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Conserved domains on  [gi|1937925751|ref|NP_074060|]
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nucleolar and coiled-body phosphoprotein 1 [Rattus norvegicus]

Protein Classification

nucleolar and coiled-body phosphoprotein 1 family protein( domain architecture ID 10523427)

nucleolar and coiled-body phosphoprotein 1 (NOLC1) family protein; similar to mammalian NOLC1 (also known as Nopp140) which may participate in the regulation of rRNA transcription by interacting with the largest subunit of RNA polymerase I, and to Saccharomyces cerevisiae suppressor protein Srp40 which is a weak suppressor of a mutant of the subunit AC40 of DNA dependent RNA polymerase I and III; may be a chaperone involved in nucleocytoplasmic transport

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP40_C pfam05022
SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae ...
 629-701 2.65e-30

SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein and its homologs. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.


:

Pssm-ID: 461525  Cd Length: 75  Bit Score: 113.78  E-value: 2.65e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1937925751 629 PFRRVREEEIEV--DSRVADNSFDAKrGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQ-VNSVKF 701
Cdd:pfam05022   1 PFQRVDPEDVVVfaDPRLADNSYEAK-GAEDDYGEKANEDLIVTRGKGFRKEKNKKKRGSYRGGAIDTNsVNSIKF 75
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 147-561 1.44e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  147 PVQQKAVKPQAKAVRPPPKKAESSESESDSSSEDEAPQTQKPKAAATAAKAPTKAQTKAPAKPGPPA-KAQPKAANGKAG 225
Cdd:PHA03247  2562 AAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpSPSPAANEPDPH 2641

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  226 ssssssSSSSSDDSEEEKKAAAPlKKTAPKKQVVAKAPVKVTAAPTQKSSSSEDSSSEEEEEQKKPMKKKAGPYSSVPPP 305
Cdd:PHA03247  2642 ------PPPTVPPPERPRDDPAP-GRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHA 2714

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  306 SVSLSKKSVGAQSPKKAAAqtQPADSSADSSEESDSSSEEEKKTPAKTVVSKTPAKPAPVKKKAESSSDSSDSDSSEDEA 385
Cdd:PHA03247  2715 LVSATPLPPGPAAARQASP--ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLS 2792

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  386 PAKPvSATKSPLSKPAVTPKPPAAKAVATPKQPAGSGQKPQSrkADSSSSEEESSSSEEEATKKSVTTPKARVTAKAAPS 465
Cdd:PHA03247  2793 ESRE-SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS--AQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR 2869

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  466 LPAKQAPRAGGDSSSDSESSSSEEEKKTPPKPPAKKKAAGAAVPKPTPVKKAAAESSSSSSSSEDSSEEEKKKPKSKATP 545
Cdd:PHA03247  2870 SPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949

                          410
                   ....*....|....*.
gi 1937925751  546 KPQAGKANGVPASQNG 561
Cdd:PHA03247  2950 AGAGEPSGAVPQPWLG 2965
 
Name Accession Description Interval E-value
SRP40_C pfam05022
SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae ...
 629-701 2.65e-30

SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein and its homologs. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.


Pssm-ID: 461525  Cd Length: 75  Bit Score: 113.78  E-value: 2.65e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1937925751 629 PFRRVREEEIEV--DSRVADNSFDAKrGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQ-VNSVKF 701
Cdd:pfam05022   1 PFQRVDPEDVVVfaDPRLADNSYEAK-GAEDDYGEKANEDLIVTRGKGFRKEKNKKKRGSYRGGAIDTNsVNSIKF 75
PHA03247 PHA03247
large tegument protein UL36; Provisional
 147-561 1.44e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  147 PVQQKAVKPQAKAVRPPPKKAESSESESDSSSEDEAPQTQKPKAAATAAKAPTKAQTKAPAKPGPPA-KAQPKAANGKAG 225
Cdd:PHA03247  2562 AAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpSPSPAANEPDPH 2641

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  226 ssssssSSSSSDDSEEEKKAAAPlKKTAPKKQVVAKAPVKVTAAPTQKSSSSEDSSSEEEEEQKKPMKKKAGPYSSVPPP 305
Cdd:PHA03247  2642 ------PPPTVPPPERPRDDPAP-GRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHA 2714

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  306 SVSLSKKSVGAQSPKKAAAqtQPADSSADSSEESDSSSEEEKKTPAKTVVSKTPAKPAPVKKKAESSSDSSDSDSSEDEA 385
Cdd:PHA03247  2715 LVSATPLPPGPAAARQASP--ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLS 2792

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  386 PAKPvSATKSPLSKPAVTPKPPAAKAVATPKQPAGSGQKPQSrkADSSSSEEESSSSEEEATKKSVTTPKARVTAKAAPS 465
Cdd:PHA03247  2793 ESRE-SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS--AQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR 2869

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  466 LPAKQAPRAGGDSSSDSESSSSEEEKKTPPKPPAKKKAAGAAVPKPTPVKKAAAESSSSSSSSEDSSEEEKKKPKSKATP 545
Cdd:PHA03247  2870 SPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949

                          410
                   ....*....|....*.
gi 1937925751  546 KPQAGKANGVPASQNG 561
Cdd:PHA03247  2950 AGAGEPSGAVPQPWLG 2965
 
Name Accession Description Interval E-value
SRP40_C pfam05022
SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae ...
 629-701 2.65e-30

SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein and its homologs. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.


Pssm-ID: 461525  Cd Length: 75  Bit Score: 113.78  E-value: 2.65e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1937925751 629 PFRRVREEEIEV--DSRVADNSFDAKrGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQ-VNSVKF 701
Cdd:pfam05022   1 PFQRVDPEDVVVfaDPRLADNSYEAK-GAEDDYGEKANEDLIVTRGKGFRKEKNKKKRGSYRGGAIDTNsVNSIKF 75
PHA03247 PHA03247
large tegument protein UL36; Provisional
 147-561 1.44e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  147 PVQQKAVKPQAKAVRPPPKKAESSESESDSSSEDEAPQTQKPKAAATAAKAPTKAQTKAPAKPGPPA-KAQPKAANGKAG 225
Cdd:PHA03247  2562 AAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpSPSPAANEPDPH 2641

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  226 ssssssSSSSSDDSEEEKKAAAPlKKTAPKKQVVAKAPVKVTAAPTQKSSSSEDSSSEEEEEQKKPMKKKAGPYSSVPPP 305
Cdd:PHA03247  2642 ------PPPTVPPPERPRDDPAP-GRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHA 2714

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  306 SVSLSKKSVGAQSPKKAAAqtQPADSSADSSEESDSSSEEEKKTPAKTVVSKTPAKPAPVKKKAESSSDSSDSDSSEDEA 385
Cdd:PHA03247  2715 LVSATPLPPGPAAARQASP--ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLS 2792

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  386 PAKPvSATKSPLSKPAVTPKPPAAKAVATPKQPAGSGQKPQSrkADSSSSEEESSSSEEEATKKSVTTPKARVTAKAAPS 465
Cdd:PHA03247  2793 ESRE-SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS--AQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR 2869

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751  466 LPAKQAPRAGGDSSSDSESSSSEEEKKTPPKPPAKKKAAGAAVPKPTPVKKAAAESSSSSSSSEDSSEEEKKKPKSKATP 545
Cdd:PHA03247  2870 SPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949

                          410
                   ....*....|....*.
gi 1937925751  546 KPQAGKANGVPASQNG 561
Cdd:PHA03247  2950 AGAGEPSGAVPQPWLG 2965
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
205-474 4.45e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.22  E-value: 4.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751 205 APAKPGPPAKAQPKAANGKAGSSSSSSSSSSSDDSEEEKKAAAPLKKTAPKKQVVAKAPVKVTAAPTQKSSSSEDSSSEE 284
Cdd:PRK07003  361 AVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGD 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751 285 EEEQKKPMKKKAGPY-SSVPPPSVSLSKKSVGAQSPKKAAAQTQPadssadsseesdsssEEEKKTPAKTVVSKTPAKPA 363
Cdd:PRK07003  441 DAADGDAPVPAKANArASADSRCDERDAQPPADSGSASAPASDAP---------------PDAAFEPAPRAAAPSAATPA 505

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937925751 364 PVKKKAESSSDSSDSDSSEDEAPAkPVSATKSPlskPAVTPKPPAAKAVATPKQPAGSGQKPQSRKADSSSSEEESSSSE 443
Cdd:PRK07003  506 AVPDARAPAAASREDAPAAAAPPA-PEARPPTP---AAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAP 581

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1937925751 444 EEATKK-------SVTTPKARVTAKAAPSLPAKQAPRA 474
Cdd:PRK07003  582 AAAPKPaaprvavQVPTPRARAATGDAPPNGAARAEQA 619
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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