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Conserved domains on  [gi|254588079|ref|NP_081919|]
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N-alpha-acetyltransferase 40 [Mus musculus]

Protein Classification

N-acetyltransferase( domain architecture ID 1000386)

N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate; similar to Drosophila melanogaster arylalkylamine N-acetyltransferase 1 that catalyzes N-acetylation of tryptamine, tyramine, dopamine, serotonin, and octopamine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI super family cl33885
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 131-199 1.33e-04

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG0456:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 39.64  E-value: 1.33e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254588079 131 GDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVMLTVFKHNHGAYQFFrEALQFEIDDSSP 199
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALY-EKLGFEEVGERP 77
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 131-199 1.33e-04

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 39.64  E-value: 1.33e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254588079 131 GDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVMLTVFKHNHGAYQFFrEALQFEIDDSSP 199
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALY-EKLGFEEVGERP 77
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 80-188 2.03e-04

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 39.81  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254588079   80 NMQTMYEQSEWGWKDREKREEMTDDRAWYLIAWENSSIPVAFSHFRFDvecGDEVLYCYEVQLE--SKVRRKGLGKFLIQ 157
Cdd:pfam00583   6 ELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSII---DDEPPVGEIEGLAvaPEYRGKGIGTALLQ 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 254588079  158 ILQLMANSTQMKKVMLTVFKHNHGAYQFFRE 188
Cdd:pfam00583  83 ALLEWARERGCERIFLEVAADNLAAIALYEK 113
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 131-199 1.33e-04

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 39.64  E-value: 1.33e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254588079 131 GDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVMLTVFKHNHGAYQFFrEALQFEIDDSSP 199
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALY-EKLGFEEVGERP 77
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 80-188 2.03e-04

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 39.81  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254588079   80 NMQTMYEQSEWGWKDREKREEMTDDRAWYLIAWENSSIPVAFSHFRFDvecGDEVLYCYEVQLE--SKVRRKGLGKFLIQ 157
Cdd:pfam00583   6 ELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSII---DDEPPVGEIEGLAvaPEYRGKGIGTALLQ 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 254588079  158 ILQLMANSTQMKKVMLTVFKHNHGAYQFFRE 188
Cdd:pfam00583  83 ALLEWARERGCERIFLEVAADNLAAIALYEK 113
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
85-217 2.88e-04

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 39.98  E-value: 2.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254588079  85 YEQSEWGWKDREKR-EEMTDDRAWYLIAWENSSIpVAFSHF-RFDVECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLM 162
Cdd:COG1247   30 FETEPPSEEEREAWfAAILAPGRPVLVAEEDGEV-VGFASLgPFRPRPAYRGTAEESIYVDPDARGRGIGRALLEALIER 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 254588079 163 ANSTQMKKVMLTVFKHNHGAYQFFrEALQFEIDDSSPSMSGCCGEDCSYEILSRR 217
Cdd:COG1247  109 ARARGYRRLVAVVLADNEASIALY-EKLGFEEVGTLPEVGFKFGRWLDLVLMQKR 162
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 94-187 8.20e-03

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 35.41  E-value: 8.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254588079  94 DREKREEMTDDRAWYLIAWENSSIPVAFSHFRfdvECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVML 173
Cdd:COG0454   21 DAELKAMEGSLAGAEFIAVDDKGEPIGFAGLR---RLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALEL 97

                         90
                 ....*....|....
gi 254588079 174 TVFKHNHGAYQFFR 187
Cdd:COG0454   98 DTLDGNPAAIRFYE 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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