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Conserved domains on  [gi|13375654|ref|NP_078792|]
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PAXIP1-associated glutamate-rich protein 1 [Homo sapiens]

Protein Classification

PAXIP1_C domain-containing protein( domain architecture ID 10634041)

PAXIP1_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAXIP1_C pfam15364
PAXIP1-associated-protein-1 C term PTIP binding protein; This protein domain family is the ...
 86-218 2.26e-49

PAXIP1-associated-protein-1 C term PTIP binding protein; This protein domain family is the C-terminal domain of PAXIP1-associated-protein-1, which also goes by the name PTIP-associated protein 1. This family of proteins is found in eukaryotes. The function of this protein is to localize at the site of DNA damage and form foci with PTIP at the DNA break point. Furthermore, studies have shown that depletion of PA1 increases cellular sensitivity to ionizing radiation. Proteins in this family are typically between 122 and 254 amino acids in length.


:

Pssm-ID: 464674  Cd Length: 134  Bit Score: 158.77  E-value: 2.26e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13375654    86 DWCVPCSDEEVELPadgQPWMPPPSEIQRLYELLAAHGTLELQAEILPRRPPTP----EAQSEEERSDEEPEAKEEEEEK 161
Cdd:pfam15364   1 DWRIPCSDEELEDP---ENWMPPPAEIVRLYELIAKGGVLELQWEILPRRPPTPqrepEPEEDREEDGEEPKESEEEEKK 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 13375654   162 PHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQI 218
Cdd:pfam15364  78 PSVPTEFDFDEEPTTPSNSFLPRRRTPGSHRPSQKRVARMDKVLSDMKRHKKLDESI 134
 
Name Accession Description Interval E-value
PAXIP1_C pfam15364
PAXIP1-associated-protein-1 C term PTIP binding protein; This protein domain family is the ...
 86-218 2.26e-49

PAXIP1-associated-protein-1 C term PTIP binding protein; This protein domain family is the C-terminal domain of PAXIP1-associated-protein-1, which also goes by the name PTIP-associated protein 1. This family of proteins is found in eukaryotes. The function of this protein is to localize at the site of DNA damage and form foci with PTIP at the DNA break point. Furthermore, studies have shown that depletion of PA1 increases cellular sensitivity to ionizing radiation. Proteins in this family are typically between 122 and 254 amino acids in length.


Pssm-ID: 464674  Cd Length: 134  Bit Score: 158.77  E-value: 2.26e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13375654    86 DWCVPCSDEEVELPadgQPWMPPPSEIQRLYELLAAHGTLELQAEILPRRPPTP----EAQSEEERSDEEPEAKEEEEEK 161
Cdd:pfam15364   1 DWRIPCSDEELEDP---ENWMPPPAEIVRLYELIAKGGVLELQWEILPRRPPTPqrepEPEEDREEDGEEPKESEEEEKK 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 13375654   162 PHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQI 218
Cdd:pfam15364  78 PSVPTEFDFDEEPTTPSNSFLPRRRTPGSHRPSQKRVARMDKVLSDMKRHKKLDESI 134
 
Name Accession Description Interval E-value
PAXIP1_C pfam15364
PAXIP1-associated-protein-1 C term PTIP binding protein; This protein domain family is the ...
 86-218 2.26e-49

PAXIP1-associated-protein-1 C term PTIP binding protein; This protein domain family is the C-terminal domain of PAXIP1-associated-protein-1, which also goes by the name PTIP-associated protein 1. This family of proteins is found in eukaryotes. The function of this protein is to localize at the site of DNA damage and form foci with PTIP at the DNA break point. Furthermore, studies have shown that depletion of PA1 increases cellular sensitivity to ionizing radiation. Proteins in this family are typically between 122 and 254 amino acids in length.


Pssm-ID: 464674  Cd Length: 134  Bit Score: 158.77  E-value: 2.26e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13375654    86 DWCVPCSDEEVELPadgQPWMPPPSEIQRLYELLAAHGTLELQAEILPRRPPTP----EAQSEEERSDEEPEAKEEEEEK 161
Cdd:pfam15364   1 DWRIPCSDEELEDP---ENWMPPPAEIVRLYELIAKGGVLELQWEILPRRPPTPqrepEPEEDREEDGEEPKESEEEEKK 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 13375654   162 PHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQI 218
Cdd:pfam15364  78 PSVPTEFDFDEEPTTPSNSFLPRRRTPGSHRPSQKRVARMDKVLSDMKRHKKLDESI 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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