NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|94536788|ref|NP_078948|]
View 

DNA transposase THAP9 isoform 1 [Homo sapiens]

Protein Classification

THAP and Tnp_P_element domain-containing protein( domain architecture ID 10527375)

THAP and Tnp_P_element domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-88 3.52e-18

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


:

Pssm-ID: 461662  Cd Length: 76  Bit Score: 79.50  E-value: 3.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94536788     5 CSAVGCSTRDtvlSRERGLSFHQFPTDTIQRSKWIRAVNRVDprskkiWIPGPGAILCSKHFQESDFESYGIRRKLKKGA 84
Cdd:pfam05485   1 CSVPGCTNRK---KKNPRTSFHKFPKDPERRKKWLNACKRKD------LPPPSNSYVCSLHFEENDFEKSGGKRKLKPGA 71


                  ....
gi 94536788    85 VPSV 88
Cdd:pfam05485  72 IPTL 75
Tnp_P_element super family cl20443
Transposase protein; Protein in this family are transposases found in insects. This region is ...
 216-388 2.25e-03

Transposase protein; Protein in this family are transposases found in insects. This region is about 230 amino acids in length and is found associated with pfam05485.


The actual alignment was detected with superfamily member pfam12017:

Pssm-ID: 288840  Cd Length: 219  Bit Score: 40.56  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94536788   216 ACTLYLCSSKVYDYVRKILK--LPHSSILRTWLSKCQPSPGFNSNIFSFLQRRVENGDQLYQYCSLLIKSMPLKQQLQWD 293
Cdd:pfam12017  63 AFTLRYFSKRAYVYLKNELNypLPGLSTLQRWAKTIEMRNGILEDVLNLMKLKGDQLNDYEKLTVLMFDEVKISNTMEYD 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94536788   294 psshslqgfmdfglgKLDADETPLASETVLLMAVGIFGHWRTPLGYFFVNRasgyLQAQLLRLTIGKLSDIGITVLAVTS 373
Cdd:pfam12017 143 ---------------KLRDEVIGPHNQMQVVMARGVASNWKQPIFVDFDKK----MTKEILFDIIEKLDKIGFKVISCVS 203

                         170
                  ....*....|....*
gi 94536788   374 DATAHSVQMAKALGI 388
Cdd:pfam12017 204 DMGGGNVSLWKALDI 218
 
Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-88 3.52e-18

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 79.50  E-value: 3.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94536788     5 CSAVGCSTRDtvlSRERGLSFHQFPTDTIQRSKWIRAVNRVDprskkiWIPGPGAILCSKHFQESDFESYGIRRKLKKGA 84
Cdd:pfam05485   1 CSVPGCTNRK---KKNPRTSFHKFPKDPERRKKWLNACKRKD------LPPPSNSYVCSLHFEENDFEKSGGKRKLKPGA 71


                  ....
gi 94536788    85 VPSV 88
Cdd:pfam05485  72 IPTL 75
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-90 7.12e-17

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 75.93  E-value: 7.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94536788      4 SCSAVGCSTRDtvlSRERGLSFHQFPT-DTIQRSKWIRAVNRVDPRSKKIWipgPGAILCSKHFQESDFESYgiRRKLKK 82
Cdd:smart00980   1 KCCVPGCGNRS---KKNPGLSFFRFPKeDPELRKKWLENLGLPDDPNRKPK---KRSRICSRHFEPDDFDNS--GRRLKP 72


                   ....*...
gi 94536788     83 GAVPSVSL 90
Cdd:smart00980  73 GAVPTLFL 80
Tnp_P_element pfam12017
Transposase protein; Protein in this family are transposases found in insects. This region is ...
 216-388 2.25e-03

Transposase protein; Protein in this family are transposases found in insects. This region is about 230 amino acids in length and is found associated with pfam05485.


Pssm-ID: 288840  Cd Length: 219  Bit Score: 40.56  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94536788   216 ACTLYLCSSKVYDYVRKILK--LPHSSILRTWLSKCQPSPGFNSNIFSFLQRRVENGDQLYQYCSLLIKSMPLKQQLQWD 293
Cdd:pfam12017  63 AFTLRYFSKRAYVYLKNELNypLPGLSTLQRWAKTIEMRNGILEDVLNLMKLKGDQLNDYEKLTVLMFDEVKISNTMEYD 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94536788   294 psshslqgfmdfglgKLDADETPLASETVLLMAVGIFGHWRTPLGYFFVNRasgyLQAQLLRLTIGKLSDIGITVLAVTS 373
Cdd:pfam12017 143 ---------------KLRDEVIGPHNQMQVVMARGVASNWKQPIFVDFDKK----MTKEILFDIIEKLDKIGFKVISCVS 203

                         170
                  ....*....|....*
gi 94536788   374 DATAHSVQMAKALGI 388
Cdd:pfam12017 204 DMGGGNVSLWKALDI 218
 
Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-88 3.52e-18

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 79.50  E-value: 3.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94536788     5 CSAVGCSTRDtvlSRERGLSFHQFPTDTIQRSKWIRAVNRVDprskkiWIPGPGAILCSKHFQESDFESYGIRRKLKKGA 84
Cdd:pfam05485   1 CSVPGCTNRK---KKNPRTSFHKFPKDPERRKKWLNACKRKD------LPPPSNSYVCSLHFEENDFEKSGGKRKLKPGA 71


                  ....
gi 94536788    85 VPSV 88
Cdd:pfam05485  72 IPTL 75
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-90 7.12e-17

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 75.93  E-value: 7.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94536788      4 SCSAVGCSTRDtvlSRERGLSFHQFPT-DTIQRSKWIRAVNRVDPRSKKIWipgPGAILCSKHFQESDFESYgiRRKLKK 82
Cdd:smart00980   1 KCCVPGCGNRS---KKNPGLSFFRFPKeDPELRKKWLENLGLPDDPNRKPK---KRSRICSRHFEPDDFDNS--GRRLKP 72


                   ....*...
gi 94536788     83 GAVPSVSL 90
Cdd:smart00980  73 GAVPTLFL 80
DM3 smart00692
Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;
25-90 1.84e-08

Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;


Pssm-ID: 128933  Cd Length: 59  Bit Score: 51.54  E-value: 1.84e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94536788     25 FHQFPTDTIQRSKWIRAVnRVDPRSKKIWIPgpgaILCSKHFQESDFESygiRRKLKKGAVPSVSL 90
Cdd:smart00692   1 LFRFPKDPELLKKWEHNL-RLSPDEKKLKNS----RICSRHFEPECFGK---RRRLKPGAVPTLEL 58
Tnp_P_element pfam12017
Transposase protein; Protein in this family are transposases found in insects. This region is ...
 216-388 2.25e-03

Transposase protein; Protein in this family are transposases found in insects. This region is about 230 amino acids in length and is found associated with pfam05485.


Pssm-ID: 288840  Cd Length: 219  Bit Score: 40.56  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94536788   216 ACTLYLCSSKVYDYVRKILK--LPHSSILRTWLSKCQPSPGFNSNIFSFLQRRVENGDQLYQYCSLLIKSMPLKQQLQWD 293
Cdd:pfam12017  63 AFTLRYFSKRAYVYLKNELNypLPGLSTLQRWAKTIEMRNGILEDVLNLMKLKGDQLNDYEKLTVLMFDEVKISNTMEYD 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94536788   294 psshslqgfmdfglgKLDADETPLASETVLLMAVGIFGHWRTPLGYFFVNRasgyLQAQLLRLTIGKLSDIGITVLAVTS 373
Cdd:pfam12017 143 ---------------KLRDEVIGPHNQMQVVMARGVASNWKQPIFVDFDKK----MTKEILFDIIEKLDKIGFKVISCVS 203

                         170
                  ....*....|....*
gi 94536788   374 DATAHSVQMAKALGI 388
Cdd:pfam12017 204 DMGGGNVSLWKALDI 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH