NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|205360930|ref|NP_065998|]
View 

MTOR-associated protein MEAK7 [Homo sapiens]

Protein Classification

TLD domain-containing protein( domain architecture ID 10651862)

TLD domain-containing protein similar to Homo sapiens MTOR-associated protein MEAK7 that activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration

PubMed:  26668325|28707022

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
244-412 3.05e-66

domain in TBC and LysM domain containing proteins;


:

Pssm-ID: 214733  Cd Length: 165  Bit Score: 209.49  E-value: 3.05e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930   244 SILDVLSVMYINAQLPREQRHR-WCLLFSSELHGHSFSQLCGHIT-HRGPCVAVLEDHDKHVFGGFASCSWEVKPQFQGD 321
Cdd:smart00584   2 SILSEEILALINSHLPTRAEGYpWTLLYSSSQHGYSLNTLYRKVEgYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYGT 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930   322 NRCFLFSICPSMAVYTHTGYNdHYMYLNHGQQTIPNGLGMGGqhnyFGLWVDVDFGKGHSRAkptCTTY-NSPQLSAQEN 400
Cdd:smart00584  82 GESFLFQLNPKFVVYDWTGKN-KYYYINGTPDSLPIGGGGGG----FGLWIDEDLNHGSSSH---CKTFgNPPLSTKQED 153
                          170
                   ....*....|..
gi 205360930   401 FQFDKMEVWAVG 412
Cdd:smart00584 154 FLILDIEVWGFG 165
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
244-412 3.05e-66

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 209.49  E-value: 3.05e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930   244 SILDVLSVMYINAQLPREQRHR-WCLLFSSELHGHSFSQLCGHIT-HRGPCVAVLEDHDKHVFGGFASCSWEVKPQFQGD 321
Cdd:smart00584   2 SILSEEILALINSHLPTRAEGYpWTLLYSSSQHGYSLNTLYRKVEgYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYGT 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930   322 NRCFLFSICPSMAVYTHTGYNdHYMYLNHGQQTIPNGLGMGGqhnyFGLWVDVDFGKGHSRAkptCTTY-NSPQLSAQEN 400
Cdd:smart00584  82 GESFLFQLNPKFVVYDWTGKN-KYYYINGTPDSLPIGGGGGG----FGLWIDEDLNHGSSSH---CKTFgNPPLSTKQED 153
                          170
                   ....*....|..
gi 205360930   401 FQFDKMEVWAVG 412
Cdd:smart00584 154 FLILDIEVWGFG 165
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
268-412 5.27e-46

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 156.23  E-value: 5.27e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930  268 LLFSSELHGHSFSQLCGHITHRGPCVAVLEDHDKHVFGGFASCSWEVKPQ-FQGDNRCFLFSICPSMAVYTHTGYNDHYM 346
Cdd:pfam07534   1 LLYSTSRDGSSYQTFLEKIDNKGPTLLIIKDNDGYIFGAFASQPWKVSGKkFYGDGESFLFSLSPQFDPYKWTGKNNAYF 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205360930  347 YLNHgqqtipNGLGMGGQHNYFGLWVDVDFGKGHSRakpTCTTYNSPQLSA--QENFQFDKMEVWAVG 412
Cdd:pfam07534  81 NCTS------DGLGFGGGQPKFDLWIDSDLEFGYSR---HCETFGNGQLSGsgQERFKIDDVEVWGLG 139
OXR1 COG5142
Oxidation resistance protein [DNA replication, recombination, and repair];
266-412 1.76e-10

Oxidation resistance protein [DNA replication, recombination, and repair];


Pssm-ID: 227471  Cd Length: 212  Bit Score: 60.68  E-value: 1.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930 266 WCLLFSSELHG---HSFSQLCGHIT---HRGPCVAVLEDHDKHVFGGFASCSWEVKPQFQGDNRCFLFS--------ICP 331
Cdd:COG5142   59 WRLLYSLFENGfslRTFYESFGENEwpfRRVGFVLACRDKDGDLFGAFFEDRIRPARHYYGRDEMFLWKaarrpadrLAD 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930 332 S-MAVYTHTGYNDHYMYlnhgqqTIPNGLGMGGQHNYFGLWVDVDFGKGHSraKPTCTTYNSPQLSAQENFQFDKMEVWA 410
Cdd:COG5142  139 KeVAVYPISGGKGFGIY------CTPDFLAFGCGGGRYGLLIDKSLLDGES--HPVETFGNCLLSSKGHFFRIVYLELWL 210

                 ..
gi 205360930 411 VG 412
Cdd:COG5142  211 VQ 212
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
244-412 3.05e-66

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 209.49  E-value: 3.05e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930   244 SILDVLSVMYINAQLPREQRHR-WCLLFSSELHGHSFSQLCGHIT-HRGPCVAVLEDHDKHVFGGFASCSWEVKPQFQGD 321
Cdd:smart00584   2 SILSEEILALINSHLPTRAEGYpWTLLYSSSQHGYSLNTLYRKVEgYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYGT 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930   322 NRCFLFSICPSMAVYTHTGYNdHYMYLNHGQQTIPNGLGMGGqhnyFGLWVDVDFGKGHSRAkptCTTY-NSPQLSAQEN 400
Cdd:smart00584  82 GESFLFQLNPKFVVYDWTGKN-KYYYINGTPDSLPIGGGGGG----FGLWIDEDLNHGSSSH---CKTFgNPPLSTKQED 153
                          170
                   ....*....|..
gi 205360930   401 FQFDKMEVWAVG 412
Cdd:smart00584 154 FLILDIEVWGFG 165
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
268-412 5.27e-46

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 156.23  E-value: 5.27e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930  268 LLFSSELHGHSFSQLCGHITHRGPCVAVLEDHDKHVFGGFASCSWEVKPQ-FQGDNRCFLFSICPSMAVYTHTGYNDHYM 346
Cdd:pfam07534   1 LLYSTSRDGSSYQTFLEKIDNKGPTLLIIKDNDGYIFGAFASQPWKVSGKkFYGDGESFLFSLSPQFDPYKWTGKNNAYF 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205360930  347 YLNHgqqtipNGLGMGGQHNYFGLWVDVDFGKGHSRakpTCTTYNSPQLSA--QENFQFDKMEVWAVG 412
Cdd:pfam07534  81 NCTS------DGLGFGGGQPKFDLWIDSDLEFGYSR---HCETFGNGQLSGsgQERFKIDDVEVWGLG 139
OXR1 COG5142
Oxidation resistance protein [DNA replication, recombination, and repair];
266-412 1.76e-10

Oxidation resistance protein [DNA replication, recombination, and repair];


Pssm-ID: 227471  Cd Length: 212  Bit Score: 60.68  E-value: 1.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930 266 WCLLFSSELHG---HSFSQLCGHIT---HRGPCVAVLEDHDKHVFGGFASCSWEVKPQFQGDNRCFLFS--------ICP 331
Cdd:COG5142   59 WRLLYSLFENGfslRTFYESFGENEwpfRRVGFVLACRDKDGDLFGAFFEDRIRPARHYYGRDEMFLWKaarrpadrLAD 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360930 332 S-MAVYTHTGYNDHYMYlnhgqqTIPNGLGMGGQHNYFGLWVDVDFGKGHSraKPTCTTYNSPQLSAQENFQFDKMEVWA 410
Cdd:COG5142  139 KeVAVYPISGGKGFGIY------CTPDFLAFGCGGGRYGLLIDKSLLDGES--HPVETFGNCLLSSKGHFFRIVYLELWL 210

                 ..
gi 205360930 411 VG 412
Cdd:COG5142  211 VQ 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH