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Conserved domains on  [gi|1616014184|ref|NP_075649|]
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probable N-acetyltransferase CML1 [Mus musculus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
107-199 9.52e-17

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 73.97  E-value: 9.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184 107 ACFWVAESGGQVVGIVAAQPVKDPPlGRKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLETSAlqqGAVT 186
Cdd:COG3153    39 GLSLVAEDDGEIVGHVALSPVDIDG-EGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDP---SLLP 114

                          90
                  ....*....|...
gi 1616014184 187 LYLGMGFKKAGQY 199
Cdd:COG3153   115 FYERFGFRPAGEL 127
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
107-199 9.52e-17

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 73.97  E-value: 9.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184 107 ACFWVAESGGQVVGIVAAQPVKDPPlGRKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLETSAlqqGAVT 186
Cdd:COG3153    39 GLSLVAEDDGEIVGHVALSPVDIDG-EGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDP---SLLP 114

                          90
                  ....*....|...
gi 1616014184 187 LYLGMGFKKAGQY 199
Cdd:COG3153   115 FYERFGFRPAGEL 127
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 91-193 4.46e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 66.00  E-value: 4.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184  91 QTDMVDITKSYLNVHGACFWVAESGGQVVGIVAAQPVKDPPlgrKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSY 170
Cdd:pfam00583  17 PDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEP---PVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGC 93

                          90       100
                  ....*....|....*....|...
gi 1616014184 171 SDVVLETSALQQGAVTLYLGMGF 193
Cdd:pfam00583  94 ERIFLEVAADNLAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 109-176 1.10e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 55.36  E-value: 1.10e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1616014184 109 FWVAESGGQVVGIVAaqpVKDPPLGRKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLE 176
Cdd:cd04301     1 FLVAEDDGEIVGFAS---LSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
107-199 9.52e-17

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 73.97  E-value: 9.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184 107 ACFWVAESGGQVVGIVAAQPVKDPPlGRKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLETSAlqqGAVT 186
Cdd:COG3153    39 GLSLVAEDDGEIVGHVALSPVDIDG-EGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDP---SLLP 114

                          90
                  ....*....|...
gi 1616014184 187 LYLGMGFKKAGQY 199
Cdd:COG3153   115 FYERFGFRPAGEL 127
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 97-198 5.28e-16

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 71.56  E-value: 5.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184  97 ITKSYLNVHGACFWVAESGGQVVGIVAAQPvkdppLGRKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLE 176
Cdd:COG1246    18 IRPYALEEEIGEFWVAEEDGEIVGCAALHP-----LDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLL 92

                          90       100
                  ....*....|....*....|..
gi 1616014184 177 TSalqQGAVTLYLGMGFKKAGQ 198
Cdd:COG1246    93 TT---SAAIHFYEKLGFEEIDK 111
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 78-199 7.15e-16

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 71.24  E-value: 7.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184  78 ARQPWKEYVAKCLQTDmvditksylnvHGACFWVAESGGQVVGIVAAQPvkdppLGRKQLQLFRLSVSSQHRGQGIAKAL 157
Cdd:COG0454    16 LIEALDAELKAMEGSL-----------AGAEFIAVDDKGEPIGFAGLRR-----LDDKVLELKRLYVLPEYRGKGIGKAL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1616014184 158 TRTVLQFARDQSYSDVVLETSALQQGAVTLYLGMGFKKAGQY 199
Cdd:COG0454    80 LEALLEWARERGCTALELDTLDGNPAAIRFYERLGFKEIERY 121
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
105-199 9.71e-16

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 71.56  E-value: 9.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184 105 HGACFWVAESGGQVVGIVAAQPVKDPPlGRKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLETSALQQGA 184
Cdd:COG1247    50 PGRPVLVAEEDGEVVGFASLGPFRPRP-AYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEAS 128

                          90
                  ....*....|....*
gi 1616014184 185 VTLYLGMGFKKAGQY 199
Cdd:COG1247   129 IALYEKLGFEEVGTL 143
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 91-193 4.46e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 66.00  E-value: 4.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184  91 QTDMVDITKSYLNVHGACFWVAESGGQVVGIVAAQPVKDPPlgrKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSY 170
Cdd:pfam00583  17 PDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEP---PVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGC 93

                          90       100
                  ....*....|....*....|...
gi 1616014184 171 SDVVLETSALQQGAVTLYLGMGF 193
Cdd:pfam00583  94 ERIFLEVAADNLAAIALYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 106-195 2.54e-12

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 60.55  E-value: 2.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184 106 GACFWVAESGGQVVGIVAAQPVKDpplgRKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLETsalQQGAV 185
Cdd:pfam13508   2 GGRFFVAEDDGKIVGFAALLPLDD----EGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELET---TNRAA 74

                          90
                  ....*....|
gi 1616014184 186 TLYLGMGFKK 195
Cdd:pfam13508  75 AFYEKLGFEE 84
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 120-198 5.11e-12

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 60.05  E-value: 5.11e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1616014184 120 GIVAAQPVKDPPLGRkqlqLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLETSALQQGAVTLYLGMGFKKAGQ 198
Cdd:COG0456     1 GFALLGLVDGGDEAE----IEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGE 75
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 109-176 1.10e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 55.36  E-value: 1.10e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1616014184 109 FWVAESGGQVVGIVAaqpVKDPPLGRKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLE 176
Cdd:cd04301     1 FLVAEDDGEIVGFAS---LSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
111-210 1.10e-09

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 54.81  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184 111 VAESGGQVVGIVAAQPvkdppLGRKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLetSAlQQGAVTLYLG 190
Cdd:COG2153    38 LAYDDGELVATARLLP-----PGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVL--SA-QAHAVGFYEK 109

                          90       100
                  ....*....|....*....|
gi 1616014184 191 MGFKKAGQYFMsifwrLAGI 210
Cdd:COG2153   110 LGFVPVGEEFL-----EAGI 124
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 109-197 3.39e-09

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 53.04  E-value: 3.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184 109 FWVAESGGQVVGIVAaqpVKDPPlgrkqlQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLETSAlQQGAVTLY 188
Cdd:pfam13673  33 FFVAFEGGQIVGVIA---LRDRG------HISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVNA-SPYAVPFY 102


                  ....*....
gi 1616014184 189 LGMGFKKAG 197
Cdd:pfam13673 103 EKLGFRATG 111
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
138-204 1.91e-08

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 49.91  E-value: 1.91e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1616014184 138 QLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLETSALQQGAVTLYLGMGFKKAGQYFMSIF 204
Cdd:COG3393    17 EISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGEYATVLF 83
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 105-197 1.30e-05

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 44.22  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616014184 105 HGACFWVAE--SGGQVVGIVAaqpVKDPPLGRKQLQLfRLSVSSQHRGQGIAKALTRTVLQFARDQ-SYSDVVLETSALQ 181
Cdd:COG1670    58 GGALPFAIEdkEDGELIGVVG---LYDIDRANRSAEI-GYWLAPAYWGKGYATEALRALLDYAFEElGLHRVEAEVDPDN 133

                          90
                  ....*....|....*.
gi 1616014184 182 QGAVTLYLGMGFKKAG 197
Cdd:COG1670   134 TASIRVLEKLGFRLEG 149
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 144-170 3.03e-04

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 38.27  E-value: 3.03e-04
                          10        20
                  ....*....|....*....|....*..
gi 1616014184 144 VSSQHRGQGIAKALTRTVLQFARDQSY 170
Cdd:pfam14542  31 VPPALRGQGIASKLVKAALDDAREEGL 57
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
144-170 3.52e-04

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 38.21  E-value: 3.52e-04
                          10        20
                  ....*....|....*....|....*..
gi 1616014184 144 VSSQHRGQGIAKALTRTVLQFARDQSY 170
Cdd:COG2388    40 VPPALRGQGIASALVEAALDDARERGL 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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