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Conserved domains on  [gi|21314720|ref|NP_078976|]
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smad nuclear-interacting protein 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FHA_SNIP1 cd22718
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and ...
 224-372 3.66e-112

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex, which associates with both the 3'end of the CCND1 gene and its mRNA. The FHA domain is a small phosphopeptide recognition module.


:

Pssm-ID: 438770  Cd Length: 149  Bit Score: 324.35  E-value: 3.66e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 224 PSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQH 303
Cdd:cd22718   1 PNFGLSGALAEDTNTFRGVVIKYSEPPEARKPKKRWRLYPFKGDEALPVLYIHRQSAYLLGRDRKIADIPIDHPSCSKQH 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21314720 304 AVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHE 372
Cdd:cd22718  81 AVLQYRLVEYTRPDGTKGRRVRPYIIDLESANGTFLNNKKIEPQRYYELKEKDVLKFGFSSREYVLLHE 149
PRK12678 super family cl36163
transcription termination factor Rho; Provisional
 24-208 4.59e-11

transcription termination factor Rho; Provisional


The actual alignment was detected with superfamily member PRK12678:

Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 64.54  E-value: 4.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   24 PAGVVVKQERLSPEVAPPAHRRPDHSGGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHS 103
Cdd:PRK12678  89 QAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAGEGGEQPATEARADAAERTEEEE 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720  104 TVKVKQEREDHPRRGREDRQHREPSEQEHRRA----RNSDRDRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEE-- 177
Cdd:PRK12678 169 RDERRRRGDREDRQAEAERGERGRREERGRDGddrdRRDRREQGDRREERGRRDGGDRRGRRRRRDRRDARGDDNREDrg 248

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 21314720  178 -----EREFYNARR----REHRQRNDVGGGGSESQELVPR 208
Cdd:PRK12678 249 drdgdDGEGRGGRRgrrfRDRDRRGRRGGDGGNEREPELR 288
 
Name Accession Description Interval E-value
FHA_SNIP1 cd22718
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and ...
 224-372 3.66e-112

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex, which associates with both the 3'end of the CCND1 gene and its mRNA. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438770  Cd Length: 149  Bit Score: 324.35  E-value: 3.66e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 224 PSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQH 303
Cdd:cd22718   1 PNFGLSGALAEDTNTFRGVVIKYSEPPEARKPKKRWRLYPFKGDEALPVLYIHRQSAYLLGRDRKIADIPIDHPSCSKQH 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21314720 304 AVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHE 372
Cdd:cd22718  81 AVLQYRLVEYTRPDGTKGRRVRPYIIDLESANGTFLNNKKIEPQRYYELKEKDVLKFGFSSREYVLLHE 149
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 281-360 5.70e-16

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 71.84  E-value: 5.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   281 YLLGRHRRiADIPIDHPSCSKQHAVFQYRlveytrADGTVgrrvkpYIIDLGSGNGTFLNNKRIEPQrYYELKEKDVLKF 360
Cdd:pfam00498   1 VTIGRSPD-CDIVLDDPSVSRRHAEIRYD------GGGRF------YLEDLGSTNGTFVNGQRLGPE-PVRLKDGDVIRL 66
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
277-361 5.36e-13

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 64.59  E-value: 5.36e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 277 RQSAYLLGRHRRiADIPIDHPSCSKQHAVFQYRlveytraDGTVgrrvkpYIIDLGSGNGTFLNNKRIepQRYYELKEKD 356
Cdd:COG1716  19 DGGPLTIGRAPD-NDIVLDDPTVSRRHARIRRD-------GGGW------VLEDLGSTNGTFVNGQRV--TEPAPLRDGD 82


                ....*
gi 21314720 357 VLKFG 361
Cdd:COG1716  83 VIRLG 87
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 281-344 6.64e-12

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 59.88  E-value: 6.64e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21314720    281 YLLGRHRRIADIPIDHPSCSKQHAVFQYRlvEYTRAdgtvgrrvkpYIIDLGSGNGTFLNNKRI 344
Cdd:smart00240   1 VTIGRSSEDCDIQLDGPSISRRHAVIVYD--GGGRF----------YLIDLGSTNGTFVNGKRI 52
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 24-208 4.59e-11

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 64.54  E-value: 4.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   24 PAGVVVKQERLSPEVAPPAHRRPDHSGGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHS 103
Cdd:PRK12678  89 QAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAGEGGEQPATEARADAAERTEEEE 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720  104 TVKVKQEREDHPRRGREDRQHREPSEQEHRRA----RNSDRDRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEE-- 177
Cdd:PRK12678 169 RDERRRRGDREDRQAEAERGERGRREERGRDGddrdRRDRREQGDRREERGRRDGGDRRGRRRRRDRRDARGDDNREDrg 248

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 21314720  178 -----EREFYNARR----REHRQRNDVGGGGSESQELVPR 208
Cdd:PRK12678 249 drdgdDGEGRGGRRgrrfRDRDRRGRRGGDGGNEREPELR 288
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 111-205 2.18e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 40.26  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   111 REDHPRRGRED-RQH-REPSEQEHR---RARNSDRDRHRGHSHQRRTSNERPgsgqgqgRDRDTQNLQAQEEEREFYNAR 185
Cdd:TIGR01642   1 RDEEPDREREKsRGRdRDRSSERPRrrsRDRSRFRDRHRRSRERSYREDSRP-------RDRRRYDSRSPRSLRYSSVRR 73

                          90       100
                  ....*....|....*....|
gi 21314720   186 RReHRQRNDVGGGGSESQEL 205
Cdd:TIGR01642  74 SR-DRPRRRSRSVRSIEQHR 92
 
Name Accession Description Interval E-value
FHA_SNIP1 cd22718
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and ...
 224-372 3.66e-112

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex, which associates with both the 3'end of the CCND1 gene and its mRNA. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438770  Cd Length: 149  Bit Score: 324.35  E-value: 3.66e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 224 PSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQH 303
Cdd:cd22718   1 PNFGLSGALAEDTNTFRGVVIKYSEPPEARKPKKRWRLYPFKGDEALPVLYIHRQSAYLLGRDRKIADIPIDHPSCSKQH 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21314720 304 AVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHE 372
Cdd:cd22718  81 AVLQYRLVEYTRPDGTKGRRVRPYIIDLESANGTFLNNKKIEPQRYYELKEKDVLKFGFSSREYVLLHE 149
FHA_SNIP1_DDL-like cd22676
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA ...
 259-370 3.02e-68

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA domain-containing protein DDL, and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This family also includes Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins. DDL, also called protein DAWDLE, is involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438728 [Multi-domain]  Cd Length: 111  Bit Score: 211.00  E-value: 3.02e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 259 WRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRAdGTVGRRVKPYIIDLGSGNGTF 338
Cdd:cd22676   1 WRLYVFKGGEQLETIDIHRQSAYLIGRDRRVADIPLDHPSCSKQHAVIQFREVEKRNE-GDVIENIRPYIIDLGSTNGTF 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 21314720 339 LNNKRIEPQRYYELKEKDVLKFGFSSREYVLL 370
Cdd:cd22676  80 LNGEKIEPRRYYELREKDVLKFGLSTREYVLL 111
FHA_DDL-like cd22719
forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein ...
 244-372 2.08e-64

forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins; DDL, also called protein DAWDLE, is involved in microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438771 [Multi-domain]  Cd Length: 130  Bit Score: 201.95  E-value: 2.08e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 244 IKYSEPPEARIPKKRWRLYPFKNDEVL-PVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGR 322
Cdd:cd22719   1 LLFVEPPEARKPSKRWRLYVFKDGEPLnEPLHIHRQSCYLFGRERKVADIPTDHPSCSKQHAVIQYRLTEKEGGDGMMGK 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21314720 323 RVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHE 372
Cdd:cd22719  81 AVRPYIMDLGSTNGTFLNGERIEPQRYYELLEKDTIKFGNSSREYVLLHE 130
FHA_PML1-like cd22681
forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 ...
 244-369 1.12e-23

forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 (PML1) and similar proteins; PML1 is an FHA domain-containing protein required for efficient splicing and pre-mRNA nuclear retention. It is a component of the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3, and PML1. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438733 [Multi-domain]  Cd Length: 129  Bit Score: 95.20  E-value: 1.12e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 244 IKYSEPPEARIPKKRWRLYPFKNDEVLPVMYI--HRQSAYLLGR----HRRI--ADIPIDHPSCSKQHAVFQYRLVEytr 315
Cdd:cd22681   3 DNYFDYTGPERDRTLYKLVIYRNNSKGPIEEYelNSPSCYLIGRekgeSTEIvvADIGIPEETCSKQHCVIQFRNVK--- 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 21314720 316 adgtvgRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVL 369
Cdd:cd22681  80 ------GILKPYIMDLDSSNGTCLNDNVIPSSRYVELRSGDVITFSKSNDYELV 127
FHA_PPP1R8 cd22674
forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 ...
 265-369 4.15e-23

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438726 [Multi-domain]  Cd Length: 108  Bit Score: 93.10  E-value: 4.15e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 265 KNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRlveytradgtvGRRVKPYIIDLGSGNGTFLNNKRI 344
Cdd:cd22674  13 KDGKLIEKLMIDEKKYYLFGRNSDVCDFVLDHPSCSRVHAALVYH-----------KHLNRVFLIDLGSTHGTFVGGIRL 81

                        90       100
                ....*....|....*....|....*
gi 21314720 345 EPQRYYELKEKDVLKFGFSSREYVL 369
Cdd:cd22674  82 EPHKPQQLPIDSTLRFGASTRRYIL 106
FHA_Kanadaptin cd22677
forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also ...
 278-369 8.79e-23

forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also called human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438729 [Multi-domain]  Cd Length: 106  Bit Score: 91.85  E-value: 8.79e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 278 QSAYLLGRHRrIADIPIDHPSCSKQHAVFQYRLVEyTRADGTVgrrvkpYIIDLGSGNGTFLNNKRIEPQRYYELKEKDV 357
Cdd:cd22677  21 KSFYVFGRLP-GCDVVLEHPSISRYHAVLQYRGDA-DDHDGGF------YLYDLGSTHGTFLNKQRIPPKQYYRLRVGHV 92

                        90
                ....*....|..
gi 21314720 358 LKFGFSSREYVL 369
Cdd:cd22677  93 LKFGGSTRLYIL 104
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 281-360 5.70e-16

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 71.84  E-value: 5.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   281 YLLGRHRRiADIPIDHPSCSKQHAVFQYRlveytrADGTVgrrvkpYIIDLGSGNGTFLNNKRIEPQrYYELKEKDVLKF 360
Cdd:pfam00498   1 VTIGRSPD-CDIVLDDPSVSRRHAEIRYD------GGGRF------YLEDLGSTNGTFVNGQRLGPE-PVRLKDGDVIRL 66
FHA_PS1-like cd22691
forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) ...
 265-370 1.72e-15

forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) and similar proteins; PS1 is an FHA domain-containing protein required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. It is not involved in female meiosis. Mutations in PS1 lead to the production of diploid pollen grains. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438743 [Multi-domain]  Cd Length: 113  Bit Score: 72.07  E-value: 1.72e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 265 KNDEVLPVMYIHRQSAY-------LLGRHRRiADIPIDHPSCSKQHAvfQYRLVEYTRadgtvgrrvKPYIIDLGSGNGT 337
Cdd:cd22691   8 KNGSVLKNIFLHGKFSKseeedilVVGRHPD-CDIVLDHPSISRFHL--EIRIIPSRR---------KITLTDLSSVHGT 75

                        90       100       110
                ....*....|....*....|....*....|...
gi 21314720 338 FLNNKRIEPQRYYELKEKDVLKFGFSSREYVLL 370
Cdd:cd22691  76 WVNGQRIEPGVPVELEEGDTVRLGASTRVYRLH 108
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 260-361 2.01e-15

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 71.15  E-value: 2.01e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 260 RLYPFKNDEVLPVMYIHRQSaYLLGRHRRiADIPIDHPSCSKQHAVFQYRlveytraDGTVgrrvkpYIIDLGSGNGTFL 339
Cdd:cd00060   1 RLIVLDGDGGGREFPLTKGV-VTIGRSPD-CDIVLDDPSVSRRHARIEVD-------GGGV------YLEDLGSTNGTFV 65

                        90       100
                ....*....|....*....|..
gi 21314720 340 NNKRIEPQryYELKEKDVLKFG 361
Cdd:cd00060  66 NGKRITPP--VPLQDGDVIRLG 85
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
277-361 5.36e-13

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 64.59  E-value: 5.36e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 277 RQSAYLLGRHRRiADIPIDHPSCSKQHAVFQYRlveytraDGTVgrrvkpYIIDLGSGNGTFLNNKRIepQRYYELKEKD 356
Cdd:COG1716  19 DGGPLTIGRAPD-NDIVLDDPTVSRRHARIRRD-------GGGW------VLEDLGSTNGTFVNGQRV--TEPAPLRDGD 82


                ....*
gi 21314720 357 VLKFG 361
Cdd:COG1716  83 VIRLG 87
FHA_Par42-like cd22675
forkhead associated (FHA) domain found in Trypanosoma brucei Parvulin 42 (TbPar42) and similar ...
 270-369 2.84e-12

forkhead associated (FHA) domain found in Trypanosoma brucei Parvulin 42 (TbPar42) and similar proteins; TbPar42 is a nuclear protein that plays a key role in parasite cell proliferation. It exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, both connected by a linker. Its PPIase domain adopts a parvulin fold and reflects structural elements of Pin1-type proteins but is catalytically inactive. Its FHA domain may be involved in the binding of phosphorylated target proteins. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438727 [Multi-domain]  Cd Length: 113  Bit Score: 62.96  E-value: 2.84e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 270 LPVMYIHRQSAYLLGRhRRIADIPIDHPSCSKQHAVFQYRlveytradgtvGRRVKPYIIDLGSGNGTFLNNKRIEPQRY 349
Cdd:cd22675  20 LPPLGLDRFPFYLFGR-SPVCDYVLEHPSISSVHAVLVFH-----------GEQKCFVLMDLGSTNGVKLNGKRIEKGRP 87

                        90       100
                ....*....|....*....|
gi 21314720 350 YELKEKDVLKFGFSSREYVL 369
Cdd:cd22675  88 LPLPVGSVIQFGFSARKYKV 107
FHA_MDC1 cd22665
forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) ...
 251-361 3.59e-12

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438717 [Multi-domain]  Cd Length: 97  Bit Score: 62.25  E-value: 3.59e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 251 EARIPKKRWRLYPFKNdevlpvmyihrqsayLLGRHRRiADIPIDHPSCSKQHAVFqyrlveyTRADGTvgrrvkPYIID 330
Cdd:cd22665   8 QAHGPEKDFPLYEGEN---------------VIGRDPS-CSVVLPDKSVSKQHACI-------EVDGGT------HLIED 58

                        90       100       110
                ....*....|....*....|....*....|..
gi 21314720 331 LGSGNGTFLNNK-RIEPQRYYELKEKDVLKFG 361
Cdd:cd22665  59 LGSTNGTRIGNKvRLKPNVRYELIDGDLLLFG 90
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 281-344 6.64e-12

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 59.88  E-value: 6.64e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21314720    281 YLLGRHRRIADIPIDHPSCSKQHAVFQYRlvEYTRAdgtvgrrvkpYIIDLGSGNGTFLNNKRI 344
Cdd:smart00240   1 VTIGRSSEDCDIQLDGPSISRRHAVIVYD--GGGRF----------YLIDLGSTNGTFVNGKRI 52
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 24-208 4.59e-11

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 64.54  E-value: 4.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   24 PAGVVVKQERLSPEVAPPAHRRPDHSGGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHS 103
Cdd:PRK12678  89 QAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAGEGGEQPATEARADAAERTEEEE 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720  104 TVKVKQEREDHPRRGREDRQHREPSEQEHRRA----RNSDRDRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEE-- 177
Cdd:PRK12678 169 RDERRRRGDREDRQAEAERGERGRREERGRDGddrdRRDRREQGDRREERGRRDGGDRRGRRRRRDRRDARGDDNREDrg 248

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 21314720  178 -----EREFYNARR----REHRQRNDVGGGGSESQELVPR 208
Cdd:PRK12678 249 drdgdDGEGRGGRRgrrfRDRDRRGRRGGDGGNEREPELR 288
FHA_Cep170B cd22725
forkhead associated (FHA) domain found in centrosomal protein of 170 kDa protein B (Cep170B) ...
 298-369 1.74e-10

forkhead associated (FHA) domain found in centrosomal protein of 170 kDa protein B (Cep170B) and similar proteins; Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438777 [Multi-domain]  Cd Length: 106  Bit Score: 57.63  E-value: 1.74e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21314720 298 SCSKQHAVFQYRLveytradGTVGRRVKpyiiDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVL 369
Cdd:cd22725  38 SVDKQHAVINYDQ-------DTDEHWVK----DLGSLNGTFVNDVRIPDQKYITLKLNDVIRFGYDSNMYVL 98
FHA_Cep170 cd22704
forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) ...
 276-369 5.89e-09

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438756 [Multi-domain]  Cd Length: 102  Bit Score: 53.09  E-value: 5.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 276 HR--QSAYLLGRHRriADIPIDHPSCSKQHAVFQYRLVeytradgtvgrRVKPYIIDLGSGNGTFLNNKRIEPQRYYELK 353
Cdd:cd22704  12 HRlpRSMLFVGRED--CDLILQSRSVDKQHAVITYDQI-----------DNEFKIKDLGSLNGTFVNDSRIPEQTYITLK 78

                        90
                ....*....|....*.
gi 21314720 354 EKDVLKFGFSSREYVL 369
Cdd:cd22704  79 LGDSIRFGYDTNVYRF 94
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 39-217 2.78e-08

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 55.68  E-value: 2.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   39 APPAHRRPDHSGGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPhhSTVKVKQEREDHPRRG 118
Cdd:PRK12678  79 RAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRG--AARKAGEGGEQPATEA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720  119 REDRQHREPSEQEHRRARNSDRDRHRGHS--HQRRTSNERPGSGQGQGRDRDTQNLQAQEEEREFYNARRREHRQRNDVG 196
Cdd:PRK12678 157 RADAAERTEEEERDERRRRGDREDRQAEAerGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRDRR 236

                        170       180
                 ....*....|....*....|.
gi 21314720  197 GGGSESQELVPRPGGNNKEKE 217
Cdd:PRK12678 237 DARGDDNREDRGDRDGDDGEG 257
FHA_NBN cd22667
forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also ...
 259-361 4.86e-08

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438719 [Multi-domain]  Cd Length: 108  Bit Score: 50.79  E-value: 4.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 259 WRLYPFKNDEVLPVmYIHRQSAYLLGRhrRIADIPIDH-PSCSKQHAVFQyrLVEYTRADGTVGRRVKPYIIDLgSGNGT 337
Cdd:cd22667   1 WWLLSEQDGAGTSY-YLLPGGEYTVGR--KDCDIIIVDdSSISRKHATLT--VLHPEANLSDPDTRPELTLKDL-SKYGT 74

                        90       100
                ....*....|....*....|....
gi 21314720 338 FLNNKRIEPQRYYELKEKDVLKFG 361
Cdd:cd22667  75 FVNGEKLKGGSEVTLKDGDVITFG 98
FHA_DgcB-like cd22682
forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB ...
 278-361 5.00e-08

forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB and similar proteins; DgcB is a GGDEF enzyme that produces cyclic-di-GMP in response to an unknown stimulus. It appends the C-terminal GGDEF enzymatic domain with an N-terminal forkhead-associated (FHA) domain that acts as a consensus phosphopeptide sensor. The GGDEF and sensory FHA domains form an asymmetrical dimer.


Pssm-ID: 438734 [Multi-domain]  Cd Length: 96  Bit Score: 50.22  E-value: 5.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 278 QSAYLLGRHRRiADIPIDHPSCSKQHAVFQYRLVEYTradgtvgrrvkpyIIDLGSGNGTFLNNKRIEPQRYYELKEKDV 357
Cdd:cd22682  19 ESTIVIGRSVE-SQVQIDDDSVSRYHAKLAVNPSAVS-------------IIDLGSTNGTIVNGKKIPKLASCDLQNGDQ 84


                ....
gi 21314720 358 LKFG 361
Cdd:cd22682  85 IKIG 88
FHA_FHAD1 cd22700
forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 ...
 284-373 1.85e-07

forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 (FHAD1) and similar proteins; FHAD1, also called FHA domain-containing protein 1, is an uncharacterized FHA domain-containing protein. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438752 [Multi-domain]  Cd Length: 96  Bit Score: 48.79  E-value: 1.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 284 GRHRriADIPIDHPSCSKQHAVfqyrlVEYTRADGTVgrrvkpYIIDLGSGNGTFLNNKRIEpQRYYELKEKDVLKFGFS 363
Cdd:cd22700  21 GREG--CDLVLQSPGVEEQHAV-----IEYSEQENCF------VLQDLNTAQGTYVNDCRIQ-NAAVRLAPGDVLRFGFG 86

                        90
                ....*....|
gi 21314720 364 SREYVLLHES 373
Cdd:cd22700  87 GLPYELVVDN 96
FHA_Cep170A cd22724
forkhead associated (FHA) domain found in centrosomal protein of 170 kDa (Cep170) and similar ...
 298-370 2.70e-07

forkhead associated (FHA) domain found in centrosomal protein of 170 kDa (Cep170) and similar proteins; Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438776 [Multi-domain]  Cd Length: 106  Bit Score: 48.43  E-value: 2.70e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21314720 298 SCSKQHAVFQYRlveytraDGTVGRRVKpyiiDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLL 370
Cdd:cd22724  38 SVDKQHAVINYD-------ASTDEHKVK----DLGSLNGTFVNDVRIPEQTYITLKLDDKLRFGYDTNLFTVV 99
FHA_AGGF1 cd22686
forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 ...
 291-376 3.43e-07

forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 (AGGF1) and similar proteins; AGGF1, also called angiogenic factor VG5Q, or G patch domain-containing protein 7 (GPATC7), or vasculogenesis gene on 5q protein, is an angiogenic factor involved in vascular development, angiogenesis, specification of hemangioblasts, and differentiation of veins. It promotes angiogenesis and the proliferation of endothelial cells. It inhibits inflammatory effect and preserve vascular integrity in non-nervous system diseases. Mutated AGGF1 causes susceptibility to Klippel-Trenaunay syndrome, a vascular disorder. Increased AGGF1 expression is associated with tumor angiogenesis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438738 [Multi-domain]  Cd Length: 123  Bit Score: 48.82  E-value: 3.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 291 DIPIDHPSCSKQHAVFQYRLVEytradgtvgrrvKPY-IIDLGSGNGTFLNNKRIEPQR----YYELKEKDVLKFGfssr 365
Cdd:cd22686  39 TIRIPELGVSKFHAEIYYDDDE------------QSYtIVDLGSQNGTYLNGVRISQPKeksdPYPLTHGDELKIG---- 102

                        90
                ....*....|....
gi 21314720 366 EYVLL---HESSDT 376
Cdd:cd22686 103 ETTLLfhiHPGSDT 116
FHA_PP2C70-like cd22678
forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 ...
 283-368 7.17e-07

forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 (AtPP2C70) and similar proteins; AtPP2C70, also called kinase-associated protein phosphatase, or protein ROOT ATTENUATED GROWTH 1, dephosphorylates the serine/threonine receptor-like kinase RLK5. It may function as a signaling component in a pathway involving RLK5. It acts as a negative regulator of the CLAVATA1 signaling in plant development by binding and dephosphorylating CLAVATA1. It is also a component of a signaling pathway which mediates adaptation to NaCl stress. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438730 [Multi-domain]  Cd Length: 102  Bit Score: 47.36  E-value: 7.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 283 LGRHRRiADIPIDHPSCSKQHAVFQYrlveytraDGTVGRRvkpYIIDLGSGNGTFLNNKRIEPQ-RYYELKEKDVLKFG 361
Cdd:cd22678  27 IGRIQR-GDIALKDDEVSGKHARIEW--------NSTGSKW---ELVDLGSLNGTLVNGESISPNgRPVVLSSGDVITLG 94


                ....*..
gi 21314720 362 FSSREYV 368
Cdd:cd22678  95 SETKILV 101
FHA_MEK1-like cd22670
forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine ...
 263-360 9.09e-07

forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine/threonine-protein kinase MEK1 and similar proteins; MEK1 (EC 2.7.11.1), also known as MRE4, is a meiosis-specific protein kinase required for chromosome synapsis and meiotic recombination. The recruitment and activation of MEK1 require the phosphorylation of the chromosome axis protein Hop1 at Thr318 (pT318), which is necessary for recognition by the MEK1 FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438722 [Multi-domain]  Cd Length: 105  Bit Score: 46.84  E-value: 9.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 263 PFKNDEVLPvmyIHRQSAYLLGRHRRiADIPIDHPSCSKQHAVFqyrlveYT-RADGTVGrrVKPYIIDLgSGNGTFLNN 341
Cdd:cd22670   9 PGSTDIVLP---IYKNQVITIGRSPS-CDIVINDPFVSRTHCRI------YSvQFDESSA--PLVYVEDL-SSNGTYLNG 75

                        90
                ....*....|....*....
gi 21314720 342 KRIEPQRYYELKEKDVLKF 360
Cdd:cd22670  76 KLIGRNNTVLLSDGDVIEI 94
FHA_Ki67 cd22673
forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar ...
 281-361 1.42e-06

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438725 [Multi-domain]  Cd Length: 95  Bit Score: 46.05  E-value: 1.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 281 YLLGRHRRiADIPIDHPSCSKQHAVFqyrlveytradgTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRyyELKEKDVLKF 360
Cdd:cd22673  23 CTFGRDLS-CDIRIQLPGVSREHCRI------------EVDENGKAYLENLSTTNPTLVNGKAIEKSA--ELKDGDVITI 87


                .
gi 21314720 361 G 361
Cdd:cd22673  88 G 88
FHA_Ct664-like cd22696
forkhead associated (FHA) domain found in Chlamydia trachomatis Ct664 protein and similar ...
 279-364 1.93e-06

forkhead associated (FHA) domain found in Chlamydia trachomatis Ct664 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Chlamydia trachomatis Ct664 protein. Ct664 situates within the type III secretion system cluster that also encodes an STPK (CT673 in C. trachomatis), suggesting a role of CT664 in the chlamydial type III secretion system by mediating phosphorylation-dependent protein-protein interactions. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438748 [Multi-domain]  Cd Length: 97  Bit Score: 45.95  E-value: 1.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 279 SAYLLGRHRRIADIPIDHPSCSKQHAvfqyRLveYTRADGTVgrrvkpYIIDLGSGNGTFLNNKRIEPQryYELKEKDVL 358
Cdd:cd22696  21 KTYFIGKDPTVCDIVLQDPSISRQHA----RL--SIDQDNRV------FIEDLSSKNGVLVNGKPIEGK--EEISGSDVI 86


                ....*.
gi 21314720 359 KFGFSS 364
Cdd:cd22696  87 SLGTTS 92
FHA_RNF8 cd22663
forkhead associated (FHA) domain found in RING finger protein 8 (RNF8) and similar proteins; ...
 292-361 1.04e-05

forkhead associated (FHA) domain found in RING finger protein 8 (RNF8) and similar proteins; RNF8 is a telomere-associated E3 ubiquitin-protein ligase that plays an important role in DNA double-strand break (DSB) repair via histone ubiquitination. It is localized in the nucleus and interacts with class III E2s (UBE2E2, UbcH6, and UBE2E3), but not with other E2s (UbcH5, UbcH7, UbcH10, hCdc34, and hBendless). It recruits UBC13 for lysine 63-based self polyubiquitylation. Its deficiency causes neuronal pathology and cognitive decline, and its loss results in neuron degeneration. RNF8, together with RNF168, catalyzes a series of ubiquitylation events on substrates such as H2A and H2AX, with the H2AK13/15 ubiquitylation being particularly important for recruitment of repair factors p53-binding protein 1 (53BP1) or the RAP80-BRCA1 complex to sites of DSBs. Specially, RNF8 mediates the ubiquitination of gammaH2AX, and recruits 53BP1 and BRCA1 to DNA damage sites which promotes DNA damage response (DDR) and inhibits chromosomal instability. Moreover, RNF8 interacts with retinoid X receptor alpha (RXR alpha) and enhances its transcription-stimulating activity. It also regulates the rate of exit from mitosis and cytokinesis. RNF8 contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438715 [Multi-domain]  Cd Length: 110  Bit Score: 44.27  E-value: 1.04e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 292 IPIDHPSCSKQHAVFQYRlveytrADGTVgrrvkpYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFG 361
Cdd:cd22663  36 VSTCPLMISRNHCVLKKN------DEGQW------TIKDNKSLNGVWVNGERIEPLKPYPLNEGDLIQLG 93
FHA_ArnA-like cd22680
forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing ...
 291-361 2.41e-05

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438732 [Multi-domain]  Cd Length: 96  Bit Score: 42.71  E-value: 2.41e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21314720 291 DIPIDHPSCSKQHAVFqyrlveyTRADGTVgrrvkpYIIDLGSGNGTFLNN-KRIEPQryYELKEKDVLKFG 361
Cdd:cd22680  32 VIVIPDPFVSRNHARI-------TVDSNEI------YIEDLGSTNGTFVNDfKRIKGP--AKLHPNDIIKLG 88
FHA_DUN1-like cd22683
forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein ...
 271-361 4.73e-05

forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein kinase DUN1 and similar proteins; DUN1 is a protein kinase that controls the DNA damage response in yeast. It phosphorylates SML1 on serine residues and cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438735 [Multi-domain]  Cd Length: 96  Bit Score: 42.09  E-value: 4.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 271 PVMYIHRQSAYLLGRHRRIaDIPIDHPSCSKQHAVFQyrlVEYTRAdgtvgrrvkpYIIDLGSGNGTFLNNKRIEpQRYY 350
Cdd:cd22683  13 QKISITNRNVTTIGRSRSC-DLVLSDPSISRFHAELR---LEQNGI----------NVIDNNSANGTFINGKRIK-GKTY 77

                        90
                ....*....|.
gi 21314720 351 ELKEKDVLKFG 361
Cdd:cd22683  78 ILKNGDIIVFG 88
FHA_FhaA-like cd22668
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
 277-364 6.29e-05

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins; FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438720 [Multi-domain]  Cd Length: 91  Bit Score: 41.30  E-value: 6.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 277 RQSAYLLGRHRRiADIPIDHPSCSKQHAVFQYrlveytraDGTVGrrvkpYIIDLGSGNGTFLNNKRIEPQryYELKEKD 356
Cdd:cd22668  16 REGSNIIGRGSD-ADFRLPDTGVSRRHAEIRW--------DGQVA-----HLTDLGSTNGTTVNNAPVTPE--WRLADGD 79


                ....*...
gi 21314720 357 VLKFGFSS 364
Cdd:cd22668  80 VITLGHSE 87
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 49-204 1.00e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 44.51  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   49 SGGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHSTVKVKQEREDHPRRGREDRQHREPS 128
Cdd:PRK12678  60 GGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARR 139

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21314720  129 EQEHRRARNSDRDRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEEEREFYNARRREHRQRNDVGGGGSESQE 204
Cdd:PRK12678 140 GAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRR 215
FHA_Rv1747-like_rpt1 cd22694
first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ...
 278-344 1.94e-04

first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the first FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438746 [Multi-domain]  Cd Length: 93  Bit Score: 40.00  E-value: 1.94e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21314720 278 QSAYLLGRHRRiADIPIDHPSCSKQHAVFQYRLVEYTradgtvgrrvkpyIIDLGSGNGTFLNNKRI 344
Cdd:cd22694  15 GSSVRIGRDPD-ADVRLDDPRVSRRHALLEFDGDGWV-------------YTDLGSRNGTYLNGRRV 67
FHA_TCF19 cd22685
forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar ...
 278-378 2.51e-04

forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar proteins; TCF-19, also called transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand. TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3.


Pssm-ID: 438737 [Multi-domain]  Cd Length: 130  Bit Score: 40.48  E-value: 2.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 278 QSAYLLGRHRRIADIPIdhpsCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLgSGNGTFLNNKRIEPQRYYELKEKDV 357
Cdd:cd22685  27 LCEYRIGRNPEVCDVFL----CSSQHPNLISREHAEIHAERDGNGNWKVLIEDR-STNGTYVNDVRLQDGQRRELSDGDT 101

                        90       100
                ....*....|....*....|.
gi 21314720 358 LKFGFSSREYVLLHESSDTSE 378
Cdd:cd22685 102 ITFGHKNGRRVKQWPYQKSSE 122
FHA_RAD53-like_rpt1 cd22689
first forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine ...
 260-361 2.58e-04

first forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the first one. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438741 [Multi-domain]  Cd Length: 132  Bit Score: 40.72  E-value: 2.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720 260 RLYPFKNDEVLPVMYIHRQsAYLLGRHRRiADIPIDHPSCSKQHavFQYRLVEYTRADGTVgrrvkpyIIDLGSGNGTFL 339
Cdd:cd22689  27 RDLSGDISQVLKEKRSIKK-VWTFGRHPA-CDYHLGNSRLSNKH--FQILLGESDPSDGNV-------LLNDISSNGTWL 95

                        90       100
                ....*....|....*....|..
gi 21314720 340 NNKRIEPQRYYELKEKDVLKFG 361
Cdd:cd22689  96 NGQRLEKNSNQLLSQGDEITIG 117
FHA_SLMAP cd22679
forkhead associated (FHA) domain found in sarcolemmal membrane-associated protein (SLMAP) and ...
 300-361 2.61e-04

forkhead associated (FHA) domain found in sarcolemmal membrane-associated protein (SLMAP) and similar proteins; SLMAP, also called sarcolemmal-associated protein (SLAP), is a tail-anchored protein involved in fundamental cellular processes, such as myoblast fusion, cell cycle progression, and chromosomal inheritance. It is a cardiac membrane protein that plays an important role in E-C coupling and the adrenergic response of the heart. Overexpression of the SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. SLMAP contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438731 [Multi-domain]  Cd Length: 126  Bit Score: 40.33  E-value: 2.61e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21314720 300 SKQHAVFQYRlveytraDGtvgrrvKPYIIDLGSGNGTFLNNKRI----EPQRYYELKEKDVLKFG 361
Cdd:cd22679  50 SRNHALLWYD-------DG------KFYLQDTKSSNGTFVNNQRLskgsEESEPRELHSGDIVQFG 102
FHA_EspA-like cd22698
forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA ...
 290-363 4.63e-04

forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA is a histidine protein kinase with a fork head-associated (FHA) domain at the N-terminus and a receiver domain at the C-terminus. It functions as an inhibitor of sporulation during early fruiting body development while cells are aggregating into raised mounds. EspA is part of a two-component signal transduction system that regulates the timing of sporulation initiation. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438750 [Multi-domain]  Cd Length: 93  Bit Score: 38.93  E-value: 4.63e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21314720 290 ADIPIDHPSCSKQHAvfqyrlvEYTRADGtvgrrvKPYIIDLGSGNGTFLNNKRIEPqryYELKEKDVLKFGFS 363
Cdd:cd22698  31 NDIRLNDHSVSRHHA-------RIVRQGD------KCNLTDLGSTNGTFLNGIRVGT---HELKHGDRIQLGET 88
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 30-177 5.52e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 42.20  E-value: 5.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   30 KQERLSPEVAPPAHRRPDHSGGSPSPPtsEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHStvkvkq 109
Cdd:PRK12678 153 ATEARADAAERTEEEERDERRRRGDRE--DRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGG------ 224

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21314720  110 EREDHPRRGREDRQHREPSEQEHRRARNSDRDRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEE 177
Cdd:PRK12678 225 DRRGRRRRRDRRDARGDDNREDRGDRDGDDGEGRGGRRGRRFRDRDRRGRRGGDGGNEREPELREDDV 292
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 61-222 8.31e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.43  E-value: 8.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   61 ARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHSTVKVKQEREDhPRRGREDRQHREPSEQEHRRARnsdR 140
Cdd:PRK12678  54 AIKEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAP-AARAAAAAAAEAASAPEAAQAR---E 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720  141 DRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEEEREFYNARRREHRQRNDVGGGGSESQELVPRPGGNNKEKEVPA 220
Cdd:PRK12678 130 RRERGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRR 209


                 ..
gi 21314720  221 KE 222
Cdd:PRK12678 210 EQ 211
FHA_Rv1747-like_rpt2 cd22737
second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ...
 291-361 1.64e-03

second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the second FHA domain, which has a circularly permuted FHA domain fold with a conserved pThr-binding interface.


Pssm-ID: 439356 [Multi-domain]  Cd Length: 93  Bit Score: 37.47  E-value: 1.64e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21314720 291 DIPIDHPSCSKQHAvfqyrlvEYTRADGtvgrrvKPYIIDLGSGNGTFLNNKRIEPqryYELKEKDVLKFG 361
Cdd:cd22737  32 DIVIPEGSVSRHHA-------TLVPTPG------GTQIRDLRSTNGTFVNGLRVDA---ALLHDGDVVTIG 86
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 111-205 2.18e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 40.26  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   111 REDHPRRGRED-RQH-REPSEQEHR---RARNSDRDRHRGHSHQRRTSNERPgsgqgqgRDRDTQNLQAQEEEREFYNAR 185
Cdd:TIGR01642   1 RDEEPDREREKsRGRdRDRSSERPRrrsRDRSRFRDRHRRSRERSYREDSRP-------RDRRRYDSRSPRSLRYSSVRR 73

                          90       100
                  ....*....|....*....|
gi 21314720   186 RReHRQRNDVGGGGSESQEL 205
Cdd:TIGR01642  74 SR-DRPRRRSRSVRSIEQHR 92
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 69-171 3.78e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 39.49  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720    69 RARGVSRSPPKKKNKASGRRSKSPRSkRNRSPHHSTVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSDRDRHRGHSH 148
Cdd:TIGR01642   7 REREKSRGRDRDRSSERPRRRSRDRS-RFRDRHRRSRERSYREDSRPRDRRRYDSRSPRSLRYSSVRRSRDRPRRRSRSV 85

                          90       100
                  ....*....|....*....|...
gi 21314720   149 QRRTSNERpgsgqgQGRDRDTQN 171
Cdd:TIGR01642  86 RSIEQHRR------RLRDRSPSN 102
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 66-179 5.88e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 38.75  E-value: 5.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720    66 RGNRARGVSRSPPKKKNKASgRRSKSPRSKRNRSPHHSTVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSDRDRHRG 145
Cdd:TIGR01622   2 YRDRERERLRDSSSAGDRDR-RRDKGRERSRDRSRDRERSRSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRRRG 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 21314720   146 HSHQRRTSNERPGSGQGQGRDRDTQNLQAQEEER 179
Cdd:TIGR01622  81 DSYRRRRDDRRSRREKPRARDGTPEPLTEDERDR 114
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 78-167 6.72e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 38.34  E-value: 6.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720    78 PKKKNKASGRRSKSPRSKRNRSPHHSTVKVK-QEREDHPRRGREDRQHREPSeQEHRRARNSDRDRHRGHSHQRRTSNER 156
Cdd:TIGR01642   5 PDREREKSRGRDRDRSSERPRRRSRDRSRFRdRHRRSRERSYREDSRPRDRR-RYDSRSPRSLRYSSVRRSRDRPRRRSR 83

                          90
                  ....*....|.
gi 21314720   157 PGSGQGQGRDR 167
Cdd:TIGR01642  84 SVRSIEQHRRR 94
rne PRK10811
ribonuclease E; Reviewed
 105-194 7.30e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 38.48  E-value: 7.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720   105 VKVKQEREDHPRRGREDR------QHREPSEQEHRRARNSDRDRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEEE 178
Cdd:PRK10811  589 QEQPAPKAEAKPERQQDRrkprqnNRRDRNERRDTRDNRTRREGRENREENRRNRRQAQQQTAETRESQQAEVTEKARTQ 668

                          90
                  ....*....|....*..
gi 21314720   179 REFYNARRRE-HRQRND 194
Cdd:PRK10811  669 DEQQQAPRRErQRRRND 685
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 88-204 7.98e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 38.36  E-value: 7.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720    88 RSKSPRSKRNRSphHSTVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSDRDRHRGHSHQRRTSNERpgsgqgqGRDR 167
Cdd:TIGR01622   1 RYRDRERERLRD--SSSAGDRDRRRDKGRERSRDRSRDRERSRSRRRDRHRDRDYYRGRERRSRSRRPN-------RRYR 71

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 21314720   168 DTQNLQAQEEEREFYNARRREHRQRNDVGGGGSESQE 204
Cdd:TIGR01622  72 PREKRRRRGDSYRRRRDDRRSRREKPRARDGTPEPLT 108
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 62-182 9.50e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 37.98  E-value: 9.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720    62 RSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHSTVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSDRD 141
Cdd:TIGR01622   5 RERERLRDSSSAGDRDRRRDKGRERSRDRSRDRERSRSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRRRGDSYR 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 21314720   142 RHRG-HSHQRRTSNERPGSGQGQG---RDRDT---QNLQAQEEEREFY 182
Cdd:TIGR01622  85 RRRDdRRSRREKPRARDGTPEPLTedeRDRRTvfvQQLAARARERDLY 132
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 37-165 9.77e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 38.23  E-value: 9.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314720    37 EVAPPAHRRPDHSGGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHSTVKVKQEREDH-- 114
Cdd:PHA03307  271 EASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSrs 350

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 21314720   115 --PRRGREDRQHREPSEQEHRRARNSDRDRHRGHSHQRRTSNERPGSGQGQGR 165
Cdd:PHA03307  351 psPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDA 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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