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Conserved domains on  [gi|13129148|ref|NP_077027|]
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MICOS complex subunit MIC26 precursor [Homo sapiens]

Protein Classification

MICOS complex subunit MIC26/MIC27( domain architecture ID 10561085)

MICOS complex subunit MIC26/MIC27 is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ApoO pfam09769
Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. ...
 54-178 8.73e-46

Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.


:

Pssm-ID: 462891  Cd Length: 131  Bit Score: 147.32  E-value: 8.73e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129148    54 EEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAPPGFFPRLGVIGFAGLIGLLLAR-GSK 132
Cdd:pfam09769  10 PTPTDRLEEGVRSARLFLYPYASAAEDELNTVKSKYFNAEQSFTSTIASLAPPPEDLLPGLIYILVAGLAGSILARrRSI 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 13129148   133 IKKLVYPPGFMGLAASLYYPQQaivfAQVSGERLYDWGLRGYIVIE 178
Cdd:pfam09769  90 LKRFAYPLAFGGAAASYFLPQT----FRNTGDLLWKYEQEKFPAVA 131
 
Name Accession Description Interval E-value
ApoO pfam09769
Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. ...
 54-178 8.73e-46

Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.


Pssm-ID: 462891  Cd Length: 131  Bit Score: 147.32  E-value: 8.73e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129148    54 EEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAPPGFFPRLGVIGFAGLIGLLLAR-GSK 132
Cdd:pfam09769  10 PTPTDRLEEGVRSARLFLYPYASAAEDELNTVKSKYFNAEQSFTSTIASLAPPPEDLLPGLIYILVAGLAGSILARrRSI 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 13129148   133 IKKLVYPPGFMGLAASLYYPQQaivfAQVSGERLYDWGLRGYIVIE 178
Cdd:pfam09769  90 LKRFAYPLAFGGAAASYFLPQT----FRNTGDLLWKYEQEKFPAVA 131
 
Name Accession Description Interval E-value
ApoO pfam09769
Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. ...
 54-178 8.73e-46

Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.


Pssm-ID: 462891  Cd Length: 131  Bit Score: 147.32  E-value: 8.73e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13129148    54 EEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAPPGFFPRLGVIGFAGLIGLLLAR-GSK 132
Cdd:pfam09769  10 PTPTDRLEEGVRSARLFLYPYASAAEDELNTVKSKYFNAEQSFTSTIASLAPPPEDLLPGLIYILVAGLAGSILARrRSI 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 13129148   133 IKKLVYPPGFMGLAASLYYPQQaivfAQVSGERLYDWGLRGYIVIE 178
Cdd:pfam09769  90 LKRFAYPLAFGGAAASYFLPQT----FRNTGDLLWKYEQEKFPAVA 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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