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Conserved domains on  [gi|205360981|ref|NP_078833|]
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protein RIC-3 isoform c precursor [Homo sapiens]

Protein Classification

RIC3 domain-containing protein( domain architecture ID 10634033)

RIC3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RIC3 pfam15361
Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with ...
 24-165 7.42e-41

Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.


:

Pssm-ID: 464671  Cd Length: 142  Bit Score: 140.57  E-value: 7.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360981   24 PKAFLSRGKRqeppptPEGKLGRFPPMMHHHQAPS--DGQTPGARFQRSHLAEAFAKAKGSGGGAGgggsgRGLMGQIIP 101
Cdd:pfam15361   7 PRMFLPRGGQ------PLLGSGRFPPSSHSFKHPEsaQQRAAGHPFMRSHMEEAIAKTKGKGQGGS-----KGLMGQLMP 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205360981  102 IYGFGIFLYILYILFKL-SKG-KTTAEDGKCYTAMPGNTHRKITS-FELAQLQEKLKETEAAMEKLI 165
Cdd:pfam15361  76 IYGIGILLYILYILFKIkSKKdKTKSKESKFKPKRTEGAKKKIETeNELNQLQERLAQTERAMEKIL 142
 
Name Accession Description Interval E-value
RIC3 pfam15361
Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with ...
 24-165 7.42e-41

Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.


Pssm-ID: 464671  Cd Length: 142  Bit Score: 140.57  E-value: 7.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360981   24 PKAFLSRGKRqeppptPEGKLGRFPPMMHHHQAPS--DGQTPGARFQRSHLAEAFAKAKGSGGGAGgggsgRGLMGQIIP 101
Cdd:pfam15361   7 PRMFLPRGGQ------PLLGSGRFPPSSHSFKHPEsaQQRAAGHPFMRSHMEEAIAKTKGKGQGGS-----KGLMGQLMP 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205360981  102 IYGFGIFLYILYILFKL-SKG-KTTAEDGKCYTAMPGNTHRKITS-FELAQLQEKLKETEAAMEKLI 165
Cdd:pfam15361  76 IYGIGILLYILYILFKIkSKKdKTKSKESKFKPKRTEGAKKKIETeNELNQLQERLAQTERAMEKIL 142
 
Name Accession Description Interval E-value
RIC3 pfam15361
Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with ...
 24-165 7.42e-41

Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.


Pssm-ID: 464671  Cd Length: 142  Bit Score: 140.57  E-value: 7.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360981   24 PKAFLSRGKRqeppptPEGKLGRFPPMMHHHQAPS--DGQTPGARFQRSHLAEAFAKAKGSGGGAGgggsgRGLMGQIIP 101
Cdd:pfam15361   7 PRMFLPRGGQ------PLLGSGRFPPSSHSFKHPEsaQQRAAGHPFMRSHMEEAIAKTKGKGQGGS-----KGLMGQLMP 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205360981  102 IYGFGIFLYILYILFKL-SKG-KTTAEDGKCYTAMPGNTHRKITS-FELAQLQEKLKETEAAMEKLI 165
Cdd:pfam15361  76 IYGIGILLYILYILFKIkSKKdKTKSKESKFKPKRTEGAKKKIETeNELNQLQERLAQTERAMEKIL 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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