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Conserved domains on  [gi|31982546|ref|NP_080290|]
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DNA replication factor Cdt1 [Mus musculus]

Protein Classification

DNA replication factor Cdt1 C-terminal domain-containing protein( domain architecture ID 10171419)

DNA replication factor Cdt1 C-terminal domain-containing protein may directly interact with the MCM2-7 helicase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cdt1_m cd08674
The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit ...
 181-364 1.77e-88

The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA; Cdt1 is a replication licensing factor in eukaryotes that recruits the Minichromosome Maintenance Complex (MCM2-7) to the origin recognition complex (ORC). The Cdt1 protein is divided into three regions based on sequence comparison and biochemical analyses: the N-terminal region (Cdt1_n) binds DNA in a sequence-, strand-, and conformation-independent manner; the middle winged helix fold (Cdt1_m) binds geminin to inhibit both binding of the MCM complex to origins of replication and DNA; and the C-terminal region (Cdt1_c) is essential for Cdt1 activity and directly interacts with the MCM2-7 helicase. Precise duplication of chromosomal DNA is required for genomic stability during replication. Assembly of replication factors to start DNA replication in eukaryotes must occur only once per cell cycle. To form a pre-replicative complex on replication origins in the G phase, ORC first binds origin DNA and triggers the binding of Cdc6 and Cdt1. These two factors recruit a putative replicative helicase and the MCM2-7. The MCM2-7 complex promotes the unwinding of DNA origins, and the binding of additional factors to initiate the DNA replication in S-phase. Cdt1 is present during G1 and early S phase of the cell cycle and degraded during the late S, G2, and M phases. The winged helix fold structure of Cdt1_m is similar to the structures of Cdt1_c and other archaeal homologues of the eukaryotic replication initiator, without apparent sequence similarity.


:

Pssm-ID: 176571  Cd Length: 185  Bit Score: 270.72  E-value: 1.77e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546 181 PAYQRFHALAQPGLPGLVLPYKYQVLVEMFRSMDTIVSMLHNRSETVTFAKVKQGVQEMMRKRFEERNVGQIKTVYPTSY 260
Cdd:cd08674   1 PAYQRYHSLASSVRPSLKLPEKYEVLAELFRSLDTIVRLLFNRKETCTFDKLKPAVERMTRRRFSEKHLAQIKHIYPEAY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546 261 RFRQECNVPTfKDSIKRSDYQLTIEPLLGQ--EAGGATQLTATCLLQRRQVFRQNLVERVKEQHKVFLASLNPPMAVPDD 338
Cdd:cd08674  81 TLRQEKNHDE-GSLCKKPDYQLTLEPNLVEglELGGSPKLSESRLLARRQVFRSRLLDFVKAHHEEFLISLDPPPPIPDD 159

                       170       180
                ....*....|....*....|....*.
gi 31982546 339 QLTRWHPRFNVDEVPDIEPAELPQPP 364
Cdd:cd08674 160 KLTRWHPKFDLESVPDIEPAELPQPP 185
Cdt1_c cd08767
The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and ...
 427-549 7.61e-53

The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase; Cdt1 is a replication licensing factor in eukaryotes that recruits the Minichromosome Maintenance Complex (MCM2-7) to the Origin Recognition Complex (ORC). The Cdt1 protein is divided into three regions based on sequence comparison and biochemical analyses: the N-terminal region (Cdt1_n) binds DNA in a sequence-, strand-, and conformation-independent manner; the middle winged helix fold (Cdt1_m) binds geminin to inhibit both binding of the MCM complex to origins of replication and DNA; and the C-terminal region (Cdt1_c) is essential for Cdt1 activity and directly interacts with the MCM2-7 helicase. Precise duplication of chromosomal DNA is required for genomic stability during replication. Assembly of replication factors to start DNA replication in eukaryotes must occur only once per cell cycle. To form a pre-replicative complex on replication origins in the G phase, ORC first binds origin DNA and triggers the binding of Cdc6 and Cdt1. These two factors recruit a putative replicative helicase and the MCM2-7. The MCM2-7 complex promotes the unwinding of DNA origins, and the binding of additional factors to initiate the DNA replication in S-phase. Cdt1 is present during G1 and early S phase of the cell cycle and is degraded during the late S, G2, and M phases. The winged helix fold structure of Cdt1_m is similar to the structures of Cdt1_c and archaeal homologues of the eukaryotic replication initiator, without apparent sequence similarity.


:

Pssm-ID: 176572  Cd Length: 126  Bit Score: 175.93  E-value: 7.61e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546 427 LKGVSQALLERIRAKEVQKQLARMTRCPEQELRLQRLERLPELARVLRNVFVSERKPALTMEVVCARMVDSCQTALSPGE 506
Cdd:cd08767   4 LKGVPKSLLERIRAKEAAKALEKMTRRPEQEKRRRMYARLPELARILRNIFVSEKKTVLPLEELVYKLQASYPSILSRGE 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 31982546 507 MEKHLVLLAELLPDWLSLHRIRTDTYVKLDKAVDLAGLTARLA 549
Cdd:cd08767  84 VEEHLRLLAELAPDWISEKSLRKGDYLKIDKKVDLEKVRKRLE 126
 
Name Accession Description Interval E-value
Cdt1_m cd08674
The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit ...
 181-364 1.77e-88

The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA; Cdt1 is a replication licensing factor in eukaryotes that recruits the Minichromosome Maintenance Complex (MCM2-7) to the origin recognition complex (ORC). The Cdt1 protein is divided into three regions based on sequence comparison and biochemical analyses: the N-terminal region (Cdt1_n) binds DNA in a sequence-, strand-, and conformation-independent manner; the middle winged helix fold (Cdt1_m) binds geminin to inhibit both binding of the MCM complex to origins of replication and DNA; and the C-terminal region (Cdt1_c) is essential for Cdt1 activity and directly interacts with the MCM2-7 helicase. Precise duplication of chromosomal DNA is required for genomic stability during replication. Assembly of replication factors to start DNA replication in eukaryotes must occur only once per cell cycle. To form a pre-replicative complex on replication origins in the G phase, ORC first binds origin DNA and triggers the binding of Cdc6 and Cdt1. These two factors recruit a putative replicative helicase and the MCM2-7. The MCM2-7 complex promotes the unwinding of DNA origins, and the binding of additional factors to initiate the DNA replication in S-phase. Cdt1 is present during G1 and early S phase of the cell cycle and degraded during the late S, G2, and M phases. The winged helix fold structure of Cdt1_m is similar to the structures of Cdt1_c and other archaeal homologues of the eukaryotic replication initiator, without apparent sequence similarity.


Pssm-ID: 176571  Cd Length: 185  Bit Score: 270.72  E-value: 1.77e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546 181 PAYQRFHALAQPGLPGLVLPYKYQVLVEMFRSMDTIVSMLHNRSETVTFAKVKQGVQEMMRKRFEERNVGQIKTVYPTSY 260
Cdd:cd08674   1 PAYQRYHSLASSVRPSLKLPEKYEVLAELFRSLDTIVRLLFNRKETCTFDKLKPAVERMTRRRFSEKHLAQIKHIYPEAY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546 261 RFRQECNVPTfKDSIKRSDYQLTIEPLLGQ--EAGGATQLTATCLLQRRQVFRQNLVERVKEQHKVFLASLNPPMAVPDD 338
Cdd:cd08674  81 TLRQEKNHDE-GSLCKKPDYQLTLEPNLVEglELGGSPKLSESRLLARRQVFRSRLLDFVKAHHEEFLISLDPPPPIPDD 159

                       170       180
                ....*....|....*....|....*.
gi 31982546 339 QLTRWHPRFNVDEVPDIEPAELPQPP 364
Cdd:cd08674 160 KLTRWHPKFDLESVPDIEPAELPQPP 185
CDT1 pfam08839
DNA replication factor CDT1 like; CDT1 is a component of the replication licensing system and ...
 199-361 2.98e-85

DNA replication factor CDT1 like; CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin. Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin. This region of CDT1 binds to Geminin.


Pssm-ID: 462618  Cd Length: 172  Bit Score: 261.87  E-value: 2.98e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546   199 LPYKYQVLVEMFRSMDTIVSMLHNRSETVTFAKVKQGVQEMMRKRFEERNVGQIKTVYPTSYRFRQECNVPTFKDSIKRS 278
Cdd:pfam08839   1 LPYKYEVLAEMFRALDTIVSMLFNRNETITFDKLKPAVQRMTRKSFTEKHLAQIKHVYPEAYKLRQEKNLRNFGSGGKKD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546   279 DYQLTIEPLLG--------QEAGGATQLTATCLLQRRQVFRQNLVERVKEQHKVFLASLNPPMAVPD-DQLTRWHPRFNV 349
Cdd:pfam08839  81 DYQLVIEPNLEddledlatAATDGRRRLSASRLLERRHKFRRNLLNIVKKHHEEFLASLDPPMSVPDlDKLTRWHPEFDL 160

                         170
                  ....*....|..
gi 31982546   350 DEVPDIEPAELP 361
Cdd:pfam08839 161 DTVPDIEPAELP 172
CDT1 smart01075
DNA replication factor CDT1 like; CDT1 is a component of the replication licensing system and ...
 199-362 7.11e-78

DNA replication factor CDT1 like; CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin. Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin. This region of CDT1 binds to Geminin.


Pssm-ID: 215014  Cd Length: 164  Bit Score: 242.69  E-value: 7.11e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546    199 LPYKYQVLVEMFRSMDTIVSMLHNRSETVTFAKVKQGVQEMMRKRFEERNVGQIKTVYPTSYRFRQECNVPTFKDSIKRS 278
Cdd:smart01075   1 LPEKYEVLAEMFKGLDTIVAMLLNRNETPTFAKLKPGVQNLTRKRFSEDHLAQIKHIYPEAIEFKQEKNVKTFGSGTKVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546    279 DYQLTIEPLLGQE--AGGATQLTATCLLQRRQVFRQNLVERVKEQHKVFLASLNPPmaVPDDQLTRWHPRFNVDEVPDIE 356
Cdd:smart01075  81 TYQLTIEPNLEDEdrSKVRPSLNASRLLERRKVFRRKLVKIVKEHHQEFLASLNPN--IPKDKLTRWHPRFNLEECPDIP 158


                   ....*.
gi 31982546    357 PAELPQ 362
Cdd:smart01075 159 KAELPE 164
Cdt1_c cd08767
The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and ...
 427-549 7.61e-53

The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase; Cdt1 is a replication licensing factor in eukaryotes that recruits the Minichromosome Maintenance Complex (MCM2-7) to the Origin Recognition Complex (ORC). The Cdt1 protein is divided into three regions based on sequence comparison and biochemical analyses: the N-terminal region (Cdt1_n) binds DNA in a sequence-, strand-, and conformation-independent manner; the middle winged helix fold (Cdt1_m) binds geminin to inhibit both binding of the MCM complex to origins of replication and DNA; and the C-terminal region (Cdt1_c) is essential for Cdt1 activity and directly interacts with the MCM2-7 helicase. Precise duplication of chromosomal DNA is required for genomic stability during replication. Assembly of replication factors to start DNA replication in eukaryotes must occur only once per cell cycle. To form a pre-replicative complex on replication origins in the G phase, ORC first binds origin DNA and triggers the binding of Cdc6 and Cdt1. These two factors recruit a putative replicative helicase and the MCM2-7. The MCM2-7 complex promotes the unwinding of DNA origins, and the binding of additional factors to initiate the DNA replication in S-phase. Cdt1 is present during G1 and early S phase of the cell cycle and is degraded during the late S, G2, and M phases. The winged helix fold structure of Cdt1_m is similar to the structures of Cdt1_c and archaeal homologues of the eukaryotic replication initiator, without apparent sequence similarity.


Pssm-ID: 176572  Cd Length: 126  Bit Score: 175.93  E-value: 7.61e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546 427 LKGVSQALLERIRAKEVQKQLARMTRCPEQELRLQRLERLPELARVLRNVFVSERKPALTMEVVCARMVDSCQTALSPGE 506
Cdd:cd08767   4 LKGVPKSLLERIRAKEAAKALEKMTRRPEQEKRRRMYARLPELARILRNIFVSEKKTVLPLEELVYKLQASYPSILSRGE 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 31982546 507 MEKHLVLLAELLPDWLSLHRIRTDTYVKLDKAVDLAGLTARLA 549
Cdd:cd08767  84 VEEHLRLLAELAPDWISEKSLRKGDYLKIDKKVDLEKVRKRLE 126
CDT1_C pfam16679
DNA replication factor Cdt1 C-terminal domain; This is the C-terminal domain of DNA ...
 433-528 2.01e-35

DNA replication factor Cdt1 C-terminal domain; This is the C-terminal domain of DNA replication factor Cdt1. This domain binds the MCM complex.


Pssm-ID: 465230  Cd Length: 96  Bit Score: 128.08  E-value: 2.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546   433 ALLERIRAKEVQKQLARMTRCPEQELRLQRLERLPELARVLRNVFVSERKPALTMEVVCARMVDSCQTALSPGEMEKHLV 512
Cdd:pfam16679   1 SLLERIRAKEAAKALAAMPRKPELERRAALLSRLPEVARVLRLLFVSEKRSSFTMEELVQKLKDSLRTPISKEEIEEHLR 80

                          90
                  ....*....|....*.
gi 31982546   513 LLAELLPDWLSLHRIR 528
Cdd:pfam16679  81 LLAELAPDWISIVKVG 96
 
Name Accession Description Interval E-value
Cdt1_m cd08674
The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit ...
 181-364 1.77e-88

The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA; Cdt1 is a replication licensing factor in eukaryotes that recruits the Minichromosome Maintenance Complex (MCM2-7) to the origin recognition complex (ORC). The Cdt1 protein is divided into three regions based on sequence comparison and biochemical analyses: the N-terminal region (Cdt1_n) binds DNA in a sequence-, strand-, and conformation-independent manner; the middle winged helix fold (Cdt1_m) binds geminin to inhibit both binding of the MCM complex to origins of replication and DNA; and the C-terminal region (Cdt1_c) is essential for Cdt1 activity and directly interacts with the MCM2-7 helicase. Precise duplication of chromosomal DNA is required for genomic stability during replication. Assembly of replication factors to start DNA replication in eukaryotes must occur only once per cell cycle. To form a pre-replicative complex on replication origins in the G phase, ORC first binds origin DNA and triggers the binding of Cdc6 and Cdt1. These two factors recruit a putative replicative helicase and the MCM2-7. The MCM2-7 complex promotes the unwinding of DNA origins, and the binding of additional factors to initiate the DNA replication in S-phase. Cdt1 is present during G1 and early S phase of the cell cycle and degraded during the late S, G2, and M phases. The winged helix fold structure of Cdt1_m is similar to the structures of Cdt1_c and other archaeal homologues of the eukaryotic replication initiator, without apparent sequence similarity.


Pssm-ID: 176571  Cd Length: 185  Bit Score: 270.72  E-value: 1.77e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546 181 PAYQRFHALAQPGLPGLVLPYKYQVLVEMFRSMDTIVSMLHNRSETVTFAKVKQGVQEMMRKRFEERNVGQIKTVYPTSY 260
Cdd:cd08674   1 PAYQRYHSLASSVRPSLKLPEKYEVLAELFRSLDTIVRLLFNRKETCTFDKLKPAVERMTRRRFSEKHLAQIKHIYPEAY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546 261 RFRQECNVPTfKDSIKRSDYQLTIEPLLGQ--EAGGATQLTATCLLQRRQVFRQNLVERVKEQHKVFLASLNPPMAVPDD 338
Cdd:cd08674  81 TLRQEKNHDE-GSLCKKPDYQLTLEPNLVEglELGGSPKLSESRLLARRQVFRSRLLDFVKAHHEEFLISLDPPPPIPDD 159

                       170       180
                ....*....|....*....|....*.
gi 31982546 339 QLTRWHPRFNVDEVPDIEPAELPQPP 364
Cdd:cd08674 160 KLTRWHPKFDLESVPDIEPAELPQPP 185
CDT1 pfam08839
DNA replication factor CDT1 like; CDT1 is a component of the replication licensing system and ...
 199-361 2.98e-85

DNA replication factor CDT1 like; CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin. Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin. This region of CDT1 binds to Geminin.


Pssm-ID: 462618  Cd Length: 172  Bit Score: 261.87  E-value: 2.98e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546   199 LPYKYQVLVEMFRSMDTIVSMLHNRSETVTFAKVKQGVQEMMRKRFEERNVGQIKTVYPTSYRFRQECNVPTFKDSIKRS 278
Cdd:pfam08839   1 LPYKYEVLAEMFRALDTIVSMLFNRNETITFDKLKPAVQRMTRKSFTEKHLAQIKHVYPEAYKLRQEKNLRNFGSGGKKD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546   279 DYQLTIEPLLG--------QEAGGATQLTATCLLQRRQVFRQNLVERVKEQHKVFLASLNPPMAVPD-DQLTRWHPRFNV 349
Cdd:pfam08839  81 DYQLVIEPNLEddledlatAATDGRRRLSASRLLERRHKFRRNLLNIVKKHHEEFLASLDPPMSVPDlDKLTRWHPEFDL 160

                         170
                  ....*....|..
gi 31982546   350 DEVPDIEPAELP 361
Cdd:pfam08839 161 DTVPDIEPAELP 172
CDT1 smart01075
DNA replication factor CDT1 like; CDT1 is a component of the replication licensing system and ...
 199-362 7.11e-78

DNA replication factor CDT1 like; CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin. Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin. This region of CDT1 binds to Geminin.


Pssm-ID: 215014  Cd Length: 164  Bit Score: 242.69  E-value: 7.11e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546    199 LPYKYQVLVEMFRSMDTIVSMLHNRSETVTFAKVKQGVQEMMRKRFEERNVGQIKTVYPTSYRFRQECNVPTFKDSIKRS 278
Cdd:smart01075   1 LPEKYEVLAEMFKGLDTIVAMLLNRNETPTFAKLKPGVQNLTRKRFSEDHLAQIKHIYPEAIEFKQEKNVKTFGSGTKVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546    279 DYQLTIEPLLGQE--AGGATQLTATCLLQRRQVFRQNLVERVKEQHKVFLASLNPPmaVPDDQLTRWHPRFNVDEVPDIE 356
Cdd:smart01075  81 TYQLTIEPNLEDEdrSKVRPSLNASRLLERRKVFRRKLVKIVKEHHQEFLASLNPN--IPKDKLTRWHPRFNLEECPDIP 158


                   ....*.
gi 31982546    357 PAELPQ 362
Cdd:smart01075 159 KAELPE 164
Cdt1_c cd08767
The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and ...
 427-549 7.61e-53

The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase; Cdt1 is a replication licensing factor in eukaryotes that recruits the Minichromosome Maintenance Complex (MCM2-7) to the Origin Recognition Complex (ORC). The Cdt1 protein is divided into three regions based on sequence comparison and biochemical analyses: the N-terminal region (Cdt1_n) binds DNA in a sequence-, strand-, and conformation-independent manner; the middle winged helix fold (Cdt1_m) binds geminin to inhibit both binding of the MCM complex to origins of replication and DNA; and the C-terminal region (Cdt1_c) is essential for Cdt1 activity and directly interacts with the MCM2-7 helicase. Precise duplication of chromosomal DNA is required for genomic stability during replication. Assembly of replication factors to start DNA replication in eukaryotes must occur only once per cell cycle. To form a pre-replicative complex on replication origins in the G phase, ORC first binds origin DNA and triggers the binding of Cdc6 and Cdt1. These two factors recruit a putative replicative helicase and the MCM2-7. The MCM2-7 complex promotes the unwinding of DNA origins, and the binding of additional factors to initiate the DNA replication in S-phase. Cdt1 is present during G1 and early S phase of the cell cycle and is degraded during the late S, G2, and M phases. The winged helix fold structure of Cdt1_m is similar to the structures of Cdt1_c and archaeal homologues of the eukaryotic replication initiator, without apparent sequence similarity.


Pssm-ID: 176572  Cd Length: 126  Bit Score: 175.93  E-value: 7.61e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546 427 LKGVSQALLERIRAKEVQKQLARMTRCPEQELRLQRLERLPELARVLRNVFVSERKPALTMEVVCARMVDSCQTALSPGE 506
Cdd:cd08767   4 LKGVPKSLLERIRAKEAAKALEKMTRRPEQEKRRRMYARLPELARILRNIFVSEKKTVLPLEELVYKLQASYPSILSRGE 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 31982546 507 MEKHLVLLAELLPDWLSLHRIRTDTYVKLDKAVDLAGLTARLA 549
Cdd:cd08767  84 VEEHLRLLAELAPDWISEKSLRKGDYLKIDKKVDLEKVRKRLE 126
CDT1_C pfam16679
DNA replication factor Cdt1 C-terminal domain; This is the C-terminal domain of DNA ...
 433-528 2.01e-35

DNA replication factor Cdt1 C-terminal domain; This is the C-terminal domain of DNA replication factor Cdt1. This domain binds the MCM complex.


Pssm-ID: 465230  Cd Length: 96  Bit Score: 128.08  E-value: 2.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982546   433 ALLERIRAKEVQKQLARMTRCPEQELRLQRLERLPELARVLRNVFVSERKPALTMEVVCARMVDSCQTALSPGEMEKHLV 512
Cdd:pfam16679   1 SLLERIRAKEAAKALAAMPRKPELERRAALLSRLPEVARVLRLLFVSEKRSSFTMEELVQKLKDSLRTPISKEEIEEHLR 80

                          90
                  ....*....|....*.
gi 31982546   513 LLAELLPDWLSLHRIR 528
Cdd:pfam16679  81 LLAELAPDWISIVKVG 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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