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Conserved domains on  [gi|29789148|ref|NP_075661|]
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NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 1 [Mus musculus]

Protein Classification

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9( domain architecture ID 14448744)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis

Gene Ontology:  GO:0006120|GO:0008137|GO:0032981|GO:0005747

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_NDUFB9_LYRM3 cd20263
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ...
 12-88 2.73e-42

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380758  Cd Length: 77  Bit Score: 136.15  E-value: 2.73e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29789148  12 HQQKVLRLYKRALRHLESWCIHRDKYRYFACLMRARFEEHKNEKDMMRATQLLREAEEEFWQNQHPQPYIFPDSPGG 88
Cdd:cd20263   1 HKQRVLRLYRRALKTLLSWCVDRDIFRYEAVLLRARFDANKDVKDPRKAEKLLEEGEAELWENQHPDPYIFPTSPGG 77
 
Name Accession Description Interval E-value
Complex1_LYR_NDUFB9_LYRM3 cd20263
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ...
 12-88 2.73e-42

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380758  Cd Length: 77  Bit Score: 136.15  E-value: 2.73e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29789148  12 HQQKVLRLYKRALRHLESWCIHRDKYRYFACLMRARFEEHKNEKDMMRATQLLREAEEEFWQNQHPQPYIFPDSPGG 88
Cdd:cd20263   1 HKQRVLRLYRRALKTLLSWCVDRDIFRYEAVLLRARFDANKDVKDPRKAEKLLEEGEAELWENQHPDPYIFPTSPGG 77
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 14-73 1.51e-10

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 54.12  E-value: 1.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789148    14 QKVLRLYKRALRHLESWCiHRDKYRYFACLMRARFEEHKNEKDMMRATQLLREAEEEFWQ 73
Cdd:pfam05347   1 RQVLSLYRALLRAARKFP-DYNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
 
Name Accession Description Interval E-value
Complex1_LYR_NDUFB9_LYRM3 cd20263
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ...
 12-88 2.73e-42

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380758  Cd Length: 77  Bit Score: 136.15  E-value: 2.73e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29789148  12 HQQKVLRLYKRALRHLESWCIHRDKYRYFACLMRARFEEHKNEKDMMRATQLLREAEEEFWQNQHPQPYIFPDSPGG 88
Cdd:cd20263   1 HKQRVLRLYRRALKTLLSWCVDRDIFRYEAVLLRARFDANKDVKDPRKAEKLLEEGEAELWENQHPDPYIFPTSPGG 77
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 14-73 1.51e-10

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 54.12  E-value: 1.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789148    14 QKVLRLYKRALRHLESWCiHRDKYRYFACLMRARFEEHKNEKDMMRATQLLREAEEEFWQ 73
Cdd:pfam05347   1 RQVLSLYRALLRAARKFP-DYNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
 16-73 1.16e-07

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 46.38  E-value: 1.16e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 29789148  16 VLRLYKRALRHLESwCIHRDKYRYFACLMRARFEEHKNEKDMMRATQLLREAEEEFWQ 73
Cdd:cd20251   1 VLKLYRDLLRLARK-GLPSRKRDALRQRIREEFRKNKNETDPEKIEELLAEARRGLKN 57
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 16-69 3.58e-03

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 463812  Cd Length: 79  Bit Score: 35.01  E-value: 3.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 29789148    16 VLRLYKRALRHLESwcIHRDKYRYFACLMRARFEEHKNEKDMMRATQLLREAEE 69
Cdd:pfam13233   1 VLSLYRALLRELRE--LPPNGRSYGRQYLRAEFRRHKHLTDPEEIAEFLKSWRE 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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