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Conserved domains on  [gi|11277470|ref|NP_068355|]
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apoptosis regulatory protein Siva isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Siva super family cl09371
Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology ...
 1-110 1.36e-40

Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. Indeed, the unique amphipathic helical region (SAH) present in Siva-1 is required for its binding to BCL-X(L) and sensitising cells to UV radiation. Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis. This family contains both Siva-1 and the shorter Siva-2 lacking the sequence coded by exon 2. It has been suggested that Siva-2 could regulate the function of Siva-1.


The actual alignment was detected with superfamily member pfam05458:

Pssm-ID: 283184  Cd Length: 173  Bit Score: 132.36  E-value: 1.36e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11277470     1 MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVF----------------------------------------- 39
Cdd:pfam05458   1 MPKRSCPFPDVAPLQLKVHVGQRELSNGVFGERYSQEIFektkqllfngakavlghiwtegcgihlpepgkpgetsapql 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11277470    40 -----------------------DPSGvASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVDCSDM 96
Cdd:pfam05458  81 argqmligqdgklmrataqsseaSPTG-ASIACSSCVRSVDGKAVCSQCERALCGQCVRTCSGCSSLACSLCTLVDYSDQ 159

                         170
                  ....*....|....
gi 11277470    97 YEKVLCTSCAMFET 110
Cdd:pfam05458 160 YEKVLCTSCSMFET 173
 
Name Accession Description Interval E-value
Siva pfam05458
Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology ...
 1-110 1.36e-40

Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. Indeed, the unique amphipathic helical region (SAH) present in Siva-1 is required for its binding to BCL-X(L) and sensitising cells to UV radiation. Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis. This family contains both Siva-1 and the shorter Siva-2 lacking the sequence coded by exon 2. It has been suggested that Siva-2 could regulate the function of Siva-1.


Pssm-ID: 283184  Cd Length: 173  Bit Score: 132.36  E-value: 1.36e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11277470     1 MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVF----------------------------------------- 39
Cdd:pfam05458   1 MPKRSCPFPDVAPLQLKVHVGQRELSNGVFGERYSQEIFektkqllfngakavlghiwtegcgihlpepgkpgetsapql 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11277470    40 -----------------------DPSGvASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVDCSDM 96
Cdd:pfam05458  81 argqmligqdgklmrataqsseaSPTG-ASIACSSCVRSVDGKAVCSQCERALCGQCVRTCSGCSSLACSLCTLVDYSDQ 159

                         170
                  ....*....|....
gi 11277470    97 YEKVLCTSCAMFET 110
Cdd:pfam05458 160 YEKVLCTSCSMFET 173
 
Name Accession Description Interval E-value
Siva pfam05458
Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology ...
 1-110 1.36e-40

Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. Indeed, the unique amphipathic helical region (SAH) present in Siva-1 is required for its binding to BCL-X(L) and sensitising cells to UV radiation. Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis. This family contains both Siva-1 and the shorter Siva-2 lacking the sequence coded by exon 2. It has been suggested that Siva-2 could regulate the function of Siva-1.


Pssm-ID: 283184  Cd Length: 173  Bit Score: 132.36  E-value: 1.36e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11277470     1 MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVF----------------------------------------- 39
Cdd:pfam05458   1 MPKRSCPFPDVAPLQLKVHVGQRELSNGVFGERYSQEIFektkqllfngakavlghiwtegcgihlpepgkpgetsapql 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11277470    40 -----------------------DPSGvASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVDCSDM 96
Cdd:pfam05458  81 argqmligqdgklmrataqsseaSPTG-ASIACSSCVRSVDGKAVCSQCERALCGQCVRTCSGCSSLACSLCTLVDYSDQ 159

                         170
                  ....*....|....
gi 11277470    97 YEKVLCTSCAMFET 110
Cdd:pfam05458 160 YEKVLCTSCSMFET 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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