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Conserved domains on  [gi|91807119|ref|NP_079417|]
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TM2 domain-containing protein 3 isoform b precursor [Homo sapiens]

Protein Classification

TM2 domain-containing protein( domain architecture ID 10524121)

TM2 domain-containing protein similar to Homo sapiens TM2 domain-containing protein 1 (TM2D1) that may participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42

Gene Ontology:  GO:0097190|GO:0004930|GO:0001540

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 156-205 2.40e-16

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


:

Pssm-ID: 428337  Cd Length: 50  Bit Score: 70.21  E-value: 2.40e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 91807119   156 GGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVL 205
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
 
Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 156-205 2.40e-16

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


Pssm-ID: 428337  Cd Length: 50  Bit Score: 70.21  E-value: 2.40e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 91807119   156 GGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVL 205
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
TM2 COG2314
Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction ...
 159-207 1.00e-09

Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction only];


Pssm-ID: 441888  Cd Length: 79  Bit Score: 53.38  E-value: 1.00e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 91807119 159 KWSTALALSITLGGFGADRFYLGQWREGLGKLFSF--GGLGIWTLIDVLLI 207
Cdd:COG2314   9 SKLVAGLLAIFLGGFGIHRFYLGKTGTGIIYLLFFwtGIPGIIGLIDGILY 59
PHA01886 PHA01886
TM2 domain-containing protein
 159-207 4.74e-05

TM2 domain-containing protein


Pssm-ID: 222840  Cd Length: 78  Bit Score: 40.72  E-value: 4.74e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 91807119  159 KWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLI 207
Cdd:PHA01886   3 STAIAYVLWFFLGFFGIHRFYTGNIATGIIWLFTGGLFGIGWFIDLFLT 51
 
Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 156-205 2.40e-16

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


Pssm-ID: 428337  Cd Length: 50  Bit Score: 70.21  E-value: 2.40e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 91807119   156 GGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVL 205
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
TM2 COG2314
Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction ...
 159-207 1.00e-09

Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction only];


Pssm-ID: 441888  Cd Length: 79  Bit Score: 53.38  E-value: 1.00e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 91807119 159 KWSTALALSITLGGFGADRFYLGQWREGLGKLFSF--GGLGIWTLIDVLLI 207
Cdd:COG2314   9 SKLVAGLLAIFLGGFGIHRFYLGKTGTGIIYLLFFwtGIPGIIGLIDGILY 59
PHA01886 PHA01886
TM2 domain-containing protein
 159-207 4.74e-05

TM2 domain-containing protein


Pssm-ID: 222840  Cd Length: 78  Bit Score: 40.72  E-value: 4.74e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 91807119  159 KWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLI 207
Cdd:PHA01886   3 STAIAYVLWFFLGFFGIHRFYTGNIATGIIWLFTGGLFGIGWFIDLFLT 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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