NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|18497288|ref|NP_066548|]
View 

latent-transforming growth factor beta-binding protein 3 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
414-455 5.95e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 5.95e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 18497288    414 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPTDGTAAFKEIC 455
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
929-971 4.40e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 4.40e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 18497288    929 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 971
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-390 9.99e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 9.99e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 18497288     355 DINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPS 390
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
744-783 1.73e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.73e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     744 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 783
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
785-825 2.11e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.11e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 18497288     785 DVDECEAGDVCDNG-ICSNTPGSFQCQCLSGYHlsrDRSHCE 825
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
660-694 4.87e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.87e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 18497288  660 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 694
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
PHA03247 super family cl33720
large tegument protein UL36; Provisional
487-577 1.79e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18497288   487 PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSeERSVQQSHPTATTTPARPYPELISRP--SPPTMRWFLPDLPPSRSA 564
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR-RRPPSRSPAAKPAAPARPPVRRLARPavSRSTESFALPPDQPERPP 2909
                          90
                  ....*....|...
gi 18497288   565 VEIAPTQVTETDE 577
Cdd:PHA03247 2910 QPQAPPPPQPQPQ 2922
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
1099-1134 3.21e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 42.26  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 18497288   1099 GMCAGPLAGpALTFDDCCCR-QGRGWGAQCRPCPPRG 1134
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
866-899 5.11e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 5.11e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 18497288     866 DIDECSqDPSLCLPHGACKNLQGSYVCVCDEGFT 899
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
826-865 6.22e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 6.22e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     826 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 865
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1036-1064 4.45e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.45e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 18497288    1036 DVDECLDESNCRNG-VCENTRGGYRCACTP 1064
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
703-736 1.60e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.60e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 18497288     703 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 736
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
616-659 1.76e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.76e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 18497288     616 DVNECEAE-PCGPGrGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 659
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
291-321 4.27e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.27e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    291 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 321
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1207-1241 9.89e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.92  E-value: 9.89e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 18497288    1207 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGF 1241
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGY 32
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
414-455 5.95e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 5.95e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 18497288    414 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPTDGTAAFKEIC 455
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
929-971 4.40e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 4.40e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 18497288    929 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 971
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-390 9.99e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 9.99e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 18497288     355 DINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPS 390
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
744-783 1.73e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.73e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     744 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 783
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
785-825 2.11e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.11e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 18497288     785 DVDECEAGDVCDNG-ICSNTPGSFQCQCLSGYHlsrDRSHCE 825
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
660-694 4.87e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.87e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 18497288  660 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 694
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
660-692 7.54e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 7.54e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 18497288     660 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 692
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
487-577 1.79e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18497288   487 PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSeERSVQQSHPTATTTPARPYPELISRP--SPPTMRWFLPDLPPSRSA 564
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR-RRPPSRSPAAKPAAPARPPVRRLARPavSRSTESFALPPDQPERPP 2909
                          90
                  ....*....|...
gi 18497288   565 VEIAPTQVTETDE 577
Cdd:PHA03247 2910 QPQAPPPPQPQPQ 2922
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
355-387 1.85e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.85e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 18497288  355 DINECAMPGVCR-HGDCLNNPGSYRCVCPPGHSL 387
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
785-819 1.92e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.92e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 18497288  785 DVDECEAGDVCDN-GICSNTPGSFQCQCLSGYHLSR 819
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
1099-1134 3.21e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 42.26  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 18497288   1099 GMCAGPLAGpALTFDDCCCR-QGRGWGAQCRPCPPRG 1134
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
744-774 3.54e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.54e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 18497288  744 DVNECAEGSPCSP-GWCENLPGSFRCTCAQGY 774
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
866-899 5.11e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 5.11e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 18497288     866 DIDECSqDPSLCLPHGACKNLQGSYVCVCDEGFT 899
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
826-865 6.22e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 6.22e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     826 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 865
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
866-899 8.15e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 8.15e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 18497288  866 DIDECSQdPSLCLPHGACKNLQGSYVCVCDEGFT 899
Cdd:cd00054    1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
826-865 1.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.53e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 18497288  826 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 865
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1036-1064 4.45e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.45e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 18497288    1036 DVDECLDESNCRNG-VCENTRGGYRCACTP 1064
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
826-855 6.45e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 6.45e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    826 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 855
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
785-814 6.45e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 6.45e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    785 DVDEC-EAGDVCD-NGICSNTPGSFQCQCLSG 814
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1036-1064 1.43e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.43e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 18497288 1036 DVDECLDESNCRN-GVCENTRGGYRCACTP 1064
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
355-384 1.58e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 1.58e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    355 DINECAMPG-VC-RHGDCLNNPGSYRCVCPPG 384
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
703-736 1.60e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.60e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 18497288     703 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 736
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
616-659 1.76e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.76e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 18497288     616 DVNECEAE-PCGPGrGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 659
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
616-650 3.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.20e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 18497288  616 DVNECE-AEPCGPGrGICMNTGGSYNCHCNRGYRLH 650
Cdd:cd00054    1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
703-735 3.23e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.23e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 18497288  703 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYR 735
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
767-788 4.03e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.85  E-value: 4.03e-03
                           10        20
                   ....*....|....*....|..
gi 18497288    767 RCTCAQGYAPAPDGRSCLDVDE 788
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
291-321 4.27e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.27e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    291 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 321
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1207-1241 9.89e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.92  E-value: 9.89e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 18497288    1207 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGF 1241
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGY 32
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
414-455 5.95e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 5.95e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 18497288    414 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPTDGTAAFKEIC 455
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
929-971 4.40e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 4.40e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 18497288    929 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 971
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-390 9.99e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 9.99e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 18497288     355 DINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPS 390
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
744-783 1.73e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.73e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     744 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 783
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
785-825 2.11e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.11e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 18497288     785 DVDECEAGDVCDNG-ICSNTPGSFQCQCLSGYHlsrDRSHCE 825
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
660-694 4.87e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.87e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 18497288  660 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 694
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
660-692 7.54e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 7.54e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 18497288     660 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 692
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
487-577 1.79e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18497288   487 PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSeERSVQQSHPTATTTPARPYPELISRP--SPPTMRWFLPDLPPSRSA 564
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR-RRPPSRSPAAKPAAPARPPVRRLARPavSRSTESFALPPDQPERPP 2909
                          90
                  ....*....|...
gi 18497288   565 VEIAPTQVTETDE 577
Cdd:PHA03247 2910 QPQAPPPPQPQPQ 2922
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
355-387 1.85e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.85e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 18497288  355 DINECAMPGVCR-HGDCLNNPGSYRCVCPPGHSL 387
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
785-819 1.92e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.92e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 18497288  785 DVDECEAGDVCDN-GICSNTPGSFQCQCLSGYHLSR 819
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
1099-1134 3.21e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 42.26  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 18497288   1099 GMCAGPLAGpALTFDDCCCR-QGRGWGAQCRPCPPRG 1134
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
744-774 3.54e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.54e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 18497288  744 DVNECAEGSPCSP-GWCENLPGSFRCTCAQGY 774
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
866-899 5.11e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 5.11e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 18497288     866 DIDECSqDPSLCLPHGACKNLQGSYVCVCDEGFT 899
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
826-865 6.22e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 6.22e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     826 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 865
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
866-899 8.15e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 8.15e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 18497288  866 DIDECSQdPSLCLPHGACKNLQGSYVCVCDEGFT 899
Cdd:cd00054    1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
826-865 1.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.53e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 18497288  826 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 865
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1036-1064 4.45e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.45e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 18497288    1036 DVDECLDESNCRNG-VCENTRGGYRCACTP 1064
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
826-855 6.45e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 6.45e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    826 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 855
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
785-814 6.45e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 6.45e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    785 DVDEC-EAGDVCD-NGICSNTPGSFQCQCLSG 814
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1036-1064 1.43e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.43e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 18497288 1036 DVDECLDESNCRN-GVCENTRGGYRCACTP 1064
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
355-384 1.58e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 1.58e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    355 DINECAMPG-VC-RHGDCLNNPGSYRCVCPPG 384
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
703-736 1.60e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.60e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 18497288     703 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 736
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
616-659 1.76e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.76e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 18497288     616 DVNECEAE-PCGPGrGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 659
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF smart00181
Epidermal growth factor-like domain;
788-820 2.37e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.73  E-value: 2.37e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 18497288     788 ECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRD 820
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF smart00181
Epidermal growth factor-like domain;
358-390 2.57e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.73  E-value: 2.57e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 18497288     358 ECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPS 390
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
739-782 3.08e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.45  E-value: 3.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 18497288  739 GGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRS 782
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
616-650 3.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.20e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 18497288  616 DVNECE-AEPCGPGrGICMNTGGSYNCHCNRGYRLH 650
Cdd:cd00054    1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
703-735 3.23e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.23e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 18497288  703 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYR 735
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
767-788 4.03e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.85  E-value: 4.03e-03
                           10        20
                   ....*....|....*....|..
gi 18497288    767 RCTCAQGYAPAPDGRSCLDVDE 788
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
291-321 4.27e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.27e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    291 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 321
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
663-696 4.37e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 4.37e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 18497288  663 ECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696
Cdd:cd00053    1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDRS 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1207-1241 9.89e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.92  E-value: 9.89e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 18497288    1207 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGF 1241
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGY 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH