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Conserved domains on  [gi|12232485|ref|NP_073626|]
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interleukin-25 isoform 1 precursor [Homo sapiens]

Protein Classification

interleukin-17 family protein( domain architecture ID 10532846)

interleukin-17 (IL-17) family protein such as IL-17A, a key cytokine that links T cell activation to neutrophil mobilization and activation, and IL-25, also known as IL-7E, which induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL17 pfam06083
Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T ...
 85-171 1.82e-23

Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The IL-17 family is thought to represent a distinct signaling system that appears to have been highly conserved across vertebrate evolution.


:

Pssm-ID: 461823  Cd Length: 81  Bit Score: 88.09  E-value: 1.82e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232485    85 RAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQTGSHmDPRGNSELLYHNQTVFYRRPChgekgTHKGYCLERRLYRV 164
Cdd:pfam06083   1 RSLSPWTYRIDHDPNRYPQTIAEARCLCSGCINPATGQE-DRSLNSVPIYQEILVLRRESC-----AGCRYSYRLEYETV 74


                  ....*..
gi 12232485   165 SLACVCV 171
Cdd:pfam06083  75 TVGCTCV 81
 
Name Accession Description Interval E-value
IL17 pfam06083
Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T ...
 85-171 1.82e-23

Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The IL-17 family is thought to represent a distinct signaling system that appears to have been highly conserved across vertebrate evolution.


Pssm-ID: 461823  Cd Length: 81  Bit Score: 88.09  E-value: 1.82e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232485    85 RAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQTGSHmDPRGNSELLYHNQTVFYRRPChgekgTHKGYCLERRLYRV 164
Cdd:pfam06083   1 RSLSPWTYRIDHDPNRYPQTIAEARCLCSGCINPATGQE-DRSLNSVPIYQEILVLRRESC-----AGCRYSYRLEYETV 74


                  ....*..
gi 12232485   165 SLACVCV 171
Cdd:pfam06083  75 TVGCTCV 81
 
Name Accession Description Interval E-value
IL17 pfam06083
Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T ...
 85-171 1.82e-23

Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The IL-17 family is thought to represent a distinct signaling system that appears to have been highly conserved across vertebrate evolution.


Pssm-ID: 461823  Cd Length: 81  Bit Score: 88.09  E-value: 1.82e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12232485    85 RAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQTGSHmDPRGNSELLYHNQTVFYRRPChgekgTHKGYCLERRLYRV 164
Cdd:pfam06083   1 RSLSPWTYRIDHDPNRYPQTIAEARCLCSGCINPATGQE-DRSLNSVPIYQEILVLRRESC-----AGCRYSYRLEYETV 74


                  ....*..
gi 12232485   165 SLACVCV 171
Cdd:pfam06083  75 TVGCTCV 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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