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Conserved domains on  [gi|12656655|ref|NP_066976|]
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cadherin-19 isoform 1 preproprotein [Homo sapiens]

Protein Classification

cadherin( domain architecture ID 10182681)

cadherin is a calcium-dependent cell adhesion protein that preferentially interacts with itself in a homophilic manner in connecting cells; it plays a crucial role in tissue morphogenesis and homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 706-765 3.15e-31

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 116.10  E-value: 3.15e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655   706 ANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFG 765
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-252 3.89e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 3.89e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 152 PYEAIVPEMSPEGTLVIQVTASDADdpsSGNNARLLYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM 229
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|...
gi 12656655 230 IGQPgaLSGTTSVLIKLSDVNDN 252
Cdd:cd11304  78 GGPP--LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 375-466 9.66e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 9.66e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 375 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIE 449
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 12656655 450 QISSIPLYVQVLNINDH 466
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 261-366 3.55e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 3.55e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 261 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 339
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....*..
gi 12656655 340 HVPEQlmkyhteASTTFIKIQVEDVDE 366
Cdd:cd11304  78 GGPPL-------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-144 5.68e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 5.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655  49 QFFVPEEMnTTSHHIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIAtGR 126
Cdd:cd11304   3 EVSVPENA-PPGTVVLTVSaTDPDSGENGeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GP 80

                        90
                ....*....|....*...
gi 12656655 127 AVEPESEFVIKVSDINDN 144
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 474-572 8.65e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 8.65e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 474 YETYVCENAGSGQVIQTISAVDRDESIEEHHFYfnlSVEDTNNSSFTIIDNqdNTAVILTNRTgFNLQEEPVFYISILIA 553
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGLFSIDP--STGEITTAKP-LDREEQSSYTLTVTAT 75

                        90
                ....*....|....*....
gi 12656655 554 DNGIPSLTSTNTLTIHVCD 572
Cdd:cd11304  76 DGGGPPLSSTATVTITVLD 94
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 706-765 3.15e-31

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 116.10  E-value: 3.15e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655   706 ANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFG 765
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-252 3.89e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 3.89e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 152 PYEAIVPEMSPEGTLVIQVTASDADdpsSGNNARLLYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM 229
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|...
gi 12656655 230 IGQPgaLSGTTSVLIKLSDVNDN 252
Cdd:cd11304  78 GGPP--LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 375-466 9.66e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 9.66e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 375 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIE 449
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 12656655 450 QISSIPLYVQVLNINDH 466
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 171-254 6.07e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 6.07e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655    171 TASDADdpsSGNNARLLYSLLQG--QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPgaLSGTTSVLIKLSD 248
Cdd:smart00112   1 SATDAD---SGENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 12656655    249 VNDNKP 254
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 261-366 3.55e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 3.55e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 261 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 339
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....*..
gi 12656655 340 HVPEQlmkyhteASTTFIKIQVEDVDE 366
Cdd:cd11304  78 GGPPL-------SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
153-246 4.22e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 4.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655   153 YEAIVPEMSPEGTLVIQVTASDADDpssGNNARLLYSLLQGQPY--FSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMI 230
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*.
gi 12656655   231 GQPgaLSGTTSVLIKL 246
Cdd:pfam00028  78 GPP--LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-144 5.68e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 5.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655  49 QFFVPEEMnTTSHHIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIAtGR 126
Cdd:cd11304   3 EVSVPENA-PPGTVVLTVSaTDPDSGENGeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GP 80

                        90
                ....*....|....*...
gi 12656655 127 AVEPESEFVIKVSDINDN 144
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 68-146 8.71e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 8.71e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655     68 SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDiATGRAVEPESEFVIKVSDINDNEP 146
Cdd:smart00112   3 TDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 474-572 8.65e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 8.65e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 474 YETYVCENAGSGQVIQTISAVDRDESIEEHHFYfnlSVEDTNNSSFTIIDNqdNTAVILTNRTgFNLQEEPVFYISILIA 553
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGLFSIDP--STGEITTAKP-LDREEQSSYTLTVTAT 75

                        90
                ....*....|....*....
gi 12656655 554 DNGIPSLTSTNTLTIHVCD 572
Cdd:cd11304  76 DGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 393-468 9.22e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 9.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655    393 SATDPD-NRKSPIRYSITRS---KVFNINDN-GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHA 467
Cdd:smart00112   1 SATDADsGENGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 12656655    468 P 468
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
375-461 2.12e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 2.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655   375 YVFEVFEETPQGSFVGVVSATDPD---NRKspIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYN 447
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDlgpNGR--IFYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 12656655   448 IEQISSIPLYVQVL 461
Cdd:pfam00028  79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
49-121 1.63e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 1.63e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12656655    49 QFFVPEEMNTTSHhIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVID 121
Cdd:pfam00028   2 SASVPENAPVGTE-VLTVTaTDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75
Cadherin pfam00028
Cadherin domain;
261-362 2.87e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 2.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655   261 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 339
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 12656655   340 HVPEQlmkyhteASTTFIKIQVE 362
Cdd:pfam00028  77 GGPPL-------SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 280-368 3.61e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 3.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655    280 AYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQlmkyhteASTTFIK 358
Cdd:smart00112   2 ATDADSGENGKVTYSIlSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATVT 70

                           90
                   ....*....|.
gi 12656655    359 IQVEDV-DEPP 368
Cdd:smart00112  71 ITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
474-571 5.97e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 5.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655   474 YETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNssFTIidnQDNTAVILTNRtgfNLQEEPV-FY-ISIL 551
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FRI---DPDTGDISTTK---PLDRESIgEYeLTVE 72

                          90       100
                  ....*....|....*....|
gi 12656655   552 IADNGIPSLTSTNTLTIHVC 571
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 492-575 2.36e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.11  E-value: 2.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655    492 SAVDRDeSIEEHHFYFNLsVEDTNNSSFTIidnQDNTAVILTNRTgFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVC 571
Cdd:smart00112   1 SATDAD-SGENGKVTYSI-LSGNDDGLFSI---DPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....
gi 12656655    572 DCGD 575
Cdd:smart00112  75 DVND 78
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 706-765 3.15e-31

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 116.10  E-value: 3.15e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655   706 ANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFG 765
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-252 3.89e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 3.89e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 152 PYEAIVPEMSPEGTLVIQVTASDADdpsSGNNARLLYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM 229
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|...
gi 12656655 230 IGQPgaLSGTTSVLIKLSDVNDN 252
Cdd:cd11304  78 GGPP--LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 375-466 9.66e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 9.66e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 375 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIE 449
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 12656655 450 QISSIPLYVQVLNINDH 466
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 171-254 6.07e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 6.07e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655    171 TASDADdpsSGNNARLLYSLLQG--QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPgaLSGTTSVLIKLSD 248
Cdd:smart00112   1 SATDAD---SGENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 12656655    249 VNDNKP 254
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 261-366 3.55e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 3.55e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 261 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 339
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....*..
gi 12656655 340 HVPEQlmkyhteASTTFIKIQVEDVDE 366
Cdd:cd11304  78 GGPPL-------SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
153-246 4.22e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 4.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655   153 YEAIVPEMSPEGTLVIQVTASDADDpssGNNARLLYSLLQGQPY--FSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMI 230
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*.
gi 12656655   231 GQPgaLSGTTSVLIKL 246
Cdd:pfam00028  78 GPP--LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-144 5.68e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 5.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655  49 QFFVPEEMnTTSHHIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIAtGR 126
Cdd:cd11304   3 EVSVPENA-PPGTVVLTVSaTDPDSGENGeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GP 80

                        90
                ....*....|....*...
gi 12656655 127 AVEPESEFVIKVSDINDN 144
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 68-146 8.71e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 8.71e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655     68 SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDiATGRAVEPESEFVIKVSDINDNEP 146
Cdd:smart00112   3 TDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 474-572 8.65e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 8.65e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655 474 YETYVCENAGSGQVIQTISAVDRDESIEEHHFYfnlSVEDTNNSSFTIIDNqdNTAVILTNRTgFNLQEEPVFYISILIA 553
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGLFSIDP--STGEITTAKP-LDREEQSSYTLTVTAT 75

                        90
                ....*....|....*....
gi 12656655 554 DNGIPSLTSTNTLTIHVCD 572
Cdd:cd11304  76 DGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 393-468 9.22e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 9.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655    393 SATDPD-NRKSPIRYSITRS---KVFNINDN-GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHA 467
Cdd:smart00112   1 SATDADsGENGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 12656655    468 P 468
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
375-461 2.12e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 2.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655   375 YVFEVFEETPQGSFVGVVSATDPD---NRKspIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYN 447
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDlgpNGR--IFYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 12656655   448 IEQISSIPLYVQVL 461
Cdd:pfam00028  79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
49-121 1.63e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 1.63e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12656655    49 QFFVPEEMNTTSHhIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVID 121
Cdd:pfam00028   2 SASVPENAPVGTE-VLTVTaTDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75
Cadherin pfam00028
Cadherin domain;
261-362 2.87e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 2.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655   261 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 339
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 12656655   340 HVPEQlmkyhteASTTFIKIQVE 362
Cdd:pfam00028  77 GGPPL-------SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 280-368 3.61e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 3.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655    280 AYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQlmkyhteASTTFIK 358
Cdd:smart00112   2 ATDADSGENGKVTYSIlSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATVT 70

                           90
                   ....*....|.
gi 12656655    359 IQVEDV-DEPP 368
Cdd:smart00112  71 ITVLDVnDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 52-144 5.75e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 51.19  E-value: 5.75e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655  52 VPEEMNTTSHhIGQLRSDLDNGNNSFqYKLLGAGA---GSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDiATGRAV 128
Cdd:cd00031   6 AVEGRSRGSF-RVSIPTDLIASSGEI-IKISAAGKealPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAAS-LGANVP 82

                        90
                ....*....|....*.
gi 12656655 129 EPESEFVIKVSDINDN 144
Cdd:cd00031  83 QTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
474-571 5.97e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 5.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655   474 YETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNssFTIidnQDNTAVILTNRtgfNLQEEPV-FY-ISIL 551
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FRI---DPDTGDISTTK---PLDRESIgEYeLTVE 72

                          90       100
                  ....*....|....*....|
gi 12656655   552 IADNGIPSLTSTNTLTIHVC 571
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 492-575 2.36e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.11  E-value: 2.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12656655    492 SAVDRDeSIEEHHFYFNLsVEDTNNSSFTIidnQDNTAVILTNRTgFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVC 571
Cdd:smart00112   1 SATDAD-SGENGKVTYSI-LSGNDDGLFSI---DPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....
gi 12656655    572 DCGD 575
Cdd:smart00112  75 DVND 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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