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Conserved domains on  [gi|227116268|ref|NP_080836|]
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borealin [Mus musculus]

Protein Classification

Nbl1_Borealin_N and Borealin domain-containing protein( domain architecture ID 10564529)

Nbl1_Borealin_N and Borealin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Borealin pfam10512
Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, ...
 170-284 6.73e-36

Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters.


:

Pssm-ID: 463127  Cd Length: 120  Bit Score: 124.79  E-value: 6.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116268  170 RSKRLShdFVTPAMSRLEP-----SLVKPTPGMTPRFDSRVFKTPGLRTPAAKEQVYNISinGSPLADS----KEISLSV 240
Cdd:pfam10512   1 RSSRSK--LRTPMAARPKAqsadrSPLGGTPLITPKFDPRTPKTPFLRTPRAGERVYSIS--GSPLATGvmpeEDANVNI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 227116268  241 PIGGGASLRLLASDLQRIDIAQLNPEALGNIRKLSSRLAQICSS 284
Cdd:pfam10512  77 PVGDGESLSLLASDLDSVDLPQLDPETLGQIKLLQSNLAKICKK 120
Nbl1_Borealin_N pfam10444
Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger ...
 20-76 1.09e-15

Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localization, stability, integrity, and function. The N terminus of Borealin is homologous to Nbl1. This family contains both Nbl1, and the N terminal region of Borealin.


:

Pssm-ID: 463095  Cd Length: 57  Bit Score: 69.90  E-value: 1.09e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 227116268   20 KLASFLKDFDREVQVRTKQIESDRQTLLKEVENLYNIEILRLPKALQGMKWLDYFAL 76
Cdd:pfam10444   1 KKEALLQNFDLEVEERVRRLRSKLELLLKTLRNRYELRLLRIPKAVRKMTLRELLAK 57
 
Name Accession Description Interval E-value
Borealin pfam10512
Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, ...
 170-284 6.73e-36

Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters.


Pssm-ID: 463127  Cd Length: 120  Bit Score: 124.79  E-value: 6.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116268  170 RSKRLShdFVTPAMSRLEP-----SLVKPTPGMTPRFDSRVFKTPGLRTPAAKEQVYNISinGSPLADS----KEISLSV 240
Cdd:pfam10512   1 RSSRSK--LRTPMAARPKAqsadrSPLGGTPLITPKFDPRTPKTPFLRTPRAGERVYSIS--GSPLATGvmpeEDANVNI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 227116268  241 PIGGGASLRLLASDLQRIDIAQLNPEALGNIRKLSSRLAQICSS 284
Cdd:pfam10512  77 PVGDGESLSLLASDLDSVDLPQLDPETLGQIKLLQSNLAKICKK 120
Nbl1_Borealin_N pfam10444
Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger ...
 20-76 1.09e-15

Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localization, stability, integrity, and function. The N terminus of Borealin is homologous to Nbl1. This family contains both Nbl1, and the N terminal region of Borealin.


Pssm-ID: 463095  Cd Length: 57  Bit Score: 69.90  E-value: 1.09e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 227116268   20 KLASFLKDFDREVQVRTKQIESDRQTLLKEVENLYNIEILRLPKALQGMKWLDYFAL 76
Cdd:pfam10444   1 KKEALLQNFDLEVEERVRRLRSKLELLLKTLRNRYELRLLRIPKAVRKMTLRELLAK 57
 
Name Accession Description Interval E-value
Borealin pfam10512
Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, ...
 170-284 6.73e-36

Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters.


Pssm-ID: 463127  Cd Length: 120  Bit Score: 124.79  E-value: 6.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116268  170 RSKRLShdFVTPAMSRLEP-----SLVKPTPGMTPRFDSRVFKTPGLRTPAAKEQVYNISinGSPLADS----KEISLSV 240
Cdd:pfam10512   1 RSSRSK--LRTPMAARPKAqsadrSPLGGTPLITPKFDPRTPKTPFLRTPRAGERVYSIS--GSPLATGvmpeEDANVNI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 227116268  241 PIGGGASLRLLASDLQRIDIAQLNPEALGNIRKLSSRLAQICSS 284
Cdd:pfam10512  77 PVGDGESLSLLASDLDSVDLPQLDPETLGQIKLLQSNLAKICKK 120
Nbl1_Borealin_N pfam10444
Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger ...
 20-76 1.09e-15

Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localization, stability, integrity, and function. The N terminus of Borealin is homologous to Nbl1. This family contains both Nbl1, and the N terminal region of Borealin.


Pssm-ID: 463095  Cd Length: 57  Bit Score: 69.90  E-value: 1.09e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 227116268   20 KLASFLKDFDREVQVRTKQIESDRQTLLKEVENLYNIEILRLPKALQGMKWLDYFAL 76
Cdd:pfam10444   1 KKEALLQNFDLEVEERVRRLRSKLELLLKTLRNRYELRLLRIPKAVRKMTLRELLAK 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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