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Conserved domains on  [gi|16753221|ref|NP_067071|]
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cadherin-22 precursor [Homo sapiens]

Protein Classification

cadherin( domain architecture ID 10182681)

cadherin is a calcium-dependent cell adhesion protein that preferentially interacts with itself in a homophilic manner in connecting cells; it plays a crucial role in tissue morphogenesis and homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 401-495 8.88e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 8.88e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 401 LEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRESDlDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQ 479
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 16753221 480 LSRASLRIRILDVNDN 495
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 172-273 8.26e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 8.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 172 PYIGSVAELSPTGTSVMQVMASDADDptyGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATD 249
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 16753221 250 MAGQlgGLSGSTTVTIVVTDVNDN 273
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-390 7.96e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 7.96e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 282 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLkdESSSGGDVFKVttdsDTQEAIIVVQKRLDFESQPVHTVILEAL 361
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*....
gi 16753221 362 NKFVDPRFAdlgtfrdQAIVRVAVTDVDE 390
Cdd:cd11304  76 DGGGPPLSS-------TATVTITVLDVND 97
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 758-817 3.72e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 81.81  E-value: 3.72e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221   758 ADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYA 817
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 502-600 5.44e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 5.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 502 PYEAAVCEDAKPGQLIQTISVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIQDNTAAVHTQHvGFNRQEQDVFFLPILV 581
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDG-LFS---IDPSTGEITTAK-PLDREEQSSYTLTVTA 74

                        90
                ....*....|....*....
gi 16753221 582 VDSGPPTLSSTGTLTIRIC 600
Cdd:cd11304  75 TDGGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 83-163 1.13e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.13e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221  83 VGKIH-SDSDEGD-GAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRlLEPESEFIIKVQD 160
Cdd:cd11304  16 VLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP-LSSTATVTITVLD 94


                ...
gi 16753221 161 IND 163
Cdd:cd11304  95 VND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 401-495 8.88e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 8.88e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 401 LEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRESDlDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQ 479
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 16753221 480 LSRASLRIRILDVNDN 495
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 172-273 8.26e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 8.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 172 PYIGSVAELSPTGTSVMQVMASDADDptyGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATD 249
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 16753221 250 MAGQlgGLSGSTTVTIVVTDVNDN 273
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-390 7.96e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 7.96e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 282 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLkdESSSGGDVFKVttdsDTQEAIIVVQKRLDFESQPVHTVILEAL 361
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*....
gi 16753221 362 NKFVDPRFAdlgtfrdQAIVRVAVTDVDE 390
Cdd:cd11304  76 DGGGPPLSS-------TATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 417-497 1.26e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.26e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221    417 TARDPDA-ANRPVRYAIDRESDlDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDN 495
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 16753221    496 PP 497
Cdd:smart00112  80 AP 81
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 758-817 3.72e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 81.81  E-value: 3.72e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221   758 ADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYA 817
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
173-253 6.72e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.96  E-value: 6.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221   173 YIGSVAELSPTGTSVMQVMASDADDPTygsSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDM 250
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGpgGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76


                  ...
gi 16753221   251 AGQ 253
Cdd:pfam00028  77 GGP 79
Cadherin pfam00028
Cadherin domain;
402-490 1.20e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 1.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221   402 EVQEDAQVGSLVGVVTARDPD-AANRPVRYAIdRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL 480
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDlGPNGRIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 16753221   481 SRASLRIRIL 490
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 502-600 5.44e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 5.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 502 PYEAAVCEDAKPGQLIQTISVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIQDNTAAVHTQHvGFNRQEQDVFFLPILV 581
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDG-LFS---IDPSTGEITTAK-PLDREEQSSYTLTVTA 74

                        90
                ....*....|....*....
gi 16753221 582 VDSGPPTLSSTGTLTIRIC 600
Cdd:cd11304  75 TDGGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 83-163 1.13e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.13e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221  83 VGKIH-SDSDEGD-GAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRlLEPESEFIIKVQD 160
Cdd:cd11304  16 VLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP-LSSTATVTITVLD 94


                ...
gi 16753221 161 IND 163
Cdd:cd11304  95 VND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 88-166 2.72e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 2.72e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221     88 SDSDEGD-GAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRlLEPESEFIIKVQDINDSEP 166
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 192-275 6.58e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 6.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221    192 ASDADDptyGSSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDMAGQlgGLSGSTTVTIVVTD 269
Cdd:smart00112   2 ATDADS---GENGKVTYSILSGNddGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLD 75


                   ....*.
gi 16753221    270 VNDNPP 275
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
76-159 1.12e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221    76 TGTEPLYVGKIhsDSDEGD-GAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRlLEPESEF 154
Cdd:pfam00028  11 VGTEVLTVTAT--DPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP-LSSTATV 87


                  ....*
gi 16753221   155 IIKVQ 159
Cdd:pfam00028  88 TITVL 92
Cadherin pfam00028
Cadherin domain;
503-600 2.93e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 2.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221   503 YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLvpEAPSNPHFSlldIQDNTAAVHTQHVgFNRQEQDVFFLPILVV 582
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFR---IDPDTGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 16753221   583 DSGPPTLSSTGTLTIRIC 600
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
282-370 2.60e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.39  E-value: 2.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221   282 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKdeSSSGGDVFKVTTDSDTqeaiIVVQKRLDFESQPVHTVILEAL 361
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEAT 74


                  ....*....
gi 16753221   362 NKFVDPRFA 370
Cdd:pfam00028  75 DSGGPPLSS 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 300-392 8.82e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 8.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221    300 KAEDSDVGENTDMTYHLkdESSSGGDVFKVTTDSDtqeaIIVVQKRLDFESQPVHTVILEALNKFVDPRFAdlgtfrdQA 379
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67

                           90
                   ....*....|....
gi 16753221    380 IVRVAVTDV-DEPP 392
Cdd:smart00112  68 TVTITVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 521-603 3.47e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 3.47e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221    521 SVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIQDNTAAVHTQHVgFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRIC 600
Cdd:smart00112   1 SATDADSGENG-KVTYSILSGNDDG-LFS---IDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ...
gi 16753221    601 GCD 603
Cdd:smart00112  75 DVN 77
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 401-495 8.88e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 8.88e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 401 LEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRESDlDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQ 479
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 16753221 480 LSRASLRIRILDVNDN 495
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 172-273 8.26e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 8.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 172 PYIGSVAELSPTGTSVMQVMASDADDptyGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATD 249
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 16753221 250 MAGQlgGLSGSTTVTIVVTDVNDN 273
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-390 7.96e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 7.96e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 282 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLkdESSSGGDVFKVttdsDTQEAIIVVQKRLDFESQPVHTVILEAL 361
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*....
gi 16753221 362 NKFVDPRFAdlgtfrdQAIVRVAVTDVDE 390
Cdd:cd11304  76 DGGGPPLSS-------TATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 417-497 1.26e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.26e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221    417 TARDPDA-ANRPVRYAIDRESDlDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDN 495
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 16753221    496 PP 497
Cdd:smart00112  80 AP 81
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 758-817 3.72e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 81.81  E-value: 3.72e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221   758 ADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYA 817
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
173-253 6.72e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.96  E-value: 6.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221   173 YIGSVAELSPTGTSVMQVMASDADDPTygsSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDM 250
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGpgGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76


                  ...
gi 16753221   251 AGQ 253
Cdd:pfam00028  77 GGP 79
Cadherin pfam00028
Cadherin domain;
402-490 1.20e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 1.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221   402 EVQEDAQVGSLVGVVTARDPD-AANRPVRYAIdRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL 480
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDlGPNGRIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 16753221   481 SRASLRIRIL 490
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 502-600 5.44e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 5.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221 502 PYEAAVCEDAKPGQLIQTISVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIQDNTAAVHTQHvGFNRQEQDVFFLPILV 581
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDG-LFS---IDPSTGEITTAK-PLDREEQSSYTLTVTA 74

                        90
                ....*....|....*....
gi 16753221 582 VDSGPPTLSSTGTLTIRIC 600
Cdd:cd11304  75 TDGGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 83-163 1.13e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.13e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221  83 VGKIH-SDSDEGD-GAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRlLEPESEFIIKVQD 160
Cdd:cd11304  16 VLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP-LSSTATVTITVLD 94


                ...
gi 16753221 161 IND 163
Cdd:cd11304  95 VND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 88-166 2.72e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 2.72e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221     88 SDSDEGD-GAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRlLEPESEFIIKVQDINDSEP 166
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 192-275 6.58e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 6.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221    192 ASDADDptyGSSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDMAGQlgGLSGSTTVTIVVTD 269
Cdd:smart00112   2 ATDADS---GENGKVTYSILSGNddGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLD 75


                   ....*.
gi 16753221    270 VNDNPP 275
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
76-159 1.12e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221    76 TGTEPLYVGKIhsDSDEGD-GAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRlLEPESEF 154
Cdd:pfam00028  11 VGTEVLTVTAT--DPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP-LSSTATV 87


                  ....*
gi 16753221   155 IIKVQ 159
Cdd:pfam00028  88 TITVL 92
Cadherin pfam00028
Cadherin domain;
503-600 2.93e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 2.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221   503 YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLvpEAPSNPHFSlldIQDNTAAVHTQHVgFNRQEQDVFFLPILVV 582
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFR---IDPDTGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 16753221   583 DSGPPTLSSTGTLTIRIC 600
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
282-370 2.60e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.39  E-value: 2.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221   282 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKdeSSSGGDVFKVTTDSDTqeaiIVVQKRLDFESQPVHTVILEAL 361
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEAT 74


                  ....*....
gi 16753221   362 NKFVDPRFA 370
Cdd:pfam00028  75 DSGGPPLSS 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 300-392 8.82e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 8.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221    300 KAEDSDVGENTDMTYHLkdESSSGGDVFKVTTDSDtqeaIIVVQKRLDFESQPVHTVILEALNKFVDPRFAdlgtfrdQA 379
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67

                           90
                   ....*....|....
gi 16753221    380 IVRVAVTDV-DEPP 392
Cdd:smart00112  68 TVTITVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 521-603 3.47e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 3.47e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16753221    521 SVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIQDNTAAVHTQHVgFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRIC 600
Cdd:smart00112   1 SATDADSGENG-KVTYSILSGNDDG-LFS---IDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ...
gi 16753221    601 GCD 603
Cdd:smart00112  75 DVN 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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