|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00092 |
PTZ00092 |
aconitate hydratase-like protein; Provisional |
3-961 |
0e+00 |
|
aconitate hydratase-like protein; Provisional
Pssm-ID: 240263 [Multi-domain] Cd Length: 898 Bit Score: 1370.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 3 SPSAGYTFEYLIETLNGNSQKKFFNVPKLGGTKYDILPYSIRVLLEAAVRNCDGFLMKKEDVMNILDWK-TKQSNVEVPF 81
Cdd:PTZ00092 9 SSSRPNPFEKVLKTLKDGGSYKYYSLNELHDPRLKKLPYSIRVLLESAVRNCDEFDVTSKDVENILNWEeNSKKQIEIPF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 82 FPARVVLQDFTGIPAMVDFAAMREAVKTLGGDPKKVHPACPTDLTVDHSLQIDFSKcaiqnapnpgggdlqkagklsplk 161
Cdd:PTZ00092 89 KPARVLLQDFTGVPAVVDLAAMRDAMKRLGGDPAKINPLVPVDLVIDHSVQVDFSR------------------------ 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 162 vqskklpcrgqttcrgscdsgelsrnsgtfssqientpvlcpfhlqpvpEPETVLKNQEVEFGRNRERLQFFKWSSGAFK 241
Cdd:PTZ00092 145 -------------------------------------------------SPDALELNQEIEFERNLERFEFLKWGSKAFK 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 242 NVAVIPPGTGMAHQVNLEYLSRVVFEETDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGC 321
Cdd:PTZ00092 176 NLLIVPPGSGIVHQVNLEYLARVVFNKDGLLYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQPISMVLPEVVGF 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 322 ELTGSSNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGF 401
Cdd:PTZ00092 256 KLTGKLSEHVTATDLVLTVTSMLRKRGVVGKFVEFYGPGVKTLSLADRATIANMAPEYGATMGFFPIDEKTLDYLKQTGR 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 402 DKTKLESMEKYLKAVKLFRNDenSSEPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQVAA 481
Cdd:PTZ00092 336 SEEKVELIEKYLKANGLFRTY--AEQIEYSDVLELDLSTVVPSVAGPKRPHDRVPLSDLKKDFTACLSAPVGFKGFGIPE 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 482 EKQSDTVSVRYDGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEIGLRVKPYIRTSLSPGSGMVTHYLSSSG 561
Cdd:PTZ00092 414 EKHEKKVKFTYKGKEYTLTHGSVVIAAITSCTNTSNPSVMLAAGLLAKKAVEKGLKVPPYIKTSLSPGSKVVTKYLEASG 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 562 VLPYLSKLGFDIVGYGCSTCVGNTAPLSEAVLNAVKQGDLVTCGVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGTV 641
Cdd:PTZ00092 494 LLKYLEKLGFYTAGYGCMTCIGNSGDLDPEVSEAITNNDLVAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAYALAGRV 573
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 642 NIDFQTEPLGTDSTGKEIYLHDIWPSREEVHQMEEEHVILSMFKTLKEKVEMGNKRWNSLEAPDSVLFPWDVKSTYIRCP 721
Cdd:PTZ00092 574 NIDFETEPLGSDKTGKPVFLRDIWPSREEIQALEAKYVKPEMFKEVYSNITQGNKQWNELQVPKGKLYEWDEKSTYIHNP 653
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 722 SFFDKLTKEPAASQPIENAHVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFAN 801
Cdd:PTZ00092 654 PFFQTMELEPPPIKSIENAYCLLNLGDSITTDHISPAGNIAKNSPAAKYLMERGVERKDFNTYGARRGNDEVMVRGTFAN 733
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 802 IKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKD 881
Cdd:PTZ00092 734 IRLINKLCGKVGPNTVHVPTGEKMSIYDAAEKYKQEGVPLIVLAGKEYGSGSSRDWAAKGPYLQGVKAVIAESFERIHRS 813
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 882 HLIGIGIAPLEFLPGENADSLGLSGREVFSLSFPE-ELFPGITLNIKTSTGKEFSVIASFANDVEITLYKHGGLLNFVAR 960
Cdd:PTZ00092 814 NLVGMGILPLQFLNGENADSLGLTGKEQFSIDLNSgELKPGQDVTVKTDTGKTFDTILRIDTEVEVEYFKHGGILQYVLR 893
|
.
gi 254281215 961 K 961
Cdd:PTZ00092 894 K 894
|
|
| PRK09277 |
PRK09277 |
aconitate hydratase AcnA; |
9-963 |
0e+00 |
|
aconitate hydratase AcnA;
Pssm-ID: 236445 [Multi-domain] Cd Length: 888 Bit Score: 1279.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 9 TFEYLiETLNGNSQK-KFFNVPKL---GGTKYDILPYSIRVLLEAAVRNCDGFLMKKEDVMNILDW-KTKQSNVEVPFFP 83
Cdd:PRK09277 6 SFKAR-KTLEVGGKSyDYYSLRALeakGLGDISRLPYSLRVLLENLLRNEDGRSVTEEDIEALAEWlPKAKPDREIPFRP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 84 ARVVLQDFTGIPAMVDFAAMREAVKTLGGDPKKVHPACPTDLTVDHSLQIDFskcaiqnapnpgGGDlqkagklsplkvq 163
Cdd:PRK09277 85 ARVVMQDFTGVPAVVDLAAMRDAIADLGGDPAKINPLVPVDLVIDHSVQVDY------------FGT------------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 164 skklpcrgqttcrgscdsgelsrnsgtfssqientpvlcpfhlqpvpePETVLKNQEVEFGRNRERLQFFKWSSGAFKNV 243
Cdd:PRK09277 140 ------------------------------------------------PDAFEKNVELEFERNEERYQFLKWGQKAFDNF 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 244 AVIPPGTGMAHQVNLEYLSRVVFEETD---LLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVG 320
Cdd:PRK09277 172 RVVPPGTGICHQVNLEYLAPVVWTREDgelVAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPSSMLIPEVVG 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 321 CELTGSSNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTG 400
Cdd:PRK09277 252 VKLTGKLPEGVTATDLVLTVTEMLRKKGVVGKFVEFFGEGLASLSLADRATIANMAPEYGATCGFFPIDEETLDYLRLTG 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 401 FDKTKLESMEKYLKAVKLFRNDEnsSEPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSDFQAclNEKVGFKGFQVA 480
Cdd:PRK09277 332 RDEEQVALVEAYAKAQGLWRDPL--EEPVYTDVLELDLSTVEPSLAGPKRPQDRIPLSDVKEAFAK--SAELGVQGFGLD 407
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 481 AEKQsdtvsvrydGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEIGLRVKPYIRTSLSPGSGMVTHYLSSS 560
Cdd:PRK09277 408 EAEE---------GEDYELPDGAVVIAAITSCTNTSNPSVMIAAGLLAKKAVEKGLKVKPWVKTSLAPGSKVVTDYLEKA 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 561 GVLPYLSKLGFDIVGYGCSTCVGNTAPLSEAVLNAVKQGDLVTCGVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGT 640
Cdd:PRK09277 479 GLLPYLEALGFNLVGYGCTTCIGNSGPLPPEIEKAINDNDLVVTAVLSGNRNFEGRIHPLVKANYLASPPLVVAYALAGT 558
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 641 VNIDFQTEPLGTDSTGKEIYLHDIWPSREEVHQMEEEHVILSMFKTLKEKVEMGNKRWNSLEAPDSVLFPWDVKSTYIRC 720
Cdd:PRK09277 559 VDIDLEKDPLGTDKDGNPVYLKDIWPSDEEIDAVVAKAVKPEMFRKEYADVFEGDERWNAIEVPEGPLYDWDPDSTYIRN 638
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 721 PSFFDKLTKEPAASQPIENAHVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFA 800
Cdd:PRK09277 639 PPYFEGMLAEPGPVRDIKGARVLALLGDSITTDHISPAGAIKADSPAGKYLLEHGVEPKDFNSYGSRRGNHEVMMRGTFA 718
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 801 NIKLFNKFI-GKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIH 879
Cdd:PRK09277 719 NIRIRNEMVpGVEGGYTRHFPEGEVMSIYDAAMKYKEEGTPLVVIAGKEYGTGSSRDWAAKGTRLLGVKAVIAESFERIH 798
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 880 KDHLIGIGIAPLEFLPGENADSLGLSGREVFSLSFPEELFPG--ITLNIKTSTG--KEFSVIASFANDVEITLYKHGGLL 955
Cdd:PRK09277 799 RSNLVGMGVLPLQFKPGESRKTLGLDGTETFDIEGLEDLKPGatVTVVITRADGevVEFPVLCRIDTAVEVDYYRNGGIL 878
|
....*...
gi 254281215 956 NFVARKFL 963
Cdd:PRK09277 879 QYVLRDLL 886
|
|
| AcnA |
COG1048 |
Aconitase A [Energy production and conversion]; Aconitase A is part of the Pathway/BioSystem: ... |
19-963 |
0e+00 |
|
Aconitase A [Energy production and conversion]; Aconitase A is part of the Pathway/BioSystem: Lysine biosynthesisTCA cycle
Pssm-ID: 440669 [Multi-domain] Cd Length: 891 Bit Score: 1262.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 19 GNSQKKFFNVPKLGGTKYDI--LPYSIRVLLEAAVRNCDGFLMKKEDVMNILDW-KTKQSNVEVPFFPARVVLQDFTGIP 95
Cdd:COG1048 14 GGKPYTYYSLPALEEAGGDIsrLPYSLKILLENLLRNEDGETVTEEDIKALANWlPKARGDDEIPFRPARVLMQDFTGVP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 96 AMVDFAAMREAVKTLGGDPKKVHPACPTDLTVDHSLQIDFSkcaiqnapnpgggdlqkagklsplkvqskklpcrgqttc 175
Cdd:COG1048 94 AVVDLAAMRDAVARLGGDPKKINPLVPVDLVIDHSVQVDYF--------------------------------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 176 rGSCDSGElsrnsgtfssqientpvlcpfhlqpvpepetvlKNQEVEFGRNRERLQFFKWSSGAFKNVAVIPPGTGMAHQ 255
Cdd:COG1048 135 -GTPDALE---------------------------------KNLELEFERNRERYQFLKWGQQAFDNFRVVPPGTGIVHQ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 256 VNLEYLSRVVFEE----TDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSSNAFV 331
Cdd:COG1048 181 VNLEYLAFVVWTReedgETVAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPVSMLIPEVVGVKLTGKLPEGV 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 332 TSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFDKTKLESMEK 411
Cdd:COG1048 261 TATDLVLTVTEMLRKKGVVGKFVEFFGPGLASLSLADRATIANMAPEYGATCGFFPVDEETLDYLRLTGRSEEQIELVEA 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 412 YLKAVKLFRNDEnSSEPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSDFQACLNEKVGfkgfqvaaEKQSDTVSVR 491
Cdd:COG1048 341 YAKAQGLWRDPD-APEPYYSDVLELDLSTVEPSLAGPKRPQDRIPLSDLKEAFRAALAAPVG--------EELDKPVRVE 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 492 YDGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEIGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGF 571
Cdd:COG1048 412 VDGEEFELGHGAVVIAAITSCTNTSNPSVMIAAGLLAKKAVEKGLKVKPWVKTSLAPGSKVVTDYLERAGLLPYLEALGF 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 572 DIVGYGCSTCVGNTAPLSEAVLNAVKQGDLVTCGVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLG 651
Cdd:COG1048 492 NVVGYGCTTCIGNSGPLPPEISEAIEENDLVVAAVLSGNRNFEGRIHPDVKANFLASPPLVVAYALAGTVDIDLTTDPLG 571
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 652 TDSTGKEIYLHDIWPSREEVHQMEEEHVILSMFKTLKEKVEMGNKRWNSLEAPDSVLFPWDVKSTYIRCPSFFDKLTKEP 731
Cdd:COG1048 572 TDKDGKPVYLKDIWPSGEEIPAAVFKAVTPEMFRARYADVFDGDERWQALEVPAGELYDWDPDSTYIRRPPFFEGLQLEP 651
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 732 AASQPIENAHVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFI-G 810
Cdd:COG1048 652 EPFKDIKGARVLAKLGDSITTDHISPAGAIKADSPAGRYLLEHGVEPKDFNSYGSRRGNHEVMMRGTFANIRIKNLLApG 731
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 811 KPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAP 890
Cdd:COG1048 732 TEGGYTKHQPTGEVMSIYDAAMRYKAEGTPLVVLAGKEYGTGSSRDWAAKGTRLLGVKAVIAESFERIHRSNLVGMGVLP 811
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254281215 891 LEFLPGENADSLGLSGREVFSLS-FPEELFPG--ITLNIKTSTG--KEFSVIASFANDVEITLYKHGGLLNFVARKFL 963
Cdd:COG1048 812 LQFPEGESAESLGLTGDETFDIEgLDEGLAPGktVTVTATRADGstEEFPVLHRIDTPVEVEYYRAGGILQYVLRQLL 889
|
|
| PLN00070 |
PLN00070 |
aconitate hydratase |
1-963 |
0e+00 |
|
aconitate hydratase
Pssm-ID: 215047 [Multi-domain] Cd Length: 936 Bit Score: 1144.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 1 MDSPSAGYTFEYLIETL---NGNSQKKFFNVPKLGGTKYDILPYSIRVLLEAAVRNCDGFLMKKEDVMNILDW-KTKQSN 76
Cdd:PLN00070 36 FASMASENPFKGILTSLpkpGGGEFGKYYSLPALNDPRIDKLPYSIRILLESAIRNCDNFQVTKEDVEKIIDWeNTSPKQ 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 77 VEVPFFPARVVLQDFTGIPAMVDFAAMREAVKTLGGDPKKVHPACPTDLTVDHSLQIDFSKCAiqNApnpgggdlqkagk 156
Cdd:PLN00070 116 VEIPFKPARVLLQDFTGVPAVVDLACMRDAMNNLGGDPNKINPLVPVDLVIDHSVQVDVARSE--NA------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 157 lsplkvqskklpcrgqttcrgscdsgelsrnsgtfssqientpvlcpfhlqpvpepetVLKNQEVEFGRNRERLQFFKWS 236
Cdd:PLN00070 181 ----------------------------------------------------------VQANMELEFQRNKERFAFLKWG 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 237 SGAFKNVAVIPPGTGMAHQVNLEYLSRVVFEETDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLP 316
Cdd:PLN00070 203 STAFQNMLVVPPGSGIVHQVNLEYLGRVVFNTDGILYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLP 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 317 EVVGCELTGSSNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHL 396
Cdd:PLN00070 283 GVVGFKLSGKLRDGVTATDLVLTVTQMLRKHGVVGKFVEFYGEGMSELSLADRATIANMSPEYGATMGFFPVDHVTLQYL 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 397 EHTGFDKTKLESMEKYLKAVKLFRN-DENSSEPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSDFQACLNEKVGFK 475
Cdd:PLN00070 363 KLTGRSDETVAMIEAYLRANKMFVDyNEPQQERVYSSYLELDLEDVEPCISGPKRPHDRVPLKEMKADWHSCLDNKVGFK 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 476 GFQVAAEKQSDTVSVRYDGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEIGLRVKPYIRTSLSPGSGMVTH 555
Cdd:PLN00070 443 GFAVPKEAQSKVAKFSFHGQPAELRHGSVVIAAITSCTNTSNPSVMLGAGLVAKKACELGLEVKPWIKTSLAPGSGVVTK 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 556 YLSSSGVLPYLSKLGFDIVGYGCSTCVGNTAPLSEAVLNAVKQGDLVTCGVLSGNKHFEGRLCDCVRANYLASPPLVVAY 635
Cdd:PLN00070 523 YLLKSGLQKYLNQQGFHIVGYGCTTCIGNSGELDESVASAITENDIVAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAY 602
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 636 AIAGTVNIDFQTEPLGTDSTGKEIYLHDIWPSREEVHQMEEEHVILSMFKTLKEKVEMGNKRWNSLEAPDSVLFPWDVKS 715
Cdd:PLN00070 603 ALAGTVDIDFEKEPIGTGKDGKDVFFRDIWPSNEEVAEVVQSSVLPDMFKSTYEAITKGNPMWNQLSVPSGTLYSWDPKS 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 716 TYIRCPSFFDKLTKEPAASQPIENAHVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFNSYGARRGNDAVMT 795
Cdd:PLN00070 683 TYIHEPPYFKNMTMSPPGPHGVKDAYCLLNFGDSITTDHISPAGSIHKDSPAAKYLMERGVDRKDFNSYGSRRGNDEIMA 762
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 796 RGTFANIKLFNKFI-GKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAES 874
Cdd:PLN00070 763 RGTFANIRIVNKLLkGEVGPKTVHIPTGEKLSVFDAAMKYKSEGHDTIILAGAEYGSGSSRDWAAKGPMLLGVKAVIAKS 842
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 875 YEKIHKDHLIGIGIAPLEFLPGENADSLGLSGREVFSLSFP---EELFPGITLNIKTSTGKEFSVIASFANDVEITLYKH 951
Cdd:PLN00070 843 FERIHRSNLVGMGIIPLCFKSGEDADTLGLTGHERYTIDLPsniSEIKPGQDVTVTTDNGKSFTCTLRFDTEVELAYFDH 922
|
970
....*....|..
gi 254281215 952 GGLLNFVARKFL 963
Cdd:PLN00070 923 GGILPYVIRNLI 934
|
|
| aconitase_1 |
TIGR01341 |
aconitate hydratase 1; This model represents one form of the TCA cycle enzyme aconitate ... |
25-963 |
0e+00 |
|
aconitate hydratase 1; This model represents one form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It is found in bacteria, archaea, and eukaryotic cytosol. It has been shown to act also as an iron-responsive element binding protein in animals and may have the same role in other eukaryotes. [Energy metabolism, TCA cycle]
Pssm-ID: 273562 [Multi-domain] Cd Length: 876 Bit Score: 1140.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 25 FFNVPKLGGTKYDI--LPYSIRVLLEAAVRNCDGFLMKKEDVMNILDWKTKQ-SNVEVPFFPARVVLQDFTGIPAMVDFA 101
Cdd:TIGR01341 5 YYSLKALEESGGKIskLPYSIRILLESVLRNLDGFSITEEDIENILKWKIGEvADTEIAFKPARVVMQDFTGVPAVVDLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 102 AMREAVKTLGGDPKKVHPACPTDLTVDHSLQIDfskcaiqnapnpgggdlqKAGklsplkvqskklpcrgqttcrgscds 181
Cdd:TIGR01341 85 AMREAMKNLGGDPKKINPLVPVDLVIDHSVQVD------------------YYG-------------------------- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 182 gelsrnsgtfssqientpvlcpfhlqpvpEPETVLKNQEVEFGRNRERLQFFKWSSGAFKNVAVIPPGTGMAHQVNLEYL 261
Cdd:TIGR01341 121 -----------------------------TEYALEFNMELEFERNLERYQFLKWAQKAFRNFRVVPPGTGIIHQVNLEYL 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 262 SRVVFEE----TDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSSNAFVTSIDIV 337
Cdd:TIGR01341 172 ATVVFKAevdgELTAYPDSLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPYYMNVPEVIGVKLTGKLQEGVTATDLV 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 338 LGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFDKTKLESMEKYLKAVK 417
Cdd:TIGR01341 252 LTVTQMLRKKGVVGKFVEFFGPGLSELSLADRATIANMAPEYGATCGFFPIDDVTLQYLRLTGRDGDHVELVEKYARAQG 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 418 LFRNDenSSEPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQVAAEKQSDTVsvryDGSEY 497
Cdd:TIGR01341 332 LFYDD--SEEPRYTDVVELDLSDVEPSVAGPKRPQDRIPLREVKAKFSKELEKNGGDKGFTLRKEPLKKKV----NGQNK 405
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 498 KLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEIGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFDIVGYG 577
Cdd:TIGR01341 406 QLEDGAVVIAAITSCTNTSNPSVMLGAGLLAKKAVELGLKVPPYVKTSLAPGSKVVTDYLAESGLLPYLEELGFNLVGYG 485
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 578 CSTCVGNTAPLSEAVLNAVKQGDLVTCGVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDSTGK 657
Cdd:TIGR01341 486 CTTCIGNSGPLPKYVEEAIKKNDLEVYAVLSGNRNFEGRIHPLVKGNYLASPPLVVAYALAGNIDINLYTEPIGTDKDGK 565
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 658 EIYLHDIWPSREEVHQMEEEHVILSMFKTLKEKVEMGNKRWNSLEAPDSVLFPWDVKSTYIRCPSFFDKLTKEPAASQPI 737
Cdd:TIGR01341 566 PVYLRDIWPSNKEIAAYVNMAVKPEMFKKEYENIFEGNERWNSIKTPSGDTYSWDEKSTYIRLPPFFEEMKQDPEEVEDI 645
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 738 ENAHVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFI-GKPAPKT 816
Cdd:TIGR01341 646 KGARILLLLGDSITTDHISPAGSITKDSPAGKYLQERGVSRRDFNSYGSRRGNHEVMMRGTFANIRIKNLMVkGKEGGYT 725
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 817 IHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLEFLPG 896
Cdd:TIGR01341 726 VHFPDGKVASVYDAAMQYKKEGTPLVVIAGKEYGSGSSRDWAAKGTKLLGVKAVIAESFERIHRSNLVGMGVIPLQFPQG 805
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254281215 897 ENADSLGLSGREVFSLSFPEELFPGITLNIKTSTGK----EFSVIASFANDVEITLYKHGGLLNFVARKFL 963
Cdd:TIGR01341 806 EDAETLGLTGDETIDIDGIKDLKPGKEVTVTFTNSKgekiTFKCVLRIDTEVELDYYKHGGILQYVLRKFL 876
|
|
| acnA |
PRK12881 |
aconitate hydratase AcnA; |
9-963 |
0e+00 |
|
aconitate hydratase AcnA;
Pssm-ID: 237246 [Multi-domain] Cd Length: 889 Bit Score: 1111.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 9 TFEYLIETLNGNSQKKFFNVPKLG---GTKYDILPYSIRVLLEAAVRNCDGFLMKKEDVMNILDWK-TKQSNVEVPFFPA 84
Cdd:PRK12881 5 LHKTLKEFDVGGKTYKFYSLPALGkelGGDLARLPVSLRVLLENLLRNEDGKKVTEEHLEALANWLpERKSDDEIPFVPA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 85 RVVLQDFTGIPAMVDFAAMREAVKTLGGDPKKVHPACPTDLTVDHSLQIDFskcaiqnapnpgGGDlqkagklsplkvqs 164
Cdd:PRK12881 85 RVVMQDFTGVPALVDLAAMRDAAAEAGGDPAKINPLVPVDLVVDHSVAVDY------------FGQ-------------- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 165 kklpcrgqttcrgscdsgelsrnsgtfssqientpvlcpfhlqpvpePETVLKNQEVEFGRNRERLQFFKWSSGAFKNVA 244
Cdd:PRK12881 139 -----------------------------------------------KDALDLNMKIEFQRNAERYQFLKWGMQAFDNFR 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 245 VIPPGTGMAHQVNLEYLSRVVFEETD----LLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVG 320
Cdd:PRK12881 172 VVPPGTGIMHQVNLEYLARVVHTKEDdgdtVAYPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAVMLGQPVYMLIPDVVG 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 321 CELTGSSNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTG 400
Cdd:PRK12881 252 VELTGKLREGVTATDLVLTVTEMLRKEGVVGKFVEFFGEGVASLTLGDRATIANMAPEYGATMGFFPVDEQTLDYLRLTG 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 401 FDKTKLESMEKYLKAVKLFRNDENssEPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQVA 480
Cdd:PRK12881 332 RTEAQIALVEAYAKAQGLWGDPKA--EPRYTRTLELDLSTVAPSLAGPKRPQDRIALGNVKSAFSDLFSKPVAENGFAKK 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 481 AEkqsdtvsvryDGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEIGLRVKPYIRTSLSPGSGMVTHYLSSS 560
Cdd:PRK12881 410 AQ----------TSNGVDLPDGAVAIAAITSCTNTSNPSVLIAAGLLAKKAVERGLTVKPWVKTSLAPGSKVVTEYLERA 479
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 561 GVLPYLSKLGFDIVGYGCSTCVGNTAPLSEAVLNAVKQGDLVTCGVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGT 640
Cdd:PRK12881 480 GLLPYLEKLGFGIVGYGCTTCIGNSGPLTPEIEQAITKNDLVAAAVLSGNRNFEGRIHPNIKANFLASPPLVVAYALAGT 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 641 VNIDFQTEPLGTDSTGKEIYLHDIWPSREEVHQMEEEHVILSMFKTLKEKVEMGNKRWNSLEAPDSVLFPWDVKSTYIRC 720
Cdd:PRK12881 560 VRRDLMTEPLGKGKDGRPVYLKDIWPSSAEIDALVAFAVDPEDFRKNYAEVFKGSELWAAIEAPDGPLYDWDPKSTYIRR 639
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 721 PSFFDKLTKEPAASQPIENAHVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFA 800
Cdd:PRK12881 640 PPFFDFSMGPAASIATVKGARPLAVLGDSITTDHISPAGAIKADSPAGKYLKENGVPKADFNSYGSRRGNHEVMMRGTFA 719
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 801 NIKLFNKFI-GKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIH 879
Cdd:PRK12881 720 NVRIKNLMIpGKEGGLTLHQPSGEVLSIYDAAMRYQAAGTPLVVIAGEEYGTGSSRDWAAKGTRLLGVKAVIAESFERIH 799
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 880 KDHLIGIGIAPLEFLPGENADSLGLSGREVFSLS-FPEELFPG--ITLNIKTSTGKEFSVIASFAND--VEITLYKHGGL 954
Cdd:PRK12881 800 RSNLVGMGVLPLQFKGGDSRQSLGLTGGETFDIEgLPGEIKPRqdVTLVIHRADGSTERVPVLCRIDtpIEVDYYKAGGI 879
|
....*....
gi 254281215 955 LNFVARKFL 963
Cdd:PRK12881 880 LPYVLRQLL 888
|
|
| AcnA_IRP |
cd01586 |
Aconitase A catalytic domain; Aconitase A catalytic domain. This is the major form of the TCA ... |
85-641 |
0e+00 |
|
Aconitase A catalytic domain; Aconitase A catalytic domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydrolyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group also includes sequences that have been shown to act as an iron-responsive element (IRE) binding protein in animals and may have the same role in other eukaryotes.
Pssm-ID: 153136 Cd Length: 404 Bit Score: 702.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 85 RVVLQDFTGIPAMVDFAAMREAVKTLGGDPKKVHPACPTDLTVDHSLQIDFSKCaiqnapnpgggdlqkagklsplkvqs 164
Cdd:cd01586 1 RVILQDFTGVPAVVDLAAMRDAVKRLGGDPEKINPLIPVDLVIDHSVQVDFYGT-------------------------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 165 kklpcrgqttcrgscdsgelsrnsgtfssqientpvlcpfhlqpvpePETVLKNQEVEFGRNRERLQFFKWSSGAFKNVA 244
Cdd:cd01586 55 -----------------------------------------------ADALAKNMKLEFERNRERYEFLKWGQKAFKNLR 87
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 245 VIPPGTGMAHQVNLEYLSRVVF----EETDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVG 320
Cdd:cd01586 88 VVPPGTGIIHQVNLEYLARVVFtseeDGDGVAYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQPISMLLPEVVG 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 321 CELTGSSNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDnvtlrhlehtg 400
Cdd:cd01586 168 VKLTGKLRPGVTATDLVLTVTQMLRKVGVVGKFVEFFGPGVAKLSVADRATIANMAPEYGATCGFFPVD----------- 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 401 fdktklesmekylkavklfrndenssepeySQVIQINLNSIVASVSGPKRPQDRVAVtdmksdfqaclnekvgfkgfqva 480
Cdd:cd01586 237 ------------------------------TQVVELDLSTVEPSVSGPKRPQDRVPL----------------------- 263
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 481 aekqsdtvsvrydgseyklsHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEIGLRVKPYIRTSLSPGSGMVTHYLSSS 560
Cdd:cd01586 264 --------------------HGSVVIAAITSCTNTSNPSVMLAAGLLAKKAVELGLKVKPYVKTSLAPGSRVVTKYLEAS 323
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 561 GVLPYLSKLGFDIVGYGCSTCVGNTAPLSEAVLNAVKQGDLVTCGVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGT 640
Cdd:cd01586 324 GLLPYLEKLGFHVVGYGCTTCIGNSGPLPEEVEEAIKENDLVVAAVLSGNRNFEGRIHPLVRANYLASPPLVVAYALAGT 403
|
.
gi 254281215 641 V 641
Cdd:cd01586 404 V 404
|
|
| Aconitase |
pfam00330 |
Aconitase family (aconitate hydratase); |
78-639 |
0e+00 |
|
Aconitase family (aconitate hydratase);
Pssm-ID: 459764 Cd Length: 460 Bit Score: 534.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 78 EVPFFPARVVLQDFTGIPAMVDFAAMREAVKTLGGDPKKVHPACPTDLTVDHSlqidfskcaiqnapnpgggdlqkagkl 157
Cdd:pfam00330 15 SLLYIPDRVLMHDVTSPQAFVDLRAAGRAVRRPGGTPATIDHLVPTDLVIDHA--------------------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 158 splkvqskklpcrgqttcrgscdsgelsrnsgtfssqientpvlcpfhlqpvpePETVLKNQEVEFGRNRERLQFFKWSS 237
Cdd:pfam00330 68 ------------------------------------------------------PDALDKNIEDEISRNKEQYDFLEWNA 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 238 GAFkNVAVIPPGTGMAHQVNLEYLsrvvfeetdLLFPD-SVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLP 316
Cdd:pfam00330 94 KKF-GIRFVPPGQGIVHQVGLEYG---------LALPGmTIVGTDSHTTTHGGLGALAFGVGGSEAEHVLATQPLEMKKP 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 317 EVVGCELTGSSNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHL 396
Cdd:pfam00330 164 KVVGVKLTGKLPPGVTAKDVILAIIGKLGVKGGTGKVVEFFGPGVRSLSMEGRATICNMAIEYGATAGLFPPDETTFEYL 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 397 EHTGFDKTKLEsmEKYLKAVKLFRNDENsSEPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSD-FQACLNEKVGFK 475
Cdd:pfam00330 244 RATGRPEAPKG--EAYDKAVAWKTLASD-PGAEYDKVVEIDLSTIEPMVTGPTRPQDAVPLSELVPDpFADAVKRKAAER 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 476 gfqvaaekqsdTVSVRYDGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLaKKAVEIGLRVKPYIRTSLSPGSGMVTH 555
Cdd:pfam00330 321 -----------ALEYMGLGPGTPLSDGKVDIAFIGSCTNSSIEDLRAAAGLL-KKAVEKGLKVAPGVKASVVPGSEVVRA 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 556 YLSSSGVLPYLSKLGFDIVGYGCSTCVGNTAPLSEavlnavkqGDlvtCGVLSGNKHFEGRLCDCVRAnYLASPPLVVAY 635
Cdd:pfam00330 389 YAEAEGLDKILEEAGFEWRGPGCSMCIGNSDRLPP--------GE---RCVSSSNRNFEGRQGPGGRT-HLASPALVAAA 456
|
....
gi 254281215 636 AIAG 639
Cdd:pfam00330 457 AIAG 460
|
|
| Aconitase |
cd01351 |
Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and ... |
85-641 |
1.38e-129 |
|
Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Aconitase catalytic domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. Aconitase, in its active form, contains a 4Fe-4S iron-sulfur cluster; three cysteine residues have been shown to be ligands of the 4Fe-4S cluster. This is the Aconitase core domain, including structural domains 1, 2 and 3, which binds the Fe-S cluster. The aconitase family also contains the following proteins: - Iron-responsive element binding protein (IRE-BP), a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5'UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'UTR of transferrin receptor mRNA. IRE-BP also express aconitase activity. - 3-isopropylmalate dehydratase (isopropylmalate isomerase), the enzyme that catalyzes the second step in the biosynthesis of leucine. - Homoaconitase (homoaconitate hydratase), an enzyme that participates in the alpha-aminoadipate pathway of lysine biosynthesis and that converts cis-homoaconitate into homoisocitric acid.
Pssm-ID: 153129 [Multi-domain] Cd Length: 389 Bit Score: 396.48 E-value: 1.38e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 85 RVVLQDFTGIPAMVDFAAMREAVKtlggdpkkVHPACPTDLTVDHSLQIDFskcaiqnapnpgggdlqkagklsplkvqs 164
Cdd:cd01351 1 RVMLQDATGPMAMKAFEILAALGK--------VADPSQIACVHDHAVQLEK----------------------------- 43
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 165 kklpcrgqttcrgscdsgelsrnsgtfssqientpvlcpfhlqpvpepetvlknqevefGRNRERLQFFKWSSgAFKNVA 244
Cdd:cd01351 44 -----------------------------------------------------------PVNNEGHKFLSFFA-ALQGIA 63
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 245 VIPPGTGMAHQVNLEYLsrvvfeetdLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELT 324
Cdd:cd01351 64 FYRPGVGIIHQIMVENL---------ALPGDLLVGSDSHTTSYGGLGAISTGAGGGDVAFVMAGGPAWLKKPEVVGVNLT 134
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 325 GSSNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFDKT 404
Cdd:cd01351 135 GKLSPGVTGKDVVLKLGGIVGVDGVLNRIVEFYGEGVSSLSIEDRLTICNMMAELGATTGIFPEDKTTLKWLEATGRPLL 214
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 405 KLesmekylkAVKLFRNDENSS-EPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSdfqaclnekvgfkgfqvaaek 483
Cdd:cd01351 215 KN--------LWLAFPEELLADeGAEYDQVIEIDLSELEPDISGPNRPDDAVSVSEVEG--------------------- 265
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 484 qsdtvsvrydgseyklshGSVVIAAVISCTNNCnPSVMLAAGLLAKKAVeiglrVKPYIRTSLSPGSGMVTHYLSSSGVL 563
Cdd:cd01351 266 ------------------TKIDQVLIGSCTNNR-YSDMLAAAKLLKGAK-----VAPGVRLIVTPGSRMVYATLSREGYY 321
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254281215 564 PYLSKLGFDIVGYGCSTCVGNTAPLseavlnavkqGDLVTCGVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGTV 641
Cdd:cd01351 322 EILVDSGARILPPGCGPCMGNGARL----------VADGEVGVSSGNRNFPGRLGTYERHVYLASPELAAATAIAGKI 389
|
|
| AcnA_IRP_Swivel |
cd01580 |
Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, ... |
745-913 |
2.91e-107 |
|
Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group also includes sequences that have been shown to act as an iron-responsive element (IRE) binding protein in animals and may have the same role in other eukaryotes. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism.
Pssm-ID: 238812 [Multi-domain] Cd Length: 171 Bit Score: 329.24 E-value: 2.91e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 745 YLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPS-GQ 823
Cdd:cd01580 1 LLGDSVTTDHISPAGSIAKDSPAGKYLAERGVKPRDFNSYGSRRGNDEVMMRGTFANIRLRNKLVPGTEGGTTHHPPtGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 824 TLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLEFLPGENADSLG 903
Cdd:cd01580 81 VMSIYDAAMRYKEEGVPLVILAGKEYGSGSSRDWAAKGPFLLGVKAVIAESFERIHRSNLVGMGILPLQFPPGENADSLG 160
|
170
....*....|
gi 254281215 904 LSGREVFSLS 913
Cdd:cd01580 161 LTGEETYDII 170
|
|
| PRK07229 |
PRK07229 |
aconitate hydratase; Validated |
247-961 |
3.19e-66 |
|
aconitate hydratase; Validated
Pssm-ID: 235974 [Multi-domain] Cd Length: 646 Bit Score: 234.66 E-value: 3.19e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 247 PPGTGMAHQVNLEYLSrvvfeetdllFP-DSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTG 325
Cdd:PRK07229 94 KPGNGICHQVHLERFA----------FPgKTLLGSDSHTPTAGGLGMLAIGAGGLDVALAMAGGPYYLKMPKVVGVKLTG 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 326 SSNAFVTSIDIVLgitKHLRQVGVAG---KFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFD 402
Cdd:PRK07229 164 KLPPWVSAKDVIL---ELLRRLTVKGgvgKIIEYFGPGVATLSVPERATITNMGAELGATTSIFPSDERTREFLKAQGRE 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 403 KTKLEsmekyLKAvklfrnDENSsepEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKsdfqaclnekvgfkgfqvaae 482
Cdd:PRK07229 241 DDWVE-----LLA------DPDA---EYDEVIEIDLSELEPLIAGPHSPDNVVPVSEVA--------------------- 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 483 kqsdtvsvrydgseyklshGSVVIAAVI-SCTnncNPS---VMLAAGLLAKKaveiglRVKPyiRTSL--SPGSGMVTHY 556
Cdd:PRK07229 286 -------------------GIKVDQVLIgSCT---NSSyedLMRAASILKGK------KVHP--KVSLviNPGSRQVLEM 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 557 LSSSGVLPYLSKLGFDIVGYGCSTCVGNT-APLSEAVLnavkqgdlvtcgVLSGNKHFEGR---LCDCVranYLASPPLV 632
Cdd:PRK07229 336 LARDGALADLIAAGARILENACGPCIGMGqAPATGNVS------------LRTFNRNFPGRsgtKDAQV---YLASPETA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 633 VAYAIAGTVnidfqTEPLG-TDSTGKEIYLhdiwpsreevhQM-EEEHVILSMFKTLKE---KVEMgnkrwnsLEAPDSV 707
Cdd:PRK07229 401 AASALTGVI-----TDPRTlALENGEYPKL-----------EEpEGFAVDDAGIIAPAEdgsDVEV-------VRGPNIK 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 708 LFPwdvkstyircpsffdklTKEPAASqpIENAHVLLYLGDSVTTDHISPAGsiarssaaAKYLTNRGltprefnsygar 787
Cdd:PRK07229 458 PLP-----------------LLEPLPD--LLEGKVLLKVGDNITTDHIMPAG--------AKWLPYRS------------ 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 788 rgndavmtrgtfaNIklfnkfigkpaPKTIHFpsgqtldVFEAA--ELYQ--KEGIPLIILAGKKYGSGNSRDWAAKGPY 863
Cdd:PRK07229 499 -------------NI-----------PNISEF-------VFEGVdnTFPEraKEQGGGIVVGGENYGQGSSREHAALAPR 547
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 864 LLGVKAVLAESYEKIHKDHLIGIGIAPLEFLPGENADSLGLSgrEVFSLSFPEELFPGITLNIKTST-GKEFSVIASFaN 942
Cdd:PRK07229 548 YLGVKAVLAKSFARIHKANLINFGILPLTFADPADYDKIEEG--DVLEIEDLREFLPGGPLTVVNVTkDEEIEVRHTL-S 624
|
730
....*....|....*....
gi 254281215 943 DVEITLYKHGGLLNFVARK 961
Cdd:PRK07229 625 ERQIEILLAGGALNLIKKK 643
|
|
| AcnA_Bact |
cd01585 |
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA ... |
248-641 |
1.09e-43 |
|
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Bacterial Aconitase-like catalytic domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. This distinct subfamily is found only in bacteria and Archaea. Its exact characteristics are not known.
Pssm-ID: 153135 Cd Length: 380 Bit Score: 163.39 E-value: 1.09e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 248 PGTGMAHQVNLEYLSRvvfeetdllfP-DSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGS 326
Cdd:cd01585 66 PGNGICHQVHLERFAV----------PgKTLLGSDSHTPTAGGLGMLAIGAGGLDVALAMAGEPYYIPMPKVVGVRLTGE 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 327 SNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFDKTKL 406
Cdd:cd01585 136 LPPWVTAKDVILELLRRLTVKGGVGKIFEYTGPGVATLSVPERATITNMGAELGATTSIFPSDERTREFLAAQGREDDWV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 407 EsmekyLKAvklfrnDENSsepEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKsdfqaclnekvGFKGFQVaaekqsd 486
Cdd:cd01585 216 E-----LAA------DADA---EYDEEIEIDLSELEPLIARPHSPDNVVPVREVA-----------GIKVDQV------- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 487 tvsvrydgseyklshgsvviaAVISCTNNCNPSVMLAAGLLAkkaveiGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYL 566
Cdd:cd01585 264 ---------------------AIGSCTNSSYEDLMTVAAILK------GRRVHPHVSMVVAPGSKQVLEMLARNGALADL 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254281215 567 SKLGFDIVGYGCSTCVG-NTAPLSEAVlnavkqgdlvtcGVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGTV 641
Cdd:cd01585 317 LAAGARILESACGPCIGmGQAPPTGGV------------SVRTFNRNFEGRSGTKDDLVYLASPEVAAAAALTGVI 380
|
|
| AcnA_Mitochondrial |
cd01584 |
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA ... |
226-640 |
2.37e-41 |
|
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Mitochondrial aconitase A catalytic domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediary product during the course of the reaction. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. This is the mitochondrial form. The mitochondrial product is coded by a nuclear gene. Most members of this subfamily are mitochondrial but there are some bacterial members.
Pssm-ID: 153134 Cd Length: 412 Bit Score: 157.22 E-value: 2.37e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 226 NRERLQFFKwSSGAFKNVAVIPPGTGMAHQVNLEYLSrvvfeetdllFPDS-VVGTDSHITMVNGLGILGWGVGGIETEA 304
Cdd:cd01584 53 NKEVYDFLA-SAGAKYGIGFWKPGSGIIHQIVLENYA----------FPGLlMIGTDSHTPNAGGLGGIAIGVGGADAVD 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 305 VMLGLPVTLTLPEVVGCELTGSSNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILS 384
Cdd:cd01584 122 VMAGIPWELKCPKVIGVKLTGKLSGWTSPKDVILKVAGILTVKGGTGAIVEYFGPGVDSLSCTGMGTICNMGAEIGATTS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 385 FFPVDNVTLRHLEHTGfdKTKLESMEKYLKAvKLFRNDENSsepEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSdf 464
Cdd:cd01584 202 VFPYNERMKKYLKATG--RAEIADLADEFKD-DLLVADEGA---EYDQLIEINLSELEPHINGPFTPDLATPVSKFKE-- 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 465 qaclnekvgfkgfqvAAEKQSDTVSVRydgseyklshgsvvIAAVISCTNNCNPSVMLAAGlLAKKAVEIGLRVKpyIRT 544
Cdd:cd01584 274 ---------------VAEKNGWPLDLR--------------VGLIGSCTNSSYEDMGRAAS-IAKQALAHGLKCK--SIF 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 545 SLSPGSGMVTHYLSSSGVLPYLSKLGFDIVGYGCSTCVGntaplsEAVLNAVKQGDLVTCgVLSGNKHFEGRlCDCVRA- 623
Cdd:cd01584 322 TITPGSEQIRATIERDGLLQTFRDAGGIVLANACGPCIG------QWDRKDIKKGEKNTI-VTSYNRNFTGR-NDANPAt 393
|
410
....*....|....*...
gi 254281215 624 -NYLASPPLVVAYAIAGT 640
Cdd:cd01584 394 hAFVASPEIVTAMAIAGT 411
|
|
| Aconitase_C |
pfam00694 |
Aconitase C-terminal domain; Members of this family usually also match to pfam00330. This ... |
767-896 |
1.06e-40 |
|
Aconitase C-terminal domain; Members of this family usually also match to pfam00330. This domain undergoes conformational change in the enzyme mechanism.
Pssm-ID: 459908 [Multi-domain] Cd Length: 131 Bit Score: 145.97 E-value: 1.06e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 767 AAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFI-GKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILA 845
Cdd:pfam00694 1 MPVFLKLKGKTTPDFNSNVDTDLIIPKQFLGTIANIGIGNINFeGWRYGKVRYLPDGENPDFYDAAMRYKQHGAPIVVIG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 254281215 846 GKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLEFLPG 896
Cdd:pfam00694 81 GKNFGCGSSREHAAWALRDLGIKAVIAESFARIHRNNLIKNGLLPLEFPEE 131
|
|
| IPMI |
cd01583 |
3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and ... |
264-641 |
5.98e-32 |
|
3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Aconatase-like catalytic domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-isopropylmalate. IPMI is involved in fungal and bacterial leucine biosynthesis and is also found in eukaryotes.
Pssm-ID: 153133 Cd Length: 382 Bit Score: 128.85 E-value: 5.98e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 264 VVFEETDLLFP-DSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSSNAFVTSIDIVLGITK 342
Cdd:cd01583 74 VILPEKGLTLPgMTIVGGDSHTCTHGAFGAFATGIGTTDVAHVLATGKLWFRVPETMRVNVEGKLPPGVTAKDVILYIIG 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 343 HLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFdktklesmekylKAVKLFRND 422
Cdd:cd01583 154 KIGVDGATYKAMEFAGEAIESLSMEERMTLCNMAIEAGAKAGIVAPDETTFEYLKGRGK------------AYWKELKSD 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 423 ENSsepEYSQVIQINLNSIVASVSGPKRPQDRVAVtdmksdfqaclNEKVGFKGFQVaaekqsdtvsvrYDGseyklshg 502
Cdd:cd01583 222 EDA---EYDKVVEIDASELEPQVAWPHSPDNVVPV-----------SEVEGIKIDQV------------FIG-------- 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 503 svviaaviSCTNNCNPSVMLAAGLLAKKaveiglRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFDIVGYGCSTCV 582
Cdd:cd01583 268 --------SCTNGRLEDLRAAAEILKGR------KVADGVRLIVVPASQRVYKQAEKEGLIEIFIEAGAEVRPPGCGACL 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 254281215 583 GntapLSEAVLNAvkqGDLVtcgVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGTV 641
Cdd:cd01583 334 G----GHMGVLAP---GERC---VSTSNRNFKGRMGSPGARIYLASPATAAASAITGEI 382
|
|
| LeuC |
COG0065 |
Homoaconitase/3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism] ... |
277-641 |
1.33e-29 |
|
Homoaconitase/3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Homoaconitase/3-isopropylmalate dehydratase large subunit is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439835 Cd Length: 417 Bit Score: 122.45 E-value: 1.33e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 277 VVGTDSHITMVNGLGILGWGVGGIETEAVMlglpVTLTL----PEVVGCELTGSSNAFVTSIDIVLGItkhLRQVGVAG- 351
Cdd:COG0065 117 IVGGDSHTCTHGAFGAFAFGIGTTDVAHVL----ATGTLwfkvPETMRIEVTGKLPPGVTAKDLILAI---IGKIGADGa 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 352 --KFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFdktklesmekylKAVKLFRNDENSsepE 429
Cdd:COG0065 190 tgKAIEFAGEAIRALSMEERMTLCNMAIEAGAKAGIIAPDETTFEYLKGRPF------------APWRTLKSDEDA---V 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 430 YSQVIQINLNSIVASVSGPKRPQDRVAVTDMksdfqaclnekvgfKGFQVaaekqsDTVsvrydgseyklshgsvviaaV 509
Cdd:COG0065 255 YDKEVEIDASDLEPQVAWPHSPDNVVPVSEL--------------EGIKI------DQV--------------------F 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 510 I-SCTNNcnpsvML-----AAGLLAkkaveiGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFDIVGYGCSTCVG 583
Cdd:COG0065 295 IgSCTNG-----RIedlraAAEILK------GRKVAPGVRAIVVPGSQEVYRQAEAEGLDEIFIEAGAEWREPGCGMCLG 363
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 254281215 584 -NTAPLSEavlnavkqGDLVtcgVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGTV 641
Cdd:COG0065 364 mNMGVLAP--------GERC---ASTSNRNFEGRMGSPGSRTYLASPATAAASAIAGRI 411
|
|
| PRK00402 |
PRK00402 |
3-isopropylmalate dehydratase large subunit; Reviewed |
249-639 |
2.87e-23 |
|
3-isopropylmalate dehydratase large subunit; Reviewed
Pssm-ID: 234748 Cd Length: 418 Bit Score: 103.72 E-value: 2.87e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 249 GTGMAHQVnleylsrvvFEETDLLFP-DSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSS 327
Cdd:PRK00402 97 GEGICHQV---------LPEKGLVRPgDVVVGADSHTCTYGALGAFATGMGSTDMAAAMATGKTWFKVPETIKVVLEGKL 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 328 NAFVTSIDIVLGItkhLRQVGVAG---KFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEhtgfdkt 404
Cdd:PRK00402 168 PPGVTAKDVILHI---IGDIGVDGatyKALEFTGETIEALSMDERMTLANMAIEAGAKAGIFAPDEKTLEYLK------- 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 405 klesmEKYLKAVKLFRNDENSsepEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKsdfqaclNEKVgfkgfqvaaekq 484
Cdd:PRK00402 238 -----ERAGRDYKPWKSDEDA---EYEEVYEIDLSKLEPQVAAPHLPDNVKPVSEVE-------GTKV------------ 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 485 sDTVsvrydgseyklshgsvviaaVI-SCTNncnpsvmlaaGLLA--KKAVEI--GLRVKPYIRTSLSPGSGMVTHYLSS 559
Cdd:PRK00402 291 -DQV--------------------FIgSCTN----------GRLEdlRIAAEIlkGRKVAPGVRLIVIPASQKIYLQALK 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 560 SGVLPYLSKLGFdIVGY-GCSTCVGNtaplSEAVLnavkqGDLVTCgVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIA 638
Cdd:PRK00402 340 EGLIEIFVDAGA-VVSTpTCGPCLGG----HMGVL-----APGEVC-LSTTNRNFKGRMGSPESEVYLASPAVAAASAVT 408
|
.
gi 254281215 639 G 639
Cdd:PRK00402 409 G 409
|
|
| PRK12466 |
PRK12466 |
3-isopropylmalate dehydratase large subunit; |
264-639 |
8.14e-22 |
|
3-isopropylmalate dehydratase large subunit;
Pssm-ID: 183543 Cd Length: 471 Bit Score: 99.98 E-value: 8.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 264 VVFEETDLLFPDSVVGT-DSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSSNAFVTSIDIVLGITK 342
Cdd:PRK12466 112 VVAPELGLTLPGMVIVCgDSHTTTYGALGALAFGIGTSEVEHVLATQTLVYRKPKTMRVRVDGELPPGVTAKDLILALIA 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 343 HLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFDkTKLESMEKYLKAVKLFRND 422
Cdd:PRK12466 192 RIGADGATGYAIEFAGEAIRALSMEGRMTLCNMAVEAGARGGLIAPDETTFDYLRGRPRA-PKGALWDAALAYWRTLRSD 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 423 ENSsepEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSDFQACLNekvgfkgfqvAAEKQSDTVSVRYDGSEYKLSHG 502
Cdd:PRK12466 271 ADA---VFDREVEIDAADIAPQVTWGTSPDQAVPITGRVPDPAAEAD----------PARRAAMERALDYMGLTPGTPLA 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 503 SVVIAAVI--SCTNNCNPSVMLAAGLLAkkaveiGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFDIVGYGCST 580
Cdd:PRK12466 338 GIPIDRVFigSCTNGRIEDLRAAAAVLR------GRKVAPGVRAMVVPGSGAVRRQAEAEGLARIFIAAGFEWREPGCSM 411
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254281215 581 CVGntaplseavLNavkqGDLVTCG---VLSGNKHFEGRLCDCVRAnYLASPPLVVAYAIAG 639
Cdd:PRK12466 412 CLA---------MN----DDVLAPGercASTTNRNFEGRQGPGART-HLMSPAMVAAAAVAG 459
|
|
| Homoaconitase |
cd01582 |
Homoaconitase and other uncharacterized proteins of the Aconitase family; Homoaconitase ... |
247-641 |
9.99e-18 |
|
Homoaconitase and other uncharacterized proteins of the Aconitase family; Homoaconitase catalytic domain. Homoaconitase and other uncharacterized proteins of the Aconitase family. Homoaconitase is part of an unusual lysine biosynthesis pathway found only in filamentous fungi, in which lysine is synthesized via the alpha-aminoadipate pathway. In this pathway, homoaconitase catalyzes the conversion of cis-homoaconitic acid into homoisocitric acid. The reaction mechanism is believed to be similar to that of other aconitases.
Pssm-ID: 153132 [Multi-domain] Cd Length: 363 Bit Score: 86.13 E-value: 9.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 247 PPGTGMAHQVNLEylsrvvfeeTDLLFPDSV-VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTG 325
Cdd:cd01582 64 PAGRGIGHQIMIE---------EGYAFPGTLaVASDSHSNMYGGVGCLGTPIVRTDAAAIWATGQTWWQIPPVAKVELKG 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 326 SSNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDnvtlrhlehtgfdktk 405
Cdd:cd01582 135 QLPKGVTGKDVIVALCGLFNKDQVLNHAIEFTGSGLNSLSVDTRLTIANMTTEWGALSGLFPTD---------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 406 lesmekylkAVKLFrndenssepeysqviqINLNSIVASVSGPKrpqdrvavtdmksdfqaclnekvgfkgfqvaaekqs 485
Cdd:cd01582 199 ---------AKHLI----------------LDLSTLSPYVSGPN------------------------------------ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 486 dtvSVRYDGSEYKLSHGSVVI--AAVISCTNNCNPSVMLAAGLLAKKAVEIG-LRVKPYIRTSLSPGSGMVTHYLSSSGV 562
Cdd:cd01582 218 ---SVKVSTPLKELEAQNIKInkAYLVSCTNSRASDIAAAADVVKGKKEKNGkIPVAPGVEFYVAAASSEVQAAAEKNGD 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254281215 563 LPYLSKLGFDIVGYGCSTCVGNTAPLseavlnaVKQGDLvtcGVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGTV 641
Cdd:cd01582 295 WQTLLEAGATPLPAGCGPCIGLGQGL-------LEPGEV---GISATNRNFKGRMGSTEALAYLASPAVVAASAISGKI 363
|
|
| Aconitase_swivel |
cd00404 |
Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible ... |
840-902 |
2.65e-17 |
|
Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme mechanism. The aconitase family contains the following proteins: - Iron-responsive element binding protein (IRE-BP). IRE-BP is a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5'UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'UTR of transferrin receptor mRNA. IRE-BP also express aconitase activity. - 3-isopropylmalate dehydratase (isopropylmalate isomerase), the enzyme that catalyzes the second step in the biosynthesis of leucine. - Homoaconitase (homoaconitate hydratase), an enzyme that participates in the alpha-aminoadipate pathway of lysine biosynthesis and that converts cis-homoaconitate into homoisocitric acid.
Pssm-ID: 238236 [Multi-domain] Cd Length: 88 Bit Score: 77.51 E-value: 2.65e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254281215 840 PLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLEFLPGENADSL 902
Cdd:cd00404 16 PGVVIGDENYGTGSSREHAALELRLLGGRAVIAKSFARIFFRNLVDQGLLPLEFADPEDYLKL 78
|
|
| AcnA_Bact_Swivel |
cd01579 |
Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) ... |
746-893 |
2.44e-16 |
|
Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism. This distinct subfamily is found only in bacteria and archea. Its exact characteristics are not known.
Pssm-ID: 238811 [Multi-domain] Cd Length: 121 Bit Score: 75.94 E-value: 2.44e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 746 LGDSVTTDHISPAGsiarssaaAKYLTNRgltprefnsygarrgndavmtrgtfANIKLFNKFIGKPAPKTIHfpsgqtl 825
Cdd:cd01579 2 VGDNITTDHIMPAG--------AKVLPLR-------------------------SNIPAISEFVFHRVDPTFA------- 41
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254281215 826 dvfEAAelyqKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLEF 893
Cdd:cd01579 42 ---ERA----KAAGPGFIVGGENYGQGSSREHAALAPMYLGVRAVLAKSFARIHRANLINFGILPLTF 102
|
|
| IPMI_Swivel |
cd01577 |
Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized ... |
842-909 |
3.46e-08 |
|
Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-isopropylmalate. IPMI is involved in fungal and bacterial leucine biosynthesis and is also found in eukaryotes. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism.
Pssm-ID: 238809 [Multi-domain] Cd Length: 91 Bit Score: 51.82 E-value: 3.46e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254281215 842 IILAGKKYGSGNSR---DWAAKGpylLGVKAVLAESYEKIHKDHLIGIGIAPLEFLPGENADSLGLSGREV 909
Cdd:cd01577 20 IIVAGKNFGCGSSRehaPWALKD---AGIRAVIAESFARIFFRNAINNGLLPVTLADEDVEEVEAKPGDEV 87
|
|
| PRK11413 |
PRK11413 |
putative hydratase; Provisional |
277-378 |
9.29e-06 |
|
putative hydratase; Provisional
Pssm-ID: 183125 [Multi-domain] Cd Length: 751 Bit Score: 49.62 E-value: 9.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 277 VVGTDSHiTMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSSNAFVTSIDIVLGITKHLRQVG-VAGKFVE 355
Cdd:PRK11413 145 ILGSDSH-TRYGALGTMAVGEGGGELVKQLLNDTYDIDYPGVVAVYLTGKPAPGVGPQDVALAIIGAVFKNGyVKNKVME 223
|
90 100
....*....|....*....|...
gi 254281215 356 FFGSGVSQLSIVDRTTIANMCPE 378
Cdd:PRK11413 224 FVGPGVSALSTDFRNGVDVMTTE 246
|
|
| LeuD |
COG0066 |
3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; ... |
842-902 |
1.51e-05 |
|
3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; 3-isopropylmalate dehydratase small subunit is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439836 [Multi-domain] Cd Length: 195 Bit Score: 46.70 E-value: 1.51e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254281215 842 IILAGKKYGSGNSRD---WAAKGpylLGVKAVLAESYEKIHKDHLIGIGIAPLEfLPGENADSL 902
Cdd:COG0066 67 ILVAGRNFGCGSSREhapWALKD---YGFRAVIAPSFADIFYRNAINNGLLPIE-LPEEAVDAL 126
|
|
| PLN00072 |
PLN00072 |
3-isopropylmalate isomerase/dehydratase small subunit; Provisional |
706-892 |
5.96e-05 |
|
3-isopropylmalate isomerase/dehydratase small subunit; Provisional
Pssm-ID: 177701 [Multi-domain] Cd Length: 246 Bit Score: 45.62 E-value: 5.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 706 SVLFPWDVKSTYIRCPSFFDKLTKEPAASQPIenaHVLLY-LGDSVTTDHISPAGsiarssaaakYLTNRGLTPREFNSY 784
Cdd:PLN00072 38 SSIFPFKPLTTSSGTSSPTISDSAESTSSTTF---HGLCFvVGDNIDTDQIIPAE----------YLTLVPSKPDEYEKL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 785 GArrgndavmtrgtFAniklfnkFIGKPAPKTIHFpsgqtldvFEAAELYQKEGIpliILAGKKYGSGNSRDWAakgPYL 864
Cdd:PLN00072 105 GS------------YA-------LIGLPAFYKTRF--------VEPGEMKTKYSI---IIGGENFGCGSSREHA---PVA 151
|
170 180 190
....*....|....*....|....*....|..
gi 254281215 865 LG---VKAVLAESYEKIHKDHLIGIG-IAPLE 892
Cdd:PLN00072 152 LGaagAKAVVAESYARIFFRNSVATGeVYPLE 183
|
|
| leuD |
PRK00439 |
3-isopropylmalate dehydratase small subunit; Reviewed |
842-961 |
1.59e-04 |
|
3-isopropylmalate dehydratase small subunit; Reviewed
Pssm-ID: 234762 [Multi-domain] Cd Length: 163 Bit Score: 43.28 E-value: 1.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254281215 842 IILAGKKYGSGNSRD---WAAKGpylLGVKAVLAESYEKIHKDHLIGIGIAPLEFlpGENADSLGlSGREVfslsfpeel 918
Cdd:PRK00439 51 IIVAGKNFGCGSSREhapIALKA---AGVSAVIAKSFARIFYRNAINIGLPVLEC--DEAVDKIE-DGDEV--------- 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 254281215 919 fpgiTLNIKT------STGKEFSV--IASFAndVEItlYKHGGLLNFVARK 961
Cdd:PRK00439 116 ----EVDLETgvitnlTTGEEYKFkpIPEFM--LEI--LKAGGLIEYLKKK 158
|
|
| |
