NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|13027632|ref|NP_075267|]
View 

small EDRK-rich factor 1 isoform 2 [Homo sapiens]

Protein Classification

SERF family protein( domain architecture ID 10516698)

SERF (small EDRK-rich factor) family protein similar to Homo sapiens small EDRK-rich factor 1 and 2, which are positive regulators of amyloid protein aggregation and proteotoxicity

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
4F5 pfam04419
4F5 protein related disordered region; Members of this family are short proteins that are rich ...
 1-37 5.77e-08

4F5 protein related disordered region; Members of this family are short proteins that are rich in aspartate, glutamate, lysine and arginine. Although the function of these proteins is unknown, they are found to be ubiquitously expressed. This entry is named after the H4F5 protein UniProt:O75920. This region appears to be found at the N-terminus of some longer proteins. Many proteins contain a C-terminal zinc finger domain pfam12907.


:

Pssm-ID: 398223  Cd Length: 38  Bit Score: 45.29  E-value: 5.77e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 13027632     1 MARGNQRELARQKNMKKTQEIsKGKRKEDSLTASQRK 37
Cdd:pfam04419   1 MGRGNQREQARERNQKKAAKQ-KKKGAKSQLKAAQRA 36
 
Name Accession Description Interval E-value
4F5 pfam04419
4F5 protein related disordered region; Members of this family are short proteins that are rich ...
 1-37 5.77e-08

4F5 protein related disordered region; Members of this family are short proteins that are rich in aspartate, glutamate, lysine and arginine. Although the function of these proteins is unknown, they are found to be ubiquitously expressed. This entry is named after the H4F5 protein UniProt:O75920. This region appears to be found at the N-terminus of some longer proteins. Many proteins contain a C-terminal zinc finger domain pfam12907.


Pssm-ID: 398223  Cd Length: 38  Bit Score: 45.29  E-value: 5.77e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 13027632     1 MARGNQRELARQKNMKKTQEIsKGKRKEDSLTASQRK 37
Cdd:pfam04419   1 MGRGNQREQARERNQKKAAKQ-KKKGAKSQLKAAQRA 36
 
Name Accession Description Interval E-value
4F5 pfam04419
4F5 protein related disordered region; Members of this family are short proteins that are rich ...
 1-37 5.77e-08

4F5 protein related disordered region; Members of this family are short proteins that are rich in aspartate, glutamate, lysine and arginine. Although the function of these proteins is unknown, they are found to be ubiquitously expressed. This entry is named after the H4F5 protein UniProt:O75920. This region appears to be found at the N-terminus of some longer proteins. Many proteins contain a C-terminal zinc finger domain pfam12907.


Pssm-ID: 398223  Cd Length: 38  Bit Score: 45.29  E-value: 5.77e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 13027632     1 MARGNQRELARQKNMKKTQEIsKGKRKEDSLTASQRK 37
Cdd:pfam04419   1 MGRGNQREQARERNQKKAAKQ-KKKGAKSQLKAAQRA 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH