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Conserved domains on  [gi|13489095|ref|NP_075556|]
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sialoadhesin isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 21-136 4.58e-45

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05712:

Pssm-ID: 472250  Cd Length: 119  Bit Score: 158.71  E-value: 4.58e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   21 WGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSG--QRQVVSHSADPKLVEARFRGRTEFMGNPEHRVC 98
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYWVSNPVHGYWYRGGPYpkYRPPVATNNRTREVHESTQGRFRLLGDPGKKNC 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 13489095   99 NLLLKDLQPEDSGSYNFRFEISEVNRWSDV-KGTLVTVT 136
Cdd:cd05712   81 SLSISDARPEDSGKYFFRVERGDSNKYSYLsNQLSLTVT 119
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 142-228 4.45e-15

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


:

Pssm-ID: 400489  Cd Length: 89  Bit Score: 72.07  E-value: 4.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    142 PTIASPVELLEG--TEVDFNCSTpyvCLQE-QVRLQWQGQDPAR--SVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILR 216
Cdd:pfam08205    1 PTIEPPASLLEGegPEVVATCSS---AGGKpAPRITWYLDGKPLeaAETSSEQDPESGLVTVTSELKLVPSRSDHGQSLT 77

                           90
                   ....*....|..
gi 13489095    217 CQLSVANHRAQS 228
Cdd:pfam08205   78 CQVSYGALRGSI 89
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 243-321 4.52e-12

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05752:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 79  Bit Score: 63.15  E-value: 4.52e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095  243 ILLSPSGRNILPGELVTLTCQVNSSyPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAEngvGSLVSPPISL 321
Cdd:cd05752    3 VSLDPPWTTVFQGEKVTLTCQGFYS-PEQNSTQWYHNGTLISSTSSSYRIVAATVNDSGEYRCQTQ---GSSLSDPVHL 77
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 514-594 1.51e-11

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 61.64  E-value: 1.51e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    514 LISPAAEVVEGQAVTLSCRSGLSPTPDarFSWYLNGALLheGPGSSLLLPAASSTDAGSYHCRARDGHSaSGPSSPAVLT 593
Cdd:pfam13895    4 LTPSPTVVTEGEPVTLTCSAPGNPPPS--YTWYKDGSAI--SSSPNFFTLSVSAEDSGTYTCVARNGRG-GKVSNPVELT 78


                   .
gi 13489095    594 V 594
Cdd:pfam13895   79 V 79
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 898-980 4.03e-10

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05740:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 89  Bit Score: 58.17  E-value: 4.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  898 VQVSPSPELQEGQAVVLSCQVHTgvpEGTSYRWYRDGQPLQES-------TSATLRFAAITLTQAGAYHCQAQAPGSATT 970
Cdd:cd05740    4 ISSNNSNPVEDKDAVTLTCEPET---QNTSYLWWFNGQSLPVTprltlsnGNRTLTLLNVTREDAGAYQCEISNPVSANR 80

                         90
                 ....*....|
gi 13489095  971 SLaaPISLHV 980
Cdd:cd05740   81 SD--PVTLDV 88
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 1003-1080 8.91e-09

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam07679:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 90  Bit Score: 54.19  E-value: 8.91e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13489095   1003 LLCRVDSDPPAQLRLLHGDRLVAStlqgvggpegsSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
Cdd:pfam07679   20 FTCTVTGTPDPEVSWFKDGQPLRS-----------SDRFKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEAEASA 86
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 431-503 1.39e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.66  E-value: 1.39e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095     431 LHCSVVSEPLATLVLSHGGHILASTSGdsdhspRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATST 503
Cdd:smart00410   14 LSCEASGSPPPEVTWYKQGGKLLAESG------RFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSG 80
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 336-408 1.72e-08

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05752:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 79  Bit Score: 53.13  E-value: 1.72e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095  336 ILENQTVTLVCNTPNeAPSDLRYSWYKNHVLLEDAHSHtLRLHLATRADTGFYFCEVQnvhGSERSGPVSVVV 408
Cdd:cd05752   12 VFQGEKVTLTCQGFY-SPEQNSTQWYHNGTLISSTSSS-YRIVAATVNDSGEYRCQTQ---GSSLSDPVHLEV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 1263-1342 5.02e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 51.63  E-value: 5.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   1263 VILAPEAAVPEGAPITVTCADPAaHAPTLYTWYHNGRWLQEGPaaSLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQV 1342
Cdd:pfam13895    3 VLTPSPTVVTEGEPVTLTCSAPG-NPPPSYTWYKDGSAISSSP--NFFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 1096-1168 9.77e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.86  E-value: 9.77e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095   1096 TVREGQLVNLTCLVWTTHPAQltYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGpPGRAPRLSRPITLDV 1168
Cdd:pfam13895   10 VVTEGEPVTLTCSAPGNPPPS--YTWYKDGSAISSSPNFFTLSVSAEDSGTYTCVAR-NGRGGKVSNPVELTV 79
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 813-893 8.12e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam07679:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 90  Bit Score: 45.71  E-value: 8.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    813 ALFICTVDSRPLALLALFHGEHLLATSlgpqvpshGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQ 892
Cdd:pfam07679   18 ARFTCTVTGTPDPEVSWFKDGQPLRSS--------DRFKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEAEASAELT 89


                   .
gi 13489095    893 V 893
Cdd:pfam07679   90 V 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 715-792 1.88e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 1.88e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     715 PSHTLQEGTEANLTCNVSreaAGSPANFSWFRNGVLW----------AQGPLETVTLLPVARTDAALYACRILTEAGaQL 784
Cdd:smart00410    2 PSVTVKEGESVTLSCEAS---GSPPPEVTWYKQGGKLlaesgrfsvsRSGSTSTLTISNVTPEDSGTYTCAATNSSG-SA 77


                    ....*...
gi 13489095     785 STPVLLSV 792
Cdd:smart00410   78 SSGTTLTV 85
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 1552-1630 2.57e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05869:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 97  Bit Score: 41.89  E-value: 2.57e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095 1552 LDCRVDSEPLASLTLHLGSRLVASSQpqgAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630
Cdd:cd05869   22 LTCEASGDPIPSITWRTSTRNISSEE---KTLDGHIVVRSHARVSSLTLKYIQYTDAGEYLCTASNTIGQDSQSMYLEV 97
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 1169-1256 2.80e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05744:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 91  Bit Score: 41.33  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1169 LYAPRNLRLTYlleshgGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS--VPNTLR--LELRGPQPRDEGFYSCSAR 1244
Cdd:cd05744    4 LQAPGDLEVQE------GRLCRFDCKVSGLPTPDLFWQLNGKPVRPDSAHKmlVRENGRhsLIIEPVTKRDAGIYTCIAR 77

                         90
                 ....*....|..
gi 13489095 1245 SPLGQANTSLEL 1256
Cdd:cd05744   78 NRAGENSFNAEL 89
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 1455-1514 5.85e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.24  E-value: 5.85e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095   1455 VPEGAALNLSCRLLGGPGPvgnsTFAWFWNDRRLHAEPVP---------TLAFTHVARAQAGMYHCLAE 1514
Cdd:pfam13927   13 VREGETVTLTCEATGSPPP----TITWYKNGEPISSGSTRsrslsgsnsTLTISNVTRSDAGTYTCVAS 77
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 1363-1442 1.07e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05725:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 83  Bit Score: 39.69  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1363 AVIQCTVDSEPPAELALS-HDGKvlatssgvhsLASGTGHVqVARNALRLQvqDVPAGDD-TYVCTAQNLLGSISTIGRL 1440
Cdd:cd05725   15 AEFQCEVGGDPVPTVRWRkEDGE----------LPKGRYEI-LDDHSLKIR--KVTAGDMgSYTCVAENMVGKIEASATL 81


                 ..
gi 13489095 1441 QV 1442
Cdd:cd05725   82 TV 83
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 624-703 1.81e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 1.81e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     624 CRVDSDPPARLQLLHKDRVVATSlpsgggcstcggcSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703
Cdd:smart00410   16 CEASGSPPPEVTWYKQGGKLLAE-------------SGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSGTT 82
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 21-136 4.58e-45

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 158.71  E-value: 4.58e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   21 WGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSG--QRQVVSHSADPKLVEARFRGRTEFMGNPEHRVC 98
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYWVSNPVHGYWYRGGPYpkYRPPVATNNRTREVHESTQGRFRLLGDPGKKNC 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 13489095   99 NLLLKDLQPEDSGSYNFRFEISEVNRWSDV-KGTLVTVT 136
Cdd:cd05712   81 SLSISDARPEDSGKYFFRVERGDSNKYSYLsNQLSLTVT 119
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 142-228 4.45e-15

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 72.07  E-value: 4.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    142 PTIASPVELLEG--TEVDFNCSTpyvCLQE-QVRLQWQGQDPAR--SVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILR 216
Cdd:pfam08205    1 PTIEPPASLLEGegPEVVATCSS---AGGKpAPRITWYLDGKPLeaAETSSEQDPESGLVTVTSELKLVPSRSDHGQSLT 77

                           90
                   ....*....|..
gi 13489095    217 CQLSVANHRAQS 228
Cdd:pfam08205   78 CQVSYGALRGSI 89
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 243-321 4.52e-12

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 63.15  E-value: 4.52e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095  243 ILLSPSGRNILPGELVTLTCQVNSSyPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAEngvGSLVSPPISL 321
Cdd:cd05752    3 VSLDPPWTTVFQGEKVTLTCQGFYS-PEQNSTQWYHNGTLISSTSSSYRIVAATVNDSGEYRCQTQ---GSSLSDPVHL 77
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 514-594 1.51e-11

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 61.64  E-value: 1.51e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    514 LISPAAEVVEGQAVTLSCRSGLSPTPDarFSWYLNGALLheGPGSSLLLPAASSTDAGSYHCRARDGHSaSGPSSPAVLT 593
Cdd:pfam13895    4 LTPSPTVVTEGEPVTLTCSAPGNPPPS--YTWYKDGSAI--SSSPNFFTLSVSAEDSGTYTCVARNGRG-GKVSNPVELT 78


                   .
gi 13489095    594 V 594
Cdd:pfam13895   79 V 79
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 242-309 2.39e-11

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 61.04  E-value: 2.39e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13489095    242 KILLSPSGRNILPGELVTLTCQVNSSYPAvsSIKWLKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAEN 309
Cdd:pfam13927    3 VITVSPSSVTVREGETVTLTCEATGSPPP--TITWYKNGEPISSgstrsrslsgSNSTLTISNVTRSDAGTYTCVASN 78
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 898-980 4.03e-10

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 58.17  E-value: 4.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  898 VQVSPSPELQEGQAVVLSCQVHTgvpEGTSYRWYRDGQPLQES-------TSATLRFAAITLTQAGAYHCQAQAPGSATT 970
Cdd:cd05740    4 ISSNNSNPVEDKDAVTLTCEPET---QNTSYLWWFNGQSLPVTprltlsnGNRTLTLLNVTREDAGAYQCEISNPVSANR 80

                         90
                 ....*....|
gi 13489095  971 SLaaPISLHV 980
Cdd:cd05740   81 SD--PVTLDV 88
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 247-323 2.62e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 55.59  E-value: 2.62e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     247 PSGRNILPGELVTLTCQVNSSYPAvsSIKWLKDGVRL-----------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLV 315
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASGSPPP--EVTWYKQGGKLlaesgrfsvsrSGSTSTLTISNVTPEDSGTYTCAATNSSGSAS 78


                    ....*...
gi 13489095     316 SpPISLHI 323
Cdd:smart00410   79 S-GTTLTV 85
I-set pfam07679
Immunoglobulin I-set domain;
898-980 3.43e-09

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 55.34  E-value: 3.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    898 VQVSPSPELQEGQAVVLSCQVhTGVPEgTSYRWYRDGQPLQES---------TSATLRFAAITLTQAGAYHCQAQAP-GS 967
Cdd:pfam07679    4 TQKPKDVEVQEGESARFTCTV-TGTPD-PEVSWFKDGQPLRSSdrfkvtyegGTYTLTISNVQPDDSGKYTCVATNSaGE 81

                           90
                   ....*....|...
gi 13489095    968 ATTSlaapISLHV 980
Cdd:pfam07679   82 AEAS----AELTV 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 516-594 5.67e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 54.43  E-value: 5.67e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     516 SPAAEVVEGQAVTLSCRsgLSPTPDARFSWYLNGA----------LLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASg 585
Cdd:smart00410    1 PPSVTVKEGESVTLSCE--ASGSPPPEVTWYKQGGkllaesgrfsVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSA- 77


                    ....*....
gi 13489095     586 pSSPAVLTV 594
Cdd:smart00410   78 -SSGTTLTV 85
I-set pfam07679
Immunoglobulin I-set domain;
1003-1080 8.91e-09

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 54.19  E-value: 8.91e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13489095   1003 LLCRVDSDPPAQLRLLHGDRLVAStlqgvggpegsSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
Cdd:pfam07679   20 FTCTVTGTPDPEVSWFKDGQPLRS-----------SDRFKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEAEASA 86
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 431-503 1.39e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.66  E-value: 1.39e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095     431 LHCSVVSEPLATLVLSHGGHILASTSGdsdhspRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATST 503
Cdd:smart00410   14 LSCEASGSPPPEVTWYKQGGKLLAESG------RFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSG 80
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 336-408 1.72e-08

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 53.13  E-value: 1.72e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095  336 ILENQTVTLVCNTPNeAPSDLRYSWYKNHVLLEDAHSHtLRLHLATRADTGFYFCEVQnvhGSERSGPVSVVV 408
Cdd:cd05752   12 VFQGEKVTLTCQGFY-SPEQNSTQWYHNGTLISSTSSS-YRIVAATVNDSGEYRCQTQ---GSSLSDPVHLEV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 338-408 1.83e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.28  E-value: 1.83e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     338 ENQTVTLVCNTPNEAPSdlRYSWYKNHV----------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSErSGPVSVV 407
Cdd:smart00410    8 EGESVTLSCEASGSPPP--EVTWYKQGGkllaesgrfsVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSA-SSGTTLT 84


                    .
gi 13489095     408 V 408
Cdd:smart00410   85 V 85
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 1263-1342 5.02e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 51.63  E-value: 5.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   1263 VILAPEAAVPEGAPITVTCADPAaHAPTLYTWYHNGRWLQEGPaaSLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQV 1342
Cdd:pfam13895    3 VLTPSPTVVTEGEPVTLTCSAPG-NPPPSYTWYKDGSAISSSP--NFFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 1096-1168 9.77e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.86  E-value: 9.77e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095   1096 TVREGQLVNLTCLVWTTHPAQltYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGpPGRAPRLSRPITLDV 1168
Cdd:pfam13895   10 VVTEGEPVTLTCSAPGNPPPS--YTWYKDGSAISSSPNFFTLSVSAEDSGTYTCVAR-NGRGGKVSNPVELTV 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 25-136 1.13e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 51.69  E-value: 1.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     25 SPQDVQGVKGSCLLIPCIFSfPADVEVPDGITaiWYYDYSGQRQ--VVSHSaDPKLVEARFRGRTEFMGNPEHRVCNLLL 102
Cdd:pfam07686    2 TPREVTVALGGSVTLPCTYS-SSMSEASTSVY--WYRQPPGKGPtfLIAYY-SNGSEEGVKKGRFSGRGDPSNGDGSLTI 77

                           90       100       110
                   ....*....|....*....|....*....|....
gi 13489095    103 KDLQPEDSGSYNFRFEISEVNRWSdvKGTLVTVT 136
Cdd:pfam07686   78 QNLTLSDSGTYTCAVIPSGEGVFG--KGTRLTVL 109
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 331-408 1.62e-07

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.09  E-value: 1.62e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13489095    331 SPAGPILENQTVTLVCNTPNEAPSDlrYSWYKNHVLLEDahSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408
Cdd:pfam13895    6 PSPTVVTEGEPVTLTCSAPGNPPPS--YTWYKDGSAISS--SPNFFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1003-1080 1.63e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.58  E-value: 1.63e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13489095    1003 LLCRVDSDPPAQLRLLHGDrlvastlqgvGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
Cdd:smart00410   14 LSCEASGSPPPEVTWYKQG----------GKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSGT 81
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 415-495 2.60e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 49.49  E-value: 2.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    415 PVLTAFLETQAGLVG---ILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTsgpnslrLEIRDLEETDSGEYKC 491
Cdd:pfam13927    2 PVITVSPSSVTVREGetvTLTCEATGSPPPTITWYKNGEPISSGSTRSRSLSGSNST-------LTISNVTRSDAGTYTC 74


                   ....
gi 13489095    492 SATN 495
Cdd:pfam13927   75 VASN 78
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 142-229 2.75e-07

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 50.26  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  142 PTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV 221
Cdd:cd20987    1 PNIHVPEELEAGQEVTLTCSVPDNCPALSPEFSWLGAALTPLPPVLGRLEEEGTTTHSSVLTFTPRPEDHGTNLTCQVKF 80


                 ....*...
gi 13489095  222 ANHRAQSE 229
Cdd:cd20987   81 PGATVTTE 88
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 425-503 5.17e-07

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 49.03  E-value: 5.17e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095  425 AGLVGILHCSVVSEPLATLVLSHGGHILAStsgdsdHSPRFsgTSGPNSlRLEIRDLEETDSGEYKCSATNSLGNATST 503
Cdd:cd20952   13 VGGTVVLNCQATGEPVPTISWLKDGVPLLG------KDERI--TTLENG-SLQIKGAEKSDTGEYTCVALNLSGEATWS 82
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 527-584 4.27e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 46.17  E-value: 4.27e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13489095  527 VTLSCRSglSPTPDARFSWYLNGALL---------HEGPGSSLLLPAASSTDAGSYHCRARDGHSAS 584
Cdd:cd00096    1 VTLTCSA--SGNPPPTITWYKNGKPLppssrdsrrSELGNGTLTISNVTLEDSGTYTCVASNSAGGS 65
I-set pfam07679
Immunoglobulin I-set domain;
813-893 8.12e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 45.71  E-value: 8.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    813 ALFICTVDSRPLALLALFHGEHLLATSlgpqvpshGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQ 892
Cdd:pfam07679   18 ARFTCTVTGTPDPEVSWFKDGQPLRSS--------DRFKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEAEASAELT 89


                   .
gi 13489095    893 V 893
Cdd:pfam07679   90 V 90
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 1003-1080 1.88e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 44.24  E-value: 1.88e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095 1003 LLCRVDSDPPAQLRLLHGdrlvastlqgvGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTL-GQASASA 1080
Cdd:cd00096    3 LTCSASGNPPPTITWYKN-----------GKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAgGSASASV 70
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 901-980 4.09e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.65  E-value: 4.09e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     901 SPSPELQEGQAVVLSCQVhTGVPEgTSYRWYRDGQPL----------QESTSATLRFAAITLTQAGAYHCQAQapgSATT 970
Cdd:smart00410    1 PPSVTVKEGESVTLSCEA-SGSPP-PEVTWYKQGGKLlaesgrfsvsRSGSTSTLTISNVTPEDSGTYTCAAT---NSSG 75

                            90
                    ....*....|
gi 13489095     971 SLAAPISLHV 980
Cdd:smart00410   76 SASSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1093-1168 5.99e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.26  E-value: 5.99e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    1093 PGATVREGQLVNLTCLVWTTHPAQltYTWYQDGQQRLDA------------HSIPLPNVTVRDATSYRCGVGPPGraPRL 1160
Cdd:smart00410    2 PSVTVKEGESVTLSCEASGSPPPE--VTWYKQGGKLLAEsgrfsvsrsgstSTLTISNVTPEDSGTYTCAATNSS--GSA 77


                    ....*...
gi 13489095    1161 SRPITLDV 1168
Cdd:smart00410   78 SSGTTLTV 85
IgC_1_Robo cd07693
First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar ...
 1271-1342 9.39e-05

First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain in Roundabout (Robo) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit1, Slit2, Slit3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit1, Slit2,and Slit3 are expressed at the ventral midline. Robo3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site.


Pssm-ID: 409490 [Multi-domain]  Cd Length: 99  Bit Score: 42.92  E-value: 9.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1271 VPEGAPITVTCADPAAHAPTLyTWYHNGRWLQEG-----------PAASLSFL--VATR---AHAGAYSCQAQDAQGTRS 1334
Cdd:cd07693   12 VSKGDPATLNCKAEGRPTPTI-QWLKNGQPLETDkddprshrivlPSGSLFFLrvVHGRkgrSDEGVYVCVAHNSLGEAV 90


                 ....*...
gi 13489095 1335 SRPAALQV 1342
Cdd:cd07693   91 SRNASLEV 98
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 715-792 1.88e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 1.88e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     715 PSHTLQEGTEANLTCNVSreaAGSPANFSWFRNGVLW----------AQGPLETVTLLPVARTDAALYACRILTEAGaQL 784
Cdd:smart00410    2 PSVTVKEGESVTLSCEAS---GSPPPEVTWYKQGGKLlaesgrfsvsRSGSTSTLTISNVTPEDSGTYTCAATNSSG-SA 77


                    ....*...
gi 13489095     785 STPVLLSV 792
Cdd:smart00410   78 SSGTTLTV 85
IgI_NCAM-1 cd05869
Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1); The members ...
 1552-1630 2.57e-04

Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1); The members here are composed of the fourth Ig domain of Neural Cell Adhesion Molecule 1(NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-non-NCAM) interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain. One of the unique features of I-set domains is the lack of a C" strand. The structures of this group show that the Ig domain lacks this strand and thus is a member of the I-set of Ig domains.


Pssm-ID: 143277 [Multi-domain]  Cd Length: 97  Bit Score: 41.89  E-value: 2.57e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095 1552 LDCRVDSEPLASLTLHLGSRLVASSQpqgAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630
Cdd:cd05869   22 LTCEASGDPIPSITWRTSTRNISSEE---KTLDGHIVVRSHARVSSLTLKYIQYTDAGEYLCTASNTIGQDSQSMYLEV 97
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 715-775 2.64e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.01  E-value: 2.64e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    715 PSHTLQEGTEANLTCNVSreaAGSPANFSWFRNGVLWAQGPLE---------TVTLLPVARTDAALYACR 775
Cdd:pfam13927    9 SSVTVREGETVTLTCEAT---GSPPPTITWYKNGEPISSGSTRsrslsgsnsTLTISNVTRSDAGTYTCV 75
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 1090-1168 2.79e-04

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 41.14  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1090 QVWPgATVREGQLVNLTCLVWTTHPAQlTYTWYQDGQQR---LDAHSIPLPNVTVRDATSYRCgVGPPGRAPRLSRPITL 1166
Cdd:cd05753    5 QAPS-AVVFEGEPLTLRCHGWKDKKVH-KVTYYKDGKALkfsYENSNFSIPQATLSDSGSYHC-SGTVRIKRRSSESVNI 81


                 ..
gi 13489095 1167 DV 1168
Cdd:cd05753   82 TV 83
IgI_Myotilin_C_like cd05744
Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of ...
 1169-1256 2.80e-04

Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain in myotilin, palladin, and myopalladin. Myotilin, palladin, and myopalladin function as scaffolds that regulate actin organization. Myotilin and myopalladin are most abundant in skeletal and cardiac muscle; palladin is ubiquitously expressed in the organs of developing vertebrates and plays a key role in cellular morphogenesis. The three family members each interact with specific molecular partners with all three binding to alpha-actinin; In addition, palladin also binds to vasodilator-stimulated phosphoprotein (VASP) and ezrin, myotilin binds to filamin and actin, and myopalladin also binds to nebulin and cardiac ankyrin repeat protein (CARP). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409405 [Multi-domain]  Cd Length: 91  Bit Score: 41.33  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1169 LYAPRNLRLTYlleshgGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS--VPNTLR--LELRGPQPRDEGFYSCSAR 1244
Cdd:cd05744    4 LQAPGDLEVQE------GRLCRFDCKVSGLPTPDLFWQLNGKPVRPDSAHKmlVRENGRhsLIIEPVTKRDAGIYTCIAR 77

                         90
                 ....*....|..
gi 13489095 1245 SPLGQANTSLEL 1256
Cdd:cd05744   78 NRAGENSFNAEL 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1552-1627 4.20e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 4.20e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13489095    1552 LDCRVDSEPLASLT-LHLGSRLVASSqpqgapaePHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTY 1627
Cdd:smart00410   14 LSCEASGSPPPEVTwYKQGGKLLAES--------GRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSGTT 82
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 810-889 5.06e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 5.06e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     810 GHMALFICTVDSRPLALLALFHGEHLLatslgpqVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG--SSNT 887
Cdd:smart00410    9 GESVTLSCEASGSPPPEVTWYKQGGKL-------LAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGsaSSGT 81


                    ..
gi 13489095     888 SL 889
Cdd:smart00410   82 TL 83
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 1455-1514 5.85e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.24  E-value: 5.85e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095   1455 VPEGAALNLSCRLLGGPGPvgnsTFAWFWNDRRLHAEPVP---------TLAFTHVARAQAGMYHCLAE 1514
Cdd:pfam13927   13 VREGETVTLTCEATGSPPP----TITWYKNGEPISSGSTRsrslsgsnsTLTISNVTRSDAGTYTCVAS 77
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 727-793 6.33e-04

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 40.46  E-value: 6.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13489095  727 LTCnvsrEAAGSPANFSWFRNGVLWAQGPL-------ETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793
Cdd:cd05740   20 LTC----EPETQNTSYLWWFNGQSLPVTPRltlsngnRTLTLLNVTREDAGAYQCEISNPVSANRSDPVTLDVI 89
IgI_3_CSF-1R cd20936
Third immunoglobulin domain of the hematopoietic colony-stimulating factor 1 receptor (CSF-1R), ...
 809-893 7.46e-04

Third immunoglobulin domain of the hematopoietic colony-stimulating factor 1 receptor (CSF-1R), and similar domains; member of the I-set of IgSF domains; The members here are composed of the third immunoglobulin domain of the hematopoietic colony-stimulating factor 1 receptor (CSF-1R) and similar proteins. CSF-1R, a class III receptor tyrosine kinase (RTKIII), is critical to the survival, proliferation, and differentiation of mononuclear phagocytic cells such as monocytes, tissue macrophages, muscularis macrophages, microglia, osteoclasts, Paneth cells, and myeloid dendritic cells. Human colony-stimulating factor 1 receptor (hCSF-1R) is unique among the hematopoietic receptors because it is activated by two distinct cytokines, CSF-1 and interleukin-34 (IL-34). The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409530  Cd Length: 93  Bit Score: 40.32  E-value: 7.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  809 QGHMALFICTVDSRPLAL-LALFHGEHLLAtslgpqVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNT 887
Cdd:cd20936   14 RGEAAQIVCSASNVDVNFdVFLQHGDTKLA------IPQQSDFHDNRYQKVLTLNLDQVDFQDAGNYSCVASNVQGKHSA 87


                 ....*.
gi 13489095  888 SLFFQV 893
Cdd:cd20936   88 SMFFRV 93
IgI_3_Robo cd05725
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 1363-1442 1.07e-03

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409390 [Multi-domain]  Cd Length: 83  Bit Score: 39.69  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1363 AVIQCTVDSEPPAELALS-HDGKvlatssgvhsLASGTGHVqVARNALRLQvqDVPAGDD-TYVCTAQNLLGSISTIGRL 1440
Cdd:cd05725   15 AEFQCEVGGDPVPTVRWRkEDGE----------LPKGRYEI-LDDHSLKIR--KVTAGDMgSYTCVAENMVGKIEASATL 81


                 ..
gi 13489095 1441 QV 1442
Cdd:cd05725   82 TV 83
I-set pfam07679
Immunoglobulin I-set domain;
1186-1256 1.11e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 39.55  E-value: 1.11e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13489095   1186 GQLALVLCTVDSRPPAQLALSHAGRLLASS---TAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLEL 1256
Cdd:pfam07679   15 GESARFTCTVTGTPDPEVSWFKDGQPLRSSdrfKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEAEASAEL 88
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1186-1257 1.40e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.41  E-value: 1.40e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13489095    1186 GQLALVLCTVDSRPPAQLALSH-AGRLLASSTAASV---PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELR 1257
Cdd:smart00410    9 GESVTLSCEASGSPPPEVTWYKqGGKLLAESGRFSVsrsGSTSTLTISNVTPEDSGTYTCAATNSSGSASSGTTLT 84
I-set pfam07679
Immunoglobulin I-set domain;
1363-1442 1.47e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 39.55  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   1363 AVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHvqvarnalRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQ 1441
Cdd:pfam07679   18 ARFTCTVTGTPDPEVSWFKDGQPLRSSDRFKVTYEGGTY--------TLTISNVQPDDSgKYTCVATNSAGEAEASAELT 89


                   .
gi 13489095   1442 V 1442
Cdd:pfam07679   90 V 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 624-703 1.81e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 1.81e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     624 CRVDSDPPARLQLLHKDRVVATSlpsgggcstcggcSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703
Cdd:smart00410   16 CEASGSPPPEVTWYKQGGKLLAE-------------SGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSGTT 82
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1271-1342 2.35e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 2.35e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    1271 VPEGAPITVTCadPAAHAPTLY-TWYHNG----------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSrPAA 1339
Cdd:smart00410    6 VKEGESVTLSC--EASGSPPPEvTWYKQGgkllaesgrfSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASS-GTT 82


                    ...
gi 13489095    1340 LQV 1342
Cdd:smart00410   83 LTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1455-1529 3.15e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 3.15e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    1455 VPEGAALNLSCRLLGGPGPvgnsTFAWFWNDRRLHAEP----------VPTLAFTHVARAQAGMYHCLAELPTGaAASAP 1524
Cdd:smart00410    6 VKEGESVTLSCEASGSPPP----EVTWYKQGGKLLAESgrfsvsrsgsTSTLTISNVTPEDSGTYTCAATNSSG-SASSG 80


                    ....*
gi 13489095    1525 VMLRV 1529
Cdd:smart00410   81 TTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-135 4.53e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.87  E-value: 4.53e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095      26 PQDVQGVKGSCLLIPCIFSFPADVEVpdgitaIWYYDysgqrqvvshsaDPKLVEARFRgrteFMGNPEHRVCNLLLKDL 105
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASGSPPPEV------TWYKQ------------GGKLLAESGR----FSVSRSGSTSTLTISNV 58

                            90       100       110
                    ....*....|....*....|....*....|
gi 13489095     106 QPEDSGSYNFRFEISEVNRWSdvkGTLVTV 135
Cdd:smart00410   59 TPEDSGTYTCAATNSSGSASS---GTTLTV 85
I-set pfam07679
Immunoglobulin I-set domain;
1547-1625 5.83e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 37.62  E-value: 5.83e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095   1547 GLRGILDCRVDSEPLASLTLHLGSRLVASSQpqgapaepHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTS 1625
Cdd:pfam07679   15 GESARFTCTVTGTPDPEVSWFKDGQPLRSSD--------RFKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEAEAS 85
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 21-136 4.58e-45

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 158.71  E-value: 4.58e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   21 WGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSG--QRQVVSHSADPKLVEARFRGRTEFMGNPEHRVC 98
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYWVSNPVHGYWYRGGPYpkYRPPVATNNRTREVHESTQGRFRLLGDPGKKNC 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 13489095   99 NLLLKDLQPEDSGSYNFRFEISEVNRWSDV-KGTLVTVT 136
Cdd:cd05712   81 SLSISDARPEDSGKYFFRVERGDSNKYSYLsNQLSLTVT 119
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 142-228 4.45e-15

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 72.07  E-value: 4.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    142 PTIASPVELLEG--TEVDFNCSTpyvCLQE-QVRLQWQGQDPAR--SVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILR 216
Cdd:pfam08205    1 PTIEPPASLLEGegPEVVATCSS---AGGKpAPRITWYLDGKPLeaAETSSEQDPESGLVTVTSELKLVPSRSDHGQSLT 77

                           90
                   ....*....|..
gi 13489095    217 CQLSVANHRAQS 228
Cdd:pfam08205   78 CQVSYGALRGSI 89
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 243-321 4.52e-12

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 63.15  E-value: 4.52e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095  243 ILLSPSGRNILPGELVTLTCQVNSSyPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAEngvGSLVSPPISL 321
Cdd:cd05752    3 VSLDPPWTTVFQGEKVTLTCQGFYS-PEQNSTQWYHNGTLISSTSSSYRIVAATVNDSGEYRCQTQ---GSSLSDPVHL 77
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 514-594 1.51e-11

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 61.64  E-value: 1.51e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    514 LISPAAEVVEGQAVTLSCRSGLSPTPDarFSWYLNGALLheGPGSSLLLPAASSTDAGSYHCRARDGHSaSGPSSPAVLT 593
Cdd:pfam13895    4 LTPSPTVVTEGEPVTLTCSAPGNPPPS--YTWYKDGSAI--SSSPNFFTLSVSAEDSGTYTCVARNGRG-GKVSNPVELT 78


                   .
gi 13489095    594 V 594
Cdd:pfam13895   79 V 79
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 242-309 2.39e-11

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 61.04  E-value: 2.39e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13489095    242 KILLSPSGRNILPGELVTLTCQVNSSYPAvsSIKWLKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAEN 309
Cdd:pfam13927    3 VITVSPSSVTVREGETVTLTCEATGSPPP--TITWYKNGEPISSgstrsrslsgSNSTLTISNVTRSDAGTYTCVASN 78
IgC2_CD22_d3 cd20937
Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 ...
 238-323 1.18e-10

Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 (C2)-set of IgSF domains; The members here are composed of the third immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409531  Cd Length: 88  Bit Score: 59.43  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  238 PKgVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK-TGVLHLPQAAWSDAGVYTCQAENGVGSLVS 316
Cdd:cd20937    1 PK-LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQnTFTLNLREVTKDQSGKYCCQVSNDVGPGRS 79


                 ....*..
gi 13489095  317 PPISLHI 323
Cdd:cd20937   80 EEVFLQV 86
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 242-323 1.44e-10

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 58.95  E-value: 1.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    242 KILLSPSGRNILPGELVTLTCQVNSsyPAVSSIKWLKDGVRLQTKTGvLHLPQAAWSDAGVYTCQAENGVGSLVSPPISL 321
Cdd:pfam13895    1 KPVLTPSPTVVTEGEPVTLTCSAPG--NPPPSYTWYKDGSAISSSPN-FFTLSVSAEDSGTYTCVARNGRGGKVSNPVEL 77


                   ..
gi 13489095    322 HI 323
Cdd:pfam13895   78 TV 79
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 898-980 4.03e-10

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 58.17  E-value: 4.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  898 VQVSPSPELQEGQAVVLSCQVHTgvpEGTSYRWYRDGQPLQES-------TSATLRFAAITLTQAGAYHCQAQAPGSATT 970
Cdd:cd05740    4 ISSNNSNPVEDKDAVTLTCEPET---QNTSYLWWFNGQSLPVTprltlsnGNRTLTLLNVTREDAGAYQCEISNPVSANR 80

                         90
                 ....*....|
gi 13489095  971 SLaaPISLHV 980
Cdd:cd05740   81 SD--PVTLDV 88
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 258-316 5.40e-10

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 56.95  E-value: 5.40e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095  258 VTLTCQVnSSYPAVSsIKWLKDGVRLQTK----------TGVLHLPQAAWSDAGVYTCQAENGVGSLVS 316
Cdd:cd00096    1 VTLTCSA-SGNPPPT-ITWYKNGKPLPPSsrdsrrselgNGTLTISNVTLEDSGTYTCVASNSAGGSAS 67
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 247-323 2.62e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 55.59  E-value: 2.62e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     247 PSGRNILPGELVTLTCQVNSSYPAvsSIKWLKDGVRL-----------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLV 315
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASGSPPP--EVTWYKQGGKLlaesgrfsvsrSGSTSTLTISNVTPEDSGTYTCAATNSSGSAS 78


                    ....*...
gi 13489095     316 SpPISLHI 323
Cdd:smart00410   79 S-GTTLTV 85
I-set pfam07679
Immunoglobulin I-set domain;
898-980 3.43e-09

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 55.34  E-value: 3.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    898 VQVSPSPELQEGQAVVLSCQVhTGVPEgTSYRWYRDGQPLQES---------TSATLRFAAITLTQAGAYHCQAQAP-GS 967
Cdd:pfam07679    4 TQKPKDVEVQEGESARFTCTV-TGTPD-PEVSWFKDGQPLRSSdrfkvtyegGTYTLTISNVQPDDSGKYTCVATNSaGE 81

                           90
                   ....*....|...
gi 13489095    968 ATTSlaapISLHV 980
Cdd:pfam07679   82 AEAS----AELTV 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 516-594 5.67e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 54.43  E-value: 5.67e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     516 SPAAEVVEGQAVTLSCRsgLSPTPDARFSWYLNGA----------LLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASg 585
Cdd:smart00410    1 PPSVTVKEGESVTLSCE--ASGSPPPEVTWYKQGGkllaesgrfsVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSA- 77


                    ....*....
gi 13489095     586 pSSPAVLTV 594
Cdd:smart00410   78 -SSGTTLTV 85
IgC2_CD22_d3 cd20937
Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 ...
 898-982 8.70e-09

Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 (C2)-set of IgSF domains; The members here are composed of the third immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409531  Cd Length: 88  Bit Score: 54.42  E-value: 8.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  898 VQVSPSPEL-QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQ---APGSattslA 973
Cdd:cd20937    5 IKVTPSDAIvREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSndvGPGR-----S 79


                 ....*....
gi 13489095  974 APISLHVSY 982
Cdd:cd20937   80 EEVFLQVQY 88
I-set pfam07679
Immunoglobulin I-set domain;
1003-1080 8.91e-09

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 54.19  E-value: 8.91e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13489095   1003 LLCRVDSDPPAQLRLLHGDRLVAStlqgvggpegsSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
Cdd:pfam07679   20 FTCTVTGTPDPEVSWFKDGQPLRS-----------SDRFKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEAEASA 86
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 520-578 1.17e-08

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 53.34  E-value: 1.17e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13489095    520 EVVEGQAVTLSCRSGLSPTPdaRFSWYLNGALLHEGP---------GSSLLLPAASSTDAGSYHCRAR 578
Cdd:pfam13927   12 TVREGETVTLTCEATGSPPP--TITWYKNGEPISSGStrsrslsgsNSTLTISNVTRSDAGTYTCVAS 77
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 431-503 1.39e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.66  E-value: 1.39e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095     431 LHCSVVSEPLATLVLSHGGHILASTSGdsdhspRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATST 503
Cdd:smart00410   14 LSCEASGSPPPEVTWYKQGGKLLAESG------RFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSG 80
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 336-408 1.72e-08

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 53.13  E-value: 1.72e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095  336 ILENQTVTLVCNTPNeAPSDLRYSWYKNHVLLEDAHSHtLRLHLATRADTGFYFCEVQnvhGSERSGPVSVVV 408
Cdd:cd05752   12 VFQGEKVTLTCQGFY-SPEQNSTQWYHNGTLISSTSSS-YRIVAATVNDSGEYRCQTQ---GSSLSDPVHLEV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 338-408 1.83e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.28  E-value: 1.83e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     338 ENQTVTLVCNTPNEAPSdlRYSWYKNHV----------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSErSGPVSVV 407
Cdd:smart00410    8 EGESVTLSCEASGSPPP--EVTWYKQGGkllaesgrfsVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSA-SSGTTLT 84


                    .
gi 13489095     408 V 408
Cdd:smart00410   85 V 85
IgC2_CD22_d3 cd20937
Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 ...
 327-410 2.22e-08

Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 (C2)-set of IgSF domains; The members here are composed of the third immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409531  Cd Length: 88  Bit Score: 53.27  E-value: 2.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  327 EVQVSPAGPIL-ENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405
Cdd:cd20937    4 EIKVTPSDAIVrEGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVF 83


                 ....*
gi 13489095  406 VVVNH 410
Cdd:cd20937   84 LQVQY 88
I-set pfam07679
Immunoglobulin I-set domain;
242-313 2.85e-08

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 52.64  E-value: 2.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    242 KILLSPSGRNILPGELVTLTCQVnSSYPaVSSIKWLKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAENGV 311
Cdd:pfam07679    2 KFTQKPKDVEVQEGESARFTCTV-TGTP-DPEVSWFKDGQPLRSsdrfkvtyegGTYTLTISNVQPDDSGKYTCVATNSA 79


                   ..
gi 13489095    312 GS 313
Cdd:pfam07679   80 GE 81
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 1263-1342 5.02e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 51.63  E-value: 5.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   1263 VILAPEAAVPEGAPITVTCADPAaHAPTLYTWYHNGRWLQEGPaaSLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQV 1342
Cdd:pfam13895    3 VLTPSPTVVTEGEPVTLTCSAPG-NPPPSYTWYKDGSAISSSP--NFFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
IgV_EVA1 cd05880
Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are ...
 23-132 5.51e-08

Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are composed of the immunoglobulin (Ig) domain of epithelial V-like antigen 1 (EVA 1). EVA is also known as myelin protein zero-like 2. EVA is an adhesion molecule and may play a role in the structural organization of the thymus and early lymphocyte development.


Pssm-ID: 409464  Cd Length: 116  Bit Score: 52.91  E-value: 5.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   23 VSSPQDVQGVKGSCLLIPCIFSFPAdvEVPDGITAIWYY---DYSGQRQVVSHSADP-KLVEARFRGRTEFMGNPEHRVC 98
Cdd:cd05880    3 VYTSKEVEAVNGTDVRLKCTFSSSA--PIGDTLVITWNFrplDGGREESVFYYHKRPyPPPDGRFKGRVVWDGNIMRRDA 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 13489095   99 NLLLKDLQPEDSGSYnfrfeISEVNRWSDVKGTL 132
Cdd:cd05880   81 SILIWQLQPTDNGTY-----TCQVKNPPDVHGPI 109
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 901-980 9.67e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.86  E-value: 9.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    901 SPSPELQEGQAVVLSCQVHtgVPEGTSYRWYRDGQPLQESTSATLRfaAITLTQAGAYHCQAQAPGSATTSlaAPISLHV 980
Cdd:pfam13895    6 PSPTVVTEGEPVTLTCSAP--GNPPPSYTWYKDGSAISSSPNFFTL--SVSAEDSGTYTCVARNGRGGKVS--NPVELTV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 1096-1168 9.77e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.86  E-value: 9.77e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095   1096 TVREGQLVNLTCLVWTTHPAQltYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGpPGRAPRLSRPITLDV 1168
Cdd:pfam13895   10 VVTEGEPVTLTCSAPGNPPPS--YTWYKDGSAISSSPNFFTLSVSAEDSGTYTCVAR-NGRGGKVSNPVELTV 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 25-136 1.13e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 51.69  E-value: 1.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     25 SPQDVQGVKGSCLLIPCIFSfPADVEVPDGITaiWYYDYSGQRQ--VVSHSaDPKLVEARFRGRTEFMGNPEHRVCNLLL 102
Cdd:pfam07686    2 TPREVTVALGGSVTLPCTYS-SSMSEASTSVY--WYRQPPGKGPtfLIAYY-SNGSEEGVKKGRFSGRGDPSNGDGSLTI 77

                           90       100       110
                   ....*....|....*....|....*....|....
gi 13489095    103 KDLQPEDSGSYNFRFEISEVNRWSdvKGTLVTVT 136
Cdd:pfam07686   78 QNLTLSDSGTYTCAVIPSGEGVFG--KGTRLTVL 109
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 328-409 1.33e-07

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 50.86  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  328 VQVSPAGPILENQTVTLVCNTPNEAPSdlrYSWYKNHVLLEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSER 400
Cdd:cd05740    4 ISSNNSNPVEDKDAVTLTCEPETQNTS---YLWWFNGQSLPVTPrltlsngNRTLTLLNVTREDAGAYQCEISNPVSANR 80


                 ....*....
gi 13489095  401 SGPVSVVVN 409
Cdd:cd05740   81 SDPVTLDVI 89
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 331-408 1.62e-07

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.09  E-value: 1.62e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13489095    331 SPAGPILENQTVTLVCNTPNEAPSDlrYSWYKNHVLLEDahSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408
Cdd:pfam13895    6 PSPTVVTEGEPVTLTCSAPGNPPPS--YTWYKDGSAISS--SPNFFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
IgI_1_MuSK cd20970
agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...
 245-323 1.63e-07

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin-like domains (Ig1) of the Muscle-specific kinase (MuSK). MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409562 [Multi-domain]  Cd Length: 92  Bit Score: 50.58  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  245 LSPSGRNILPGELVTLTCQVnSSYPAvSSIKWLKDGVRLQT-KTGV--------LHLPQAAWSDAGVYTCQAENGVGSLV 315
Cdd:cd20970    7 QPSFTVTAREGENATFMCRA-EGSPE-PEISWTRNGNLIIEfNTRYivrengttLTIRNIRRSDMGIYLCIASNGVPGSV 84


                 ....*...
gi 13489095  316 SPPISLHI 323
Cdd:cd20970   85 EKRITLQV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1003-1080 1.63e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.58  E-value: 1.63e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13489095    1003 LLCRVDSDPPAQLRLLHGDrlvastlqgvGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
Cdd:smart00410   14 LSCEASGSPPPEVTWYKQG----------GKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSGT 81
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 415-495 2.60e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 49.49  E-value: 2.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    415 PVLTAFLETQAGLVG---ILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTsgpnslrLEIRDLEETDSGEYKC 491
Cdd:pfam13927    2 PVITVSPSSVTVREGetvTLTCEATGSPPPTITWYKNGEPISSGSTRSRSLSGSNST-------LTISNVTRSDAGTYTC 74


                   ....
gi 13489095    492 SATN 495
Cdd:pfam13927   75 VASN 78
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 142-229 2.75e-07

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 50.26  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  142 PTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV 221
Cdd:cd20987    1 PNIHVPEELEAGQEVTLTCSVPDNCPALSPEFSWLGAALTPLPPVLGRLEEEGTTTHSSVLTFTPRPEDHGTNLTCQVKF 80


                 ....*...
gi 13489095  222 ANHRAQSE 229
Cdd:cd20987   81 PGATVTTE 88
I-set pfam07679
Immunoglobulin I-set domain;
519-594 3.78e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 49.56  E-value: 3.78e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    519 AEVVEGQAVTLSCR-SGlSPTPDarFSWYLNGALLHEGP---------GSSLLLPAASSTDAGSYHCRARDghSASGPSS 588
Cdd:pfam07679   10 VEVQEGESARFTCTvTG-TPDPE--VSWFKDGQPLRSSDrfkvtyeggTYTLTISNVQPDDSGKYTCVATN--SAGEAEA 84


                   ....*.
gi 13489095    589 PAVLTV 594
Cdd:pfam07679   85 SAELTV 90
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 898-962 4.29e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 49.10  E-value: 4.29e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13489095    898 VQVSPSP-ELQEGQAVVLSCQVhTGVPEGTsYRWYRDGQPLQE---------STSATLRFAAITLTQAGAYHCQA 962
Cdd:pfam13927    4 ITVSPSSvTVREGETVTLTCEA-TGSPPPT-ITWYKNGEPISSgstrsrslsGSNSTLTISNVTRSDAGTYTCVA 76
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 425-503 5.17e-07

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 49.03  E-value: 5.17e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095  425 AGLVGILHCSVVSEPLATLVLSHGGHILAStsgdsdHSPRFsgTSGPNSlRLEIRDLEETDSGEYKCSATNSLGNATST 503
Cdd:cd20952   13 VGGTVVLNCQATGEPVPTISWLKDGVPLLG------KDERI--TTLENG-SLQIKGAEKSDTGEYTCVALNLSGEATWS 82
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 431-503 6.97e-07

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 48.09  E-value: 6.97e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095  431 LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTsgpnslrLEIRDLEETDSGEYKCSATNSLGNATST 503
Cdd:cd00096    3 LTCSASGNPPPTITWYKNGKPLPPSSRDSRRSELGNGT-------LTISNVTLEDSGTYTCVASNSAGGSASA 68
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 1263-1326 1.26e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 47.56  E-value: 1.26e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13489095   1263 VILAP--EAAVPEGAPITVTCADPAAHAPTlYTWYHNGRWLQEGPA---------ASLSFLVATRAHAGAYSCQA 1326
Cdd:pfam13927    3 VITVSpsSVTVREGETVTLTCEATGSPPPT-ITWYKNGEPISSGSTrsrslsgsnSTLTISNVTRSDAGTYTCVA 76
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 1090-1149 1.61e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 47.57  E-value: 1.61e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13489095   1090 QVWPGATVREGQLVNLTCLVWTTHPaQLTYTWYQDGQQRLDAH------------SIPLPNVTVRDATSYRC 1149
Cdd:pfam00047    1 SAPPTVTVLEGDSATLTCSASTGSP-GPDVTWSKEGGTLIESLkvkhdngrttqsSLLISNVTKEDAGTYTC 71
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 23-114 1.69e-06

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 48.58  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   23 VSSPQDVQGVKGSCLLIPCIFSFPAdvEVPDGITAIWYYDYSGQRQVVS----HSADPKLVE-ARFRGRTEFMGNPEHRV 97
Cdd:cd05715    3 VYTPRELNVLNGSDVRLTCTFTSCY--TVGDAFSVTWTYQPEGGNTTESmfhySKGKPYILKvGRFKDRVSWAGNPSKKD 80

                         90
                 ....*....|....*..
gi 13489095   98 CNLLLKDLQPEDSGSYN 114
Cdd:cd05715   81 ASIVISNLQFSDNGTYT 97
I-set pfam07679
Immunoglobulin I-set domain;
421-504 1.82e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 47.64  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    421 LETQAGLVGILHCSVVSEPLATLVLSHGGHILAStsgdsdhSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNA 500
Cdd:pfam07679   10 VEVQEGESARFTCTVTGTPDPEVSWFKDGQPLRS-------SDRFKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEA 82


                   ....
gi 13489095    501 TSTL 504
Cdd:pfam07679   83 EASA 86
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 342-404 2.64e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 46.55  E-value: 2.64e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13489095  342 VTLVCNTpnEAPSDLRYSWYKNHVLLEDA---------HSHTLRLHLATRADTGFYFCEVQNVHGSERSGPV 404
Cdd:cd00096    1 VTLTCSA--SGNPPPTITWYKNGKPLPPSsrdsrrselGNGTLTISNVTLEDSGTYTCVASNSAGGSASASV 70
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 242-323 3.49e-06

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 47.07  E-value: 3.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  242 KILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ----------------TKTGVLHLPQAAWSDAGVYTC 305
Cdd:cd00098    1 TVTLLPPSPEEKGGGKVTLVCLVSGFYPKDITVTWLKNGVPLTsgvstsspvepndgtySVTSSLTVPPSDWDEGATYTC 80

                         90
                 ....*....|....*...
gi 13489095  306 QAENgvGSLvSPPISLHI 323
Cdd:cd00098   81 VVTH--ESL-KSPLSKTW 95
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 527-584 4.27e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 46.17  E-value: 4.27e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13489095  527 VTLSCRSglSPTPDARFSWYLNGALL---------HEGPGSSLLLPAASSTDAGSYHCRARDGHSAS 584
Cdd:cd00096    1 VTLTCSA--SGNPPPTITWYKNGKPLppssrdsrrSELGNGTLTISNVTLEDSGTYTCVASNSAGGS 65
IgC1_CD22_d2 cd20938
Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 ...
 142-229 5.01e-06

Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains; The members here are composed of the second immunoglobulin domain of clusters of differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C1-set of IgSF domains.


Pssm-ID: 409532  Cd Length: 98  Bit Score: 46.86  E-value: 5.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  142 PTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQD-PARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLS 220
Cdd:cd20938    3 PHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGsPMRQAAVTSTSLTIKSVFTRSELKFQPKWSHHGKIVTCQLQ 82


                 ....*....
gi 13489095  221 VANHRAQSE 229
Cdd:cd20938   83 DADGKVLSE 91
IgI_1_MuSK cd20970
agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...
 519-580 6.20e-06

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin-like domains (Ig1) of the Muscle-specific kinase (MuSK). MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409562 [Multi-domain]  Cd Length: 92  Bit Score: 46.35  E-value: 6.20e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  519 AEVVEGQAVTLSCRSGLSPTPDarFSWYLNGALLHEGP--------GSSLLLPAASSTDAGSYHCRARDG 580
Cdd:cd20970   12 VTAREGENATFMCRAEGSPEPE--ISWTRNGNLIIEFNtryivrenGTTLTIRNIRRSDMGIYLCIASNG 79
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 521-595 6.46e-06

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 46.23  E-value: 6.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  521 VVEGQAVTLSCrsgLSPTPDARFSWYLNGALLHEGP-------GSSLLLPAASSTDAGSYHCRARDGHSASgPSSPAVLT 593
Cdd:cd05740   12 VEDKDAVTLTC---EPETQNTSYLWWFNGQSLPVTPrltlsngNRTLTLLNVTREDAGAYQCEISNPVSAN-RSDPVTLD 87


                 ..
gi 13489095  594 VL 595
Cdd:cd05740   88 VI 89
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 327-394 6.84e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 45.63  E-value: 6.84e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13489095    327 EVQVSPAGPIL-ENQTVTLVCNTpnEAPSDLRYSWYKNHVLLEDAHSH---------TLRLHLATRADTGFYFCEVQN 394
Cdd:pfam13927    3 VITVSPSSVTVrEGETVTLTCEA--TGSPPPTITWYKNGEPISSGSTRsrslsgsnsTLTISNVTRSDAGTYTCVASN 78
I-set pfam07679
Immunoglobulin I-set domain;
813-893 8.12e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 45.71  E-value: 8.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    813 ALFICTVDSRPLALLALFHGEHLLATSlgpqvpshGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQ 892
Cdd:pfam07679   18 ARFTCTVTGTPDPEVSWFKDGQPLRSS--------DRFKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEAEASAELT 89


                   .
gi 13489095    893 V 893
Cdd:pfam07679   90 V 90
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 513-594 8.98e-06

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 45.37  E-value: 8.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  513 LLISPAAEVVEGQAVTLSCRsGLSPTPDARFSWYLNGALLHEGPGSS-LLLPAASSTDAGSYHCRArDGHSASGPSSPAV 591
Cdd:cd05753    3 LLQAPSAVVFEGEPLTLRCH-GWKDKKVHKVTYYKDGKALKFSYENSnFSIPQATLSDSGSYHCSG-TVRIKRRSSESVN 80


                 ...
gi 13489095  592 LTV 594
Cdd:cd05753   81 ITV 83
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 521-594 1.00e-05

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 45.05  E-value: 1.00e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13489095  521 VVEGQAVTLSCRsGLSPTPDARFSWYLNGALLHEGPgSSLLLPAASSTDAGSYHCRARDghsaSGPSSPAVLTV 594
Cdd:cd05752   12 VFQGEKVTLTCQ-GFYSPEQNSTQWYHNGTLISSTS-SSYRIVAATVNDSGEYRCQTQG----SSLSDPVHLEV 79
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 899-974 1.41e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 44.88  E-value: 1.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    899 QVSPSPELQEGQAVVLSCQVHTGVPeGTSYRWYRDGQPLQES----------TSATLRFAAITLTQAGAYHCQAQAPGSA 968
Cdd:pfam00047    1 SAPPTVTVLEGDSATLTCSASTGSP-GPDVTWSKEGGTLIESlkvkhdngrtTQSSLLISNVTKEDAGTYTCVVNNPGGS 79


                   ....*.
gi 13489095    969 TTSLAA 974
Cdd:pfam00047   80 ATLSTS 85
Ig4_Contactin-2-like cd05728
Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains; The ...
 897-963 1.51e-05

Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains; The members here are composed of the fourth Ig domain of the neural cell adhesion molecule contactin-2. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-2 (also called TAG-1, axonin-1) facilitates cell adhesion by homophilic binding between molecules in apposed membranes. The first four Ig domains form the intermolecular binding fragment which arranges as a compact U-shaped module by contacts between Ig domains 1 and 4, and domains 2 and 3. It has been proposed that a linear zipper-like array forms, from contactin-2 molecules alternatively provided by the two apposed membranes.


Pssm-ID: 143205 [Multi-domain]  Cd Length: 85  Bit Score: 44.90  E-value: 1.51e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13489095  897 WVQVSPSPELQEGQAVVLSCqVHTGVPEgTSYRWYRDGQPLQ-----ESTSATLRFAAITLTQAGAYHCQAQ 963
Cdd:cd05728    2 WLKVISDTEADIGSSLRWEC-KASGNPR-PAYRWLKNGQPLAsenriEVEAGDLRITKLSLSDSGMYQCVAE 71
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 912-972 1.81e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 44.24  E-value: 1.81e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13489095  912 VVLSCQVhTGVPEgTSYRWYRDGQPLQEST---------SATLRFAAITLTQAGAYHCQAQ--APGSATTSL 972
Cdd:cd00096    1 VTLTCSA-SGNPP-PTITWYKNGKPLPPSSrdsrrselgNGTLTISNVTLEDSGTYTCVASnsAGGSASASV 70
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 1003-1080 1.88e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 44.24  E-value: 1.88e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095 1003 LLCRVDSDPPAQLRLLHGdrlvastlqgvGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTL-GQASASA 1080
Cdd:cd00096    3 LTCSASGNPPPTITWYKN-----------GKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAgGSASASV 70
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 1003-1071 2.59e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.09  E-value: 2.59e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095   1003 LLCRVDSDPPAQLRLLHGdrlvastlqgvGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASN 1071
Cdd:pfam13927   21 LTCEATGSPPPTITWYKN-----------GEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVASN 78
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 1096-1149 3.15e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 43.71  E-value: 3.15e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13489095   1096 TVREGQLVNLTCLVwTTHPaQLTYTWYQDGQQRLDAHSIP-----------LPNVTVRDATSYRC 1149
Cdd:pfam13927   12 TVREGETVTLTCEA-TGSP-PPTITWYKNGEPISSGSTRSrslsgsnstltISNVTRSDAGTYTC 74
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 252-313 3.21e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 44.11  E-value: 3.21e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095    252 ILPGELVTLTCQVNSSYPAVSsIKWLKDGVRL-----------QTKTGVLHLPQAAWSDAGVYTCQAENGVGS 313
Cdd:pfam00047    8 VLEGDSATLTCSASTGSPGPD-VTWSKEGGTLieslkvkhdngRTTQSSLLISNVTKEDAGTYTCVVNNPGGS 79
IGc1 smart00407
Immunoglobulin C-Type;
258-308 3.83e-05

Immunoglobulin C-Type;


Pssm-ID: 214651  Cd Length: 75  Bit Score: 43.46  E-value: 3.83e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13489095     258 VTLTCQVNSSYPAVSSIKWLKDG--VRLQTKTG--------------VLHLPQAAWSDAGVYTCQAE 308
Cdd:smart00407    2 ATLVCLVSGFYPPDITVTWLRNGqeVTEGVSTTdplknsdgtyflssYLTVPASTWESGDVYTCQVT 68
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 901-980 4.09e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.65  E-value: 4.09e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     901 SPSPELQEGQAVVLSCQVhTGVPEgTSYRWYRDGQPL----------QESTSATLRFAAITLTQAGAYHCQAQapgSATT 970
Cdd:smart00410    1 PPSVTVKEGESVTLSCEA-SGSPP-PEVTWYKQGGKLlaesgrfsvsRSGSTSTLTISNVTPEDSGTYTCAAT---NSSG 75

                            90
                    ....*....|
gi 13489095     971 SLAAPISLHV 980
Cdd:smart00410   76 SASSGTTLTV 85
Ig_Pro_neuregulin cd05750
Immunoglobulin (Ig)-like domain in neuregulins; The members here are composed of the ...
 238-312 5.00e-05

Immunoglobulin (Ig)-like domain in neuregulins; The members here are composed of the immunoglobulin (Ig)-like domain in neuregulins (NRGs). NRGs are signaling molecules which participate in cell-cell interactions in the nervous system, breast, heart, and other organ systems, and are implicated in the pathology of diseases including schizophrenia, multiple sclerosis, and breast cancer. There are four members of the neuregulin gene family (NRG-1, NRG-2, NRG-3, and NRG-4). The NRG-1 protein, binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. The other NRGs proteins bind one or the other or both of these ErbBs. NRG-1 has multiple functions: in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors, while in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival. There are many NRG-1 isoforms which arise from the alternative splicing of mRNA. Less is known of the functions of the other NRGs. NRG-2 and NRG-3 are expressed predominantly in the nervous system. NRG-2 is expressed by motor neurons and terminal Schwann cells, and is concentrated near synaptic sites and may be a signal that regulates synaptic differentiation. NRG-4 has been shown to direct pancreatic islet cell development towards the delta-cell lineage.


Pssm-ID: 409408 [Multi-domain]  Cd Length: 92  Bit Score: 43.65  E-value: 5.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  238 PKgVKILLSPSGRNilpGELVTLTCQVNSSYPAVSsIKWLKDG------------VRLQTKTGVLHLPQAAWSDAGVYTC 305
Cdd:cd05750    1 PK-LKEMKSQTVQE---GSKLVLKCEATSENPSPR-YRWFKDGkelnrkrpknikIRNKKKNSELQINKAKLEDSGEYTC 75


                 ....*..
gi 13489095  306 QAENGVG 312
Cdd:cd05750   76 VVENILG 82
IgI_1_FGFR cd04973
First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of ...
 237-313 5.18e-05

First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR). Fibroblast growth factors (FGFs) participate in morphogenesis, development, angiogenesis, and wound healing. These FGF-stimulated processes are mediated by four FGFR tyrosine kinases (FGRF1-4). FGFRs are comprised of an extracellular portion consisting of three Ig-like domains, a transmembrane helix, and a cytoplasmic portion having protein tyrosine kinase activity. The highly conserved Ig-like domains 2 and 3, and the linker region between D2 and D3 define a general binding site for all FGFs.


Pssm-ID: 409362  Cd Length: 94  Bit Score: 43.73  E-value: 5.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  237 APKGVKIllSPSGRNILPGELVTLTCQVNSsypAVSSIKWLKDGVRL----QTK-TG-VLHLPQAAWSDAGVYTCQAENG 310
Cdd:cd04973    8 PPTYQIS--EVESYSAHPGDLLQLRCRLRD---DVQSINWTKDGVQLgennRTRiTGeEVQIKDAVPRDSGLYACVTSSP 82


                 ...
gi 13489095  311 VGS 313
Cdd:cd04973   83 SGS 85
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 908-980 5.25e-05

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 43.12  E-value: 5.25e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095  908 EGQAVVLSCQVhTGVPEGTSYRWYRDGQpLQESTSATLRFAAITLTQAGAYHCQAQapGSAttsLAAPISLHV 980
Cdd:cd05752   14 QGEKVTLTCQG-FYSPEQNSTQWYHNGT-LISSTSSSYRIVAATVNDSGEYRCQTQ--GSS---LSDPVHLEV 79
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 514-589 5.45e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 43.34  E-value: 5.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    514 LISPAAEVVEGQAVTLSCRSGLSpTPDARFSWYLNGALLHEGP----------GSSLLLPAASSTDAGSYHCRARDGHSA 583
Cdd:pfam00047    1 SAPPTVTVLEGDSATLTCSASTG-SPGPDVTWSKEGGTLIESLkvkhdngrttQSSLLISNVTKEDAGTYTCVVNNPGGS 79


                   ....*.
gi 13489095    584 SGPSSP 589
Cdd:pfam00047   80 ATLSTS 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1093-1168 5.99e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.26  E-value: 5.99e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    1093 PGATVREGQLVNLTCLVWTTHPAQltYTWYQDGQQRLDA------------HSIPLPNVTVRDATSYRCGVGPPGraPRL 1160
Cdd:smart00410    2 PSVTVKEGESVTLSCEASGSPPPE--VTWYKQGGKLLAEsgrfsvsrsgstSTLTISNVTPEDSGTYTCAATNSS--GSA 77


                    ....*...
gi 13489095    1161 SRPITLDV 1168
Cdd:smart00410   78 SSGTTLTV 85
IgI_3_Robo cd05725
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 1005-1080 9.18e-05

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409390 [Multi-domain]  Cd Length: 83  Bit Score: 42.77  E-value: 9.18e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13489095 1005 CRVDSDPPAQLRLLHGDrlvastlqgvggpeGSSPRLHVAVAP-NTLRLEihGAMLEDEGVYICEASNTLGQASASA 1080
Cdd:cd05725   19 CEVGGDPVPTVRWRKED--------------GELPKGRYEILDdHSLKIR--KVTAGDMGSYTCVAENMVGKIEASA 79
IgC_1_Robo cd07693
First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar ...
 1271-1342 9.39e-05

First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain in Roundabout (Robo) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit1, Slit2, Slit3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit1, Slit2,and Slit3 are expressed at the ventral midline. Robo3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site.


Pssm-ID: 409490 [Multi-domain]  Cd Length: 99  Bit Score: 42.92  E-value: 9.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1271 VPEGAPITVTCADPAAHAPTLyTWYHNGRWLQEG-----------PAASLSFL--VATR---AHAGAYSCQAQDAQGTRS 1334
Cdd:cd07693   12 VSKGDPATLNCKAEGRPTPTI-QWLKNGQPLETDkddprshrivlPSGSLFFLrvVHGRkgrSDEGVYVCVAHNSLGEAV 90


                 ....*...
gi 13489095 1335 SRPAALQV 1342
Cdd:cd07693   91 SRNASLEV 98
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 255-316 1.00e-04

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 42.76  E-value: 1.00e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095  255 GELVTLTCQVnSSYPAvSSIKWLKDGVRLQTKTGVLHLPQAA-------WSDAGVYTCQAENGVGSLVS 316
Cdd:cd20978   16 GQDVTLPCQV-TGVPQ-PKITWLHNGKPLQGPMERATVEDGTltiinvqPEDTGYYGCVATNEIGDIYT 82
IgI_2_Robo cd05724
Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 247-323 1.29e-04

Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of the Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit-2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409389 [Multi-domain]  Cd Length: 87  Bit Score: 42.39  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  247 PSGRNILPGELVTLTCQVNSSYPAvSSIKWLKDGVRLQTKT--------GVLHLPQAAWSDAGVYTCQAENGVGSLVSPP 318
Cdd:cd05724    4 PSDTQVAVGEMAVLECSPPRGHPE-PTVSWRKDGQPLNLDNervrivddGNLLIAEARKSDEGTYKCVATNMVGERESRA 82


                 ....*
gi 13489095  319 ISLHI 323
Cdd:cd05724   83 ARLSV 87
Ig_Pro_neuregulin cd05750
Immunoglobulin (Ig)-like domain in neuregulins; The members here are composed of the ...
 903-963 1.30e-04

Immunoglobulin (Ig)-like domain in neuregulins; The members here are composed of the immunoglobulin (Ig)-like domain in neuregulins (NRGs). NRGs are signaling molecules which participate in cell-cell interactions in the nervous system, breast, heart, and other organ systems, and are implicated in the pathology of diseases including schizophrenia, multiple sclerosis, and breast cancer. There are four members of the neuregulin gene family (NRG-1, NRG-2, NRG-3, and NRG-4). The NRG-1 protein, binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. The other NRGs proteins bind one or the other or both of these ErbBs. NRG-1 has multiple functions: in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors, while in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival. There are many NRG-1 isoforms which arise from the alternative splicing of mRNA. Less is known of the functions of the other NRGs. NRG-2 and NRG-3 are expressed predominantly in the nervous system. NRG-2 is expressed by motor neurons and terminal Schwann cells, and is concentrated near synaptic sites and may be a signal that regulates synaptic differentiation. NRG-4 has been shown to direct pancreatic islet cell development towards the delta-cell lineage.


Pssm-ID: 409408 [Multi-domain]  Cd Length: 92  Bit Score: 42.50  E-value: 1.30e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13489095  903 SPELQEGQAVVLSCQVHTGVPEgTSYRWYRDGQPLQESTS-----------ATLRFAAITLTQAGAYHCQAQ 963
Cdd:cd05750    8 SQTVQEGSKLVLKCEATSENPS-PRYRWFKDGKELNRKRPknikirnkkknSELQINKAKLEDSGEYTCVVE 78
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 715-792 1.88e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 1.88e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     715 PSHTLQEGTEANLTCNVSreaAGSPANFSWFRNGVLW----------AQGPLETVTLLPVARTDAALYACRILTEAGaQL 784
Cdd:smart00410    2 PSVTVKEGESVTLSCEAS---GSPPPEVTWYKQGGKLlaesgrfsvsRSGSTSTLTISNVTPEDSGTYTCAATNSSG-SA 77


                    ....*...
gi 13489095     785 STPVLLSV 792
Cdd:smart00410   78 SSGTTLTV 85
IgI_2_Titin_Z1z2-like cd20972
Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and ...
 520-577 1.89e-04

Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the titin Z1z2 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409564 [Multi-domain]  Cd Length: 91  Bit Score: 41.80  E-value: 1.89e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13489095  520 EVVEGQAVTLSCRSGLSPTPDARfsWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRA 577
Cdd:cd20972   12 EVAEGSKVRLECRVTGNPTPVVR--WFCEGKELQnspdiqihqEGDLHSLIIAEAFEEDTGRYSCLA 76
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 1273-1342 1.89e-04

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 41.58  E-value: 1.89e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1273 EGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPaASLSFLVATRAHAGAYSCQaqdAQGTRSSRPAALQV 1342
Cdd:cd05752   14 QGEKVTLTCQGFYSPEQNSTQWYHNGTLISSTS-SSYRIVAATVNDSGEYRCQ---TQGSSLSDPVHLEV 79
IgI_1_Neogenin_like cd05722
First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of ...
 244-316 1.99e-04

First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain in neogenin and related proteins. Neogenin is a cell surface protein which is expressed in the developing nervous system of vertebrate embryos in the growing nerve cells. It is also expressed in other embryonic tissues and may play a general role in developmental processes such as cell migration, cell-cell recognition, and tissue growth regulation. Included in this group is the tumor suppressor protein DCC which is deleted in colorectal carcinoma. DCC and neogenin each have four Ig-like domains followed by six fibronectin type III domains, a transmembrane domain, and an intracellular domain. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409387  Cd Length: 97  Bit Score: 42.08  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  244 LLSPSGRNILPGELVTLTCQVNSSYPAvsSIKWLKDGVRLQTK---------------TGVLHLPQAAwSDAGVYTCQAE 308
Cdd:cd05722    5 LSEPSDIVAMRGGPVVLNCSAESDPPP--KIEWKKDGVLLNLVsderrqqlpngslliTSVVHSKHNK-PDEGFYQCVAQ 81


                 ....*....
gi 13489095  309 NG-VGSLVS 316
Cdd:cd05722   82 NEsLGSIVS 90
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 430-498 2.37e-04

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 41.61  E-value: 2.37e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095  430 ILHCSVVSEPLATLVLSHGGHILastsgdSDHSPRFSGTSGpnslRLEIRDLEETDSGEYKCSATNSLG 498
Cdd:cd20978   20 TLPCQVTGVPQPKITWLHNGKPL------QGPMERATVEDG----TLTIINVQPEDTGYYGCVATNEIG 78
IgI_1_Contactin-2 cd05850
First immunoglobulin (Ig) domain of contactin-2; member of the I-set of Ig superfamily domains; ...
 244-321 2.47e-04

First immunoglobulin (Ig) domain of contactin-2; member of the I-set of Ig superfamily domains; The members here are composed of the first immunoglobulin (Ig) domain of the neural cell adhesion molecule contactin-2-like. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-2 (TAG-1, axonin-1) facilitates cell adhesion by homophilic binding between molecules in apposed membranes. It may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module by contacts between IG domains 1 and 4, and domains 2 and 3. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-2 is also expressed in retinal amacrine cells in the developing chick retina, corresponding to the period of formation and maturation of AC processes. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409437 [Multi-domain]  Cd Length: 97  Bit Score: 41.83  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  244 LLSPSGrniLPGELVTLTCQVNSSYPAVssIKWLKDGVRLQTKTG----------VLHLPQAAwSDAGVYTCQAENGVGS 313
Cdd:cd05850   12 TLFPEG---SAEEKVTLACRARASPPAT--YRWKMNGTELKMEPDsryrlvagnlVISNPVKA-KDAGSYQCLASNRRGT 85


                 ....*...
gi 13489095  314 LVSPPISL 321
Cdd:cd05850   86 VVSREASL 93
IgV_CD22_d1 cd20929
First immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the V-set of IgSF ...
 21-125 2.50e-04

First immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the V-set of IgSF domains.


Pssm-ID: 409523  Cd Length: 114  Bit Score: 42.30  E-value: 2.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   21 WGVSSPQDVQGVKGSCLLIPCIFSFP-ADVevpDGITAIWYYDYSGQRQ-----VVSHSADPKLVEARFRgRTEFMGNpE 94
Cdd:cd20929    1 WVFEHPETLYAWEGACVWIPCTYRALdGDL---ESFILFHNPEYNKATSkfdgtRLYESTKDGKVPSEQK-RVQFLGD-K 75

                         90       100       110
                 ....*....|....*....|....*....|.
gi 13489095   95 HRVCNLLLKDLQPEDSGSYNFRFEiSEVNRW 125
Cdd:cd20929   76 NKNCTLSIHPVHLNDSGQLGLRME-SKTEKW 105
IgI_NCAM-1 cd05869
Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1); The members ...
 1552-1630 2.57e-04

Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1); The members here are composed of the fourth Ig domain of Neural Cell Adhesion Molecule 1(NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-non-NCAM) interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain. One of the unique features of I-set domains is the lack of a C" strand. The structures of this group show that the Ig domain lacks this strand and thus is a member of the I-set of Ig domains.


Pssm-ID: 143277 [Multi-domain]  Cd Length: 97  Bit Score: 41.89  E-value: 2.57e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095 1552 LDCRVDSEPLASLTLHLGSRLVASSQpqgAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630
Cdd:cd05869   22 LTCEASGDPIPSITWRTSTRNISSEE---KTLDGHIVVRSHARVSSLTLKYIQYTDAGEYLCTASNTIGQDSQSMYLEV 97
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 258-323 2.60e-04

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 41.61  E-value: 2.60e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13489095  258 VTLTCqvnSSYPAVSSIKWLKDGV------RLQTKTG--VLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHI 323
Cdd:cd05740   18 VTLTC---EPETQNTSYLWWFNGQslpvtpRLTLSNGnrTLTLLNVTREDAGAYQCEISNPVSANRSDPVTLDV 88
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 715-775 2.64e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.01  E-value: 2.64e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    715 PSHTLQEGTEANLTCNVSreaAGSPANFSWFRNGVLWAQGPLE---------TVTLLPVARTDAALYACR 775
Cdd:pfam13927    9 SSVTVREGETVTLTCEAT---GSPPPTITWYKNGEPISSGSTRsrslsgsnsTLTISNVTRSDAGTYTCV 75
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 1090-1168 2.79e-04

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 41.14  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1090 QVWPgATVREGQLVNLTCLVWTTHPAQlTYTWYQDGQQR---LDAHSIPLPNVTVRDATSYRCgVGPPGRAPRLSRPITL 1166
Cdd:cd05753    5 QAPS-AVVFEGEPLTLRCHGWKDKKVH-KVTYYKDGKALkfsYENSNFSIPQATLSDSGSYHC-SGTVRIKRRSSESVNI 81


                 ..
gi 13489095 1167 DV 1168
Cdd:cd05753   82 TV 83
IgI_Myotilin_C_like cd05744
Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of ...
 1169-1256 2.80e-04

Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain in myotilin, palladin, and myopalladin. Myotilin, palladin, and myopalladin function as scaffolds that regulate actin organization. Myotilin and myopalladin are most abundant in skeletal and cardiac muscle; palladin is ubiquitously expressed in the organs of developing vertebrates and plays a key role in cellular morphogenesis. The three family members each interact with specific molecular partners with all three binding to alpha-actinin; In addition, palladin also binds to vasodilator-stimulated phosphoprotein (VASP) and ezrin, myotilin binds to filamin and actin, and myopalladin also binds to nebulin and cardiac ankyrin repeat protein (CARP). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409405 [Multi-domain]  Cd Length: 91  Bit Score: 41.33  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1169 LYAPRNLRLTYlleshgGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS--VPNTLR--LELRGPQPRDEGFYSCSAR 1244
Cdd:cd05744    4 LQAPGDLEVQE------GRLCRFDCKVSGLPTPDLFWQLNGKPVRPDSAHKmlVRENGRhsLIIEPVTKRDAGIYTCIAR 77

                         90
                 ....*....|..
gi 13489095 1245 SPLGQANTSLEL 1256
Cdd:cd05744   78 NRAGENSFNAEL 89
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 715-788 3.02e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 41.41  E-value: 3.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    715 PSHTLQEGTEANLTCNVSreAAGSPANFSWFRNG---VLWAQGPL-------ETVTLLPVARTDAALYACRILTEAG-AQ 783
Cdd:pfam00047    4 PTVTVLEGDSATLTCSAS--TGSPGPDVTWSKEGgtlIESLKVKHdngrttqSSLLISNVTKEDAGTYTCVVNNPGGsAT 81


                   ....*
gi 13489095    784 LSTPV 788
Cdd:pfam00047   82 LSTSL 86
IgI_1_hemolin-like cd20979
First immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 907-978 3.02e-04

First immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM).


Pssm-ID: 409571  Cd Length: 91  Bit Score: 41.40  E-value: 3.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  907 QEGQAVVLSCqVHTGVPEGTSYRWYRDGQP--LQESTSA------TLRFAAITLTQAGAYHCQAQAP-GSATTSlaaPIS 977
Cdd:cd20979   13 REGQPTVLEC-VTEGGDQGVKYSWLKDGKSfnWQEHNVAqrkdegSLVFLKPQASDEGQYQCFAETPaGVASSR---VIS 88


                 .
gi 13489095  978 L 978
Cdd:cd20979   89 F 89
IgC1_CH2_Mu cd16093
CH2 domain (second constant Ig domain of the heavy chain) in immunoglobulin mu chain; member ...
 244-310 3.03e-04

CH2 domain (second constant Ig domain of the heavy chain) in immunoglobulin mu chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin constant domain (IgC) of mu heavy chains. This domain is found on the Fc fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns.


Pssm-ID: 409513  Cd Length: 99  Bit Score: 41.61  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  244 LLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV------------------LHLPQAAWSDAGVYTC 305
Cdd:cd16093    6 LHAPSREEFLGNRTATFVCLATGFSPKTISFKWLRNGKEVTSSTGAvveepkedgktlysatsfLTITESEWKSQTEFTC 85


                 ....*
gi 13489095  306 QAENG 310
Cdd:cd16093   86 EFKHK 90
IgI_Myotilin_C_like cd05744
Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of ...
 520-581 3.06e-04

Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain in myotilin, palladin, and myopalladin. Myotilin, palladin, and myopalladin function as scaffolds that regulate actin organization. Myotilin and myopalladin are most abundant in skeletal and cardiac muscle; palladin is ubiquitously expressed in the organs of developing vertebrates and plays a key role in cellular morphogenesis. The three family members each interact with specific molecular partners with all three binding to alpha-actinin; In addition, palladin also binds to vasodilator-stimulated phosphoprotein (VASP) and ezrin, myotilin binds to filamin and actin, and myopalladin also binds to nebulin and cardiac ankyrin repeat protein (CARP). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409405 [Multi-domain]  Cd Length: 91  Bit Score: 41.33  E-value: 3.06e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13489095  520 EVVEGQAVTLSCRSGLSPTPDarFSWYLNGA----------LLHEGPGSSLLLPAASSTDAGSYHCRARDGH 581
Cdd:cd05744   11 EVQEGRLCRFDCKVSGLPTPD--LFWQLNGKpvrpdsahkmLVRENGRHSLIIEPVTKRDAGIYTCIARNRA 80
IgC_1_Robo cd07693
First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar ...
 242-323 3.50e-04

First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain in Roundabout (Robo) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit1, Slit2, Slit3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit1, Slit2,and Slit3 are expressed at the ventral midline. Robo3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site.


Pssm-ID: 409490 [Multi-domain]  Cd Length: 99  Bit Score: 41.38  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  242 KILLSPSGRNILPGELVTLTCQVNSSypAVSSIKWLKDGVRLQTKTG------------------VLHLPQAAwSDAGVY 303
Cdd:cd07693    2 RIVEHPSDLIVSKGDPATLNCKAEGR--PTPTIQWLKNGQPLETDKDdprshrivlpsgslfflrVVHGRKGR-SDEGVY 78

                         90       100
                 ....*....|....*....|
gi 13489095  304 TCQAENGVGSLVSPPISLHI 323
Cdd:cd07693   79 VCVAHNSLGEAVSRNASLEV 98
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 1086-1169 3.55e-04

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 41.23  E-value: 3.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1086 AVNVQVWPGATVREGQLVNLTCLVWTThpaQLTYTWYQDGQ-----QRL----DAHSIPLPNVTVRDATSYRCGVGPPGR 1156
Cdd:cd05740    1 KPFISSNNSNPVEDKDAVTLTCEPETQ---NTSYLWWFNGQslpvtPRLtlsnGNRTLTLLNVTREDAGAYQCEISNPVS 77

                         90
                 ....*....|...
gi 13489095 1157 APRlSRPITLDVL 1169
Cdd:cd05740   78 ANR-SDPVTLDVI 89
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 1277-1338 4.13e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 40.39  E-value: 4.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13489095 1277 ITVTCADPAAHAPTlYTWYHNGRWLQEGPA---------ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPA 1338
Cdd:cd00096    1 VTLTCSASGNPPPT-ITWYKNGKPLPPSSRdsrrselgnGTLTISNVTLEDSGTYTCVASNSAGGSASASV 70
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1552-1627 4.20e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 4.20e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13489095    1552 LDCRVDSEPLASLT-LHLGSRLVASSqpqgapaePHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTY 1627
Cdd:smart00410   14 LSCEASGSPPPEVTwYKQGGKLLAES--------GRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSGTT 82
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 810-889 5.06e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 5.06e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     810 GHMALFICTVDSRPLALLALFHGEHLLatslgpqVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG--SSNT 887
Cdd:smart00410    9 GESVTLSCEASGSPPPEVTWYKQGGKL-------LAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGsaSSGT 81


                    ..
gi 13489095     888 SL 889
Cdd:smart00410   82 TL 83
IgI_5_Dscam cd20958
Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 255-312 5.36e-04

Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409550 [Multi-domain]  Cd Length: 89  Bit Score: 40.63  E-value: 5.36e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13489095  255 GELVTLTCQVnSSYPaVSSIKWLKDGVRLQTK---------TGVLHLPQAAwSDAGVYTCQAENGVG 312
Cdd:cd20958   15 GQTLRLHCPV-AGYP-ISSITWEKDGRRLPLNhrqrvfpngTLVIENVQRS-SDEGEYTCTARNQQG 78
IgI_3_Robo cd05725
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 247-313 5.40e-04

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409390 [Multi-domain]  Cd Length: 83  Bit Score: 40.46  E-value: 5.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095  247 PSGRNILPGELVTLTCQVNSSypAVSSIKWLKDGVRL-QTKTGVLH-----LPQAAWSDAGVYTCQAENGVGS 313
Cdd:cd05725    4 PQNQVVLVDDSAEFQCEVGGD--PVPTVRWRKEDGELpKGRYEILDdhslkIRKVTAGDMGSYTCVAENMVGK 74
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 1545-1630 5.55e-04

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 40.45  E-value: 5.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1545 EGGLRGILDCRVDSEPLASLT-LHLGSRLvassqpQGAPAEPHIHvlasPNALRvdIEALRPSDQGEYICSASNVLGSAS 1623
Cdd:cd20978   14 KGGQDVTLPCQVTGVPQPKITwLHNGKPL------QGPMERATVE----DGTLT--IINVQPEDTGYYGCVATNEIGDIY 81


                 ....*..
gi 13489095 1624 TSTYFGV 1630
Cdd:cd20978   82 TETLLHV 88
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 1455-1514 5.85e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.24  E-value: 5.85e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095   1455 VPEGAALNLSCRLLGGPGPvgnsTFAWFWNDRRLHAEPVP---------TLAFTHVARAQAGMYHCLAE 1514
Cdd:pfam13927   13 VREGETVTLTCEATGSPPP----TITWYKNGEPISSGSTRsrslsgsnsTLTISNVTRSDAGTYTCVAS 77
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 727-793 6.33e-04

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 40.46  E-value: 6.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13489095  727 LTCnvsrEAAGSPANFSWFRNGVLWAQGPL-------ETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793
Cdd:cd05740   20 LTC----EPETQNTSYLWWFNGQSLPVTPRltlsngnRTLTLLNVTREDAGAYQCEISNPVSANRSDPVTLDVI 89
C1-set pfam07654
Immunoglobulin C1-set domain;
244-309 6.59e-04

Immunoglobulin C1-set domain;


Pssm-ID: 462221  Cd Length: 85  Bit Score: 40.31  E-value: 6.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    244 LLSPSgrnilPGEL---VTLTCQVNSSYPAVSSIKWLKDGVRLQ----------------TKTGVLHLPQAAWSDAGVYT 304
Cdd:pfam07654    3 VFPPS-----PEELgkpNTLTCLVTGFYPPDITVTWLKNGQEVTegvkttppspnsdwtyQLSSYLTVTPSDWESGDEYT 77


                   ....*
gi 13489095    305 CQAEN 309
Cdd:pfam07654   78 CRVEH 82
IgV_P0 cd05879
Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the ...
 23-113 6.63e-04

Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin.


Pssm-ID: 409463  Cd Length: 117  Bit Score: 41.02  E-value: 6.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   23 VSSPQDVQGVKGSCLLIPCifSFPADVEVPDGITAIWYYDYSGQRQVVS--HSA--DPKLVE-ARFRGRTEFMGNPEHRV 97
Cdd:cd05879    3 VYTDREVYGTVGSDVTLSC--SFWSSEWISDDISFTWHYQPDGSRDAISifHYGkgQPYIDNvGPFKERIEWVGNPSRKD 80

                         90
                 ....*....|....*.
gi 13489095   98 CNLLLKDLQPEDSGSY 113
Cdd:cd05879   81 GSIVIHNLDYTDNGTF 96
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 329-398 6.67e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 40.26  E-value: 6.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    329 QVSPAGPILENQTVTLVCNTpNEAPSDLRYSWYKN---HVLLEDAHSHTLR-----LHL--ATRADTGFYFCEVQNVHGS 398
Cdd:pfam00047    1 SAPPTVTVLEGDSATLTCSA-STGSPGPDVTWSKEggtLIESLKVKHDNGRttqssLLIsnVTKEDAGTYTCVVNNPGGS 79
IgI_3_Contactin cd04968
Third immunoglobulin (Ig) domain of contactin; member of the I-set of Ig superfamily (IgSF) ...
 253-312 7.02e-04

Third immunoglobulin (Ig) domain of contactin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409357 [Multi-domain]  Cd Length: 88  Bit Score: 40.22  E-value: 7.02e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13489095  253 LPGELVTLTCQVNSSypAVSSIKWLK-DGV-----RLQTKTGVLHLPQAAWSDAGVYTCQAENGVG 312
Cdd:cd04968   14 LKGQTVTLECFALGN--PVPQIKWRKvDGSpssqwEITTSEPVLEIPNVQFEDEGTYECEAENSRG 77
IgI_3_CSF-1R cd20936
Third immunoglobulin domain of the hematopoietic colony-stimulating factor 1 receptor (CSF-1R), ...
 809-893 7.46e-04

Third immunoglobulin domain of the hematopoietic colony-stimulating factor 1 receptor (CSF-1R), and similar domains; member of the I-set of IgSF domains; The members here are composed of the third immunoglobulin domain of the hematopoietic colony-stimulating factor 1 receptor (CSF-1R) and similar proteins. CSF-1R, a class III receptor tyrosine kinase (RTKIII), is critical to the survival, proliferation, and differentiation of mononuclear phagocytic cells such as monocytes, tissue macrophages, muscularis macrophages, microglia, osteoclasts, Paneth cells, and myeloid dendritic cells. Human colony-stimulating factor 1 receptor (hCSF-1R) is unique among the hematopoietic receptors because it is activated by two distinct cytokines, CSF-1 and interleukin-34 (IL-34). The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409530  Cd Length: 93  Bit Score: 40.32  E-value: 7.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  809 QGHMALFICTVDSRPLAL-LALFHGEHLLAtslgpqVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNT 887
Cdd:cd20936   14 RGEAAQIVCSASNVDVNFdVFLQHGDTKLA------IPQQSDFHDNRYQKVLTLNLDQVDFQDAGNYSCVASNVQGKHSA 87


                 ....*.
gi 13489095  888 SLFFQV 893
Cdd:cd20936   88 SMFFRV 93
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 1270-1343 7.54e-04

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 40.07  E-value: 7.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1270 AVPEGAPITVTCaDPAAHAPTlYTWYHNGRWLQEGPAASLS-------FLVATRAHAGAYSCQAQDAQGTRSSRPAALQV 1342
Cdd:cd05740   11 PVEDKDAVTLTC-EPETQNTS-YLWWFNGQSLPVTPRLTLSngnrtltLLNVTREDAGAYQCEISNPVSANRSDPVTLDV 88


                 .
gi 13489095 1343 L 1343
Cdd:cd05740   89 I 89
Ig1_Tyro3_like cd20961
First immunoglobulin (Ig)-like domain of Tyro3 receptor tyrosine kinase (RTK), and similar ...
 255-323 7.68e-04

First immunoglobulin (Ig)-like domain of Tyro3 receptor tyrosine kinase (RTK), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Tyro3 receptor tyrosine kinase (RTK). Tyro3 together with Axl and Mer form the Axl/Tyro3 family of receptor tyrosine kinases (RTKs). This family includes Axl (also known as Ark, Ufo, and Tyro7), Tyro3 (also known as Sky, Rse, Brt, Dtk, and Tif), and Mer (also known as Nyk, c-Eyk, and Tyro12). Axl/Tyro3 family receptors have an extracellular portion with two Ig-like domains followed by two fibronectin-types III (FNIII) domains, a membrane-spanning single helix, and a cytoplasmic tyrosine kinase domain. Axl, Tyro3 and Mer are widely expressed in adult tissues, though they show higher expression in the brain, in the lymphatic and vascular systems, and in the testis. Axl, Tyro3, and Mer bind the vitamin K dependent protein Gas6 with high affinity, and in doing so activate their tyrosine kinase activity. Axl/Gas6 signaling may play a part in cell adhesion processes, prevention of apoptosis, and cell proliferation.


Pssm-ID: 409553  Cd Length: 87  Bit Score: 40.12  E-value: 7.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  255 GELVTLTCQVNSSYPAvsSIKWLKDGVRLQTK------------TGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322
Cdd:cd20961    8 GQPVKLNCSVEGMEEP--DIQWVKDGAVVQNLdqlyipvseqhwIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLT 85


                 .
gi 13489095  323 I 323
Cdd:cd20961   86 V 86
Ig_Pro_neuregulin-1 cd05895
Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1; The members here are composed of ...
 255-313 8.01e-04

Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1; The members here are composed of the immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1. There are many NRG-1 isoforms which arise from the alternative splicing of mRNA. NRG-1 belongs to the neuregulin gene family which is comprised of four genes. This group represents NRG-1. NRGs are signaling molecules which participate in cell-cell interactions in the nervous system, breast, and heart, and other organ systems, and are implicated in the pathology of diseases including schizophrenia, multiple sclerosis, and breast cancer. The NRG-1 protein binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. NRG-1 has multiple functions, for example, in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival.


Pssm-ID: 409476  Cd Length: 93  Bit Score: 40.36  E-value: 8.01e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13489095  255 GELVTLTCQVNSSYPAVSsIKWLKDG-----------VRLQTKTGV--LHLPQAAWSDAGVYTCQAENGVGS 313
Cdd:cd05895   14 GSKLVLRCETSSEYPSLR-FKWFKNGkeinrknkpenIKIQKKKKKseLRINKASLADSGEYMCKVSSKLGN 84
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 243-313 8.30e-04

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 40.17  E-value: 8.30e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095  243 ILLSPSGRNILPGELVTLTCQVNSSypAVSSIKWLKDGVRLQTK--------TGVLHLPQAAWSDAGVYTCQAENGVGS 313
Cdd:cd20952    2 ILQGPQNQTVAVGGTVVLNCQATGE--PVPTISWLKDGVPLLGKderittleNGSLQIKGAEKSDTGEYTCVALNLSGE 78
Ig5_Contactin cd04969
Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth ...
 1547-1630 8.76e-04

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409358 [Multi-domain]  Cd Length: 89  Bit Score: 40.14  E-value: 8.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1547 GLRGILDCRVDSEPLASLTLHLGSRLVASSqpqgapaePHIHVLASPNalrVDIEALRPSDQGEYICSASNVLGSASTST 1626
Cdd:cd04969   17 GGDVIIECKPKASPKPTISWSKGTELLTNS--------SRICILPDGS---LKIKNVTKSDEGKYTCFAVNFFGKANSTG 85


                 ....
gi 13489095 1627 YFGV 1630
Cdd:cd04969   86 SLSV 89
I-set pfam07679
Immunoglobulin I-set domain;
336-399 1.01e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 39.93  E-value: 1.01e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13489095    336 ILENQTVTLVCNTpnEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSE 399
Cdd:pfam07679   12 VQEGESARFTCTV--TGTPDPEVSWFKDgqplrssdrFKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEA 82
IgI_3_Robo cd05725
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 1363-1442 1.07e-03

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409390 [Multi-domain]  Cd Length: 83  Bit Score: 39.69  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1363 AVIQCTVDSEPPAELALS-HDGKvlatssgvhsLASGTGHVqVARNALRLQvqDVPAGDD-TYVCTAQNLLGSISTIGRL 1440
Cdd:cd05725   15 AEFQCEVGGDPVPTVRWRkEDGE----------LPKGRYEI-LDDHSLKIR--KVTAGDMgSYTCVAENMVGKIEASATL 81


                 ..
gi 13489095 1441 QV 1442
Cdd:cd05725   82 TV 83
I-set pfam07679
Immunoglobulin I-set domain;
1186-1256 1.11e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 39.55  E-value: 1.11e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13489095   1186 GQLALVLCTVDSRPPAQLALSHAGRLLASS---TAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLEL 1256
Cdd:pfam07679   15 GESARFTCTVTGTPDPEVSWFKDGQPLRSSdrfKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEAEASAEL 88
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 523-596 1.11e-03

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409540  Cd Length: 76  Bit Score: 39.40  E-value: 1.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13489095  523 EGQAVTLSCRSglSPTPDARFSWYLNGALLHEgpGSSLLLPAASSTDAGSYHCRARdgHSASGPSSPAVLTVLY 596
Cdd:cd20948    9 SGENLNLSCHA--ASNPPAQYSWTINGTFQTS--SQELFLPAITENNEGTYTCSAH--NSLTGKNISLVLSVTV 76
IgI_2_JAM1 cd20950
Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF ...
 1267-1332 1.12e-03

Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains; The members here are composed of the second Ig-like domain of Junctional adhesion molecule-1 (JAM1). JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The second Ig-like domain of JAM1 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous but lacks a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors.


Pssm-ID: 409542  Cd Length: 97  Bit Score: 39.99  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1267 PEAAVPEGAPI----TVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRA----------------HAGAYSCQA 1326
Cdd:cd20950    1 PTVNIPSSATIgnraVLTCSEPDGSPPSEYTWFKDGVVMPTNPKSTRAFSNSSYSldpttgelvfdplsasDTGEYSCEA 80


                 ....*.
gi 13489095 1327 QDAQGT 1332
Cdd:cd20950   81 RNGYGT 86
Ig6_Contactin cd04970
Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth ...
 509-598 1.14e-03

Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409359  Cd Length: 102  Bit Score: 40.23  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  509 NAARLLISP-AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH-EGPGS------------SLLLPAASSTDAGSYH 574
Cdd:cd04970    1 DATRITLAPsNADITVGENATLQCHASHDPTLDLTFTWSFNGVPIDlEKIEGhyrrrygkdsngDLEIVNAQLKHAGRYT 80

                         90       100
                 ....*....|....*....|....
gi 13489095  575 CRARDghSASGPSSPAVLTVLYPP 598
Cdd:cd04970   81 CTAQT--VVDSDSASATLVVRGPP 102
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 1552-1626 1.22e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 39.23  E-value: 1.22e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13489095 1552 LDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLaspnalrvDIEALRPSDQGEYICSASNVLGSASTST 1626
Cdd:cd00096    3 LTCSASGNPPPTITWYKNGKPLPPSSRDSRRSELGNGTL--------TISNVTLEDSGTYTCVASNSAGGSASAS 69
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1186-1257 1.40e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.41  E-value: 1.40e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13489095    1186 GQLALVLCTVDSRPPAQLALSH-AGRLLASSTAASV---PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELR 1257
Cdd:smart00410    9 GESVTLSCEASGSPPPEVTWYKqGGKLLAESGRFSVsrsGSTSTLTISNVTPEDSGTYTCAATNSSGSASSGTTLT 84
I-set pfam07679
Immunoglobulin I-set domain;
1363-1442 1.47e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 39.55  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   1363 AVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHvqvarnalRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQ 1441
Cdd:pfam07679   18 ARFTCTVTGTPDPEVSWFKDGQPLRSSDRFKVTYEGGTY--------TLTISNVQPDDSgKYTCVATNSAGEAEASAELT 89


                   .
gi 13489095   1442 V 1442
Cdd:pfam07679   90 V 90
IgC2_3_Dscam cd20957
Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 1184-1258 1.54e-03

Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the Constant 2 (C2)-set of IgSF domains; The members here are composed of the third immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C, and C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409549 [Multi-domain]  Cd Length: 88  Bit Score: 39.44  E-value: 1.54e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13489095 1184 HGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRL 1258
Cdd:cd20957   14 DFGRTAVFNCSVTGNPIHTVLWMKDGKPLGHSSRVQILSEDVLVIPSVKREDKGMYQCFVRNDGDSAQATAELKL 88
IgI_NCAM-1_like cd05732
Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1) and similar ...
 1552-1630 1.69e-03

Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1) and similar proteins; The members here are composed of the fourth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule (NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain. Also included in this group is NCAM-2 (also known as OCAM/mamFas II and RNCAM) NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE). One of the unique features of I-set domains is the lack of a C" strand. The structures of this group show that the Ig domain lacks this strand and thus is a member of the I-set of Ig domains.


Pssm-ID: 409395 [Multi-domain]  Cd Length: 96  Bit Score: 39.43  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1552 LDCRVDSEPLASLTLHLGSRLVASSQ--PQGapaepHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFG 1629
Cdd:cd05732   21 LTCEAEGDPIPEITWRRATRGISFEEgdLDG-----RIVVRGHARVSSLTLKDVQLTDAGRYDCEASNRIGGDQQSMYLE 95


                 .
gi 13489095 1630 V 1630
Cdd:cd05732   96 V 96
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 624-703 1.81e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 1.81e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095     624 CRVDSDPPARLQLLHKDRVVATSlpsgggcstcggcSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703
Cdd:smart00410   16 CEASGSPPPEVTWYKQGGKLLAE-------------SGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSGTT 82
I-set pfam07679
Immunoglobulin I-set domain;
718-792 2.07e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 38.78  E-value: 2.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    718 TLQEGTEANLTCNVSreaaGSPA-NFSWFRNGVLWAQGP---------LETVTLLPVARTDAALYACRILTEAGaQLSTP 787
Cdd:pfam07679   11 EVQEGESARFTCTVT----GTPDpEVSWFKDGQPLRSSDrfkvtyeggTYTLTISNVQPDDSGKYTCVATNSAG-EAEAS 85


                   ....*
gi 13489095    788 VLLSV 792
Cdd:pfam07679   86 AELTV 90
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 246-321 2.11e-03

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409540  Cd Length: 76  Bit Score: 38.63  E-value: 2.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13489095  246 SPSGRNILPGELVTLTCQVNSSYPAvsSIKWLKDGvRLQTKTGVLHLPQAAWSDAGVYTCQAENgvgSLVSPPISL 321
Cdd:cd20948    1 SPSDTYYLSGENLNLSCHAASNPPA--QYSWTING-TFQTSSQELFLPAITENNEGTYTCSAHN---SLTGKNISL 70
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 334-395 2.16e-03

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 39.33  E-value: 2.16e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13489095  334 GPILENQTVTLVCNTPNEAP-SDLRysWYKNHVLLEDAH-------------SHTLRLHLATRADTGFYFCEVQNV 395
Cdd:cd05761   14 SPVVEGDEITLTCTTSGSKPaADIR--WFKNDKELKGVKevqesgagktftvTSTLRFRVDRDDDGVAVICRVDHE 87
CD19_double_Ig cd23997
CD19 (Cluster of Differentiation 19), a unique double immunoglobulin (Ig)-fold domain; CD19, ...
 520-576 2.35e-03

CD19 (Cluster of Differentiation 19), a unique double immunoglobulin (Ig)-fold domain; CD19, also known as B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12, and CVID3, is a transmembrane receptor present on various types of B cells, including progenitor, naive, and memory B cells, as well as plasmablasts. Until recently, it was believed to comprise two extracellular immunoglobulin (Ig) structural domains arranged in tandem with C2 topology. However, recent crystal structures have shown that the CD19 extracellular domain contains a unique double Ig domain that is responsible for its binding to proteins such as CD21, CD81, and CD225, which regulate B cell activation and survival. A recent analysis of the CD19 extracellular domain sequence reveals two "Ig domains", but the structure demonstrates that these two domains are not folded independently and connected in tandem. Rather, they fold together as one intertwined domain that can be referred to as a "double Ig" domain. Each of the two regular Ig domain sequences has a noticeably short linker that forms a loop between strands C' and D, rather than allowing the formation of a C" strand. Additionally, the two Ig-domain sequences are separated by a long linker that is structured as a small insertion domain, enabling both Ig sequences to fold together as a unique double Ig-domain. The CD19 domain comprises four "protodomains": two formed by A'B-CC' strands and two by DE-FG strands that interdigitate to form a novel double Ig fold. When analyzing this double Ig domain in terms of the usual Ig-fold, A'B-CC' protodomain of the first Ig sequence combines with DE-FG protodomain of the second, and vice versa. Hence, the second combined Ig fold is inverted, with DE-FG protodomain of the first Ig sequence combining with A'B-CC' protodomain of the second Ig sequence and in that order, as if it were a circular permutation, obtained only through structural folding.


Pssm-ID: 467824  Cd Length: 89  Bit Score: 38.86  E-value: 2.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13489095  520 EVVEGQAVTLSCRSGLSPTPDARFSWYLNGAL--------------LHEGP-GSSLLLPAASSTDAGSYHCR 576
Cdd:cd23997    4 TVAEGSTLWLPCLVPPSDGPRGPLTWSRGHPKtpllslelgspglwVLVGPlGILLLLPNVSAQMGGFYLCE 75
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1271-1342 2.35e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 2.35e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    1271 VPEGAPITVTCadPAAHAPTLY-TWYHNG----------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSrPAA 1339
Cdd:smart00410    6 VKEGESVTLSC--EASGSPPPEvTWYKQGgkllaesgrfSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASS-GTT 82


                    ...
gi 13489095    1340 LQV 1342
Cdd:smart00410   83 LTV 85
IgI_2_Axl_Tyro3_like cd05749
Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs); ...
 1270-1338 2.41e-03

Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs); member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain in the Axl/Tyro3 family of receptor tyrosine kinases (RTKs). This family includes Axl (also known as Ark, Ufo, and Tyro7), Tyro3 (also known as Sky, Rse, Brt, Dtk, and Tif), and Mer (also known as Nyk, c-Eyk, and Tyro12). Axl/Tyro3 family receptors have an extracellular portion with two Ig-like domains followed by two fibronectin-types III (FNIII) domains, a membrane-spanning single helix, and a cytoplasmic tyrosine kinase domain. Axl, Tyro3, and Mer are widely expressed in adult tissues, though they show higher expression in the brain, lymphatic and vascular systems, and testis. Axl, Tyro3, and Mer bind the vitamin K dependent protein Gas6 with high affinity, and in doing so activate their tyrosine kinase activity. Axl/Gas6 signaling may play a part in cell adhesion processes, prevention of apoptosis, and cell proliferation.


Pssm-ID: 409407  Cd Length: 82  Bit Score: 38.60  E-value: 2.41e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1270 AVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAH-AGAYSCQAQDAQGTRSSRPA 1338
Cdd:cd05749   10 AVTANTPFNLTCQAVGPPEPVEILWWQGGSPLGGPPAPSPSVLNVPGLNeTTKFSCEAHNAKGLTSSRTA 79
IgI_NCAM-2 cd05870
Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 2 (NCAM-2); The members ...
 809-893 2.85e-03

Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 2 (NCAM-2); The members here are composed of the fourth Ig domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM). NCAM-2 is organized similarly to NCAM, including five N-terminal Ig-like domains and two fibronectin type III domains. NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE), and may function like NCAM, as an adhesion molecule. One of the unique features of I-set domains is the lack of a C" strand. The structures of this group show that the Ig domain lacks this strand and thus is a member of the I-set of Ig domains.


Pssm-ID: 143278 [Multi-domain]  Cd Length: 98  Bit Score: 38.80  E-value: 2.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  809 QGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPShGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTS 888
Cdd:cd05870   15 ENGAATLSCKAEGEPIPEITWKRASDGHTFSEGDKSPD-GRIEVKGQHGESSLHIKDVKLSDSGRYDCEAASRIGGHQKS 93


                 ....*
gi 13489095  889 LFFQV 893
Cdd:cd05870   94 MYLDI 98
IgI_2_JAM1 cd20950
Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF ...
 247-313 2.97e-03

Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains; The members here are composed of the second Ig-like domain of Junctional adhesion molecule-1 (JAM1). JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The second Ig-like domain of JAM1 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous but lacks a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors.


Pssm-ID: 409542  Cd Length: 97  Bit Score: 38.84  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  247 PSGRNIlpGELVTLTCQVNSSYPAvSSIKWLKDGV-----------------RLQTKTGVLHLPQAAWSDAGVYTCQAEN 309
Cdd:cd20950    6 PSSATI--GNRAVLTCSEPDGSPP-SEYTWFKDGVvmptnpkstrafsnssySLDPTTGELVFDPLSASDTGEYSCEARN 82


                 ....
gi 13489095  310 GVGS 313
Cdd:cd20950   83 GYGT 86
IgC2_D1_D2_LILR_KIR_like cd16843
Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer ...
 524-594 3.04e-03

Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains; The members here are composed of the first and second immunoglobulin (Ig)-like domains found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs, also known as also known as cluster of differentiation (CD) 158), and similar proteins. This group includes LILRB1 (also known as LIR-1), LILRA5 (also known as LIR9), an activating natural cytotoxicity receptor NKp46, the immune-type receptor glycoprotein VI (GPVI), and the IgA-specific receptor Fc-alphaRI (also known as cluster of differentiation (CD) 89). LILRs are a family of immunoreceptors expressed on expressed on T and B cells, on monocytes, dendritic cells, and subgroups of natural killer (NK) cells. The human LILR family contains nine proteins (LILRA1-3, and 5, and LILRB1-5). From functional assays, and as the cytoplasmic domains of various LILRs, for example LILRB1, LILRB2 (also known as LIR-2), and LILRB3 (also known as LIR-3) contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs), it is thought that LIR proteins are inhibitory receptors. Of the eight LIR family proteins, only LILRB1, and LILRB2, show detectable binding to class I MHC molecules; ligands for the other members have yet to be determined. The extracellular portions of the different LIR proteins contain different numbers of Ig-like domains for example, four in the case of LILRB1, and LILRB2, and two in the case of LILRB4 (also known as LIR-5). The activating natural cytotoxicity receptor NKp46 is expressed in natural killer cells, and is organized as an extracellular portion having two Ig-like extracellular domains, a transmembrane domain, and a small cytoplasmic portion. GPVI, which also contains two Ig-like domains, participates in the processes of collagen-mediated platelet activation and arterial thrombus formation. Fc-alphaRI is expressed on monocytes, eosinophils, neutrophils, and macrophages; it mediates IgA-induced immune effector responses such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and respiratory burst. Killer cell immunoglobulin-like receptors (KIRs; also known as CD158 for human KIR) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. KIRs are a family of highly polymorphic activating and inhibitory receptors that serve as key regulators of human NK cell function. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The major ligands for KIR are MHC class I (HLA-A, -B or -C) molecules.


Pssm-ID: 409518 [Multi-domain]  Cd Length: 90  Bit Score: 38.51  E-value: 3.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095  524 GQAVTLSCRSglsPTPDARFSWYLNGALLHEGP--------GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTV 594
Cdd:cd16843   15 GENVTIRCQG---PPEAVLFQLYKEGNSLSQGTvrekepqnKAEFYIPHMDRNHAGRYRCRYRSGTLWSEPSDPLELVV 90
Ig4_Peroxidasin cd05746
Fourth immunoglobulin (Ig)-like domain of peroxidasin; The members here are composed of the ...
 841-889 3.06e-03

Fourth immunoglobulin (Ig)-like domain of peroxidasin; The members here are composed of the fourth immunoglobulin (Ig)-like domain in peroxidasin. Peroxidasin has a peroxidase domain and interacting extracellular motifs containing four Ig-like domains. It has been suggested that peroxidasin is secreted, and has functions related to the stabilization of the extracellular matrix. It may play a part in various other important processes such as removal and destruction of cells which have undergone programmed cell death and protection of the organism against non-self.


Pssm-ID: 143223  Cd Length: 69  Bit Score: 37.93  E-value: 3.06e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 13489095  841 GPQVPSHGRFQAKAEANslkLEVRELGLGDSGSYRCEATNVLGSSNTSL 889
Cdd:cd05746   21 GVQVTESGKFHISPEGY---LAIRDVGVADQGRYECVARNTIGYASVSM 66
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1455-1529 3.15e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 3.15e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    1455 VPEGAALNLSCRLLGGPGPvgnsTFAWFWNDRRLHAEP----------VPTLAFTHVARAQAGMYHCLAELPTGaAASAP 1524
Cdd:smart00410    6 VKEGESVTLSCEASGSPPP----EVTWYKQGGKLLAESgrfsvsrsgsTSTLTISNVTPEDSGTYTCAATNSSG-SASSG 80


                    ....*
gi 13489095    1525 VMLRV 1529
Cdd:smart00410   81 TTLTV 85
IgC2_CD22_d3 cd20937
Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 ...
 1087-1157 3.25e-03

Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 (C2)-set of IgSF domains; The members here are composed of the third immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409531  Cd Length: 88  Bit Score: 38.24  E-value: 3.25e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13489095 1087 VNVQVWPG-ATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDAHSIPLPNVTVRDATSYRCGVGP---PGRA 1157
Cdd:cd20937    3 LEIKVTPSdAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTslKKQNTFTLNLREVTKDQSGKYCCQVSNdvgPGRS 79
Ig_4 pfam16680
T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is ...
 258-313 3.27e-03

T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is found on the T-cell surface glycoprotein CD3 delta chain. CD3delta and CD3epsilon complex together as part of the T-cell receptor complex.


Pssm-ID: 465231  Cd Length: 63  Bit Score: 37.62  E-value: 3.27e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 13489095    258 VTLTCQVNSSypavsSIKWLKDGVRLQ-TKTGVLHLPQAAWSDAGVYTCQAENGVGS 313
Cdd:pfam16680    4 VLLTCNSSSK-----SITWLKDGKGIKsTNTKTLDLGKFSEDPRGLYQCQGEKKKSS 55
IgC1_MHC_II_beta cd05766
Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain; member of ...
 241-317 4.06e-03

Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig) domain of major histocompatibility complex (MHC) class II beta chain. MHC class II molecules play a key role in the initiation of the antigen-specific immune reponse. These molecules have been shown to be expressed constitutively on the cell surface of professional antigen-presenting cells (APCs), including B-lymphocytes, monocytes, and macrophages in both humans and mice. The expression of these molecules has been shown to be induced in nonprofessional APCs such as keratinocyctes and they are also expressed on the surface of activated human T cells and on T cells from other species. The MHC II molecules present antigenic peptides to CD4(+) T-lymphocytes. These peptides derive mostly from proteolytic processing via the endocytic pathway of antigens internalized by the APC. These peptides bind to the MHC class II molecules in the endosome before they are transported to the cell surface. MHC class II molecules are heterodimers, comprised of two similarly-sized membrane-spanning chains, alpha and beta. Each chain has two globular domains (N- and C-terminal) and a membrane-anchoring transmembrane segment. The two chains form a compact four-domain structure. The peptide-binding site is a cleft in the structure.


Pssm-ID: 409423  Cd Length: 96  Bit Score: 38.47  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  241 VKILLSPSGRnilPGELVTLTCQVNSSYPAVSSIKWLKDGVRLqtKTGVLH---LPQAAW------------SDAGVYTC 305
Cdd:cd05766    6 VKVSPTKTGP---LEHPNLLVCSVTGFYPAEIEVKWFRNGQEE--TAGVVStelIPNGDWtfqilvmlettpRRGDVYTC 80

                         90
                 ....*....|..
gi 13489095  306 QAENgvGSLVSP 317
Cdd:cd05766   81 QVEH--SSLQSP 90
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 1002-1080 4.21e-03

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 37.86  E-value: 4.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095 1002 LLLCRVDSDPPAQLRLLHGDRLVAstlqgvggpeGSSPRLHvavAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
Cdd:cd20952   18 VLNCQATGEPVPTISWLKDGVPLL----------GKDERIT---TLENGSLQIKGAEKSDTGEYTCVALNLSGEATWSA 83
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-135 4.53e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.87  E-value: 4.53e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095      26 PQDVQGVKGSCLLIPCIFSFPADVEVpdgitaIWYYDysgqrqvvshsaDPKLVEARFRgrteFMGNPEHRVCNLLLKDL 105
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASGSPPPEV------TWYKQ------------GGKLLAESGR----FSVSRSGSTSTLTISNV 58

                            90       100       110
                    ....*....|....*....|....*....|
gi 13489095     106 QPEDSGSYNFRFEISEVNRWSdvkGTLVTV 135
Cdd:smart00410   59 TPEDSGTYTCAATNSSGSASS---GTTLTV 85
IgC1_MHC_II_beta cd05766
Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain; member of ...
 328-406 4.65e-03

Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig) domain of major histocompatibility complex (MHC) class II beta chain. MHC class II molecules play a key role in the initiation of the antigen-specific immune reponse. These molecules have been shown to be expressed constitutively on the cell surface of professional antigen-presenting cells (APCs), including B-lymphocytes, monocytes, and macrophages in both humans and mice. The expression of these molecules has been shown to be induced in nonprofessional APCs such as keratinocyctes and they are also expressed on the surface of activated human T cells and on T cells from other species. The MHC II molecules present antigenic peptides to CD4(+) T-lymphocytes. These peptides derive mostly from proteolytic processing via the endocytic pathway of antigens internalized by the APC. These peptides bind to the MHC class II molecules in the endosome before they are transported to the cell surface. MHC class II molecules are heterodimers, comprised of two similarly-sized membrane-spanning chains, alpha and beta. Each chain has two globular domains (N- and C-terminal) and a membrane-anchoring transmembrane segment. The two chains form a compact four-domain structure. The peptide-binding site is a cleft in the structure.


Pssm-ID: 409423  Cd Length: 96  Bit Score: 38.08  E-value: 4.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHT-----------LRLHLATRADTG-FYFCEVQnv 395
Cdd:cd05766    6 VKVSPTKTGPLEHPNLLVCSVTGFYPAEIEVKWFRNGQEETAGVVSTelipngdwtfqILVMLETTPRRGdVYTCQVE-- 83

                         90
                 ....*....|.
gi 13489095  396 HGSERSgPVSV 406
Cdd:cd05766   84 HSSLQS-PLTV 93
IgI_2_Titin_Z1z2-like cd20972
Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and ...
 897-971 5.25e-03

Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the titin Z1z2 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409564 [Multi-domain]  Cd Length: 91  Bit Score: 37.95  E-value: 5.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  897 WVQVSPSPELQEGQAVVLSCQVhTGVPEgTSYRWYRDGQPLQESTSA---------TLRFAAITLTQAGAYHCQAQAP-G 966
Cdd:cd20972    4 FIQKLRSQEVAEGSKVRLECRV-TGNPT-PVVRWFCEGKELQNSPDIqihqegdlhSLIIAEAFEEDTGRYSCLATNSvG 81


                 ....*
gi 13489095  967 SATTS 971
Cdd:cd20972   82 SDTTS 86
IgI_Lingo-1 cd20969
Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing ...
 798-893 5.72e-03

Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1); The members here are composed of the immunoglobulin I-set (IgI) domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1). Human Lingo-1 is a central nervous system-specific transmembrane glycoprotein also known as LERN-1, which functions as a negative regulator of neuronal survival, axonal regeneration, and oligodendrocyte differentiation and myelination. Lingo-1 is a key component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. The ligand-binding ectodomain of human Lingo-1 contains a bimodular, kinked structure composed of leucine-rich repeat (LRR) and immunoglobulin (Ig)-like modules. Diseases associated with Lingo-1 include mental retardation, autosomal recessive 64 and essential tremor. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the Lingo-1 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409561  Cd Length: 92  Bit Score: 37.75  E-value: 5.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  798 RPKLSALLDMGQGHMALFICTVD-SRPLALLALFHGEHLLATSlgpqvpSHGRFQAKAEANslkLEVRELGLGDSGSYRC 876
Cdd:cd20969    5 RDRKAQQVFVDEGHTVQFVCRADgDPPPAILWLSPRKHLVSAK------SNGRLTVFPDGT---LEVRYAQVQDNGTYLC 75

                         90
                 ....*....|....*..
gi 13489095  877 EATNVLGSSNTSLFFQV 893
Cdd:cd20969   76 IAANAGGNDSMPAHLHV 92
I-set pfam07679
Immunoglobulin I-set domain;
1547-1625 5.83e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 37.62  E-value: 5.83e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095   1547 GLRGILDCRVDSEPLASLTLHLGSRLVASSQpqgapaepHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTS 1625
Cdd:pfam07679   15 GESARFTCTVTGTPDPEVSWFKDGQPLRSSD--------RFKVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGEAEAS 85
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 714-792 6.38e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 37.37  E-value: 6.38e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13489095    714 APSHTLQEGTEANLTCNVSREAagsPANFSWFRNGVLWAQGPleTVTLLPVARTDAALYACRILTEAGAQLSTPVLLSV 792
Cdd:pfam13895    6 PSPTVVTEGEPVTLTCSAPGNP---PPSYTWYKDGSAISSSP--NFFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
Ig3_L1-CAM_like cd05731
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar ...
 476-503 7.76e-03

Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; The members here are composed of the third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, and spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM and human neurofascin.


Pssm-ID: 409394 [Multi-domain]  Cd Length: 83  Bit Score: 37.00  E-value: 7.76e-03
                         10        20
                 ....*....|....*....|....*...
gi 13489095  476 LEIRDLEETDSGEYKCSATNSLGNATST 503
Cdd:cd05731   50 LKIENVSEADSGEYQCTASNTMGSARHT 77
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 1266-1342 7.95e-03

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 37.28  E-value: 7.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095 1266 APEAAVPEGAPITVTC---ADPAAHAptlYTWYHNGRWLQEG-PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQ 1341
Cdd:cd05753    6 APSAVVFEGEPLTLRChgwKDKKVHK---VTYYKDGKALKFSyENSNFSIPQATLSDSGSYHCSGTVRIKRRSSESVNIT 82


                 .
gi 13489095 1342 V 1342
Cdd:cd05753   83 V 83
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 1186-1244 7.95e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.16  E-value: 7.95e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13489095   1186 GQLALVLCTVDSRPPAQLALSHAGRLLAS---STAASVPNTLRLELRGPQPRDEGFYSCSAR 1244
Cdd:pfam13927   16 GETVTLTCEATGSPPPTITWYKNGEPISSgstRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
BiPBP_C pfam06832
Penicillin-Binding Protein C-terminus Family; This conserved region of approximately 90 ...
 1246-1331 7.97e-03

Penicillin-Binding Protein C-terminus Family; This conserved region of approximately 90 residues is found in a sub-group of bacterial Penicillin-Binding Proteins (PBPs). A variable length loop region separates this region from the transpeptidase unit (pfam00905). It is predicted by PROF to be an all beta fold.


Pssm-ID: 429142 [Multi-domain]  Cd Length: 89  Bit Score: 37.32  E-value: 7.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095   1246 PLGQANTSLELRLEGVR--VILAPEAAVPEGAPITVTcadpAAHAPTLYTWYHNGRWLQEGPAASLSFLvatRAHAGAYS 1323
Cdd:pfam06832    2 PAQASAAAGPPRILFPPdgAVIALDPDIPAAQRLVLK----AAGGRGPLYWLLDGKPLGETGSGRELFW---LPGPGFHR 74


                   ....*...
gi 13489095   1324 CQAQDAQG 1331
Cdd:pfam06832   75 LTVVDAAG 82
IgI_6_Dscam cd20959
Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 255-313 8.11e-03

Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the sixth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409551  Cd Length: 94  Bit Score: 37.47  E-value: 8.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095  255 GELVTLTCQVNSSYPAVSsIKWLKDG-----------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGS 313
Cdd:cd20959   17 GMRAQLHCGVPGGDLPLN-IRWTLDGqpisddlgitvSRLGRRSSILSIDSLEASHAGNYTCHARNSAGS 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 899-966 9.75e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 37.44  E-value: 9.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13489095    899 QVSPSPELQEGQAVVLSCQVHTGVPEG-TSYRWYRD---------------------------GQPLQESTSATLRFAAI 950
Cdd:pfam07686    1 QTPREVTVALGGSVTLPCTYSSSMSEAsTSVYWYRQppgkgptfliayysngseegvkkgrfsGRGDPSNGDGSLTIQNL 80

                           90
                   ....*....|....*.
gi 13489095    951 TLTQAGAYHCQAQAPG 966
Cdd:pfam07686   81 TLSDSGTYTCAVIPSG 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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