281
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                         250
                  ....*....|.
gi 85861229   282 KQKPHCRGMAP 292
Cdd:PHA03247 2783 LTRPAVASLSE 2793
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 555-640 1.71e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 555 SLAWMPTrpHHHLAAGYYNGMVVFWNLPTNSPLQRIRL---------------------SDGSLKLY------PFQCFLA 607
Cdd:cd00200 140 SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLTGhtgevnsvafspdgekllsssSDGTIKLWdlstgkCLGTLRG 217

                        90       100       110
                ....*....|....*....|....*....|...
gi 85861229 608 HDQAVRTIQWCKaNSHFLVSAGSDRKIKFWDLR 640
Cdd:cd00200 218 HENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249
PHA03247 PHA03247
large tegument protein UL36; Provisional
 53-292 3.02e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 3.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229    53 PPPLPGFEDSS--DRRLPPDQESLTRLEQQDLSSEmskvsnTRASKPSGRRGGRTARGAKRPQQRKPPSTPLVPGLLDQS 130
Cdd:PHA03247 2552 PPPLPPAAPPAapDRSVPPPRPAPRPSEPAVTSRA------RRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229   131 NPLSTPMPKKRSQKSKGDLLLLKLSKGLDQPESPH---------PKRPPEDFETPsgERPRRRAAQVALLYLQELAEELS 201
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRvsrprrarrLGRAAQASSPP--QRPRRRAARPTVGSLTSLADPPP 2703

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229   202 TALPAPPLSGPKSPKVSSPTKPKKTRQASSQGEEDGSARDEDfVLQVEGEDEEESEAPSENSSDPEPVAPRSTPRGPAAG 281
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                         250
                  ....*....|.
gi 85861229   282 KQKPHCRGMAP 292
Cdd:PHA03247 2783 LTRPAVASLSE 2793
WD40 COG2319
WD40 repeat [General function prediction only];
551-640 3.40e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 3.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 551 GQCLSLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRirlsdgslklypfqcFLAHDQAVRTIQWcKANSHFLVSAGS 630
Cdd:COG2319 331 GAVRSVAFSPDG--KTLASGSDDGTVRLWDLATGELLRT---------------LTGHTGAVTSVAF-SPDGRTLASGSA 392

                        90
                ....*....|
gi 85861229 631 DRKIKFWDLR 640
Cdd:COG2319 393 DGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 601-638 5.30e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.30e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 85861229    601 PFQCFLAHDQAVRTIQWCKaNSHFLVSAGSDRKIKFWD 638
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
601-638 5.26e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 5.26e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 85861229   601 PFQCFLAHDQAVRTIQWCKaNSHFLVSAGSDRKIKFWD 638
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 555-640 1.71e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 555 SLAWMPTrpHHHLAAGYYNGMVVFWNLPTNSPLQRIRL---------------------SDGSLKLY------PFQCFLA 607
Cdd:cd00200 140 SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLTGhtgevnsvafspdgekllsssSDGTIKLWdlstgkCLGTLRG 217

                        90       100       110
                ....*....|....*....|....*....|...
gi 85861229 608 HDQAVRTIQWCKaNSHFLVSAGSDRKIKFWDLR 640
Cdd:cd00200 218 HENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 499-640 1.84e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 499 CSDGKVLLFSLPHPEALLAQQPPdamKPAIYKVQCLA------------TLQVGSVQASDPSE-----CGQCLSLAWMPT 561
Cdd:cd00200  28 SGDGTIKVWDLETGELLRTLKGH---TGPVRDVAASAdgtylasgssdkTIRLWDLETGECVRtltghTSYVSSVAFSPD 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 562 RphHHLAAGYYNGMVVFWNLPTNSPLQRIR---------------------LSDGSLKLY---PFQC---FLAHDQAVRT 614
Cdd:cd00200 105 G--RILSSSSRDKTIKVWDVETGKCLTTLRghtdwvnsvafspdgtfvassSQDGTIKLWdlrTGKCvatLTGHTGEVNS 182

                       170       180
                ....*....|....*....|....*.
gi 85861229 615 IQWCKANSHFLvSAGSDRKIKFWDLR 640
Cdd:cd00200 183 VAFSPDGEKLL-SSSSDGTIKLWDLS 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 551-640 2.14e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 2.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 551 GQCLSLAWMPtrPHHHLAAGYYNGMVVFWNLPTNSPLQRirlsdgslklypfqcFLAHDQAVRTIQWCkANSHFLVSAGS 630
Cdd:cd00200  10 GGVTCVAFSP--DGKLLATGSGDGTIKVWDLETGELLRT---------------LKGHTGPVRDVAAS-ADGTYLASGSS 71

                        90
                ....*....|
gi 85861229 631 DRKIKFWDLR 640
Cdd:cd00200  72 DKTIRLWDLE 81
PHA03247 PHA03247
large tegument protein UL36; Provisional
 53-292 3.02e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 3.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229    53 PPPLPGFEDSS--DRRLPPDQESLTRLEQQDLSSEmskvsnTRASKPSGRRGGRTARGAKRPQQRKPPSTPLVPGLLDQS 130
Cdd:PHA03247 2552 PPPLPPAAPPAapDRSVPPPRPAPRPSEPAVTSRA------RRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229   131 NPLSTPMPKKRSQKSKGDLLLLKLSKGLDQPESPH---------PKRPPEDFETPsgERPRRRAAQVALLYLQELAEELS 201
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRvsrprrarrLGRAAQASSPP--QRPRRRAARPTVGSLTSLADPPP 2703

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229   202 TALPAPPLSGPKSPKVSSPTKPKKTRQASSQGEEDGSARDEDfVLQVEGEDEEESEAPSENSSDPEPVAPRSTPRGPAAG 281
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                         250
                  ....*....|.
gi 85861229   282 KQKPHCRGMAP 292
Cdd:PHA03247 2783 LTRPAVASLSE 2793
WD40 COG2319
WD40 repeat [General function prediction only];
551-640 3.40e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 3.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 551 GQCLSLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRirlsdgslklypfqcFLAHDQAVRTIQWcKANSHFLVSAGS 630
Cdd:COG2319 331 GAVRSVAFSPDG--KTLASGSDDGTVRLWDLATGELLRT---------------LTGHTGAVTSVAF-SPDGRTLASGSA 392

                        90
                ....*....|
gi 85861229 631 DRKIKFWDLR 640
Cdd:COG2319 393 DGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
555-640 1.36e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 555 SLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTIQWCkANSHFLVSAGSDRKI 634
Cdd:COG2319 209 SVAFSPDG--KLLASGSADGTVRLWDLATGKLLRTLT---------------GHSGSVRSVAFS-PDGRLLASGSADGTV 270


                ....*.
gi 85861229 635 KFWDLR 640
Cdd:COG2319 271 RLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
554-640 2.09e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 2.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 554 LSLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRI-----------------RL----SDGSLKLY------PFQCFL 606
Cdd:COG2319 250 RSVAFSPDG--RLLASGSADGTVRLWDLATGELLRTLtghsggvnsvafspdgkLLasgsDDGTVRLWdlatgkLLRTLT 327

                        90       100       110
                ....*....|....*....|....*....|....
gi 85861229 607 AHDQAVRTIQWcKANSHFLVSAGSDRKIKFWDLR 640
Cdd:COG2319 328 GHTGAVRSVAF-SPDGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
555-642 2.13e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 2.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 555 SLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTIQWCkANSHFLVSAGSDRKI 634
Cdd:COG2319 167 SVAFSPDG--KLLASGSDDGTVRLWDLATGKLLRTLT---------------GHTGAVRSVAFS-PDGKLLASGSADGTV 228


                ....*...
gi 85861229 635 KFWDLRRP 642
Cdd:COG2319 229 RLWDLATG 236
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 601-638 5.30e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.30e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 85861229    601 PFQCFLAHDQAVRTIQWCKaNSHFLVSAGSDRKIKFWD 638
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 532-638 5.95e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 5.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229 532 QCLATLQvgsvqasdpSECGQCLSLAWMPTRphHHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQA 611
Cdd:cd00200 210 KCLGTLR---------GHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGECVQTLS---------------GHTNS 263

                        90       100
                ....*....|....*....|....*..
gi 85861229 612 VRTIQWCkANSHFLVSAGSDRKIKFWD 638
Cdd:cd00200 264 VTSLAWS-PDGKRLASGSADGTIRIWD 289
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 25-285 6.32e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.99  E-value: 6.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229   25 SPGQEELSqlDVKASETSGVEASiemSLPPPLPGFEDSSDRRLPPDQESLTRLEQQDLSSEMS-----KVSNTRASKPSG 99
Cdd:PTZ00449 497 APIEEEDS--DKHDEPPEGPEAS---GLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEgevgkKPGPAKEHKPSK 571

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229  100 -------RRGGRTARGAKRPQQRKPPSTPLVPglldqSNPLSTPMPKKrsqkskgdLLLLKLSKGLDQPESP-HPKRPPE 171
Cdd:PTZ00449 572 iptlskkPEFPKDPKHPKDPEEPKKPKRPRSA-----QRPTRPKSPKL--------PELLDIPKSPKRPESPkSPKRPPP 638

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229  172 DFETPSGERPRrraaqvallylqelaeelSTALPAPPLSgPKSPKVssPTKPK---------KTRQASSQGEEDGSARDE 242
Cdd:PTZ00449 639 PQRPSSPERPE------------------GPKIIKSPKP-PKSPKP--PFDPKfkekfyddyLDAAAKSKETKTTVVLDE 697

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 85861229  243 DFVLQVEGEDEEESEAPSENSSDPEPVAPRsTPRGPAAGKQKP 285
Cdd:PTZ00449 698 SFESILKETLPETPGTPFTTPRPLPPKLPR-DEEFPFEPIGDP 739
WD40 COG2319
WD40 repeat [General function prediction only];
565-640 6.48e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 6.48e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 85861229 565 HHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTIQWCkANSHFLVSAGSDRKIKFWDLR 640
Cdd:COG2319 133 KTLASGSADGTVRLWDLATGKLLRTLT---------------GHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLA 192
PHA03247 PHA03247
large tegument protein UL36; Provisional
 52-294 7.61e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 7.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229    52 LPPPLPGFEDSSDRRLPPDQESLTRLEQQDLSSEMSKVS-NTRASKPSGRRGGRTARGAKRPQQRKPPSTPLVpGLLDQS 130
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrPRRARRLGRAAQASSPPQRPRRRAARPTVGSLT-SLADPP 2702

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229   131 NPLSTPMPKKR---SQKSKGDLLLLKLSKGLDQPESPHPKRPPEDFETPSGERPRRRAAQVAllylqelaeelSTALPAP 207
Cdd:PHA03247 2703 PPPPTPEPAPHalvSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTA-----------GPPAPAP 2771

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85861229   208 PlSGPKSPKVSSPTKPKKTRQASSQGEEDGSARDEDFVLQVEGEDEEESEAPSENSSDPEPVAPRSTPRGPAAGKQKPH- 286
Cdd:PHA03247 2772 P-AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSl 2850

                         250
                  ....*....|
gi 85861229   287 --CRGMAPNG 294
Cdd:PHA03247 2851 plGGSVAPGG 2860
WD40 pfam00400
WD domain, G-beta repeat;
601-638 5.26e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 5.26e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 85861229   601 PFQCFLAHDQAVRTIQWCKaNSHFLVSAGSDRKIKFWD 638
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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