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Conserved domains on  [gi|223942014|ref|NP_079049|]
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bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 2 [Homo sapiens]

Protein Classification

cupin-like domain-containing protein( domain architecture ID 10613792)

cupin-like domain-containing protein adopts a beta-barrel fold, similar to Homo sapiens lysine-specific demethylase 8, tRNA wybutosine-synthesizing protein 5, HSPB1-associated protein 1, and hypoxia-inducible factor 1-alpha inhibitor

CATH:  2.60.120.10
Gene Ontology:  GO:0046872
PubMed:  19478949|14697267
SCOP:  3001825

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
195-416 2.81e-48

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


:

Pssm-ID: 463936  Cd Length: 251  Bit Score: 164.85  E-value: 2.81e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223942014  195 FREQFLVPGRPVILKGVADHWPCMQKWS----LEYIQEIAGCRTVPVEVGS-------RYTDE----EWSQTLMTVNEFI 259
Cdd:pfam13621   4 FFREYVAKNKPVVIRGAVKDWPAVQKWTdsslLDYLKDKYGDVEVTVEVTPdgradrlFYNDDftfvNPKEERMPFGEFL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223942014  260 SKYIVNEPRD---VGYLAQHQLFDQIPELKQDISIPdyCSLGDGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVMGRK 336
Cdd:pfam13621  84 DRLEAGEDTDtapYAYLQSDNLRSEFPELLEDNDLP--FATEAFGGEPDAVNLWMGNGRSVTSLHYDHYENLYCVVRGRK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223942014  337 YIRLYSPQESGALYPHD---THLLHNTSQVDVENPDLEKFPKFAKAPF-LSCILSPGEILFIPVKYWHYVRALD-LSFSV 411
Cdd:pfam13621 162 RFTLFPPSDVPNLYPGPlepTPEGQVFSLVDPLAPDFERFPRFRDAARpLVVTLNPGDVLYLPALWWHHVESLDpFNIAV 241

                  ....*
gi 223942014  412 SFWWS 416
Cdd:pfam13621 242 NYWYD 246
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
195-416 2.81e-48

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 164.85  E-value: 2.81e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223942014  195 FREQFLVPGRPVILKGVADHWPCMQKWS----LEYIQEIAGCRTVPVEVGS-------RYTDE----EWSQTLMTVNEFI 259
Cdd:pfam13621   4 FFREYVAKNKPVVIRGAVKDWPAVQKWTdsslLDYLKDKYGDVEVTVEVTPdgradrlFYNDDftfvNPKEERMPFGEFL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223942014  260 SKYIVNEPRD---VGYLAQHQLFDQIPELKQDISIPdyCSLGDGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVMGRK 336
Cdd:pfam13621  84 DRLEAGEDTDtapYAYLQSDNLRSEFPELLEDNDLP--FATEAFGGEPDAVNLWMGNGRSVTSLHYDHYENLYCVVRGRK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223942014  337 YIRLYSPQESGALYPHD---THLLHNTSQVDVENPDLEKFPKFAKAPF-LSCILSPGEILFIPVKYWHYVRALD-LSFSV 411
Cdd:pfam13621 162 RFTLFPPSDVPNLYPGPlepTPEGQVFSLVDPLAPDFERFPRFRDAARpLVVTLNPGDVLYLPALWWHHVESLDpFNIAV 241

                  ....*
gi 223942014  412 SFWWS 416
Cdd:pfam13621 242 NYWYD 246
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
195-416 2.81e-48

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 164.85  E-value: 2.81e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223942014  195 FREQFLVPGRPVILKGVADHWPCMQKWS----LEYIQEIAGCRTVPVEVGS-------RYTDE----EWSQTLMTVNEFI 259
Cdd:pfam13621   4 FFREYVAKNKPVVIRGAVKDWPAVQKWTdsslLDYLKDKYGDVEVTVEVTPdgradrlFYNDDftfvNPKEERMPFGEFL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223942014  260 SKYIVNEPRD---VGYLAQHQLFDQIPELKQDISIPdyCSLGDGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVMGRK 336
Cdd:pfam13621  84 DRLEAGEDTDtapYAYLQSDNLRSEFPELLEDNDLP--FATEAFGGEPDAVNLWMGNGRSVTSLHYDHYENLYCVVRGRK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223942014  337 YIRLYSPQESGALYPHD---THLLHNTSQVDVENPDLEKFPKFAKAPF-LSCILSPGEILFIPVKYWHYVRALD-LSFSV 411
Cdd:pfam13621 162 RFTLFPPSDVPNLYPGPlepTPEGQVFSLVDPLAPDFERFPRFRDAARpLVVTLNPGDVLYLPALWWHHVESLDpFNIAV 241

                  ....*
gi 223942014  412 SFWWS 416
Cdd:pfam13621 242 NYWYD 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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