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Conserved domains on  [gi|83320068|ref|NP_066385|]
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zinc finger protein 253 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 2.13e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.00  E-value: 2.13e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 83320068      4 LQFRDVAIEFSLEEWHCLDTAQRNLYRDVMLENYRNLVFLGIVVSKPDLVTCLEQGKKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-497 4.59e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 4.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 170 NLFKCIICGKAFKRSSTLTTHKKIHTGEKPYRC--EECGKAFNQSANLTTHKRIHTGEKPYRCEecgkafkQSSNLTTHK 247
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS-------KSLPLSNSK 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 248 KIHtgekpYKCEECGKAFNRSTDLTTHKIVHTGEKPYKCEECGK--AFKHPSHVTTHKKIHTRG-----KPYNCEECGKS 320
Cdd:COG5048 105 ASS-----SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQsnslhPPLPANSLSKD 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 321 FKHCSNLTIHKRIHTGEKPYKCEECGKAFHLSSHLTTHKILHTGEKPYRCRECGKAFNHS------TTLFSHEKIHTGEK 394
Cdd:COG5048 180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 395 PYKCDECGKTFTWPSILSKHKRTHTG-EKPYKCEECGKSFTASSTLTTHKR--IHTGE--KPYKCEE--CGKAFNWSSDL 467
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                       330       340       350
                ....*....|....*....|....*....|
gi 83320068 468 NKHKKIHIERKPYIVKNVTDLLNVPPLLIS 497
Cdd:COG5048 340 KRHILLHTSISPAKEKLLNSSSKFSPLLNN 369
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 2.13e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.00  E-value: 2.13e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 83320068      4 LQFRDVAIEFSLEEWHCLDTAQRNLYRDVMLENYRNLVFLGIVVSKPDLVTCLEQGKKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-44 1.03e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 1.03e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 83320068     6 FRDVAIEFSLEEWHCLDTAQRNLYRDVMLENYRNLVFLG 44
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-43 7.42e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.52  E-value: 7.42e-19
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 83320068   6 FRDVAIEFSLEEWHCLDTAQRNLYRDVMLENYRNLVFL 43
Cdd:cd07765   3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-497 4.59e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 4.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 170 NLFKCIICGKAFKRSSTLTTHKKIHTGEKPYRC--EECGKAFNQSANLTTHKRIHTGEKPYRCEecgkafkQSSNLTTHK 247
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS-------KSLPLSNSK 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 248 KIHtgekpYKCEECGKAFNRSTDLTTHKIVHTGEKPYKCEECGK--AFKHPSHVTTHKKIHTRG-----KPYNCEECGKS 320
Cdd:COG5048 105 ASS-----SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQsnslhPPLPANSLSKD 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 321 FKHCSNLTIHKRIHTGEKPYKCEECGKAFHLSSHLTTHKILHTGEKPYRCRECGKAFNHS------TTLFSHEKIHTGEK 394
Cdd:COG5048 180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 395 PYKCDECGKTFTWPSILSKHKRTHTG-EKPYKCEECGKSFTASSTLTTHKR--IHTGE--KPYKCEE--CGKAFNWSSDL 467
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                       330       340       350
                ....*....|....*....|....*....|
gi 83320068 468 NKHKKIHIERKPYIVKNVTDLLNVPPLLIS 497
Cdd:COG5048 340 KRHILLHTSISPAKEKLLNSSSKFSPLLNN 369
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-239 7.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.84e-05
                          10        20
                  ....*....|....*....|....*.
gi 83320068   214 NLTTHKRIHTGEKPYRCEECGKAFKQ 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 2.13e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.00  E-value: 2.13e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 83320068      4 LQFRDVAIEFSLEEWHCLDTAQRNLYRDVMLENYRNLVFLGIVVSKPDLVTCLEQGKKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-44 1.03e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 1.03e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 83320068     6 FRDVAIEFSLEEWHCLDTAQRNLYRDVMLENYRNLVFLG 44
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-43 7.42e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.52  E-value: 7.42e-19
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 83320068   6 FRDVAIEFSLEEWHCLDTAQRNLYRDVMLENYRNLVFL 43
Cdd:cd07765   3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-497 4.59e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 4.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 170 NLFKCIICGKAFKRSSTLTTHKKIHTGEKPYRC--EECGKAFNQSANLTTHKRIHTGEKPYRCEecgkafkQSSNLTTHK 247
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS-------KSLPLSNSK 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 248 KIHtgekpYKCEECGKAFNRSTDLTTHKIVHTGEKPYKCEECGK--AFKHPSHVTTHKKIHTRG-----KPYNCEECGKS 320
Cdd:COG5048 105 ASS-----SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQsnslhPPLPANSLSKD 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 321 FKHCSNLTIHKRIHTGEKPYKCEECGKAFHLSSHLTTHKILHTGEKPYRCRECGKAFNHS------TTLFSHEKIHTGEK 394
Cdd:COG5048 180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 395 PYKCDECGKTFTWPSILSKHKRTHTG-EKPYKCEECGKSFTASSTLTTHKR--IHTGE--KPYKCEE--CGKAFNWSSDL 467
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                       330       340       350
                ....*....|....*....|....*....|
gi 83320068 468 NKHKKIHIERKPYIVKNVTDLLNVPPLLIS 497
Cdd:COG5048 340 KRHILLHTSISPAKEKLLNSSSKFSPLLNN 369
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-355 4.25e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 4.25e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 198 KPYRCEECGKAFNQSANLTTHKR--IHTGE--KPYRCEE--CGKAFKQSSNLTTHKKIHTGEKPYKC--EECGKAFNRST 269
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 270 D----LTTHKIVHTGEKPYKC---EECGKAFKHPSHVTTHKKIHTRGKPYNCE--ECGKSFKHCSNLTIHKRIHTGEKPY 340
Cdd:COG5048 368 NneppQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|....*...
gi 83320068 341 KCEECGK---AFHLSSHL 355
Cdd:COG5048 448 LCSILKSfrrDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-472 7.47e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 7.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 310 KPYNCEECGKSFKHCSNLTIHKR--IHTGE--KPYKCEE--CGKAFHLSSHLTTHKILHTGEKPYRC--RECGKAFNHST 381
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 382 T-----LFSHEKIHTGEKPYKCD--ECGKTFTWPSILSKHKRTHTGEKPY--KCEECGKSFTASSTLTTHKRIHTGEKPY 452
Cdd:COG5048 368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170       180
                ....*....|....*....|
gi 83320068 453 KCEECGKaFNWSSDLNKHKK 472
Cdd:COG5048 448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
254-405 1.82e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.82e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 254 KPYKCEECGKAFNRSTDLTTHK--IVHTGE--KPYKCEE--CGKAFKHPSHVTTHKKIHTRGKPYNC--EECGKSFKHCS 325
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 326 N-----LTIHKRIHTGEKPYKCE--ECGKAFHLSSHLTTHKILHTGEKPYRCR--ECGKAFNHSTTLFSHEKIHTGEKPY 396
Cdd:COG5048 368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                ....*....
gi 83320068 397 KCDECGKTF 405
Cdd:COG5048 448 LCSILKSFR 456
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 224-304 1.85e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 1.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 224 GEKPYRCE--ECGKAFKQSSNLTTHKKiHTgekpykceECGKAFNRSTDLTTHKIVHTGEKPYKCEECGKAFKHPSHVTT 301
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 83320068 302 HKK 304
Cdd:COG5189 417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-239 7.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.84e-05
                          10        20
                  ....*....|....*....|....*.
gi 83320068   214 NLTTHKRIHTGEKPYRCEECGKAFKQ 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-267 1.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.30e-04
                          10        20
                  ....*....|....*....|....*.
gi 83320068   242 NLTTHKKIHTGEKPYKCEECGKAFNR 267
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 252-331 1.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 252 GEKPYKCE--ECGKAFNRSTDLTTHKIvhTGEKPYKCEECGKAFKHPSHVTthkkihtRGKPYNCEECGKSFKHCSNLTI 329
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML--HGHQNQKLHENPSPEKMNIFSA-------KDKPYRCEVCDKRYKNLNGLKY 416


                ..
gi 83320068 330 HK 331
Cdd:COG5189 417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-434 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....
gi 83320068   411 LSKHKRTHTGEKPYKCEECGKSFT 434
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 196-248 3.79e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 3.79e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 83320068 196 GEKPYRCE--ECGKAFNQSANLTTHKR-------------------IHTGEKPYRCEECGKAFKQSSNLTTHKK 248
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-349 4.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.15e-04
                          10        20
                  ....*....|....*....|....
gi 83320068   326 NLTIHKRIHTGEKPYKCEECGKAF 349
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-462 4.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.32e-04
                          10        20
                  ....*....|....*....|....
gi 83320068   439 LTTHKRIHTGEKPYKCEECGKAFN 462
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
187-211 5.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.26e-04
                          10        20
                  ....*....|....*....|....*
gi 83320068   187 LTTHKKIHTGEKPYRCEECGKAFNQ 211
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-406 7.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.86e-04
                          10        20
                  ....*....|....*....|....
gi 83320068   383 LFSHEKIHTGEKPYKCDECGKTFT 406
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-295 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 83320068   270 DLTTHKIVHTGEKPYKCEECGKAFKH 295
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 297-388 1.80e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83320068 297 SHVTTHKKIHTRGKPYNCEECGKSFKHCSNLTIH---KRIHT-GEKPYKCE--ECGKAF-------------HLSSHLT- 356
Cdd:COG5189 303 GGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYknqnglkyhmlhgHQNQKLHe 382

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 83320068 357 -----THKILHTGEKPYRCRECGKAFNHSTTLFSHEK 388
Cdd:COG5189 383 npspeKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-379 2.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 83320068   354 HLTTHKILHTGEKPYRCRECGKAFNH 379
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 228-250 8.18e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.18e-03
                          10        20
                  ....*....|....*....|...
gi 83320068   228 YRCEECGKAFKQSSNLTTHKKIH 250
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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