The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   382 KVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMN-AIAADMCTNARRVVRKS 460
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSGKKPLDPNKVQAIREYLEERFPSVDLDEDWkVCIQAINNKCRRLRRRK 80

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   20 LNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPaAVQPQSFQQILTFCYTGRLsMNMG 95
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGqeseSSVSEITLD-DVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*..
gi 268837281   96 DQFLLIYTAGFLQIQEIMEKGTEFFLK 122
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIK 105

The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   382 KVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMN-AIAADMCTNARRVVRKS 460
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSGKKPLDPNKVQAIREYLEERFPSVDLDEDWkVCIQAINNKCRRLRRRK 80

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  25 LQGLYCDVSVVVK--GHAFKAHRAVLAASSSYFRDLFNSSrSAVVELPAAVQPQSFQQILTFCYTGRLSMNMGDQFLLIY 102
Cdd:PHA03098   5 ELQKFCDESIIIVngGGIIKVHKIILSSSSEYFKKMFKNN-FKENEINLNIDYDSFNEVIKYIYTGKINITSNNVKDILS 83

                         90       100
                 ....*....|....*....|.
gi 268837281 103 TAGFLQIQEIMEKGTEFFLKV 123
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   1 MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQ 80
Cdd:cd18289    1 MSQMLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQ 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 268837281  81 ILTFCYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFFLKVSSPSCDSQ 131
Cdd:cd18289   81 ILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQ 131

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   5 LQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRD---LFNSSRsavVELPAAVQPQSFQQI 81
Cdd:cd18227    1 FRVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDqvlLKNSRR---IVLPDVMNPRVFENI 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 268837281  82 LTFCYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFF 120
Cdd:cd18227   78 LLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   5 LQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTF 84
Cdd:cd18220    1 IQFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 268837281  85 CYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFF 120
Cdd:cd18220   81 CYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  29 YCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPaAVQPQSFQQILTFCYTGRLSMNMGDQFLLIYTA 104
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSgmkeSSSSEIELD-DVSPEAFEALLDYIYTGELELSEENVEELLAAA 79

                 ...
gi 268837281 105 GFL 107
Cdd:cd18186   80 DKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   8 EIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSaVVELPAAvQPQSFQQILTFCYT 87
Cdd:cd18206    1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKD-VVHLDIS-NAAGLGQVLEFMYT 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 268837281  88 GRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEF 119
Cdd:cd18206   79 AKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   6 QMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAvVELPAAVQPQSFQQILTFC 85
Cdd:cd18208    2 SINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD-IEIPSVVSVQSVQKLIDFM 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 268837281  86 YTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGT 117
Cdd:cd18208   81 YSGVLRVSQSEALQILTAASILQIKTVIDECT 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  10 PNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPaAVQPQSFQQILTFC 85
Cdd:cd18198    6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSgavvDQQNVYEID-FVSPEALTALLEFA 84

                         90       100
                 ....*....|....*....|....*..
gi 268837281  86 YTGRLSMNMGDQFLLIYTAGFLQIQEI 112
Cdd:cd18198   85 YTATLTVSTANVGDILSAARLLEIPCV 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  15 SILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF--NSSRSAVVELPAAVQPQSFQQILTFCYTGRLSM 92
Cdd:cd18278   17 NILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALvgQTENDLVVSLPEEVTARGFGPLLQFAYTAKLLL 96

                         90       100
                 ....*....|....*....|
gi 268837281  93 NMGDQFLLIYTAGFLQIQEI 112
Cdd:cd18278   97 SRENIQEVIRCAEFLRMHNL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  16 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVEL-PAAVQPQSFQQILTFCYTGRLSMNM 94
Cdd:cd18217    5 LLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLdQSQVSADGFQKLLEFIYTGNLNLDS 84

                         90       100
                 ....*....|....*....|....
gi 268837281  95 GDQFLLIYTAGFLQIQEIMEKGTE 118
Cdd:cd18217   85 WNVAEIHQAASYLGMEEVVAKCKI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  14 NSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSA----VVELPaAVQPQSFQQILTFCYTGR 89
Cdd:cd18306    3 ESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGesilTVKLD-GLDPDAVEVLVNYAYTSR 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 268837281  90 LSMNmGDQFLLIY-TAGFLQIQEIMEKGTEFFLKVSSP-SC 128
Cdd:cd18306   82 LEVP-ADLVKSVYsAAKKLKMDRVKKACGDFLLEKLTPqNC 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  16 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAV----QPQSFQQILTFCYTGRLS 91
Cdd:cd18329    8 LLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATfdvfSPDTFTIILDFVYSGKLS 87

                         90       100
                 ....*....|....*....|..
gi 268837281  92 MNMGDQFLLIYTAGFLQIQEIM 113
Cdd:cd18329   88 LTSQNVIEVMSAASYLQMTDVI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  16 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSFQQILTFCYTGRLS 91
Cdd:cd18256    7 ILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGgmseSSKDVVQI-HGVEPDIFHILLDFIYTGVVE 85

                         90       100
                 ....*....|....*....|....*...
gi 268837281  92 MNMGDQFLLIYTAGFLQIQEIMEKGTEF 119
Cdd:cd18256   86 VTVSNVQELLVAADMLQLTEVVEICCEF 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  16 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSFQQILTFCYTGRLS 91
Cdd:cd18237    8 FMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSnmteSKSSEVEL-KDAEPDIIELLVEFAYTARIS 86

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 268837281  92 MNMGDQFLLIYTAGFLQIQEIMEKGTEFFLKVSSPS 127
Cdd:cd18237   87 VNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDAS 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   9 IPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF----NSSRSAVVELPAAVQPQSFQQILTF 84
Cdd:cd18230    1 ITSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYcqvqKTSDQATVTHLDIVTAQGFKAIIDF 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 268837281  85 CYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEF 119
Cdd:cd18230   81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNF 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   9 IPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFnsSRSAVVELPA-AVQPQSFQQILTFCYT 87
Cdd:cd18334    1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLV--LHDNLINLDTdMVNPTVFRQILDFIYT 78

                         90       100
                 ....*....|....*....|....*....
gi 268837281  88 GRL--SMNMGDQFL--LIYTAGFLQIQEI 112
Cdd:cd18334   79 GKLltSDQPGEQNFnaLLTAASYLQLHDL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  20 LNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSFQQILTFCYTGRLSMNMG 95
Cdd:cd18247   10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHdmveSKQDEITM-QGIEPSALEALINFAYSGRIAIDTS 88

                         90       100
                 ....*....|....*....|....*...
gi 268837281  96 D-QFLLIyTAGFLQIQEIMEKGTEFFLK 122
Cdd:cd18247   89 NvQSLLV-GASFLQLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 268837281  12 FGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFnSSRSAVVELpAAVQPQSFQQILTFCYTGRL 90
Cdd:cd18219    4 YSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLF-SVAGQVVEL-NFIRADIFAEILNYIYSSKI 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  15 SILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYF--RDLFNSSRSAVVELPAAVQPQSFQQILTFCYTGRLSM 92
Cdd:cd18277   13 NVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFhsRIVGQADAELNITLPEEVTVKGFEPLIQFAYTAKLIL 92

                         90       100
                 ....*....|....*....|....*...
gi 268837281  93 NMGDQFLLIYTAGFLQIQEIMEKGTEFF 120
Cdd:cd18277   93 SKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  16 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQpQSFQQILTFCYTGRLSMNMG 95
Cdd:cd18232    5 VLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFA-EVFGLLLDFFYTGELALTRE 83

                         90
                 ....*....|....*....
gi 268837281  96 DQFLLIYTAGFLQIQEIME 114
Cdd:cd18232   84 NRDRVLLAAKELRVPEAVE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  24 RLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPaAVQPQSFQQILTFCYTGRLSMNMGDQFL 99
Cdd:cd18264   23 RAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDytqeSKARVIHLP-VVSAAGLQRVLDFIYTSWLSLSLDTLED 101

                         90       100       110
                 ....*....|....*....|....*....|...
gi 268837281 100 LIYTAGFLQIQEIMEKGTEFFLKVSSPS--CDS 130
Cdd:cd18264  102 TLEAASYLQVTEAIGLCSQYLINNLAPEncCFS 134

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  10 PNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSsrSAVVELPAA-----VQPQSFQQILTF 84
Cdd:cd18326    6 PDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTS--GAVVDQQNVyeidfVSAEALTALLDF 83

                         90       100
                 ....*....|....*....|....*...
gi 268837281  85 CYTGRLSMNMGDQFLLIYTAGFLQIQEI 112
Cdd:cd18326   84 AYTATLTVSTSNVGDILSAARLLEIPAV 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   5 LQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFN----SSRSAVVELpAAVQPQSFQQ 80
Cdd:cd18259    8 LDFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTgdfvESISARVEI-KDVDPAVMES 86

                         90       100
                 ....*....|....*....|....*...
gi 268837281  81 ILTFCYTGRLSMNMGDQFLLIYTAGFLQ 108
Cdd:cd18259   87 LIDFAYTGKLTINQGNVEALIRTSNRLQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  17 LECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSFQQILTFCYTGRLSM 92
Cdd:cd18238    3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSemaeSKQDSITI-KDIDEEAVELLVDFAYTGKLTL 81

                         90       100
                 ....*....|....*....|....*..
gi 268837281  93 NMGDQFLLIYTAGFLQIQEIMEKGTEF 119
Cdd:cd18238   82 TVDNVQSLLYAASLLQVEEVAKACCEF 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281  14 NSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF----NSSRSAVVELPAAvQPQSFQQILTFCYTGR 89
Cdd:cd18287    7 HFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmRESQQSEIELKDT-NAEAFKALLKYIYTGR 85

                 ...
gi 268837281  90 LSM 92
Cdd:cd18287   86 LTL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268837281   5 LQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTF 84
Cdd:cd18197    1 LHFKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSKQVRITILQSAEVGRKLLLS 80