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Conserved domains on  [gi|50593008|ref|NP_071435|]
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protein lifeguard 3 isoform 1 [Homo sapiens]

Protein Classification

protein lifeguard( domain architecture ID 10179627)

protein lifeguard similar to human protein lifeguard 2, an antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis, and regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 89-308 1.41e-110

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


:

Pssm-ID: 198410  Cd Length: 217  Bit Score: 319.49  E-value: 1.41e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008  89 WDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILL 168
Cdd:cd10428   2 FDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 169 TLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGivtsIVLYFQYVYW 248
Cdd:cd10428  82 GIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFG----IVAIFFYVKW 157

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 249 LHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMG 308
Cdd:cd10428 158 LHIVYASLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 89-308 1.41e-110

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 319.49  E-value: 1.41e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008  89 WDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILL 168
Cdd:cd10428   2 FDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 169 TLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGivtsIVLYFQYVYW 248
Cdd:cd10428  82 GIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFG----IVAIFFYVKW 157

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 249 LHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMG 308
Cdd:cd10428 158 LHIVYASLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 96-307 2.15e-31

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 116.50  E-value: 2.15e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008    96 HTFIRKVYSIISVQLLITvAIIAIFTFVEPVSAFVRRNVAVYYVSY-AVFVVTYLILACCQGPRRRFPWNIILLTLFTFA 174
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIiAPLGLLFGALLLARKRKYSSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008   175 MGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLlvtgIVTSIVLYFQYVYWLHMLYA 254
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGL----IVASLVNIFLPSSALSLAIS 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 50593008   255 ALGAICFTLFLAYDTQLVLGNRKHTISpEDYITGALQIYTDIIYIFTFVLQLM 307
Cdd:pfam01027 156 YLGVLLFSGFILYDTQRIIKRYGEYGD-YDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 94-311 1.35e-23

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 96.40  E-value: 1.35e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008  94 VRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYA-----VFVVTYLILaccqgpRRRFPWNIILL 168
Cdd:COG0670  18 GLRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIaplglVFLLSKLAN------RANSAAALALL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 169 TLFTFAMGFMTGTISSMYQTKA----VIIAMIITAVVSISVTIFCFQTKVDFTSCTGlFCVLGIVLLvtgIVTSIVLYFQ 244
Cdd:COG0670  92 FAYTALMGLTLSPILLVYTGLSgpasIAQAFGGTAATFGGLSLYGYTTKRDLSFLGS-FLFMGLIGL---IIASLVNIFL 167

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50593008 245 YVYWLHMLYAALGAICFTLFLAYDTQLVlgnRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 311
Cdd:COG0670 168 QSPALSLAISVAGVLLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 89-308 1.41e-110

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 319.49  E-value: 1.41e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008  89 WDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILL 168
Cdd:cd10428   2 FDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 169 TLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGivtsIVLYFQYVYW 248
Cdd:cd10428  82 GIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFG----IVAIFFYVKW 157

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 249 LHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMG 308
Cdd:cd10428 158 LHIVYASLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 91-311 2.85e-44

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 150.83  E-value: 2.85e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008  91 DRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSyavFVVTYLILACCQGPRRRFPWNIILLTL 170
Cdd:cd10429  23 EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLIS---LIGSLILLIALYWKRHSHPVNLILLSL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 171 FTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLfcvLGIVLLVTGIVTSIVLYFQYVYWLH 250
Cdd:cd10429 100 FTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGAL---LFILLWALILLALIFQFFPYSPTFE 176

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50593008 251 MLYAALGAICFTLFLAYDTQLVLgnrkHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 311
Cdd:cd10429 177 LVYAGLGALLFSGYIVYDTQLIM----KRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 94-308 4.18e-43

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 146.79  E-value: 4.18e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008  94 VRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSafvrrnvavYYVSYAVFVVT--YLILACCQGPRRRFPWNIILLTLF 171
Cdd:cd06181   1 STKDFLRKVYMILALQLLLTAATATAFTVCDPGW---------YWSPALMGLLTsmLALMATAAMIRAKMPVNLILLFGF 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 172 TFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTG-LFCVLGIVLLvtgivTSIVLYFQYVYWLH 250
Cdd:cd06181  72 TGLMGYVVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGpLMAGLGFLLL-----SFLLNTFFYSPWLH 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 50593008 251 MLYAALGAICFTLFLAYDTQLVLGNRKHtiSPEDYITGALQIYTDIIYIFTFVLQLMG 308
Cdd:cd06181 147 LVAAAVGLVLFCGFLLYDTQLIIHKAEV--GPEDYINACISLYLDIINIFIRLLTILA 202
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 96-307 2.15e-31

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 116.50  E-value: 2.15e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008    96 HTFIRKVYSIISVQLLITvAIIAIFTFVEPVSAFVRRNVAVYYVSY-AVFVVTYLILACCQGPRRRFPWNIILLTLFTFA 174
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIiAPLGLLFGALLLARKRKYSSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008   175 MGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLlvtgIVTSIVLYFQYVYWLHMLYA 254
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGL----IVASLVNIFLPSSALSLAIS 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 50593008   255 ALGAICFTLFLAYDTQLVLGNRKHTISpEDYITGALQIYTDIIYIFTFVLQLM 307
Cdd:pfam01027 156 YLGVLLFSGFILYDTQRIIKRYGEYGD-YDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 94-311 1.35e-23

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 96.40  E-value: 1.35e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008  94 VRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYA-----VFVVTYLILaccqgpRRRFPWNIILL 168
Cdd:COG0670  18 GLRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIaplglVFLLSKLAN------RANSAAALALL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 169 TLFTFAMGFMTGTISSMYQTKA----VIIAMIITAVVSISVTIFCFQTKVDFTSCTGlFCVLGIVLLvtgIVTSIVLYFQ 244
Cdd:COG0670  92 FAYTALMGLTLSPILLVYTGLSgpasIAQAFGGTAATFGGLSLYGYTTKRDLSFLGS-FLFMGLIGL---IIASLVNIFL 167

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50593008 245 YVYWLHMLYAALGAICFTLFLAYDTQLVlgnRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 311
Cdd:COG0670 168 QSPALSLAISVAGVLLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 95-308 1.09e-19

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 85.31  E-value: 1.09e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008  95 RHTFIRKVYSIISVQLLITvAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILAccQGPRRRFPWNIILLTLFTFA 174
Cdd:cd10432   2 LRSFMKKVYGLMAAGLLLT-AVGAYVGASTPALLLIAGSPLMWVLLIAELALVFGLSF--RINKMSVATALPLFFAFAAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 175 MGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTScTGLFCVLGIVLLvtgIVTSIVLYFQYVYWLHMLYA 254
Cdd:cd10432  79 TGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSF-LGSFLFMGLIGL---IIASLVNIFLQSSALQFAIS 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 50593008 255 ALGAICFTLFLAYDTQLVL---GNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMG 308
Cdd:cd10432 155 AIGVLIFSGLIAYDTQRIKrmyEAGGGESGYKDAIMGALSLYLDFINLFLFLLRLFG 211
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 94-308 2.69e-10

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 59.14  E-value: 2.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008  94 VRHTFIRKVYSIISVQLLITVaiiaiftfvepVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTF 173
Cdd:cd10433   2 STNKVLRNTYMLLSMTLAFSA-----------LGAGVSMAGGSPIMGLLLTLVGAYGLLFLIEKTRNSAWGIVLVFAFTG 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 174 AMGFMTGTISSMYQT-----KAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGlFCVLGIVLLVTGIVTSIvlyFQYVYW 248
Cdd:cd10433  71 FMGYTLGPILNMYLAlpnggQIIMTALGGTAAIFFGLSAYALTTKKDFSFLGG-FLFVGAIVLLLAAVANI---FLQIPA 146

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 249 LHMLYAALGAICFTLFLAYDTQLVLgNRKHTispeDYITGALQIYTDIIYIFTFVLQLMG 308
Cdd:cd10433 147 LSLAISAAFVLFSSGFILYDTSRII-HGGET----NYIMATVSLYVSIYNLFVSLLNLLG 201
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 167-307 1.21e-04

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 42.59  E-value: 1.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 167 LLTLFTFAMGFMTGTIssMYQTKAVIIAMIITAVVSISVTIFCFqTKVDFTSCTGLFCVLGiVLLVTGI----VTSIVLY 242
Cdd:cd10430  70 LLLGFAFLTGASLGPL--LDLVIAINPSIIVTAFLGTAVIFACF-SLAALLAKRREYLYLG-GLLSSALsillLVSLANI 145

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50593008 243 FQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHtiSPEDYITGALQIYTDIIYIFTFVLQLM 307
Cdd:cd10430 146 FGGSKFLFQAELYLGLLVFCGFVLFDTQMIIEKAEN--GDRDYIWHALDLFVDFVALFRRLLIIL 208
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 226-308 4.47e-03

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 38.13  E-value: 4.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593008 226 LGIVLLVTGIVTSIVLYFQYVYWlhmlyaalGAICFTLFLAYDTQLVLGNRK----HTISPEDYITGALQIYTDIIYIFT 301
Cdd:cd10431 180 LGSMFLPPTTALGAGLYSVSLYG--------GLVLFGGFLLYDTQKIIKRAEthplYGVRKYDPINASMSIYMDTINIFI 251


                ....*..
gi 50593008 302 FVLQLMG 308
Cdd:cd10431 252 RLVTILA 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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