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Conserved domains on  [gi|156151377|ref|NP_079349|]
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suppressor of IKBKE 1 isoform 2 [Homo sapiens]

Protein Classification

SIKE family protein( domain architecture ID 10530487)

SIKE family protein is a DUF837 domain-containing protein; similar to Homo sapiens suppressor of IKBKE 1 and FGFR1 oncogene partner 2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIKE pfam05769
SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) ...
 2-187 3.04e-74

SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke), and FGFR1 oncogene partner 2, which may be involved in wound healing pathway.


:

Pssm-ID: 461735 [Multi-domain]  Cd Length: 180  Bit Score: 221.76  E-value: 3.04e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156151377    2 SCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMReagtalpdQYQEDASDMKDMSKYKPHILL----SQEN 77
Cdd:pfam05769   1 SLTIEQILADAKRLVGRLKEHDTAADSLIEQAQALNKKIEAMK--------QYQEELKELNEAAKHRPHSLLiagiQQEN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156151377   78 TQIRDLQQENRELWISLEEHQDALELIMSKYRKQMLQLMVAKKAVDAEPVLKAhqSHSAEIESQIDRICEMGEVMRKAVQ 157
Cdd:pfam05769  73 RQIRELQQENRELRASLEEHQSALELIMSKYREQVLQLLLASKFNFTDAYLSL--QLSEEVEQQAEKIEEMAAVMRKAIE 150

                         170       180       190
                  ....*....|....*....|....*....|
gi 156151377  158 VDDDQFCKIQEKLAQLELENKELRELLSIS 187
Cdd:pfam05769 151 VDEENSQKEQEIIAQLETENKGLRELLQIS 180
 
Name Accession Description Interval E-value
SIKE pfam05769
SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) ...
 2-187 3.04e-74

SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke), and FGFR1 oncogene partner 2, which may be involved in wound healing pathway.


Pssm-ID: 461735 [Multi-domain]  Cd Length: 180  Bit Score: 221.76  E-value: 3.04e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156151377    2 SCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMReagtalpdQYQEDASDMKDMSKYKPHILL----SQEN 77
Cdd:pfam05769   1 SLTIEQILADAKRLVGRLKEHDTAADSLIEQAQALNKKIEAMK--------QYQEELKELNEAAKHRPHSLLiagiQQEN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156151377   78 TQIRDLQQENRELWISLEEHQDALELIMSKYRKQMLQLMVAKKAVDAEPVLKAhqSHSAEIESQIDRICEMGEVMRKAVQ 157
Cdd:pfam05769  73 RQIRELQQENRELRASLEEHQSALELIMSKYREQVLQLLLASKFNFTDAYLSL--QLSEEVEQQAEKIEEMAAVMRKAIE 150

                         170       180       190
                  ....*....|....*....|....*....|
gi 156151377  158 VDDDQFCKIQEKLAQLELENKELRELLSIS 187
Cdd:pfam05769 151 VDEENSQKEQEIIAQLETENKGLRELLQIS 180
 
Name Accession Description Interval E-value
SIKE pfam05769
SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) ...
 2-187 3.04e-74

SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke), and FGFR1 oncogene partner 2, which may be involved in wound healing pathway.


Pssm-ID: 461735 [Multi-domain]  Cd Length: 180  Bit Score: 221.76  E-value: 3.04e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156151377    2 SCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMReagtalpdQYQEDASDMKDMSKYKPHILL----SQEN 77
Cdd:pfam05769   1 SLTIEQILADAKRLVGRLKEHDTAADSLIEQAQALNKKIEAMK--------QYQEELKELNEAAKHRPHSLLiagiQQEN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156151377   78 TQIRDLQQENRELWISLEEHQDALELIMSKYRKQMLQLMVAKKAVDAEPVLKAhqSHSAEIESQIDRICEMGEVMRKAVQ 157
Cdd:pfam05769  73 RQIRELQQENRELRASLEEHQSALELIMSKYREQVLQLLLASKFNFTDAYLSL--QLSEEVEQQAEKIEEMAAVMRKAIE 150

                         170       180       190
                  ....*....|....*....|....*....|
gi 156151377  158 VDDDQFCKIQEKLAQLELENKELRELLSIS 187
Cdd:pfam05769 151 VDEENSQKEQEIIAQLETENKGLRELLQIS 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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