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Conserved domains on  [gi|1519473601|ref|NP_065826|]
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endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ephrin_rec_like super family cl06646
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 272-311 4.95e-03

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


The actual alignment was detected with superfamily member pfam07699:

Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 35.79  E-value: 4.95e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1519473601  272 TSECFPCKPGTYADKQGSSFCKLCPANSYSNK-GETSCHQC 311
Cdd:pfam07699    8 LEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSpGATSISDC 48
VSP super family cl31427
Giardia variant-specific surface protein;
275-414 5.62e-03

Giardia variant-specific surface protein;


The actual alignment was detected with superfamily member pfam03302:

Pssm-ID: 146106 [Multi-domain]  Cd Length: 397  Bit Score: 40.34  E-value: 5.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473601  275 CFPCKPGT--YADKQ---GSSFCKLCPANSYSNKGETSCHQCDPDKYSEKgSSSCNvrPACTDKDYFYTHTACDANgetq 349
Cdd:pfam03302    1 CDECKPGYelSADKTkctSSAPCKTENCKACSNDKREVCEECNSNNYLTP-TSQCI--DDCAKIGNYYYTTNANNK---- 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1519473601  350 lmykwakpKICSEDLEGAVKLPASgvKTHCPPCNPGFFKtNNSTCQPC--PYGSYSNG--SDCTRCPAG 414
Cdd:pfam03302   74 --------KICKECTVANCKTCED--QGQCQACNDGFYK-SGDACSPCheSCKTCSGGtaSDCTECLTG 131
 
Name Accession Description Interval E-value
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 272-311 4.95e-03

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 35.79  E-value: 4.95e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1519473601  272 TSECFPCKPGTYADKQGSSFCKLCPANSYSNK-GETSCHQC 311
Cdd:pfam07699    8 LEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSpGATSISDC 48
VSP pfam03302
Giardia variant-specific surface protein;
275-414 5.62e-03

Giardia variant-specific surface protein;


Pssm-ID: 146106 [Multi-domain]  Cd Length: 397  Bit Score: 40.34  E-value: 5.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473601  275 CFPCKPGT--YADKQ---GSSFCKLCPANSYSNKGETSCHQCDPDKYSEKgSSSCNvrPACTDKDYFYTHTACDANgetq 349
Cdd:pfam03302    1 CDECKPGYelSADKTkctSSAPCKTENCKACSNDKREVCEECNSNNYLTP-TSQCI--DDCAKIGNYYYTTNANNK---- 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1519473601  350 lmykwakpKICSEDLEGAVKLPASgvKTHCPPCNPGFFKtNNSTCQPC--PYGSYSNG--SDCTRCPAG 414
Cdd:pfam03302   74 --------KICKECTVANCKTCED--QGQCQACNDGFYK-SGDACSPCheSCKTCSGGtaSDCTECLTG 131
 
Name Accession Description Interval E-value
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 272-311 4.95e-03

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 35.79  E-value: 4.95e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1519473601  272 TSECFPCKPGTYADKQGSSFCKLCPANSYSNK-GETSCHQC 311
Cdd:pfam07699    8 LEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSpGATSISDC 48
VSP pfam03302
Giardia variant-specific surface protein;
275-414 5.62e-03

Giardia variant-specific surface protein;


Pssm-ID: 146106 [Multi-domain]  Cd Length: 397  Bit Score: 40.34  E-value: 5.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473601  275 CFPCKPGT--YADKQ---GSSFCKLCPANSYSNKGETSCHQCDPDKYSEKgSSSCNvrPACTDKDYFYTHTACDANgetq 349
Cdd:pfam03302    1 CDECKPGYelSADKTkctSSAPCKTENCKACSNDKREVCEECNSNNYLTP-TSQCI--DDCAKIGNYYYTTNANNK---- 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1519473601  350 lmykwakpKICSEDLEGAVKLPASgvKTHCPPCNPGFFKtNNSTCQPC--PYGSYSNG--SDCTRCPAG 414
Cdd:pfam03302   74 --------KICKECTVANCKTCED--QGQCQACNDGFYK-SGDACSPCheSCKTCSGGtaSDCTECLTG 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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